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| 1 | CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta,alpha,beta,and gamma显示文摘SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,compromising the effectiveness of existing vaccines and neutralizing antibodies.An in-depth investigation on COVID-19 pathogenesis is urgently needed to develop a strategy against SARS-CoV-2 variants.Here,we identified CD147 as a universal receptor for SARS-CoV-2 and its variants.Meanwhile,Meplazeumab,a humanized anti-CD147 antibody,could block cellular entry of SARS-CoV-2 and its variants-alpha,beta,gamma,and delta,with inhibition rates of 68.7,75.7,52.1,52.1,and 62.3%at 60μg/ml,respectively.Furthermore,humanized CD147 transgenic mice were susceptible to SARS-CoV-2 and its two variants,alpha and beta.When infected,these mice developed exudative alveolar pneumonia,featured by immune responses involving alveoli-infiltrated macrophages,neutrophils,and lymphocytes and activation of IL-17 signaling pathway.Mechanistically,we proposed that severe COVID-19-related cytokine storm is induced by a'spike protein-CD147-CyPA signaling axis':Infection of SARS-CoV-2 through CD147 initiated the JAK-STAT pathway,which further induced expression of cyclophilin A(CyPA);CyPA reciprocally bound to CD147 and triggered MAPK pathway.Consequently,the MAPK pathway regulated the expression of cytokines and chemokines,which promoted the development of cytokine storm.Importantly,Meplazumab could effectively inhibit viral entry and inflammation caused by SARS-CoV-2 and its variants.Therefore,our findings provided a new perspective for severe COVID-19-related pathogenesis.Furthermore,the validated universal receptor for SARS-CoV-2 and its variants can be targeted for COVID-19 treatment. | Jiejie Geng Liang Chen Yufeng Yuan Ke Wang Youchun Wang Chuan Qin Guizhen Wu Ruo Chen Zheng Zhang Ding Wei Peng Du Jun Zhang Peng Lin Kui Zhang Yongqiang Deng Ke Xu Jiangning Liu Xiuxuan Sun Ting Guo Xu Yang Jiao Wu Jianli Jiang Ling Li Kun Zhang Zhe Wang Jing Zhang Qingguo Yan Hua Zhu Zhaohui Zheng Jinlin Miao Xianghui Fu Fengfan Yang Xiaochun Chen Hao Tang Yang Zhang Ying Shi Yumeng Zhu Zhuo Pei Fei Huo Xue Liang Yatao Wang Qingyi Wang Wen Xie Yirong Li Mingyan Shi Huijie Bian Ping Zhu Zhi-Nan Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 2 | A unified study of continuous and discontinuous Galerkin methods显示文摘A unified study is presented in this paper for the design and analysis of different finite element methods(FEMs), including conforming and nonconforming FEMs, mixed FEMs, hybrid FEMs, discontinuous Galerkin(DG) methods, hybrid discontinuous Galerkin(HDG) methods and weak Galerkin(WG) methods.Both HDG and WG are shown to admit inf-sup conditions that hold uniformly with respect to both mesh and penalization parameters. In addition, by taking the limit of the stabilization parameters, a WG method is shown to converge to a mixed method whereas an HDG method is shown to converge to a primal method. Furthermore,a special class of DG methods, known as the mixed DG methods, is presented to fill a gap revealed in the unified framework. | Qingguo Hong Fei Wang Shuonan Wu Jinchao Xu | 2019 | Science China Mathematics2019，62，1： | 5 |
| 3 | Modified micro-mechanics based multiscale model for progressive failure prediction of 2D twill woven composites显示文摘To consider fiber random distribution at the microscale for the multiscale model based on the micro-mechanics failure(MMF)theory,clustering method is used for the extraction of amplification factors.As the clustering method is a kind of unsupervised machine learning method,the elements with similar mechanical behavior under external loading can be included in a cluster automatically at the microscale.With this modification,the fiber random distribution model can be used for multiscale damage analysis in the framework of MMF theory.To validate the modified multiscale analysis method,progressive damage analysis of a kind of 2D twill woven composites is conducted based on different microscale models.The stress values for microscale models with fiber hexagonal and random distribution patterns are compared first.Much higher stress concentration is generated in the fiber random distribution model due to the smaller inter-fiber distance especially under longitudinal shear loading.The obtained cluster distribution results exhibit the characters of the stress distribution in the two microscale models.Thereafter,tensile and compressive responses of the 2D twill woven composite are predicted with the modified multiscale analysis method and accuracy of the method is verified through comparison with published experimental results.From the simulation results,it can be found that the matrix damage initiation from the model based on the fiber random distribution model is premature compared with that from the model based on the fiber hexagonal distribution model.Besides,under tensile loading,the damage all initiates from the fill tows and propagates to the wrap tows.However,under compressive loading,the matrix damage initiates from the wrap tows in the model based on the fiber random distribution model. | Meng WANG Peiwei ZHANG Qingguo FEI Fei GUO | 2020 | Chinese Journal of Aeronautics2020，33，7： | 4 |
| 4 | Modal identification of long-span Runyang Bridge using ambient responses recorded by SHMS显示文摘Runyang Bridge is a newly built cable-supported bridge that crosses the Yangtze River in China.The bridge is composed of one suspension bridge and one cable-stayed bridge.During the construction of the bridge,a structural health monitoring system(SHMS)was installed,which was designed by the Southeast University.Since the bridge was open to traffic,quantities of structural ambient responses have been recorded by the SHMS.And,it’s really important to extract structrural information from these records for health monitoring.This paper presents the study on modal identification of the bridge.The dynamic properites including modal frequencies,mode shapes and damping ratios are extracted from the ambient responses.Two identification methods are employed including the enhanced frequency domain decomposition and the stochastic subspace identification.The identified modal parameters from the two methods are compared.Results show that modal frequencies and mode shapes from the two methods are almost the same while the damping ratios are different. | QingGuo Fei AiQun Li XiaoLin Han ChangQing Miao | 2009 | Science China(Technological Sciences)2009，52，12： | 4 |
| 5 | Temperature-dependence of acoustic fatigue life for thermal protection structures显示文摘Acoustic fatigue life evaluation is essential for thermal protection structures due to the severe thermo-acoustic load in service. A study on temperaturedependence of acoustic fatigue life for a C/SiC panel is presented in this paper.Effects of temperature on both the structural responses and the S–N curves are investigated. The Dirlik method is adopted to predict the fatigue life of a C/SiC panel at three different temperatures respectively. Significant differences are observed from the results of numerical simulations between the fatigue lives of the panel in the three cases. The temperature-dependence of acoustic fatigue life of a C/SiC panel is verified, and fatigue test of the material needs to be more attentively performed. | Yadong Zhou Shaoqing Wu Zhiyong Tan Qingguo Fei | 2014 | Theoretical & Applied Mechanics Letters2014，4，2： | 3 |
| 6 | Numerical-experimental method for elastic parameters identification of a composite panel显示文摘A hybrid numerical-experimental approach to identify elastic modulus of a textile composite panel using vibration test data is proposed and investigated. Homogenization method is adopted to predict the initial values of elastic parameters of the composite, and parameter identification is transformed to an optimization problem in which the objective function is the minimization of the discrepancies between the experimental and numerical modal data. Case study is conducted employing a woven fabric reinforced composite panel. Three parameters(E11, E22, G12) with higher sensitivities are selected to be identified. It is shown that the elastic parameters can be accurately identified from experimental modal data. | Dong Jiang Rui Ma Shaoqing Wu Qingguo Fei | 2014 | Theoretical & Applied Mechanics Letters2014，4，6： | 3 |
| 7 | Feature combination for classifying single-trial ECoG during motor imagery of different sessions显示文摘大脑计算机接口(BCI ) 的输入信号可以是任何一个头皮脑电图(EEG ) 或 electrocorticogram (ECoG ) 从潜水艇记录硬脑膜的电极。使 BCI 实际,为区别不同大脑状态的分类器必须有 session-to-session 转移的能力。这篇论文为在不同会议的马达形象期间分类单个试用的 ECoG 建议一个算法。三个特征,源于二生理的现象,运动相关的潜力(MRP ) 和事件相关的 desynchronization (ERD ) ,并且由普通空间潜水艇空间分解(CSSD ) 和波形平均数提取了,被联合执行分类任务。利用的特定的信号处理方法详细被描述。算法成功地被用于设置的数据我 BCI 比赛 III,并且在测试集合上完成了 91% 的分类精确性。 | Wei Qingguo Meng Fei Wang Yijun Gao Xiaorong Gao Shangkai | 2007 | Progress in Natural Science:Materials International2007，17，7： | 3 |
| 8 | Frequency-dependent random fatigue of panel-type structures made of ceramic matrix composites显示文摘The panel-type structures used in aerospace engineering can be subjected to severe highfrequency acoustic loadings in service. This paper evaluates the frequency-dependent random fatigue of panel-type structures made of ceramic matrix composites(CMCs) under acoustic loadings. Firstly, the high-frequency random responses from the broadband random excitation will result in more stress cycles in a deinite period of time. The probability density distributions of stress amplitudes will be different in different frequency bandwidths, though the peak stress estimations are identical. Secondly, the fatigue properties of CMCs can be highly frequency-dependent. The fatigue evaluation method for the random vibration case is adopted to evaluate the fatigue damage of a representative stiffened panel structure. The frequency effect through S-N curves on random fatigue damage is numerically veriied. Finally, a parameter is demonstrated to characterize the mean vibration frequency of a random process, and hence this parameter can further be considered as a reasonable loading frequency in the fatigue tests of CMCs to obtain more reliable S-N curves.Therefore, the inluence of vibration frequency can be incorporated in the random fatigue model from the two perspectives. | Yadong Zhou Xiaochen Hang Shaoqing Wu Qingguo Fei Natasa Trisovic | 2017 | Acta Mechanica Solida Sinica2017，30，2： | 2 |
| 9 | Mesenchymal stem cells in progression and treatment of cancers显示文摘从骨头髓或本地纸巾的间充质的茎或 stromal 房间(MSC ) 在癌症的开始或前进期间被招募到癌症的几乎所有类型的基质。招募的 MSC 和他们的衍生物联系癌症的成纤维细胞与癌症房间交往支持癌症房间的 stemness,侵略和转移。指向在 MSC 和癌症房间之间的这些招募癌症的 MSC 或相互作用正在答应策略改进癌症治疗。在另一方面, MSC 的唯一的肿瘤家能力使他们成为有希望的车辆交付各种各样的反癌症代理人。这评论为癌症治疗在在 MSC 的 MSC 和癌症房间,以及潜力之间的相互作用上总结了我们的理解的最近的前进。 | Qingguo ZHAO Fei LIU | 2014 | Frontiers in Biology2014，9，3： | 2 |
| 10 | Dynamic finite element model updating using meta-model and genetic algorithm显示文摘 | Fei Qingguo Li Ai qun Miao Changqing | 2006 | Journal of Southeast University2006，22，2： | 1 |
| 11 | Feature extraction and damage Manning using time series analysis显示文摘 | Liu Yi Li Aiqun Fei Qingguo | 2007 | Journal of Southeast University2007，23，1： | 1 |
| 12 | Structural health monitoring oriented stability and dynamic analysis of a long-span transmission tower-line system 显示文摘 | Fei Qingguo Zhou Honggang Han Xiaolin | 2012 | Eng Fail Anal2012，20，3： | 1 |
| 13 | Structural healthmonitoring oriented stability and dynamic analysis of a long-spantransmission tower-line system显示文摘 | Fei Qingguo Zhou Honggang Han Xiaolin | 2012 | Eng Fail Anal2012，20，3： | 1 |
| 14 | Dynamic finite element model updating using meta-model and genetic algorithm显示文摘 | Fei Qingguo Li Aiqun Miao Changqing | 2006 | Journal of Southeast University2006，22，2： | 1 |
| 15 | Strain-Rate-Dependent In-Plane Compressive Properties of 3D Fine Weave Pierced C/C Composite:Failure Mechanism and Constitutive Model显示文摘In-plane compression experiments are performed on 3D fine weave pierced C/C composite at a wide strain rate range of 0.0001/s-1000/s.The in-plane compressive failure mechanism of the composite at quasi-static and high strain rates is analyzed by a scanning electron microscope.The results show that the in-plane compressive modulus,maximum stress and the corresponding strain increase with increasing strain rate.The quasi-static in-plane compressive failure mode of the 3D fine weave pierced C/C composite is characterized by the shear failure at the angle of 45°and the local buckling of the^direction fiber bundles.In comparison,the high strain rate in-plane compression failure mode of the composite is characterized by the compressive fracture of the interlaminar matrix and the progressive compression failure of the a>direction fiber bundles.A strain-rate-dependent in-plane compressive constitutive model is proposed to predict the dynamic in-plane compressive response of the composite.The proposed constitutive model is verified by experimental data. | Fei Guo Qingguo Fei Yanbin LiL Nikhil Gupta | 2022 | Acta Mechanica Solida Sinica2022，35，1： | 0 |
| 16 | 本刊英文版2019年62卷第1期摘要(英文)显示文摘A unified study of continuous and discontinuous Galerkin methods Qingguo Hong,Fei Wang,Shuonan Wu &Jinchao Xu Abstract A unified study is presented in this paper for the design and analysis of different finite element methods (FEMs),including conforming and nonconforming FEMs,mixed FEMs,hybrid FEMs,discontinuous Galerkin (DG)methods,hybrid discontinuous Galerkin (HDG)methods and weak Galerkin (WG)methods.Both HDG and WG are shown to admit inf-sup conditions that hold uniformly with respect to both mesh and penalization parameters.In addition,by taking the limit of the stabilization parameters,a WG method is shown to converge to a mixed method whereas an HDG method is shown to converge to a primal method.Furthermore,a special class of DG methods,known as the mixed DG methods,is presented to fill a gap revealed in the unified framework. | Qingguo Hong Fei Wang Shuonan Wu Jinchao Xu | 2019 | 中国科学:数学2019，49，1： | 0 |
| 17 | Fatigue Life of a 2.5D C/SiC Composite Under Tension–Tension Cyclic Loading:Experimental Investigation and Sensitivity Analysis显示文摘Engineering structures made of ceramic matrix composites(CMCs)usually suffer from cyclic loads during service,which could lead to disastrous failures.This work focuses on the fatigue behavior of a 2.5D C/SiC composite under tension–tension cyclic loading.Experiments of the 2.5D C/SiC composite are firstly carried out to determine the fatigue lifetime of the material at different stress levels.The fracture surfaces examined by a scanning electronic microscope indicate that the damage mechanisms under cyclic loading are closely related to crack propagation,fiber/matrix interfacial degradation,and fiber breakage.Considering the damage evolution of fibers and interfacial resistance,a micromechanical model is adopted to describe the fatigue behavior of 2.5D C/SiC composite,and the numerical results are compared with the experimental results.Further,a sensitivity analysis is performed as a function of the interfacial shear stress,fiber Weibull modulus,and fiber strength.The calculation of sensitivity factors shows that the variations of the fiber Weibull modulus and fiber strength have the most significant influence and,thereafter,the variation of interfacial shear stress. | Jingwei Yu Qingguo Fei Peiwei Zhang Yanbin Li Qiang Chen | 2021 | Acta Mechanica Solida Sinica2021，34，5： | 0 |
| 18 | Static analysis of elastic cable structures under mechanical load using discrete catenary theory显示文摘In this paper,the nonlinear mechanical response of elastic cable structures under mechanical load is studied based on the discrete catenary theory.A cable net is discretized into multiple nodes and edges in our numerical approach,which is followed by an analytical formulation of the elastic energy and the associated Hessian matrix to realize the dynamic simulation.A fully implicit framework is proposed based on the discrete differential geometry(DDG)theory.The equilibrium configuration of a target object is derived by adding damping force into the system,known as the dynamic relaxation method.The mechanical response of a single suspended cable is investigated and compared with the analytical solution for cross-validation.A more intricate scenario is further discussed in detail,where a structure consisting of multiple slender cables is connected through joints.Utilizing the robustness and efficiency of our discrete numerical framework,a systematic parameter sweep is performed to quantify the force displacement relationships of nets with the different number of cables and different directions of fibers.Finally,an empirical scaling law is provided to account for the rigidity of elastic cable net in terms of its geometric properties,material characteristics,component numbers,and cable orientations.Our results would provide new insight in revealing the connections between flexible structures and tensegrity structures,and could motivate innovative designs in both mechanical and civil engineered equipment. | Weicheng Huang Dongze He Dezhong Tong Yuzhen Chen Xiaonan Huang Longhui Qin Qingguo Fei | 2023 | Fundamental Research2023，3，6： | 0 |
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