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| 1 | Combination of rhamnolipid and biochar in assisting phytoremediation of petroleum hydrocarbon contaminated soil using Spartina anglica显示文摘Biochar (BC) and rhamnolipid (RL) is used in bioremediation of petroleum hydrocarbons,however,the combined effect of BC and RL in phytoremediation has not been studied until now.In this paper,the phytoremediation of petroleum hydrocarbon-contaminated soil using novel plant Spartina anglica was enhanced by the combination of biochar (BC) and rhamnolipid (RL).Samples of petroleum-contaminated soil (10,30 and 50 g/kg) were amended by BC,BC+ RL and rhamnolipid modified biochar (RMB),respectively.After 60 day's cultivation,the removal rate of total petroleum hydrocarbons (TPHs) for unplanted soil (UP),planted soil (P),planted soil with BC addition (P-BC),planted soil with BC and RL addition (P-BC + RL) and planted soil with addition ofRMB (P-RMB) were 8.6%,19.1%,27.7%,32.4% and 35.1% in soil with TPHs concentration of 30 g/kg,respectively.Compared with UP,the plantation of Spartina anglica significantly decreased the concentration of C8-14 and tricyclic PAHs.Furthermore,the application of BC and RMB alleviated the toxicity of petroleum hydrocarbons to Spartina anglica via improving plant growth with increasing plant height,root vitality and total chlorophyll content.High-throughput sequencing result indicated that rhizosphere microbial community of Spartina anglica was regulated by the application of BC and RMB,with increase of bacteria and plant mycorrhizal symbiotic fungus in biochar and RMB amended soil. | Meinan Zhen Hongkun Chen Qinglong Liu Benru Song Yizhi Wang Jingchun Tang | 2019 | Journal of Environmental Sciences2019，31，11： | 15 |
| 2 | Inhibitory Activity of Honeysuckle Extracts against Influenza A Virus In Vitro and In Vivo显示文摘Honeysuckle has been used in the treatment of influenza virus infection for thousands of years in China.However,its main active components and the functional mechanisms remain to be elucidated.Here,four honeysuckle extracts,including acids extract,flavonoids extract,total extract and acids-flavonoids mixture,were prepared to clarify the main active antiviral components.The cytopathic effect reduction assay showed that all the four extracts inhibited the replication of influenza viruses H1N1,H3N2 and the oseltamivir-resistant mutant strain H1N1-H275Y.The acids-flavonoids mixture had the strongest inhibitory effects in vitro with EC_(50) values of 3.8,4.1,and >20 lg/m L against H1N1,H3N2 and H1N1-H275Y,respectively,showing competitive antiviral activity with oseltamivir and ribavirin.Honeysuckle acids extract also showed the most significant antiviral activity in vivo.Oral administration of the acids extract at a dosage of 600 mg/kg/d effectively alleviated viral pneumonia,maintained body weight and improved the survival rate to 30% of the mice infected with a lethal dose of H1N1.The results of time-of-drug addition experiment and neuraminidase (NA) inhibition assay showed that honeysuckle extracts had a broad-spectrum inhibitory effect against influenza virus NAs.The flavonoid extract showed the strongest inhibitory effect on the NA of influenza virus H7N9 with an IC_(50) of 24.7 lg/m L.These results suggested that these extracts might exert their antiviral activity by suppressing the release of influenza viruses.Briefly,our findings demonstrate that acids and flavonoids extracts of honeysuckle are the major antiviral active components,and the acids extract has the potential to be developed into an antiviral agent against influenza virus,especially for oseltamivirresistant viruses. | Mengwei Li Yuxu Wang Jing Jin Jie Dou Qinglong Guo Xue Ke Changlin Zhou Min Guo | 2021 | Virologica Sinica2021，36，3： | 11 |
| 3 | An Improved Virtual Inertia Algorithm of Virtual Synchronous Generator显示文摘Virtual synchronous generator(VSG)simulates the first-order motion equation of a synchronous generator(SG)with the algorithm.VSG can improve the system voltage and frequency support capabilities of a microgrid or a weak grid.It is now widely applied at a high penetration level of distributed generation(DG)systems.However,because there is a contradiction between active power steady-state deviation of VSG and dynamic impact regulation,the VSG running in grid-connected mode with existing strategies cannot meet the steady and dynamic control requirements.Thus,an improved virtual inertial control strategy of VSG is proposed in this paper.The active power impact is reduced effectively under the circumstance of damping coefficient Dωequal to 0 and a large inertia,thus the dynamic characteristic of active power is improved and its steady-state characteristic is maintained.Firstly,based on the analysis of the damping coefficient effect on the system dynamic process,two forms of improved virtual inertia algorithms are put forward by cascading a differential link into different positions of the first-order virtual inertia forward channel.Then,by comparing the characteristics of the system with the two improved algorithms,the improved virtual inertial strategy based on differential compensation is proven to be better,and the design of its parameters is analyzed.Finally,simulation and experimental results verify the effectiveness of the proposed algorithm. | Haizhen Xu Changzhou Yu Chun Liu Qinglong Wang Xing Zhang | 2020 | Journal of Modern Power Systems and Clean Energy2020，8，2： | 10 |
| 4 | Existence and global asymptotic stability of positive almost periodic solutions of a two-species competitive system显示文摘 | Qinglong Wang Zhijun Liu Zuxiong Li Robert A. Cheke | 2014 | International Journal of Biomathematics2014，7，4： | 9 |
| 5 | COORDINATION OF A FASHION AND TEXTILE SUPPLY CHAIN WITH DEMAND VARIATIONS显示文摘由于变化时尚趋势和一种不稳定的市场状况,以时尚和纺织品(英尺) 工业要求在一短时间完全是无法预言的并且能变化并且变化,它使协调英尺供应链更困难。在产品偏爱的一个变化由于时尚趋势是英尺工业的需求比另外的工业显示出更多的变化的主要原因。在这份报纸,我们使用一个众所周知的合同,所有单位数量折扣政策(AQDP ) ,供应协调英尺与某些需求锁住,并且我们进一步在需求变化情形下面认为它调查它是否能仍然协调供应链。在卖的季节前,详细, AQDP 被制造商提供给零售商,并且在哪个下面与某个需求完成的英尺供应链协作。在卖的季节期间,需求变化在因此,制造商可以需要修订原来的 AQDP 保险供应的趋势锁住的时尚的一个突然的变化以后被认识到仍然被协调。利用机制设计理论,我们证明那:(i) 当传统的 AQDP 能协调供应时,当时,锁住没有需求变化,它不能总是在需求变化以后协调供应链;(ii ) 当 AQDP 失败时,我们能使用建议使能够的线性定价政策(CLPP ) 完成新协作;(iii ) 一个更主导的决定制造者,能设置一个更高的利润目标,对在需求变化下面的供应链系统的稳定有利。数字例子也被建议显示出我们的结果。 | Ke WANG Qinglong GOU Jinwen SUN Xiaohang YUE | 2012 | Journal of Systems Science and Systems Engineering2012，21，4： | 7 |
| 6 | The Chinese Hα Solar Explorer(CHASE) mission: An overview显示文摘The Chinese Hα Solar Explorer(CHASE), dubbed “Xihe”—Goddess of the Sun, was launched on October 14, 2021 as the first solar space mission of China National Space Administration(CNSA). The CHASE mission is designed to test a newly developed satellite platform and to acquire the spectroscopic observations in the Hα waveband. The Hα Imaging Spectrograph(HIS)is the scientific payload of the CHASE satellite. It consists of two observational modes: raster scanning mode and continuum imaging mode. The raster scanning mode obtains full-Sun or region-of-interest spectral images from 6559.7 to 6565.9 ? and from 6567.8 to 6570.6 ? with 0.024 ? pixel spectral resolution and 1 min temporal resolution. The continuum imaging mode obtains photospheric images in continuum around 6689 ? with the full width at half maximum of 13.4 ?. The CHASE mission will advance our understanding of the dynamics of solar activity in the photosphere and chromosphere. In this paper, we present an overview of the CHASE mission including the scientific objectives, HIS instrument overview, data calibration flow, and first results of on-orbit observations. | Chuan Li Cheng Fang Zhen Li MingDe Ding PengFei Chen Ye Qiu Wei You Yuan Yuan MinJie An HongJiang Tao XianSheng Li Zhe Chen Qiang Liu Gui Mei Liang Yang Wei Zhang WeiQiang Cheng JianXin Chen ChangYa Chen Qiang Gu QingLong Huang MingXing Liu ChengShan Han HongWei Xin ChangZheng Chen YiWei Ni WenBo Wang ShiHao Rao HaiTang Li Xi Lu Wei Wang Jun Lin YiXian Jiang LingJie Meng Jian Zhao | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 7 |
| 7 | COVID-19 Cases Spread Through the K350 Train-Jilin and Heilongjiang Provinces,China,January 2021显示文摘As of 16∶00 on January 13,2021,95 positive cases of coronavirus disease 2019(COVID-19)were reported in Suihua City of Heilongjiang Province and an additional 35 cases have been linked across 7 cities in 3 provinces:Qiqihar City(7 cases),Mudanjiang City(4 cases),Harbin City(3 cases),and Yichun City(1 case)of Heilongjiang Province;Changchun City(9 cases)and Tonghua City(6 cases)of Jilin Province;and Weihai City of Shandong Province(1 case). | Lei Zhou Laishun Yao Peter Hao Chao Li Qinglong Zhao Huiling Dong Jinhua Dou Shengnan Wang George F.Gao Qun Li Biao Huang | 2021 | China CDC weekly2021，3，8： | 5 |
| 8 | Retrieving the antarctic sea-ice concentration based on AMSR-E 89 GHz data显示文摘Sea-ice concentration is a key item in global climate change research.Recent progress in remotely sensed sea-ice concentration product has been stimulated by the use of a new sensor,advanced microwave scanning radiometer for EOS(AMSR-E),which offers a spatial resolution of 6 km×4 km at 89GHz.A new inversion algorithm named LASI(linear ASI) using AMSR-E 89GHz data was proposed and applied in the antarctic sea areas.And then comparisons between the LASI ice concentration products and those retrieved by the other two standard algorithms,ASI(arctic radiation and turbulence interaction study sea-ice algorithm) and bootstrap,were made.Both the spatial and temporal variability patterns of ice concentration differences,LASI minus ASI and LASI minus bootstrap,were investigated.Comparative data suggest a high result consistency,especially between LASI and ASI.On the other hand,in order to estimate the LASI ice concentration errors introduced by the tie-points uncertainties,a sensitivity analysis was carried out.Additionally an LASI algorithm error estimation based on the field measurements was also completed.The errors suggest that the moderate to high ice concentration areas(>70%) are less affected(never exceeding 10%) than those in the low ice concentration.LASI and ASI consume 75 and 112 s respectively when processing the same AMSR-E time series thourghout the year 2010.To conclude,by using the LASI algorithm,not only the seaice concentration can be retrieved with at least an equal quality as that of the two extensively demonstrated operational algorithms,ASI and bootstrap,but also in a more efficient way than ASI. | YU Qinglong WANG Hui WAN Liying BI Haibo | 2013 | Acta Oceanologica Sinica2013，32，9： | 5 |
| 9 | Effects of in-situ TiB_(2)particles on machinability and surface integrity in milling of TiB_(2)/2024 and TiB_(2)/7075 Al composites显示文摘In-situ ceramics particle reinforced aluminum matrix composites are favored in the aerospace industry due to excellent properties.However,the hard ceramic particles as the reinforcement phase bring challenges to machining.To study the effect of in-situ TiB_(2)particles on machinability and surface integrity of TiB_(2)/2024 composite and TiB_(2)/7075 composite,milling experiments were performed,and compared with conventional 2024 and 7075 aluminum alloys.In-situ TiB_(2)particles clustered at the grain boundaries and dispersed inside the matrix alloy grains hinder the dislocation movement of the matrix alloy.Therefore,the milling force and temperature of the composites are higher than those of the aluminum alloys due to the increase of the strength and the decrease of the plasticity.In the milling of composites,abrasive wear is the main wear form of carbide tools,due to the scratching of hard nano-TiB_(2)particles.The composites containing in-situ TiB_(2)particles have machining defects such as smearing,micro-scratches,micro-pits and tail on the machined surface.However,in-situ TiB_(2)particles impede the plastic deformation of the composites,which greatly reduces cutting edge marks on the machined surface.Therefore,under the same milling parameters,the surface roughness of TiB_(2)/2024 composite and TiB_(2)/7075 composite is much less than that of2024 and 7075 aluminum alloy respectively.Under the milling conditions of this experiment,the machined subsurface has no metamorphic layer,and the microhardness of the machined surface is almost the same as that of the material.Besides,compared with 2024 and 7075 aluminum alloy,machined surfaces of TiB_(2)/2024 composite and TiB_(2)/7075 composite both show tensile residual stress or low magnitude of compressive residual stress. | Jie CHEN Weiwei YU Zhenyu ZUO Yugang LI Dong CHEN Qinglong AN Jiwei GENG Ming CHEN Haowei WANG | 2021 | Chinese Journal of Aeronautics2021，34，6： | 5 |
| 10 | Genetically encoded X-ray cellular imaging for nanoscale protein localization显示文摘Spatial resolution defines the physical limit of microscopes for probing biomolecular localization and interactions in cells.Whereas synchrotron-based X-ray microscopy(XRM)represents a unique approach for imaging a whole cell with nanoscale resolution due to its intrinsic nanoscale resolution and great penetration ability,existing approaches to label biomolecules rely on the use of exogenous tags that are multi-step and error-prone.Here,we repurpose engineered peroxidases as genetically encoded X-ray-sensitive tags(GXET)for site-specific labeling of protein-of-interest in mammalian cells.We find that 3,3-diaminobenzidine(DAB)polymers that are in-situ catalytically formed by fusion-expressed peroxidases are visible under XRM.Using this new tag,we imaged the protein location associated with the alteration of a DNA-methylation pathway with an ultra-high resolution of 30 nanometers.Importantly,the excellent energy resolution of XRM enables multicolor imaging using different peroxidase tags.The development of GXET enlightens the way to nanoscopic imaging for biological studies. | Huating Kong Jichao Zhang Jiang Li Jian Wang Hyun-Joon Shin Renzhong Tai Qinglong Yan Kai Xia Jun Hu Lihua Wang Ying Zhu Chunhai Fan | 2020 | National Science Review2020，7，7： | 3 |
| 11 | 96-Week Treatment of Tenofovir Amibufenamide and Tenofovir Disoproxil Fumarate in Chronic Hepatitis B Patients显示文摘Background and Aims:Tenofovir amibufenamide(TMF)is a novel phosphoramidated prodrug of tenofovir with nonin-ferior efficacy and better bone and renal safety to tenofovir disoproxil fumarate(TDF)in 48 weeks of treatment.Here,we update 96-week comparison results.Methods:Patients with chronic hepatitis B were assigned(2:1)to receive either 25 mg TMF or 300 mg TDF with matching placebo for 96 weeks.The virological suppression was defined as HBV DNA levels<20 IU/mL at week 96.Safety was evaluated thoroughly with focusing on bone,renal,and metabolic pa-rameters.Results:Virological suppression rates at week 96 were similar between TMF and TDF group in both HBeAg-positive and HBeAg-negative populations.Noninferior efficacy was maintained in the pooled population,while it was first achieved in patients with HBV DNA≥7 or 8 log10 IU/mL at baseline.Non-indexed estimated glomerular filtration rate for renal safety assessment was adopted,while a smaller decline of which was seen in the TMF group than in the TDF group(p=0.01).For bone mineral density,patients receiv-ing TMF displayed significantly lower reduction levels in the densities of spine,hip,and femur neck at week 96 than those receiving TDF.In addition,the lipid parameters were stable after week 48 in all groups while weight change still showed the opposite trend.Conclusions:TMF maintained similar efficacy at week 96 compared with TDF with continued superior bone and renal safety profiles(NCT03903796). | Zhihong Liu Qinglong Jin Yuexin Zhang Guozhong Gong Guicheng Wu Lvfeng Yao Xiaofeng Wen Zhiliang Gao Yan Huang Daokun Yang Enqiang Chen Qing Mao Shide Lin Jia Shang Huanyu Gong Lihua Zhong Huafa Yin Fengmei Wang Peng Hu Qiong Wu Chao Pan Wen Jia Chuan Li Chang’an Sun Junqi Niu Jinlin Hou TMF Study Group | 2023 | Journal of Clinical and Translational Hepatology2023，11，3： | 3 |
| 12 | Fiber-reinforced composites in milling and grinding:machining bottlenecks and advanced strategies显示文摘Fiber-reinforced composites have become the preferred material in the fields of aviation and aerospace because of their high-strength performance in unit weight.The composite components are manufactured by near netshape and only require finishing operations to achieve final dimensional and assembly tolerances.Milling and grinding arise as the preferred choices because of their precision processing.Nevertheless,given their laminated,anisotropic,and heterogeneous nature,these materials are considered difficult-to-machine.As undesirable results and challenging breakthroughs,the surface damage and integrity of these materials is a research hotspot with important engineering significance.This review summarizes an up-to-date progress of the damage formation mechanisms and suppression strategies in milling and grinding for the fiber-reinforced composites reported in the literature.First,the formation mechanisms of milling damage,including delamination,burr,and tear,are analyzed.Second,the grinding mechanisms,covering material removal mechanism,thermal mechanical behavior,surface integrity,and damage,are discussed.Third,suppression strategies are reviewed systematically from the aspects of advanced cutting tools and technologies,including ultrasonic vibration-assisted machining,cryogenic cooling,minimum quantity lubrication(MQL),and tool optimization design.Ultrasonic vibration shows the greatest advantage of restraining machining force,which can be reduced by approximately 60%compared with conventional machining.Cryogenic cooling is the most effective method to reduce temperature with a maximum reduction of approximately 60%.MQL shows its advantages in terms of reducing friction coefficient,force,temperature,and tool wear.Finally,research gaps and future exploration directions are prospected,giving researchers opportunity to deepen specific aspects and explore new area for achieving high precision surface machining of fiber-reinforced composites. | Teng GAO Yanbin ZHANG Changhe LI Yiqi WANG Yun CHEN Qinglong AN Song ZHANG Hao Nan LI Huajun CAO Hafiz Muhammad ALI Zongming ZHOU Shubham SHARMA | 2022 | Frontiers of Mechanical Engineering2022，17，2： | 3 |
| 13 | Effectiveness of Interventions to Control Transmission of Reemergent Cases of COVID-19--Jilin Province,China,2020显示文摘What is already known about this topic?COVID-19 has a high transmissibility calculated by mathematical model.The dynamics of the disease and the effectiveness of intervention to control the transmission remain unclear in Jilin Province,China.What is added by this report?This is the first study to report the dynamic characteristics and to quantify the effectiveness of interventions implemented in the second outbreak of COVID-19 in Jilin Province,China.The effective reproduction number of the disease before and after May 10 was 4.00 and p<0.01,respectively.The combined interventions reduced the transmissibility of COVID-19 by 99% and the number of cases by 98.36%.What are the implications for public health practice?The findings of this study would add data on the transmission of COVID-19 and provide evidence to prepare the second outbreak transmission of the disease in other areas of China even in many other countries. | Qinglong Zhao Meng Yang Yao Wang Laishun Yao Jianguo Qiao Zhiyong Cheng Hanyin Liu Xingchun Liu Yuanzhao Zhu Zeyu Zhao Jia Rui Tianmu Chen | 2020 | China CDC weekly2020，2，34： | 2 |
| 14 | Preparation of Mg,N-co-doped lignin adsorbents for enhanced selectivity and high adsorption capacity of As(Ⅴ) from wastewater显示文摘Among various environmental problems,water pollution has drawn more and more attention.To develop an adsorbent with enhanced selectivity and high capacity for As(V)oxyanion,a novel lignin-based adsorbent was prepared by doping with N and modifying with Mg^(2+),using thiethylenetetramine(TETA)and MgCl_(2) as the source of N and Mg^(2+),respectively.N-doped lignin(NL)shows a high selectivity for As(Ⅴ),which is further enhanced by modifying with Mg^(2+)(MNL).MNL shows an excellent reusability.The adsorption isotherms and kinetics of MNL for As(Ⅴ)follow Langmuir isotherms model and pseudo-second-order kinetics model,respectively.The adsorption of MNL for As(Ⅴ)achieved a maximum adsorption capacity of 687.46 mg g^(−1) and the equilibrium was established within 30 min.This study offers a novel idea on the recycle of the waste of paper industry and provides a new technology for As(Ⅴ)adsorption from wastewater. | Xiaofeng Shi Junmao Hong Chao Wang Sifang Kong Junhua Li Duo Pan Jing Lin Qinglong Jiang Zhanhu Guo | 2021 | Particuology2021，19，5： | 2 |
| 15 | Arctic multiyear sea ice variability observed from satellites:a review显示文摘In comparison with seasonal sea ice(first-year ice,FY ice),multiyear(MY)sea ice is thicker and has more opportunity to survive through the summer melting seasons.Therefore,the variability of wintertime MY ice plays a vital role in modulating the variations in the Arctic sea ice minimum extent during the following summer.As a response,the ice-ocean-atmosphere interactions may be significantly affected by the variations in the MY ice cover.Satellite observations are characterized by their capability to capture the spatiotemporal changes of Arctic sea ice.During the recent decades,many active and passive sensors onboard a variety of satellites(QuikSCAT,ASCAT,SSMIS,ICESat,CryoSat-2,etc.)have been used to monitor the dramatic loss of Arctic MY ice.The main objective of this study is to outline the advances and remaining challenges in monitoring the MY ice changes through the utilization of multiple satellite observations.We summarize the primary satellite data sources that are used to identify MY ice.The methodology to classify MY ice and derive MY ice concentration is reviewed.The interannual variability and trends in the MY ice time series in terms of coverage,thickness,volume,and age composition are evaluated.The potential causes associated with the observed Arctic MY ice loss are outlined,which are primarily related to the export and melting mechanisms.In addition,the causes to the MY ice depletion from the perspective of the oceanic water inflow from Pacific and Atlantic Oceans and the water vapor intrusion,as well as the roles of synoptic weather,are analyzed.The remaining challenges and possible upcoming research subjects in detecting the rapidly changing Arctic MY ice using the combined application of multisource remote sensing techniques are discussed.Moreover,some suggestions for the future application of satellite observations on the investigations of MY ice cover changes are proposed. | BI Haibo LIANG Yu WANG Yunhe LIANG Xi ZHANG Zehua DU Tingqin YU Qinglong HUANG Jue KONG Mei HUANG Haijun | 2020 | Journal of Oceanology and Limnology2020，38，4： | 2 |
| 16 | Robust H Model Reference Tracking Control for Networked Control Systems withCommunication Constraints 显示文摘 | Wang Yulong Han Qinglong | 2009 | International Journal of Control Automation and Systems2009，7，6： | 1 |
| 17 | Modelling and Observer- based H Controller Design for Networked Control Systems显示文摘 | Wang Yulong Han Qinglong | 2014 | IET Control Theory & Applications2014，8，15： | 1 |
| 18 | GC-MS Analysis of Liposoluble Constituents from Buds,Flowers and Fruits of Millettia speciosa Champ.显示文摘[Objectives] To study the material foundation of liposoluble constituents from buds,flowers and fruits of Millettia speciosa Champ.and provide a reference for the development of flowers and fruits of Millettia speciosa Champ.[Methods]The liposoluble constituents were extracted from buds,flowers and fruits of Millettia speciosa by Soxhlet extraction and solvent extraction method,and analyzed by GC-MS.[Results]24 compounds were identified from the liposoluble constituents of buds,accounting for 88. 31 % of the total liposoluble constituents,mainly comprising alkanes and olefins compounds( 52. 00%) and alcohols compounds( 17. 46%); 29 compounds were identified from the liposoluble constituents of flowers,accounting for 91. 38 % of the total liposoluble constituents,mainly comprising alkanes and olefins compounds( 60. 64%) and alcohols compounds( 17. 17%); 32 compounds were identified from the liposoluble constituents of fruits,accounting for 80. 01 % of the total liposoluble constituents,mainly comprising alkanes and olefins compounds( 32. 56%),phenyl and its derivatives compounds( 22. 46%) and fatty acids compounds( 12. 54%). 6 compounds were common in buds,flowers and fruits. [Conclusions] Although there were some differences in liposoluble constituents from flowers,fruits,leaves and roots of Millettia speciosa Champ.,the different parts of Millettia speciosa Champ. had development value. | Maoyuan WANG Qing YANG Qinglong WANG Xiaoxia YAN Jianrong WANG Zhunian WANG | 2017 | Medicinal Plant2017，8，4： | 1 |
| 19 | Effect of Stocking Density on Water Quality and(Growth, Body Composition and Plasma Cortisol Content) Performance of Pen-Reared Rainbow Trout(Oncorhynchus mykiss)显示文摘The goal of the study was to examine the effect of stocking density on the water quality of culture area, as well as the growth, body composition and cortisol content of rainbow trout(Oncorhynchus mykiss). Pen-reared trout were stocked in densities of 40, 60, 80 fish individuals m^(-3)(4.6, 6.6, 8.6 kg m^(-3), SD1, SD2 and SD3 groups, respectively) for 300 days. Compared to the water from SD1 and SD2, that from SD3 exhibited significantly higher NH_4^+-N content and COD(chemical-oxygen-demand), and a significant reduction of dissolved oxygen in day 180(40.6 kg m^(-3)). Stocking density was significantly associated with body weight, standard length, VSI(viscerosomatic index), CF(condition factor) and FC(food coefficient) in group SD3, particularly in day 240 and day 300(45 or 49.3 kg m^(-3)). Increased crude fat and decreased crude protein were displayed in high density group when the density reached to 36 kg m^(-3). As a cumulative effect of density-related stress, VSI, CF, FC, moisture, and crude protein content varied over time in each density group(SD1, SD2, and SD3). In summary, trout exhibited a better growth performance in low density(26.3 kg m^(-3)) than those reared in high densities(36 and 45 kg m^(-3)). The results indicate that rainbow trout(114.44 g ± 6.21 g, 19.69 cm ± 0.31 cm) initially stocked in 6.6 or 8.6 kg m^(-3) should be lightened to less than 36 kg m^(-3) after an intensive rearing for 240 days. | LIU Qun HOU Zhishuai WEN Haishen LI Jifang HE Feng WANG Jinhuan GUAN Biao WANG Qinglong | 2016 | Journal of Ocean University of China2016，15，4： | 1 |
| 20 | Cholesterol-associated lysosomal disorder triggers cell death of hematological malignancy:Dynamic analysis on cytotoxic effects of LW-218显示文摘The integrity of lysosomes is of vital importance to survival of tumor cells.We demonstrated that LW-218,a synthetic flavonoid,induced rapid lysosomal enlargement accompanied with lysosomal membrane permeabilization in hematological malignancy.LW-218-induced lysosomal damage and lysosome-dependent cell death were mediated by cathepsin D,as the lysosomal damage and cell apoptosis could be suppressed by depletion of cathepsin D or lysosome alkalization agents,which can alter the activity of cathepsins.Lysophagy,was initiated for cell self-rescue after LW-218 treatment and correlated with calcium release and nuclei translocation of transcription factor EB.LW-218 treatment enhanced the expression of autophagy-related genes which could be inhibited by intracellular calcium chelator.Sustained exposure to LW-218 exhausted the lysosomal capacity so as to repress the normal autophagy.LW-218-induced enlargement and damage of lysosomes were triggered by abnormal cholesterol deposition on lysosome membrane which caused by interaction between LW-218 and NPC intracellular cholesterol transporter 1.Moreover,LW-218 inhibited the leukemia cell growth in vivo.Thus,the necessary impact of integral lysosomal function in cell rescue and death were illustrated. | Po Hu Hui Li Wenzhuo Sun Hongzheng Wang Xiaoxuan Yu Yingjie Qing Zhanyu Wang Mengyuan Zhu Jingyan Xu Qinglong Guo Hui Hui | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 1 |
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