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| 1 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 2 | Mn3O4 nanoparticles@reduced graphene oxide composite:An efficient electrocatalyst for artificial N2 fixation to NH3 at ambient conditions显示文摘Currently,industrial-scale NH3 production almost relies on energy-intensive Haber-Bosch process from atmospheric N2 with large amount of CO2 emission,while low-cost and high-efficient catalysts are demanded for the N2 reduction reaction (NRR).In this study,Mn3O4 nanoparticles@reduced graphene oxide (Mn3O4@rGO) composite is reported as an efficient NRR electrocatalyst with excellent selectivity for NH3 formation.In 0.1 M Na2SO4 solution,such catalyst obtains a NH3 yield of 17.4 μg·h^-1·mg^-1cat.and a Faradaic efficiency of 3.52% at-0.85 V vs.reversible hydrogen electrode.Notably,it also shows high electrochemical stability during electrolysis process.Density functional theory (DFT) calculations also demonstrate that the (112) planes of Mn3O4 possess superior NRR activity. | Hong Huang Feng Gong Yuan Wang Huanbo Wang Xiufeng Wu Wenbo Lu Runbo Zhao Hongyu Chen Xifeng Shi Abdullah M.Asiri Tingshuai Li Qian Liu Xuping Sun | 2019 | Nano Research2019，12，5： | 8 |
| 3 | Regulatory mechanism of hormones of the pituitary-target gland axes in kidney-Yang deficiency based on a support vector machine model显示文摘OBJECTIVE:To study the development mechanism of kidney-Yang deficiency through the establishment of support vector machine models of relevant hormones of the pituitary-target gland axes in rats with kidney-Yang deficiency syndrome.METHODS:The kidney-Yang deficiency rat model was created by intramuscular injection of hydrocortisone,and contents of the hormones of the pituita- ry-thyroid axis:thyroid stimulating hormone(TSH),3,3',5-triiodothyronine(T_3) and thyroxine(T_4);hormones of the pituitary-adrenal gland axis:adrenocorticotropic hormone(ACTH) and Cortisol(CORT);and hormones of the pituitary-gonadal axis:luteinizing hormone(LH),follicle-stimulating hormone(FSH),and testosterone(T),were determined in the early,middle,and advanced stages.Ten support vector regression(SVR) models of the hormones were established to analyze the mutual relationships among the hormones of the three axes.RESULTS:The feedback control action of the pituitary-adrenal axis began to lose efficacy from the middle stage of kidney-Kong deficiency.The contents all hormones of the three pituitary-target gland axes decreased in the advanced stage.Relative errors of the jackknife test of the SVR models all were less than 10%.CONCLUSION:Imbalances in mutual regulation among the hormones of the pituitary-target gland axes,especially loss of effectiveness of the pituitary-adrenal axis,is one pathogenesis of kidney-Yang deficiency.The SVR model can accurately reflect the complicated non-linear relationships among pituitary-target gland axes in rats with of kidney-Yang deficiency. | Wang Xiufeng Zhang Lei Huang Rongbo Wu Qinghua Min Jianxin Ma Na Luo Laicheng | 2015 | Journal of Traditional Chinese Medicine2015，35，2： | 7 |
| 4 | Integration of InSAR and GPS for hydraulic engineering显示文摘Interferometric synthetic aperture radar (InSAR) is a potential earth observation approach, and it has been demonstrated to have a variety of applications in measuring ground movement, urban subsidence and landslides. Currently InSAR provides the ability to map accurate DEM and measure ground deformation to sub-centimeter accuracy. However, many factors affect InSAR to measure ground movement since dam constructions are built in a large scale area with a complicated climate and unstable geology. This paper discusses potential applications of integrated InSAR and GPS to monitor a large-scale ground movement due to hydropower developments. The integration of InSAR and GPS can provide a cost-effective means for monitoring deformation of hydropower developments. Moreover, two novel methods, both the improved spatial interpolating method and estimation of 3D surface motion velocities method, are proposed and the experimental results and analysis are given in this paper. | HE XiuFeng LUO HaiBin HUANG QiHuan HE Min | 2007 | Science China(Technological Sciences)2007，50，z1： | 5 |
| 5 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 6 | Scheduling Policies for Federated Learning in Wireless Networks: An Overview显示文摘Due to the increasing need for massive data analysis and machine learning model training at the network edge, as well as the rising concerns about data privacy, a new distrib?uted training framework called federated learning (FL) has emerged and attracted much at?tention from both academia and industry. In FL, participating devices iteratively update the local models based on their own data and contribute to the global training by uploading mod?el updates until the training converges. Therefore, the computation capabilities of mobile de?vices can be utilized and the data privacy can be preserved. However, deploying FL in re?source-constrained wireless networks encounters several challenges, including the limited energy of mobile devices, weak onboard computing capability, and scarce wireless band?width. To address these challenges, recent solutions have been proposed to maximize the convergence rate or minimize the energy consumption under heterogeneous constraints. In this overview, we first introduce the backgrounds and fundamentals of FL. Then, the key challenges in deploying FL in wireless networks are discussed, and several existing solu?tions are reviewed. Finally, we highlight the open issues and future research directions in FL scheduling. | SHI Wenqi SUN Yuxuan HUANG Xiufeng ZHOU Sheng NIU Zhisheng | 2020 | ZTE Communications2020，18，2： | 2 |
| 7 | Association of assisted reproductive technology, germline de novo mutations and congenital heart defects in a prospective birth cohort study显示文摘Emerging evidence suggests that children conceived through assisted reproductive technology(ART)have a higher risk of congenital heart defects(CHDs)even when there is no family history.De novo mutation(DNM)is a well-known cause of sporadic congenital diseases;however,whether ART procedures increase the number of germline DNM(gDNM)has not yet been well studied.Here,we performed whole-genome sequencing of 1137 individuals from 160 families conceived through ART and 205 families conceived spontaneously.Children conceived via ART carried 4.59 more gDNMs than children conceived spontaneously,including 332 paternal and 1.26 maternal DNMs,after correcting for parental age at conception,cigarette smoking,alcohol drinking,and exercise behaviors.Paternal DNMs in offspring conceived via ART are characterized by C>T substitutions at CpG sites,which potentially affect protein-coding genes and are significantly associated with the increased risk of CHD.In addition,the accumulation of non-coding functional mutations was independently associated with CHD and 87.9% of the mutations were originated from the father.Among ART offspring,infertility of the father was associated with elevated paternal DNMs;usage of both recombinant and urinary follicle-stimulating hormone and high-dosage human chorionic gonadotropin trigger was associated with an increase of maternal DNMs.In sum,the increased gDNMs in offspring conceived by ART were primarily originated from fathers,indicating that ART itself may not be a major reason for the accumulation of gDNMs.Our findings emphasize the importance of evaluating the germline status of the fathers in families with the use of ART. | Cheng Wang Hong Lv Xiufeng Ling Hong Li Feiyang Diao Juncheng Dai Jiangbo Du Ting Chen Qi Xi Yang Zhao Kun Zhou Bo Xu Xiumei Han Xiaoyu Liu Meijuan Peng Congcong Chen Shiyao Tao Lei Huang Cong Liu Mingyang Wen Yangqian Jiang Tao Jiang Chuncheng Lu Wei Wu Di Wu Minjian Chen Yuan Lin Xuejiang Guo Ran Huo Jiayin Liu Hongxia Ma Guangfu Jin Yankai Xia Jiahao Sha Hongbing Shen Zhibin Hu | 2021 | Cell Research2021，31，8： | 2 |
| 8 | Application of low-emissivity Pt layer on Ni alloy to high temperature显示文摘Platinum films were sputter-deposited on two groups of nickel alloy substrates,in which the first group was the samples with rough surface,and the other group with polished surface.The platinum thin-films were applied to serve as the low-emissivity layers to reflect thermal radiation.Then,the platinum-coated samples were heated in air at 600℃ for 200 h to explore the effect of high-temperature environment on the emissivity of coated platinum film.After annealing,the average IR emissivity(at the wavelength of 3-14 μm) of the platinum film was only about 0.1 for polished sample and 0.45 for rough sample.The diffusion between platinum and the nickelalloy elements at 600℃ had been also discussed. | Zhibin HUANG Wancheng ZHOU Xiufeng TANG | 2010 | Acta Metallurgica Sinica(English Letters)2010，23，1： | 2 |
| 9 | A study on mental nurs- ing care of postoperative cervix cancer patients 显示文摘 | Lao Lifang Huang Xiufeng Xu Qianru | 2007 | Chinese Nursing Research2007，21，2： | 1 |
| 10 | Comparison of Mastoscopic and Conventional Axillary Lymph Node Dissection in Breast Cancer: Long-term Results From a Randomized, Multicenter Trial显示文摘 | Chengyu Luo Wenbin Guo Jie Yang Qiuru Sun Wei Wei Suhua Wu Shubing Fang Qingliang Zeng Zhensheng Zhao Fanjie Meng Xuandong Huang Xianlan Zhang Ruihua Li Xiufeng Ma Chaoying Luo Yun Yang | 2012 | Mayo Clinic Proceedings2012，，12： | 1 |
| 11 | Endometrial nerve fibers in women with endometriosis, adenomyosis, and uterine fibroids显示文摘 | Xinmei Zhang Bangchun Lu Xiufeng Huang Hong Xu Caiyun Zhou Jun Lin | 2009 | Fertility and Sterility2009，，5： | 1 |
| 12 | Seismic analysis of long span double-curved arch bridge 显示文摘 | ZHANG Yun HUANG Xiufeng LI Bei | 2012 | Advanced Materials Research2012，594，： | 1 |
| 13 | Construction of a single chain variable fragment antibody (scFv) against tetrodotoxin (TTX) and its interaction with TTX显示文摘 | Rongzhi Wang Ailing Huang Licai Liu Shuangshuang Xiang Xiufeng Li Sumei Ling Lei Wang Tun Lu Shihua Wang | 2014 | Toxicon2014，，： | 1 |
| 14 | Nerve fibers in ovarian endometriotic lesions in women with ovarian endometriosis显示文摘 | Xinmei Zhang Huijiao Yao Xiufeng Huang | 2010 | Hum Reprod2010，25，2： | 1 |
| 15 | Endometrial nerve fibers in women with endometriosis, adenomyosis, and uterine fibroids 显示文摘 | Xinmei Zhang Bangchun Lu Xiufeng Huang | 2009 | Fertil and Steril2009，92，5： | 1 |
| 16 | A nomogram predicting clinical pregnancy in the first fresh embryo transfer for women undergoing in vitro fertilization and intracytoplasmic sperm injection(IVF/ICSI) treatments显示文摘The extent to which factors affect the probability of clinical pregnancy in the first fresh embryo transfer after assisted conception is unknown.In order to examine the predictors of clinical pregnancy,a retrospective cohort study was launched between January 1,2013 and December 31,2016 in four infertility clinics including 19837 in vitro fertilization and intracytoplasmic sperm injection(IVF/ICSI)fresh cycles with known outcomes and relevant records.A multivariable logistic regression was used to select the most significant predictors in the final nomogram for predicting clinical pregnancy.Furthermore,the model was validated by an independent validation set and the performance of the model was evaluated by the receiver operating characteristic(ROC)curves along with the area under the ROC curve(AUC)and calibration plots.In a training set including 17854 participants,we identified that female age,tubal factor,number of embryos transferred,endometrial thickness and number of good-quality embryos were independent predictors for clinical pregnancy.We developed a nomogram using these five factors and the predictive ability was 0.66 for AUC(95%CI=0.64−0.68),which was independently validated in the validation set(AUC=0.66,95%CI=0.65−0.68).Our results show that some specific factors can be used to provide infertile couples with an accurate assessment of clinical pregnancy following assisted conception and facilitate to guide couples and clinicians. | Fang Wu Feng Liu Yichun Guan Jiangbo Du Jichun Tan Hong Lv Qun Lu Shiyao Tao Lei Huang Kun Zhou Yankai Xia Xinru Wang Hongbing Shen Xiufeng Ling Feiyang Diao Zhibin Hu Guangfu Jin | 2019 | The Journal of Biomedical Research2019，33，6： | 1 |
| 17 | Analysis ofpopulation structure of Puccinia strii formis in YunnanProvince of China by using AFLP 显示文摘 | Xiufeng Liu Chong Huang Zhenyu Sun | 2011 | Eur J Plant Pathol2011，129，： | 1 |
| 18 | Effects of substrate roughness on infrared - emissivity character- istics of Au films deposited on Nialloy 显示文摘 | Zhibin Huang Wancheng Zhou Xiufeng Tang | 2011 | Thin Solid Films2011，519，： | 1 |
| 19 | Genetic evidence supports demic diffusion of Han culture显示文摘 | LI Hui LU Daru SONG Xiufeng ZHANG Feng HE Yungang LI Feng GAO Yang MAO Xianyun ZHANG Liang QIAN Ji TAN Jingze JIN Jianzhong HUANG Wei DEKA Ranjan SU Bing CHAKRABORTY Ranajit JIN Li | | NATURE0，2004，： | 1 |
| 20 | Effective modification of MgO with surface transition metal oxides for NF_3 decomposition显示文摘NF3 decomposition over transition metal oxides coated MgO reagents in the absence of water is investigated. The results show that NF3 can be decomposed completely over pure MgO but the time of NF3 steady full conversion kept as short as 80 min, while the reactivities of coated MgO reagents were remarkably enhanced by transition metal oxides, for example the time of NF3 complete conversion over 12%Fe/MgO extended to 380 min. It is suggested that not only an increase in surface area but also a significant enhancement in the fluorination of MgO substrate caused by the surface transition metal oxides result in an improved reactivity of coated MgO reagents for NF3 decomposition. | Yanan Wang Xiufeng Xu PeiSheng Hongguang Li Tingting Wang Youfen Huang Fangshu Liu | 2011 | Journal of Natural Gas Chemistry2011，20，5： | 1 |
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