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| 1 | New mutation points in 23S rRNA gene associated with Helicobacter pyloriresistance to clarithromycin in northeast China显示文摘AIM: TO investigate the resistance rate of Helicobacter pylori(H pylori) to clarithromycin, metronidazole, amoxicillin and tetracycline to guide clinical practice, and to study the mechanism of Hpylori resistant to clarithromycin. METHODS: Thirty Hpyloristrains were isolated from the mucosa of peptic ulcer, gastric tumor and chronic gastritis patients, then the minimal inhibitory concentration (MIC) to clarithromycin, metronidazole, amoxicillin and tetracycline was evaluated by E-test method. The sequence analysis of PCR fragments was conducted in 23S rRNA gene of H pylori resistant to clarithromycin to get the resistance mechanism of the bacteria. RESULTS: Among 30 Hpyloristrains, 7 cases were resistant to clarithromycin, 12 to metronidazole, 2 to tetracycline and no strain was found to be resistant to amoxicillin. The resistance rates were 23.3%, 40%, 6.7% and 0%, respectively. Three new mutation points were found to be related to the clarithromycin resistance in Hpyloriisolates, which were G2224A, C2245T and T2289C. CONCLUSION: In northeast China, H pylori shows high resistance to metronidazole, while sensitive to amoxicillin. The mechanism of resistance to clarithromycin may be related to the mutation of G2224A, C2245T and T2289C in the 23S rRNA gene. | QingHao YanLi Zhi-JieZhang YongLiu HongGao | 2004 | World Journal of Gastroenterology2004，10，7： | 23 |
| 2 | Design of unballasted track bridges on Beijing——Tianjin intercity railway显示文摘Beijing-Tianjin intercity railway is the first newly-built passenger dedicated line with operating speed of 350 km/h in our country. During design,new ideas of bridge construction were carried out to ensure the requirements of safety,comfort and stability of the train under high-speed condition. At the same time,concepts of environmental adaptability,service to transportation and comprehensive benefits were observed. On the whole line,long-bridge schemes were adopted and the most advanced technologies of unballasted track were utilized on bridges,the length of which accounts for 87.7 % of the total line. The success of design and construction of the bridges on this rail has accumulated valuable experience for high-speed railway construction on a large scale in the future,and made it a marking,demonstrating,and model project to follow. | Sun Shuli Zhang Wenjian Wang Zhaohu Su Wei Wu Cailan Bu Qinghao | 2011 | Engineering Sciences2011，9，4： | 3 |
| 3 | Novel C-17 spirost protostane-type triterpenoids from Alisma plantago-aquatica with antiinflammatory activity in Caco-2 cells显示文摘Twenty-one protostane-type triterpenoids with diverse structures, including nine new compounds(1 e9), were isolated from the of Alisma plantago-aquatica Linn. Structurally, alisolides A-F(1 e6), composed of an oxole group coupled to a five-membered ring, represent unusual C-17 spirost protostane-type triterpenoids. Alisolide H(8) is a novel triterpenoid with an unreported endoperoxide bridge. Alisolide I(9) represents the first example of 23,24-acetal triterpenoid. Their structures were elucidated based on spectroscopic analysis, wherein the absolute configurations of 4-6, 8 were further confirmed by the Mo2(OAc)4-induced ECD method. Furthermore, all isolates were evaluated for their inhibitory effects on LPS-induced NO production in Caco-2 cells, and all the compounds showed remarkable inhibitory activities, with IC50 values in the range of 0.76 e38.20 mmol/L. | Qinghao Jin Jianqing Zhang Jinjun Hou Min Lei Chen Liu Xia Wang Yong Huang Shuai Yao Bang Yeon Hwang Wanying Wu Dean Guo | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 3 |
| 4 | Progress of Jinping Underground laboratory for Nuclear Astrophysics(JUNA)显示文摘Jinping Underground laboratory for Nuclear Astrophysics(JUNA) will take the advantage of the ultra-low background of CJPL lab and high current accelerator based on an ECR source and a highly sensitive detector to directly study for the first time a number of crucial reactions occurring at their relevant stellar energies during the evolution of hydrostatic stars. In its first phase, JUNA aims at the direct measurements of^(25)Mg(p,γ)^(26)Al,^(19)F(p,α)^(16)O,^(13)C(α,n)^(16)O and ^(12)C(α,γ)^(16)O reactions. The experimental setup,which includes an accelerator system with high stability and high intensity, a detector system, and a shielding material with low background, will be established during the above research. The current progress of JUNA will be given. | WeiPing Liu ZhiHong Li JiangJun He XiaoDong Tang Gang Lian Zhu An JianJun Chang Han Chen QingHao Chen XiongJun Chen ZhiJun Chen BaoQun Cui XianChao Du ChangBo Fu Lin Gan Bing Guo GuoZhu He Alexander Heger SuQing Hou HanXiong Huang Ning Huang BaoLu Jia LiYang Jiang Shigeru Kubono JianMin Li KuoAng Li Tao Li YunJu Li Maria Lugaro XiaoBing Luo HongYi Ma ShaoBo Ma DongMing Mei YongZhong Qian JiuChang Qin Jie Ren YangPing Shen Jun Su LiangTing Sun WanPeng Tan Isao Tanihata Shuo Wang Peng Wang YouBao Wang Qi Wu ShiWei Xu ShengQuan Yan LiTao Yang Yao Yang XiangQing Yu Qian Yue Sheng Zeng HuanYu Zhang Hui Zhang LiYong Zhang NingTao Zhang QiWei Zhang Tao Zhang XiaoPeng Zhang XueZhen Zhang ZiMing Zhang Wei Zhao Zuo Zhao Chao Zhou | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，4： | 3 |
| 5 | First results on ^(76)Ge neutrinoless double beta decay from CDEX-1 experiment显示文摘We report the first results on ^(76)Ge neutrinoless double beta decay from stage one of the China dark-matter experiment(CDEX).A p-type point-contact high-purity germanium detector with a mass of 994 g has been installed to detect neutrinoless double beta decay events, as well as to directly detect dark matter particles. An exposure of 304 kg d has been analyzed over a wide spectral band from 500 keV to 3 MeV. The average event rate obtained was about 0.012 counts per keV per kg per day over the 2.039 MeV energy range. The half-life of ^(76)Ge neutrinoless double beta decay derived based on this result is T^(0ν)1/2>6.4×10^(22) yr(90% C.L.). An upper limit on the effective Majorana-neutrino mass of 5.0 eV has been achieved. | Li Wang Qian Yue KeJun Kang JianPing Cheng YuanJing Li TszKing Henry Wong ShinTed Lin JianPing Chang JingHan Chen QingHao Chen YunHua Chen Zhi Deng Qiang Du Hui Gong Li He QingJu He JinWei Hu HanXiong Huang TengRui Huang LiPing Jia Hao Jiang HauBin Li Hong Li JianMin Li Jin Li Jun Li Xia Li XueQian Li YuLan Li FongKay Lin ShuKui Liu Hao Ma JingLu Ma XingYu Pan Jie Ren XiChao Ruan ManBin Shen Vivek Sharma Lakhwinder Singh Manoj Kumar Singh Manoj Kumar Singh Arun Kumar Soma ChangJian Tang WeiYou Tang ChaoHsiung Tseng JiMin Wang Qing Wang ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue LiTao Yang SongWei Yang Nan Yi ChunXu Yu HaiJun Yu WeiHe Zeng XiongHui Zeng Zhi Zeng Lan Zhang YunHua Zhang MingGang Zhao Wei Zhao JiFang Zhou ZuYing Zhou JingJun Zhu WeiBin Zhu ZhongHua Zhu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，7： | 3 |
| 6 | Measuremeut of Sheet Resistance of Cross Microareas Using a Modified van der Pauw显示文摘 | Yicai Sun Jungsheng Shi Qinghao Meng | 1996 | Semi Conductor Sci & Tech1996，11，： | 1 |
| 7 | A poly (ethylene glycol)based smart phase change materiai显示文摘 | Meng Qinghao Hu Jinlian | 2008 | Solar Energy Materials and So lar Cells2008，92，10： | 1 |
| 8 | A review of shape memory polymer composites and blends显示文摘 | Qinghao Meng Jinlian Hu | 2009 | Composites Part A2009，，11： | 1 |
| 9 | Measurement of Sheet Resistance of Cross Microareas using a Modified Van der Pauw Method显示文摘 | Sun Yieai Shi Jtmsheng Meng Qinghao | 1996 | Semicond Sei Teehnol1996，11，： | 1 |
| 10 | Autophagy sustains the replication of porcine reproductive and respiratory virus in host cells显示文摘 | Qinghao Liu Yixian Qin Lei Zhou Qiuwen Kou Xin Guo Xinna Ge Hanchun Yang Hongbo Hu | 2012 | Virology2012，，2： | 1 |
| 11 | Normalizingthepolynomial-matchforthenon-linearsignalintransducers 显示文摘 | Sun Yicai Meng Qinghao Chen Zhiyong | 2005 | Sensors and Actuators A2005，，125： | 1 |
| 12 | A combined single photon ionization and photoelectron ion- ization source for orthogonal acceleration time-of-flight mass spectrometer显示文摘 | WU QINGHAO HUA LEI HOU KEYONG | 2010 | International Journal of Mass Spec- trometry2010，295，12： | 1 |
| 13 | Measurement of sheet resistance of cross microareas using a modified Van der Pauw method 显示文摘 | Sun Yicai Shi Junsheng Meng Qinghao | 1996 | Semieond Sci Technol1996，，11： | 1 |
| 14 | A temperature-regulating fiber made of PEG-based smart copolymer显示文摘 | Meng Qinghao Hu Jinlian | 2008 | Solar Energ Mater Solar Cells2008，92，10： | 1 |
| 15 | Odometry based pose determination and errors measurement for a mobile robot with two steerable drive wheels 显示文摘 | Meng Qinghao Bischoff R | 2005 | Journal of Intelligent and Robotic Systems: Theory and Applications2005，41，4： | 1 |
| 16 | Self - organizing alignment of carbon, nanotube in shape memory segmented fiber prepared by in situ polymerization and melt spinning 显示文摘 | Meng Qinghao Hu Jinlian | 2008 | Composites : Part A2008，39，： | 1 |
| 17 | A temperature-regulating fber made of PEG-based smart copolymer显示文摘 | Qinghao Meng Jinlian Hu | 2008 | Solar Energy Materials & Solar Cells2008，，10： | 1 |
| 18 | A temperature-regulating fiber made of PEG-based smart copolymer显示文摘 | Meng Qinghao Hu Jinlian | 2008 | Sol Energy Mater Sol Cells2008，92，10： | 1 |
| 19 | Adaptive extended Kalman filter(AEKF)-based mobile robot localization using sonar显示文摘 | Meng Qinghao Sun Yicai Cao Zuoliang | 2000 | Robotica2000，18，： | 1 |
| 20 | Measurement of sheet resistance of cross microareas using a modified Van der Pauw method显示文摘 | Yicai Sun Junsheng Shi Qinghao Meng | 1996 | Semicondor Science and Technology1996，11，5： | 1 |
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