|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | Irinotecan plus S-1 versus S-1 in patients with previously treated recurrent or metastatic esophageal cancer(ESWN 01):a prospective randomized,multicenter,open-labeled phase 3 trial显示文摘Background:The benefit of systemic treatments in esophageal squamous cell carcinoma(ESCC)which has pro-gressed after chemotherapy is still uncertain and optimal regimens based on randomized trials have not yet been established.We aimed to compare the efficacy of irinotecan plus S-1 with S-1 monotherapy in recurrent or metastatic ESCC patients who had resistance to platinum-or taxane-based chemotherapy.Methods:We conducted a prospective randomized,multicenter,open-label,phase 3 trial in 15 centers across China.Eligible patients were adults with histologically confirmed recurrent or metastatic ESCC,and were randomly assigned(ratio,1:1)to receive either irinotecan plus S-1(intravenous infusion of irinotecan[160 mg/m2]on day 1 and oral S-1[80-120 mg]on days 1-10,repeated every 14 days)or oral S-1 monotherapy(80-120 mg/day on days 1-14,repeated every 21 days)using a central computerized minimization procedure.The primary endpoint was progression-free survival(PFS).Results:Between December 23,2014 and July 25,2016,we screened 148 patients and randomly assigned 123 patients to receive either irinotecan plus S-1 regimen(n=61)or S-1 monotherapy(n=62).After a median follow-up of 29.2 months(95%confidence interval[CI]17.5-40.9 months),the median PFS was significantly longer in the irinotecan plus S-1 group than in the S-1 monotherapy group(3.8 months[95%CI 2.9-4.3 months]vs.1.7 months[95%CI 1.4-2.7 months],hazard ratio=0.58,95%CI 0.38-0.86,P=0.006).The objective response rates were 24.6%in the irinotecan plus S-1 group and 9.7%in the S-1 monotherapy group(P=0.002).The patients in the irinotecan plus S-1 group presented with increased rates of grade 3-4 leukopenia(16.4%vs.0%),neutropenia(14.8%vs.1.6%),and nausea(4.9%vs.0%).No significant difference in grade 3-4 diarrhea and no treatment-related deaths were observed in both groups.Conclusions: The combination of irinotecan with S-1 was similarly tolerable but significantly prolonged PFS compared to S-1 monotherapy as a second- or third-line treatment in patients with recurrent or metastatic ESCC. | Jing Huang Binghe Xu Ying Liu Junxing Huang Ping Lu Yi Ba Lin Wu Yuxian Bai Shu Zhang Jifeng Feng Ying Cheng Jie Li Lu Wen Xianglin Yuan Changwu Ma Chunhong Hu Qingxia Fan Xi Wang | 2019 | Cancer Communications2019，39，1： | 8 |
| 3 | A 15-year analysis of molecular epidemiology of avian infectious bronchitis coronavirus in China显示文摘 | Zongxi Han Chuyang Sun Baolong Yan Xiaonan Zhang Yu Wang Chengren Li Qingxia Zhang Yazhen Ma Yuhao Shao Qiaoran Liu Xiangang Kong Shengwang Liu | 2010 | Infection Genetics and Evolution2010，，1： | 2 |
| 4 | Pure organic room-temperature phosphorescent N-allylquinolinium salts as anti-counterfeiting materials显示文摘Pure organic room-temperature phosphorescence (RTP) materials have been attracting much attention recently. Herein, we report a facile approach combining heavy atom effect and external solvent stimuli to realize RTP. N-Allylquinolinium bromide under 365 nm UV exhibited intense green RTP emission with response upon adding chloroform. This interesting phenomenon endowed N-allylquinolinium bromide great potential as an anti-counterfeiting material. | Qingxia Xiong Chao Xu Nianming Jiao Xiang Ma Yanqiang Zhang Suojiang Zhang | 2019 | Chinese Chemical Letters2019，30，7： | 2 |
| 5 | A 15-year analysis of molecular epidemiology of avian infectious bronchitis coronavirus in China显示文摘 | Zongxi Han Chuyang Sun Baolong Yan Xiaonan Zhang Yu Wang Chengren Li Qingxia Zhang Yazhen Ma Yuhao Shao Qiaoran Liu Xiangang Kong Shengwang Liu | 2010 | Infection Genetics and Evolution2010，，1： | 2 |
| 6 | Prevalence of transmitted drug resistance mutations among patients infected with human immunodeficiency virus type 1 (HIV-1) in Henan Province, China显示文摘To the Editor:Even with the emergence of highly active antiretroviral therapy,human immunodeficiency virus type 1(HIV-1)remains a serious public health problem worldwide.The widespread use of antiretroviral therapy(ART)has,on the one hand,significantly improved life expectancy in patients infected with HIV-1;on the other hand,it has inevitably brought along with it a difficult problem—viral resistance.Viral resistance is a common phenomenon evolutionarily,particularly in patients with poor adherence and suboptimal drug levels. | Jinjin Liu Xiaohua Zhang Mingjie Hou Shuguang Wei Jie Ma Lixia Xu Xuan Yang Yan Sun Chunli Liu Qingxia Zhao Yuqi Huo | 2022 | Chinese Medical Journal2022，135，22： | 2 |
| 7 | Existence and stability for periodic boundary value problem of first order differential equations显示文摘 | Li Yanling Liu Anping Ma Qingxia | 2007 | Dynamics of Continuous Discrete and Impulsive Sysyems : A2007，14，： | 1 |
| 8 | Remediation of petroleum-contaminated soil after composting by sequential treatment with Fenton-like oxidation and biodegradation显示文摘 | Mang Lu Zhongzhi Zhang Wei Qiao Xiaofang Wei Yueming Guan Qingxia Ma Yingchun Guan | 2009 | Bioresource Technology2009，，7： | 1 |
| 9 | 奥沙利铂联合替尼泊甙对胃癌BGC-823细胞的生长抑制和诱导凋亡的协同作用(英文)显示文摘Objective:The aim of this study was to investigate the synergistic effects of oxaliplatin and teniposide on proliferation and apoptosis of gastric cancer cell line BGC-823.Methods:MTT assay was carried to examine the inhibition rate of oxaliplatin and teniposide on gastric cancer cell line BGC-823 with various concentrations separately and associatively.The apoptosis rate of BGC-823 cells under the treatment of oxaliplatin or/and teniposide was examined by flow cytometry.The expression level of livin, an apoptosis-associated protein, was explored by western blot.Results:Oxaliplatin or teniposide could remarkably inhibit the BGC-823 gastric cancer cell growth with a dose-response manner, separately and associatively.The inhibition rate of oxaliplatin combined with teniposide on BGC-823 cells was higher than that of single oxaliplatin or single teniposide(P < 0.05), with 0.46 as combination index(CI) value.The apoptosis rates of cells treated by oxaliplatin for 12 h, 24 h and 48 h were 6.13%, 13.86% and 21.48%, respectively, while which of teniposide were 4.60%, 10.72%, 17.07%.But when the two medicines were carried associatively, the apoptosis rates for 12 h, 24 h and 48 h were 11.73%, 24.14% and 44.75%, respectively.Western blot showed that the expression level of livin was more down-regulated when cells were treated by oxaliplatin + teniposide than by oxaliplatin singly.Conclusion:The combination of oxaliplatin and teniposide can exert a synergistic effect on gastric cancer cell BGC-823. | Wang Ma Ming Gao Wei He Qingxia Fan | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，3： | 1 |
| 10 | Climatology and Trends of the Temporal and Spatial Distribution of Sandstorms in Inner Mongolia显示文摘 | Tao Gao Xiao Yu Qingxia Ma Haiying Li Xicang Li Yaobing Si | 2003 | Water Air and Soil Pollution: Focus2003，，2： | 1 |
| 11 | A moonlighting function of choline kinase alpha 2 in the initiation of lipid droplet lipolysis in cancer cells显示文摘Cancer cells in the tumormicroenvironment,where nutrient availability is consistently changing during tumor progression,harness lipid metabolism to support their proliferation,survival,migration,invasion,and metastasis[1].When nutrients in the tumor microenvironment are sufficient,lipids such as triglycerides,steryl esters,and retinyl esters are stored in lipid droplets,which are dynamic lipid-rich cellular organelles surrounded by a single layer of polar and amphipathic phospholipids and structural proteins in the perilipin(PLIN)family. | Qingxia Ma Zhaoyuan Meng Ying Meng Rui Liu Zhimin Lu | 2021 | Cancer Communications2021，41，10： | 1 |
| 12 | Existence and stability for periodic boundary value problem of first order differential equations显示文摘 | Li YanLing Liu Anping Ma Qingxia Wang Xiaomei | 2007 | Dynamics of Continuous Discrete and Impulsive Sysyems-Series A-Mathematical Analysis2007，14，： | 1 |
| 13 | Oscillation of nonlinear impulsive parabolic equations of neutral type显示文摘 | Liu Anping Ma Qingxia He Mengxing | 2006 | Rocky Mountain Journal of Mathematics2006，36，3： | 1 |
| 14 | Experiments and evidences: jellyfish (Nemopilema nomurai) decomposing and nutrients (nitrogen and phosphorus) released显示文摘The aim of this study was to investigate nitrogen and phosphorus released in the process of the decomposition of giant jellyfish in the laboratory and found the evidence to verify the influence of nutrients released by the decomposition of jellyfish on the ecosystem in the field. The release of nitrogen and phosphorus from the decomposition of Nemopilema nomurai was examined in a series of experiments under different incubation conditions such as different p H values, salinity values, temperatures and nitrogen and phosphorus concentrations. The results showed that the complete decomposition of Nemopilema nomurai generally took about 4–8 d. The release of nitrogen and phosphorus from the decomposition of Nemopilema nomurai could be divided into two stages: the early stage and the later stage, although the efflux rate of nitrogen was one order more than phosphorus. In the early stage of the decomposition of Nemopilema nomurai, the concentrations of dissolved nitrogen, dissolved phosphorus, total nitrogen and total phosphorus in seawater increased rapidly, and the concentration of nitrogen could reach the highest level in the whole degradation process. In the later stage of the decomposition, the concentrations of dissolved nitrogen and total nitrogen declined slowly, while the concentration of phosphorus in water could reach a maximum in the degradation process. High p H, low salinity,high temperature and N/P will promote the release of nitrogen; low p H is unfavorable to the release of nitrogen but favorable to the release of phosphorus. In addition, we found the concentrations of ammonium and phosphate in the bottom water were higher than those in the surface water during the period of jellyfish bloom in the Jiaozhou Bay, proving that nutrients released by the decomposition of jellyfish have significant influence on nitrogen and phosphorus in the field. For the whole Yellow Sea, nutrients released by jellyfish carcasses may reach up to(2.63±2.98)×107 mol/d of dissolved nitrogen(DN) and(0.74±0.84)×106 mol/d of dissolved phosphorus(DP) during the period of jellyfish bloom. The values are comparable to riverine inputs in a day, but much higher than sediment–water exchange flux in the Yellow Sea. The great amounts of nutrients must have significant influence on the nutrients balance of the Yellow Sea during the period of jellyfish dead and decomposition. Both the experimental data and field observations proved that the decomposition of jellyfish may release a great amount of nutrient to the surrounding environment during the period of jellyfish decomposition. | LI Xuegang SONG Jinming MA Qingxia LI Ning YUAN Huamao DUAN Liqin QU Baoxiao | 2015 | Acta Oceanologica Sinica2015，34，8： | 1 |
| 15 | Governing glutaminolysis by regulation of glutaminase succinylation显示文摘Of the 20 ribosomally coded amino acid residues,lysine(K)can be frequently and uniquely modified by many types of posttranslational acylation,including acetylation,succinylation,crotonylation,propionylation,butyrylation,glutarylation,malonylation,β-hydroxybutyrylation,and 2-hydroxyisobutyrylation in histones and other proteins(Li et al.,2018a;Xu et al.,2021).Among these acylations,succinylation is a commonly occurred modification,and histone H3K79 succinylation is identified in the transcription start sites of more than 7,000 genes,implying its critical role in the expression regulation of a large number of genes(Wang et al.,2017).Protein succinylation requires the highenergy metabolite,succinyl-coenzyme A(CoA). | Qingxia Ma Hongfei Jiang Leina Ma Ying Meng Dong Guo Yingying Tong Zhimin Lu | 2022 | Protein & Cell2022，13，3： | 0 |
| 16 | Molecular dynamics simulations of ovalbumin adsorption at squalene/water interface显示文摘The adsorption of protein molecules to oil/water(O/W)interface is of critical importance for the product design in a wide range of technologies and industries such as biotechnology,food industry and pharmaceutical industry.In this work,with ovalbumin(OVA)as the model protein,the adsorption conformations at the O/W interface and the adsorption stability have been systematically studied via multiple simulation methods,including all-atom molecular dynamic(AAMD)simulations,coarse-grained molecular dynamic(CGMD)simulations and enhanced sampling methods.The computational results of AAMD and CGMD show that the hydrophobic tail of OVA tends to be folded under long time relaxation in aqueous phase,and multiple adsorption conformations can exist at the interface due to heterogeneous interactions raising from oil and water respectively.To further study the adsorption sites of the protein,the adsorption kinetics of OVA at the O/W interface is simulated using metadynamics method combined with CGMD simulations,and the result suggests the existence of multiple adsorption conformations of OVA at interface with the head-on conformation as the most stable one.In all,this work focuses on the adsorption behaviors of OVA at squalene/water interface,and provides a theoretical basis for further functionalization of the proteins in emulsion-based products and engineering. | Qingxia Xiong Ying Ren Yufei Xia Guanghui Ma Reiji Noda Wei Ge | 2022 | Chinese Journal of Chemical Engineering2022，，10： | 0 |
| 17 | Zfhx3 is essential for progesterone/progesterone receptor signaling to drive ductal side-branching and alveologenesis in mouse mammary glands显示文摘Progesterone(Pg)/progesterone receptor(PR) signaling drives mammary gland side-branching and alveologenesis, but the mechanisms through which Pg/PR signaling functions remain to be clarified.Using in vitro and in vivo models and histological and molecular analyses, we determined the role of Zfhx3 transcription factor in mammary gland development driven by Pg/PR signaling. Postnatal deletion of Zfhx3 in mouse mammary epithelial cells attenuated side-branching morphogenesis and alveologenesis. These effects were undetectable in the absence of Pg/PR signaling. During the estrus cycle, Zfhx3 expression corresponded to that of Pg, being at the highest level at the diestrus stage; Zfhx3 deletion inhibited mammary gland branching more potently at diestrus than estrus stage. Loss of Zfhx3 not only attenuated the expansion of stem/progenitor cells driven by Pg/PR signaling, but also impaired the function of Pg/PR signaling in the transcriptional activation of multiple genes. In addition, Pg/PR signaling significantly expanded PR-and Zfhx3-positive epithelial cells, and induced the physical association of ZFHX3 with PR. These findings establish Zfhx3 as an integral transcription factor of Pg/PR signaling in driving side-branching and alveologenesis during mammary gland development. | Gui Ma Ang Gao Yinan Yang Yuan He Xi Zhang Baotong Zhang Zhiqian Zhang Mei Li Xing Fu Dan Zhao Rui Wu Leilei Qi Qingxia Hu Juan Li Liya Fu Zhengmao Zhu Jin-Tang Dong | 2019 | Journal of Genetics and Genomics2019，46，3： | 0 |
| 18 | Cancer-macrophage hybrid membrane-camouflaged photochlor for enhanced sonodynamic therapy against triple-negative breast cancer显示文摘Sonodynamic therapy(SDT)has aroused considerable momentum in cancer therapy due to its abilities of deep penetration,low toxicity,and noninvasion,while insufficient tumor accumulation of sonosensitizers is a major obstacle for SDT effect.Here,we developed a 4T1 cancer cell-macrophage hybrid membrane(HM)-camouflaged sonosensitizer nanoplatform by encapsulating photochlor(HPPH)-loaded albumin nanoparticles(PHNPs).The experimental results proved that the HM-coated biomimetic NPs(PHNPs@HM)could express the characteristic membrane proteins of both cancer cells and macrophages,remarkedly enhancing the effective targeting and endocytosis to 4T1 cells through homologous adhesion recognition and immune escaping.Meanwhile,as a novel sonosensitizer,HPPH could generate amount of reactive oxygen species(ROS)under ultrasound(US)irradiation and exhibit obvious SDT efficiency to inhibit 4T1 tumor growth through ROS-induced cell apoptosis.This study provides a novel and multifunctional biomimetic sonosensitizer system to enhance SDT efficiency. | Lishan Zhang Ting Yin Baozhen Zhang Chong Yan Chengyu Lu Lanlan Liu Ze Chen Hui Ran Qingxia Shi Hong Pan Aiqing Ma Lintao Cai | 2022 | Nano Research2022，15，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员