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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | ACC/AHA guidelines for the management of patients with unstable angina and non–st-segment elevation myocardial infarction显示文摘 | Eugene Braunwald Elliott M Antman John W Beasley Robert M Califf Melvin D Cheitlin Judith S Hochman Robert H Jones Dean Kereiakes Joel Kupersmith Thomas N Levin Carl J Pepine John W Schaeffer Earl E Smith David E Steward Pierre Theroux Raymond J Gibbons J | 2000 | Journal of the American College of Cardiology2000，，3： | 4 |
| 3 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 4 | B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy显示文摘 | Vijay K Kuchroo Mercy Prabhu Das Julia A Brown Ann M Ranger Scott S Zamvil Raymond A Sobel Howard L Weiner Nasrin Nabavi Laurie H Glimcher | 1995 | Cell1995，，5： | 2 |
| 5 | Genetic and biochemical characterization of field-evolved resistance to Bacillus thuringiensis toxin CrylAc in the diamondback moth,Plutella xylostella显示文摘 | SAYYED A H RAYMOND B IBIZA-PALACIOS M S | 2004 | Appl Environ Microbiol2004，70，12： | 1 |
| 6 | An evaluation of the spectral characteristics of switching converters with chaotic carrier-frequency modulation显示文摘 | TSE K K RAYMOND W M N HENRY S H C | 2003 | IEEE Transactions on Industrial Electronics2003，50，1： | 1 |
| 7 | Mapping Surface-Energy Balance Components by Combining Landsat Thematic Mapper and Ground-Based Meteorological Data显示文摘 | MORAN M S JACKSON R D RAYMOND L H | 1989 | Remote Sensing of Environment1989，30，1： | 1 |
| 8 | Stakeholder orientation and business perform- ance:The case of service companies in China显示文摘 | Luk C Yau Oliver H M Chow Raymond P M | 2005 | Journal of International Marketing2005，13，13： | 1 |
| 9 | Keratinocytes display normal proliferation, survival and differentiation in conditional beta4-integrin knockout mice 显示文摘 | Raymond K Kreft M Janssen H | 2005 | J Cell Sci2005，118，5： | 1 |
| 10 | Syntheses of 4'epi-antino-4'-deoxyavermectins B1显示文摘 | Raymond J C Dennis H K Lisa M D | 1994 | J Org Chem1994，59，： | 1 |
| 11 | Approaches to the reversal of malnutrition, inflammation, and atherosclerosis in end- stage renal disease显示文摘 | Kayser C Raymond M H Alp I | 2002 | Nutrition Reviews2002，60，11： | 1 |
| 12 | Genetic and biochemical characterization of field-evolved resistance to Bacillus thuringiensis toxin Cry1Ac in the diamondback moth,Plutella xylostella显示文摘 | SAYYED A H RAYMOND B IBIZA-PALACIOS M S | 2004 | Appl Environ Microbiol2004，70，12： | 1 |
| 13 | High power (>1W) good beam quality surface-emitting semiconductor laser显示文摘 | ALFORD W J RAYMOND T D CRAWFORD M H | 2002 | J O S A2002，19，4： | 1 |
| 14 | Genetic and biochemical characterization of field-evolved resistance to Bacillus thuringiensis toxin Cry1Ac in the diamondback moth,Plutella xylostella显示文摘 | Sayyed A H Raymond B Ibiza-Pallcios M | 2004 | Appl Environ Microbiol2004，70，12： | 1 |
| 15 | High serum pmcMcitonin concentrations in fmtimts with sepsis and infection显示文摘 | Assicon M Gendrel D Garsin H Raymond J Bohuon C | 1993 | Lancet1993，341，： | 1 |
| 16 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 1 |
| 17 | Evidence for free radical mediated lipid peroxidation at reperfusion of human orthotopie liver transplantats显示文摘 | Terence H R Warren M Raymond P W | 1994 | Surgery1994，115，： | 1 |
| 18 | Response Surface Methodology-Current Status and Future Directions 显示文摘 | RAYMOND H M | 1999 | Journal of Quality Tech- nology1999，31，1： | 1 |
| 19 | Major ecological transitions in wild sunflowers facilitated by hybridization显示文摘 | RIESEBERG L H RAYMOND O ROSENTHAL D M | | 0，，： | 1 |
| 20 | Mitochondrial sensitivity and altered calcium handling underlie enhanced NMDA-induced apoptosis in YAC128 model of Huntington' s disease显示文摘 | Fernandes H B Baimbridge K G Church J Hayden M R Raymond L A | 2007 | J Neurosci2007，27，13： | 1 |
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