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| 1 | A Review on Cable-driven Parallel Robots显示文摘Cable-driven parallel robots(CDPRs) are categorized as a type of parallel manipulators. In CDPRs, flexible cables are used to take the place of rigid links. The particular property of cables provides CDPRs several advantages, including larger workspaces, higher payload-to-weight ratio and lower manufacturing costs rather than rigid-link robots. In this paper, the history of the development of CDPRs is introduced and several successful latest application cases of CDPRs are presented. The theory development of CDPRs is introduced focusing on design, performance analysis and control theory. Research on CDPRs gains wide attention and is highly motivated by the modern engineering demand for large load capacity and workspace. A number of exciting advances in CDPRs are summarized in this paper since it is proposed in the 1980 s, which points to a fruitful future both in theory and application. In order to meet the increasing requirements of robot in different areas, future steps foresee more in-depth research and extension applications of CDPRs including intelligent control, composite materials, integrated and reconfigurable design. | Sen Qian Bin Zi Wei-Wei Shang Qing-Song Xu | 2018 | Chinese Journal of Mechanical Engineering2018，31，4： | 19 |
| 2 | Increased Chondrocyte Apoptosis in Kashin-Beck Disease and Rats Induced by T-2 Toxin and Selenium Deficiency显示文摘Objective To investigate chondrocyte apoptosis and the expression of biochemical markers associated with apoptosis in Kashin-Beck disease(KBD) and in an established T-2 toxin-and selenium(Se) deficiency-induced rat model. Methods Cartilages were collected from the hand phalanges of five patients with KBD and five healthy children. Sprague-Dawley rats were administered a selenium-deficient diet for 4 weeks prior to T-2 toxin exposure. The apoptotic chondrocytes were observed by terminal deoxynucleotidyl transferase d UTP nick end labeling staining. Caspase-3, p53, Bcl-2, and Bax proteins in the cartilages were visualized by immunohistochemistry, their protein levels were determined by Western blotting, and m RNA levels were determined by real-time reverse transcription polymerase chain reaction. Results Increased chondrocyte apoptosis was observed in the cartilages of children with KBD. Increased apoptotic and caspase-3-stained cells were observed in the cartilages of rats fed with normal and Se-deficient diets plus T-2 toxin exposure compared to those in rats fed with normal and Se-deficient diets. Caspase-3, p53, and Bax proteins and m RNA levels were higher, whereas Bcl-2 levels were lower in rats fed with normal or Se-deficiency diets supplemented with T-2 toxin than the corresponding levels in rats fed with normal diet. Conclusion T-2 toxin under a selenium-deficient nutritional status induces chondrocyte death, which emphasizes the role of chondrocyte apoptosis in cartilage damage and progression of KBD. | YANG Hao Jie ZHANG Ying WANG Zhi Lun XUE Sen Hai LI Si Yuan ZHOU Xiao Rong ZHANG Meng FANG Qian WANG Wen Jun CHEN Chen DENG Xiang Hua CHEN Jing Hong | 2017 | Biomedical and Environmental Sciences2017，30，5： | 7 |
| 3 | Neuroimage-Based Consciousness Evaluation of Patients with Secondary Doubtful Hydrocephalus Before and After Lumbar Drainage显示文摘Hydrocephalus is often treated with a cerebrospinal fluid shunt(CFS) for excessive amounts of cerebrospinal fluid in the brain.However,it is very difficult to distinguish whether the ventricular enlargement is due to hydrocephalus or other causes,such as brain atrophy after brain damage and surgery.The non-trivial evaluation of the consciousness level,along with a continuous drainage test of the lumbar cistern is thus clinically important before the decision for CFS is made.We studied 32 secondary mild hydrocephalus patients with different consciousness levels,who received T1 and diffusion tensor imaging magnetic resonance scans before and after lumbar cerebrospinal fluid drainage.We applied a novel machine-learning method to find the most discriminative features from the multi-modal neuroimages.Then,we built a regression model to regress the JFK Coma Recovery Scale-Revised(CRS-R) scores to quantify the level of consciousness.The experimental results showed that our method not only approximated the CRS-R scores but also tracked the temporal changes in individual patients.The regression model has high potential for the evaluation of consciousness in clinical practice. | Jiayu Huo Zengxin Qi Sen Chen Qian Wang Xuehai Wu Di Zang Tanikawa Hiromi Jiaxing Tan Lichi Zhang Weijun Tang Dinggang Shen | 2020 | Neuroscience Bulletin2020，36，9： | 7 |
| 4 | Algebraic Method‑Based Point‑to‑Point Trajectory Planning of an Under‑Constrained Cable‑Suspended Parallel Robot with Variable Angle and Height Cable Mast显示文摘To avoid impacts and vibrations during the processes of acceleration and deceleration while possessing flexible working ways for cable-suspended parallel robots(CSPRs),point-to-point trajectory planning demands an under-constrained cable-suspended parallel robot(UCPR)with variable angle and height cable mast as described in this paper.The end-effector of the UCPR with three cables can achieve three translational degrees of freedom(DOFs).The inverse kinematic and dynamic modeling of the UCPR considering the angle and height of cable mast are completed.The motion trajectory of the end-effector comprising six segments is given.The connection points of the trajectory segments(except for point P3 in the X direction)are devised to have zero instantaneous velocities,which ensure that the acceleration has continuity and the planned acceleration curve achieves smooth transition.The trajectory is respectively planned using three algebraic methods,including fifth degree polynomial,cycloid trajectory,and double-S velocity curve.The results indicate that the trajectory planned by fifth degree polynomial method is much closer to the given trajectory of the end-effector.Numerical simulation and experiments are accomplished for the given trajectory based on fifth degree polynomial planning.At the points where the velocity suddenly changes,the length and tension variation curves of the planned and unplanned three cables are compared and analyzed.The OptiTrack motion capture system is adopted to track the end-effector of the UCPR during the experiment.The effectiveness and feasibility of fifth degree polynomial planning are validated. | Tao Zhao Bin Zi Sen Qian Jiahao Zhao | 2020 | Chinese Journal of Mechanical Engineering2020，33，4： | 7 |
| 5 | FRUCTOKINASE-LIKE PROTEIN 1 interacts with TRXz to regulate chloroplast development in rice显示文摘Chloroplast genes are transcribed by the plastidencoded RNA polymerase(PEP) or nucleus-encoded RNA polymerase. FRUCTOKINASE-LIKE PROTEINS(FLNs) are phosphofructokinase-B(Pfk B)-type carbohydrate kinases that act as part of the PEP complex; however, the molecular mechanisms underlying FLN activity in rice remain elusive.Previously, we identified and characterized a heat-stress sensitive albino(hsa_1) mutant in rice. Map-based cloning revealed that HSA_1 encodes a putative OsFLN_2. Here, we further demonstrated that knockdown or knockout of the OsFLN_1, a close homolog of HSA_1/OsFLN_2, considerably inhibits chloroplast biogenesis and the fln_1 knockout mutants, created by clustered regularly interspaced short palindromic repeats(CRISPR) and CRISPR-associate protein_9, exhibit severe albino phenotype and seedling lethality. Moreover, OsFLN_1 localizes to the chloroplast.Yeast two-hybrid, pull-down and bimolecular fluorescencecomplementation experiments revealed that OsFLN_1 and HSA_1/OsFLN_2 interact with THIOREDOXINZ(OsTRXz) to regulate chloroplast development. In agreement with this,knockout of OsTRXz resulted in a similar albino and seedling lethality phenotype to that of the fln_1 mutants. Quantitative reverse transcription polymerase chain reaction and immunoblot analysis revealed that the transcription and translation of PEP-dependent genes were strongly inhibited in fln_1 and trxz mutants, indicating that loss of OsFLN_1, HSA_1/OsFLN_2, or OsTRXz function perturbs the stability of the transcriptionally active chromosome complex and PEP activity. These results show that OsFLN_1 and HSA_1/OsFLN_2 contribute to chloroplast biogenesis and plant growth. | Lei He Sen Zhang Zhennan Qiu Juan Zhao Wendan Nie Haiyan Lin Zhengge Zhu Dali Zeng Qian Qian Li Zhu | 2018 | Journal of Integrative Plant Biology2018，60，2： | 6 |
| 6 | Plate-like carbon-supported Fe_(3)C nanoparticles with superior electrochemical performance显示文摘Iron-based anodes for lithium-ion batteries(LIBs)with higher theoretical capacity,natural abundance and cheapness have received considerable attention,but they still suffer from the fast capacity fading.To address this issue,we report a facile synthesis of plate-like carbonsupported Fe_(3)C nanoparticles through chemical blowing/carbonization under calcination.The ultrafine Fe_(3)C nanoparticles are prone to be oxidized when exposing in air;thus,Fe_(3)C/C with mild oxidization and the fully oxidized product of Fe_(2)O_(3)/C are successfully prepared by controlling the oxidization condition.When applied as an anode material in LIB,the Fe_(3)C/C electrode demonstrates excellent cycle stability(826 mAh·g^(-1)after 120 cycles under 500 mA·g^(-1))and rate performance(410.6 mAh·g^(-1) under 2 A·g^(-1)),compared with the Fe_(2)O_(3)/C counterpart.The enhanced electrochemical performance can be ascribed to the synergetic effect of the Fe_(3)C with mild oxidation and the unique hierarchical structure of plate-like carbon decorated with Fe_(3)C catalyst.More importantly,this work may offer new approaches to synthesize other transition metal(e.g.,Co,Ni)-based anode material by replacing the precursor ingredient. | Chuan Chen Sen Qian Tian-Hao Yao Jing-Hong Guo Hong-Kang Wang | 2021 | Rare Metals2021，40，6： | 2 |
| 7 | Spectral and spatial complexitybased hyperspectral unmixing显示文摘 | Jia Sen Qian Yuntao | | 0，，12： | 1 |
| 8 | Hyperspeetral Unmixing via L1/2 Sparsity-Constrained Nonnegative Matrix Factorization 显示文摘 | QIAN Yuntao JIA Sen ZHOU Jun | 2011 | IEEE Trans Geo Remote Se2011，49，11： | 1 |
| 9 | New Algorithm Rules Out Acute-on-chronic Liver Failure Development within 28 Days from Acute Decompensation of Cirrhosis显示文摘Background and Aims:Approximately 10%of patients with acute decompensated(AD)cirrhosis develop acute-on-chronic liver failure(ACLF)within 28 days.Such cases have high mortality and are difficult to predict.Therefore,we aimed to establish and validate an algorithm to identify these patients on hospitalization.Methods:Hospitalized patients with AD who developed ACLF within 28 days were considered pre-ACLF.Organ dysfunction was defined accord-ing to the chronic liver failure-sequential organ failure as-sessment(CLIF-SOFA)criteria,and proven bacterial infec-tion was taken to indicate immune system dysfunction.A retrospective multicenter cohort and prospective one were used to derive and to validate the potential algorithm,re-spectively.A miss rate of<5%was acceptable for the calcu-lating algorithm to rule out pre-ACLF.Results:In the deri-vation cohort(n=673),46 patients developed ACLF within 28 days.Serum total bilirubin,creatinine,international normalized ratio,and present proven bacterial infection at admission were associated with the development of ACLF.AD patients with≥2 organ dysfunctions had a higher risk for pre-ACLF patients[odds ratio=16.58195%confidence interval:(4.271-64.363),p<0.001].In the derivation co-hort,67.5%of patients(454/673)had≤1 organ dysfunction and two patients(0.4%)were pre-ACLF,with a miss rate of 4.3%(missed/total,2/46).In the validation cohort,65.9%of patients(914/1388)had≤1 organ dysfunction,and four(0.3%)of them were pre-ACLF,with a miss rate of 3.4%(missed/total,4/117).Conclusions:AD patients with≤1 organ dysfunction had a significantly lower risk of developing ACLF within 28 days of admission and could be safely ruled out with a pre-ACLF miss rate of<5%. | Xiaoting Tang Hai Li Guohong Deng Xin Zheng Xianbo Wang Yan Huang Yanhang Gao Zhongji Meng Zhiping Qian Feng Liu Xiaobo Lu Yu Shi Beiling Li Wenyi Gu Xiaomei Xiang Yan Xiong Yixin Hou Jun Chen Na Gao Sen Luo Liujuan Ji Jing Li Rongjiong Zheng Haotang Ren Jinjun Chen | 2023 | Journal of Clinical and Translational Hepatology2023，11，3： | 1 |
| 10 | Constrained nonnegative matrix factorization for hyperspectral unmixing显示文摘 | Jia Sen Qian Yuntao | | 0，，01： | 1 |
| 11 | Localization,obstacle avoidance planning and control of a cooperative cable parallel robots for multiple mobile cranes显示文摘 | ZI Bin LIN Jun QIAN Sen | 2015 | Robotics and Computer-Integrated Manufacturing2015，34，： | 1 |
| 12 | Fecal Nucleic Acid Test as a Complementary Standard for Cured COVID-19 Patients显示文摘To date,no vaccine or specific antiviral treatment is yet available for COVID-19.The most effective control measures for the disease mainly depend on early diagnosis,strict patient quarantine,and close contact monitoring[1].Thus,reliable and accurate diagnostic methods play a critical role in global disease control and prevention.Reverse transcription-polymerase chain reaction(RT-PCR)assays are widely used for the laboratory diagnosis of virus-borne diseases. | HAN Mei ZOU Jing Bo LI Huan WEI Xiao Yu YANG Song ZHANG Hui Zheng WANG Peng Sen QIU Qian WANG Le Le CHEN Yao Kai PAN Pin Liang | 2020 | Biomedical and Environmental Sciences2020，33，12： | 1 |
| 13 | Self-Adaptive Grinding for Blind Tip Reconstruction of AFM Diamond Probe显示文摘Blind tip reconstruction(BTR) method is one of the favorable methods to estimate the atomic force microscopy(AFM) probe shape. The exact shape of the characterizer is not required for BTR, while the geometry of the sample may affect the reconstruction significantly. A cone-shaped array sample was chosen as a characterizer to be evaluated. The target AFM probe to be reconstructed was a diamond triangular pyramid probe with two feature angles, namely front angle(FA) and back angle(BA). Four conical structures with different semi-angles were dilated by the pyramid probe. Simulation of scanning process demonstrates that it is easy to judge from the images of the isolated rotary structure, cone-shaped, the suitability of the sample to be a tip characterizer for a pyramid probe. The cone-shaped array sample was repeatedly scanned 50 times by the diamond probe using an AFM. The series of scanning images shrank gradually and more information of the probe was exhibited in the images, indicating that the characterizer has been more suitable for BTR. The feature angle FA of the characterizer increasingly reduces during the scanning process. A self-adaptive grinding between the probe and the characterizer contributes to BTR of the diamond pyramid probe. | Linyan Xu Qishan Guo Shuangbei Qian Sen Wu | 2018 | Nanotechnology and Precision Engineering2018，1，2： | 1 |
| 14 | Expression of the SOD gene from Trichoderma harzianum in Saccharomyces cerevisiae显示文摘Superoxide dismutases are metalloproteins which play a major role in defense against oxygen radical-mediated toxicity in aerobic organisms.Such proteins are important endogeneity cytoprotection factor in-volving defence.A 751-bp full-length cDNA sequence of an SOD gene was isolated from the Tr/chodermaharzianum.The full-length cDNA of the SOD gene consists of one 465-bp open reading frame nu-cleotide,which encodes a 15.7-kDa polypeptide consisting of 154 amino acid residues.Sequence analy-sis revealed that SOD gene has more than 72%-86% amino acid sequence homology with those of otherfungi.The SOD gene was integrated into the genomic DNA of pYES2 by insertion into a single site for re-combination,yielding the recombinant pYES2-SOD.SOD expressed by pYES2-SOD was induced bygalactose.We test whether SOD could offer abiotic stress resistance when it was introduced into yeastcells.A transgenic yeast harboring T.harzianum SOD was generated under the control of a constitutivelyexpressed GAL promoter.The results indicated that SOD yeast transformants had significantly higher re-sistance to salt and drought stress. | 杨力明 Yang Qian Liu Pigang Li Sen | 2008 | High Technology Letters2008，14，3： | 1 |
| 15 | Design and analysis of cooperative cable parallel manipulators for multiple mobile cranes显示文摘 | ZI Bin QIAN Sen DING Huafeng | 2012 | International journal of advanced robotic systems2012，9，： | 1 |
| 16 | Constrained Nonnegative Ma-trix Factorization for Hyperspectral Unmixing 显示文摘 | Jia Sen Qian Yuntao | 2009 | IEEE Transactions on Geoscience and Remote Sens-ing2009，47，1： | 1 |
| 17 | A new design of large area MCP-PMT for the next generation neutrino experiment显示文摘 | Wang Yifang Qian Sen Zhao T | 2012 | Nuclear Instruments and Methods in Physics Research A:Accelerators Spectrometers Detectors and Associated Equipment2012，695，： | 1 |
| 18 | Explicit formulas for pricing of callable mortgage-backed securities in a case of prepayment rate negatively correlated with interest rates显示文摘 | Xiao-song Qian Li-shang Jiang Cheng-long Xu Sen Wu | 2012 | Journal of Mathematical Analysis and Applications2012，，2： | 1 |
| 19 | Constrained nonnegative matrix factorization for hyperspectral unmixing显示文摘 | JIA Sen QIAN Yuntao | 2009 | IEEE Transactions Geoscience Remote Sensing2009，47，1： | 1 |
| 20 | Design and analysis of cooperative cable parallel manipulators for multiple mobile cranes 显示文摘 | ZI Bin SEN Qian DING Hua feng | 2012 | International Journal of Advanced Robotic Systems2012，9，207： | 1 |
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