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| 1 | Platelet-rich plasma for muscle injuries: A systematic review of the basic science literature显示文摘BACKGROUND Platelet-rich plasma(PRP) is an increasingly used biologic adjunct for muscle injuries, as it is thought to expedite healing. Despite its widespread use, little is known regarding the mechanisms by which PRP produces its efficacious effects in some patients.AIM To clarify the effects of PRP on muscular pathologies at the cellular and tissue levels by evaluating the basic science literature.METHODS A systematic review of PubMed/MEDLINE and EMBASE databases was performed using the Preferred Reporting Items for Systematic Reviews and MetaAnalyses(PRISMA) guidelines and checklist. Level III in vivo and in vitro studies examining PRP effects on muscles, myocytes and/or myoblasts were eligible for inclusion. Extracted data included PRP preparation methods and study results.RESULTS Twenty-three studies were included(15 in vivo, 6 in vitro, 2 in vitro/in vivo). Only one reported a complete PRP cytology(platelets, and red and white blood cell counts). Five in vitro studies reported increased cellular proliferation, four reported increased gene expression, and three reported increased cellular differentiation. Five in vivo studies reported increased gene expression, three reported superior muscle regeneration, and seven reported improved histological quality of muscular tissue.CONCLUSION The basic science literature on the use of PRP in muscle pathology demonstrates that PRP treatment confers several potentially beneficial effects on healing in comparison to controls. Future research is needed to determine optimal cytology,dosing, timing, and delivery methods of PRP for muscle pathologies. | Kyle N Kunze Charles P Hannon Jared D Fialkoff Rachel M Frank Brian J Cole | 2019 | World Journal of Orthopedics2019，10，7： | 6 |
| 2 | BRCA mutated pancreatic cancer:A change is coming显示文摘Pancreatic cancer remains a leading cause of cancer-related death with few available therapies for advanced disease.Recently,patients with germline BRCA mutations have received increased attention due to advances in the management of BRCA mutated ovarian and breast tumors.Germline BRCA mutations significantly increase risk of developing pancreatic cancer and can be found in up to 8%of patients with sporadic pancreatic cancer.In patients with germline BRCA mutations,platinum-based chemotherapies and poly(ADP-ribose)polymerase inhibitors are effective treatment options which may offer survival benefits.This review will focus on the molecular biology,epidemiology,and management of BRCA-mutated pancreatic cancer.Further-more,we will discuss future directions for this area of research and promising active areas of research. | Michael N Rosen Rachel A Goodwin Michael M Vickers | 2021 | World Journal of Gastroenterology2021，27，17： | 2 |
| 3 | Randomized, Placebo-Controlled, Clinical Trial of Donepezil in Vascular Dementia: Differential Effects by Hippocampal Size显示文摘 | Gustavo C. Román Stephen Salloway Sandra E. Black Donald R. Royall Charles DeCarli Michael W. Weiner Margaret Moline Dinesh Kumar Rachel Schindler Holly Posner | 2010 | Stroke2010，，6： | 2 |
| 4 | A School-Based Intervention to Reduce Aggressive Behavior in Maladjusted Adolescents显示文摘 | Zipora S Rachel N | 1996 | Journal of Applied Developmental Psychology1996，，17： | 1 |
| 5 | Anti-inflammatory activity of Chinese medicinal vine plants显示文摘 | Rachel W Li G David Lin Stephen P Myers David N Leach | 2002 | Journal of Ethnopharmacology2002，，1： | 1 |
| 6 | Determination of endocrine disrupters in sewage treatment and receiving waters显示文摘 | Rachel L Gomes Mark D Scrimshaw John N Lester | 2003 | Trends in Analytical Chemistry2003，22，10： | 1 |
| 7 | Blood lead levels and risk factors for lead poisoning among children in Jakarta显示文摘 | Rachel A Gary N Sharunda B | 2003 | Environmental Reseanch2003，，301： | 1 |
| 8 | Use of supplementary cementing materials to increase the resistance to chloride ion penetration of concrete cured at elevated temperatures显示文摘 | RACHEL J D CHRIS A F JENNIFER N | 1994 | ACI Materials Journal1994，91，1： | 1 |
| 9 | Sleep disturbances,daytime sleepi-ness,and quality of life in adults with growth hormone deficiency显示文摘 | Georges C Arlet N Rachel L | 2010 | J Clin Endocrinol Metab2010，95，5： | 1 |
| 10 | Assessment of Benzo(a)pyrene-equivalent Carcinogenicity and Mutagenicity of Residential Indoor versus Outdoor Polycyclic Aromatic Hydrocarbons Exposing Young Children in New York City显示文摘 | Jung Kyung Hwa Yan Beizhan Chillrud Steven N Perera Frederica P Whyatt Robin Camann David Kinney Patrick L Miller Rachel L | 2010 | International Journal of Environmental Research and Public Health2010，，5： | 1 |
| 11 | Apolipoprotein E Polymorphism and Age at Onset of Alzheimer’s Disease in a Quadriethnic Sample显示文摘 | Kwon Oh Dae Khaleeq Aisha Chan Wenyaw Pavlik Valory N Doody Rachelle S | 2011 | Dementia and Geriatric Cognitive Disorders2011，，6： | 1 |
| 12 | MACROPHAGE MIGRATION INHIBITORY FACTOR LEVELS CORRELATE WITH FATAL OUTCOME IN SEPSIS显示文摘 | Fernando A Bozza Rachel N Gomes André M Japiassú Marcio Soares Hugo C Castro-Faria-Neto Patrìcia T Bozza Marcelo T Bozza | 2004 | Shock2004，，4： | 1 |
| 13 | The Use of English Textbooks for Teaching English to 'Vocational' Students in Singapore Secondary Schools:a Survey of Teachers' Beliefs显示文摘 | LEE RACHEL N F | | 0，，03： | 1 |
| 14 | Propicpropiconazole increases reactive oxygen species levels in mouse hepatic cells in culture and in mouse liver by a cytochrome P450 enzyme mediated process 显示文摘 | Stephen N Rachel D G Guy L | 2011 | Chemica Biological Interac?tions2011，194，： | 1 |
| 15 | Do R&D tax credits work? Evidence from a panel of countries 1979-1997显示文摘 | Bloom N Rachel G Reenen J V | | 0，，01： | 1 |
| 16 | Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial显示文摘 | Raj R Makkar Rachel R Smith Ke Cheng Konstantinos Malliaras Louise EJ Thomson Daniel Berman Lawrence SC Czer Linda Marbán Adam Mendizabal Peter V Johnston Stuart D Russell Karl H Schuleri Albert C Lardo Gary Gerstenblith Eduardo Marbán | 2012 | The Lancet2012，，9819： | 1 |
| 17 | Bacterial population changes in a membrane bioreactor for graywater treatment monitored by denaturing gradient ge electrophoretic analysis of 16S rRNA gene fragments 显示文摘 | David M Stamper M W Rachel N J | 2003 | Appl Environ Microbiol2003，69，： | 1 |
| 18 | Antioxidant effects of N-acetylcysteine and succimer in red blood cells from lead-exposed rats 显示文摘 | Hande G Hilal O Rachel N | 1998 | Toxicology1998，128，3： | 1 |
| 19 | The association of plasma fibrinogen concentration with diabetic microvascular complications in young adults with early - onset of type 2 dia- betes 显示文摘 | Duc Son N T L Rachelle M Peter J | 2008 | Diabetes Research and Clinical Practice2008，82，31： | 1 |
| 20 | Efficacy of a prophylactic adjuvanted bivalent L1 virus-like-particle vaccine against infection with human papillomavirus types 16 and 18 in young women: an interim analysis of a phase III double-blind, randomised controlled trial显示文摘 | Jorma Paavonen David Jenkins F Xavier Bosch Paulo Naud Jorge Salmerón Cosette M Wheeler Song-Nan Chow Dan L Apter Henry C Kitchener Xavier Castellsague Newton S de Carvalho S Rachel Skinner Diane M Harper James A Hedrick Unnop Jaisamrarn Genara AM Limson | 2007 | The Lancet2007，，9580： | 1 |
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