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| 1 | Clinically relevant factors associated with quantitative optical coherence tomography angiography metrics in deep capillary plexus in patients with diabetes显示文摘Background:To test clinically relevant factors associated with quantitative artifact-free deep capillary plexus(DCP)metrics in patients with diabetes mellitus(DM).Methods:563 eligible eyes(221 with no diabetic retinopathy[DR],135 with mild DR,130 with moderate DR,and 77 with severe DR)from 334 subjects underwent optical coherence tomography-angiography(OCT-A)with a swept-source OCT(Triton DRI-OCT,Topcon,Inc.,Tokyo,Japan).Strict criteria were applied to exclude from analysis those DCP images with artifacts and of poor quality,including projection artifacts,motion artifacts,blurriness,signal loss,B-scan segmentation error,or low-quality score.A customized MATLAB program was then used to quantify DCP morphology from the artifact-free DCP images by calculating three metrics:foveal avascular zone(FAZ),vessel density(VD),and fractal dimension(FD).Results:166(29.5%)eyes were excluded after quality control,leaving in the analysis 397 eyes(170 with no DR,101 with mild DR,90 with moderate DR,36 with severe DR)from 250 subjects.In the multiple regression models,larger FAZ area was associated with more severe DR(β=0.687;p=0.037),shorter axial length(AL)(β=−0.171;p=0.003),thinner subfoveal choroid thickness(β=−0.122;p=0.031),and lower body mass index(BMI)(β=−0.090;p=0.047).Lower VD was associated with more severe DR(β=−0.842;p=0.001),shorter AL(β=0.107;p=0.039),and poorer visual acuity(VA)(β=−0.133;p=0.021).Lower FD was associated with more severe DR(β=−0.891;p<0.001)and with older age(β=−0.142;p=0.004).Conclusions:Quantitative artifact-free DCP metrics are associated with VA,DR severity,AL,subfoveal choroidal thickness,age,and BMI in diabetic patients.The effects of ocular and systemic factors should be considered for meaningful interpretations of DCP changes in DM patients. | Fang Yao Tang Erica O.Chan Zihan Sun Raymond Wong Jerry Lok Simon Szeto Jason C.Chan Alexander Lam Clement C.Tham Danny S.Ng Carol Y.Cheung | 2020 | Eye and Vision2020，7，1： | 7 |
| 2 | Evolutionary Optimization: Pitfalls and Booby Traps显示文摘Evolutionary computation (EC), a collective name for a range of metaheuristic black-box optimization algorithms, is one of the fastest-growing areas in computer science. Many manuals and 'how-to's on the use of different EC methods as well as a variety of free or commercial software libraries are widely available nowadays. However, when one of these methods is applied to a real-world task, there can be many pitfalls and booby traps lurking - certain aspects of the optimization problem that may lead to unsatisfactory results even if the algorithm appears to be correctly implemented and executed. These include the convergence issues, ruggedness, deceptiveness, and neutrality in the fitness landscape, epistasis, non-separability, noise leading to the need for robustness, as well as dimensionality and scalability issues, among others. In this article, we systematically discuss these related hindrances and present some possible remedies. The goal is to equip practitioners and researchers alike with a clear picture and understanding of what kind of problems can render EC applications unsuccessful and how to avoid them from the start. | Thomas Weise Raymond Chiong Ke Tang | 2012 | Journal of Computer Science & Technology2012，27，5： | 5 |
| 3 | Whole-genome sequencing of monozygotic twins discordant for schizophrenia indicates multiple genetic risk factors for schizophrenia显示文摘Schizophrenia is a common disorder with a high heritability, but its genetic architecture is still elusive.We implemented whole-genome sequencing(WGS) analysis of 8 families with monozygotic(MZ) twin pairs discordant for schizophrenia to assess potential association of de novo mutations(DNMs) or inherited variants with susceptibility to schizophrenia. Eight non-synonymous DNMs(including one splicing site) were identified and shared by twins, which were either located in previously reported schizophrenia risk genes(p.V24689 I mutation in TTN, p.S2506 T mutation in GCN1L1, IVS3+1G > T in DOCK1) or had a benign to damaging effect according to in silico prediction analysis. By searching the inherited rare damaging or loss-of-function(LOF) variants and common susceptible alleles from three classes of schizophrenia candidate genes, we were able to distill genetic alterations in several schizophrenia risk genes, including GAD1, PLXNA2, RELN and FEZ1. Four inherited copy number variations(CNVs; including a large deletion at 16p13.11) implicated for schizophrenia were identified in four families, respectively. Most of families carried both missense DNMs and inherited risk variants, which might suggest that DNMs, inherited rare damaging variants and common risk alleles together conferred to schizophrenia susceptibility. Our results support that schizophrenia is caused by a combination of multiple genetic factors, with each DNM/variant showing a relatively small effect size. | Jinsong Tang Yu Fan Hong Li Qun Xiang Deng-Feng Zhang Zongchang Li Ying He Yanhui Liao Ya Wang Fan He Fengyu Zhang Yin Yao Shugart Chunyu Liu Yanqing Tang Raymond C.K.Chan Chuan-Yue Wang Yong-Gang Yao Xiaogang Chen | 2017 | Journal of Genetics and Genomics2017，44，6： | 4 |
| 4 | Charge Control:Modeling,Analysis,and Design显示文摘 | Wei Tang Fred C Lee Raymond B Ridley Isaac Cohen | 2003 | IEEE Transactions on Power Electronics2003，，10： | 1 |
| 5 | 查看详情显示文摘 | Tang H Webb J B Bardwell J A Raymond S Salzman J Uzan- Saguy C | | 0，，： | 1 |
| 6 | Is uric acid protective or deleterious in acute ischemic stroke? A prospective cohort study显示文摘 | Raymond C.S. Seet Katherine Kasiman Jan Gruber Soon-Yew Tang Meng-Cheong Wong Hui-Meng Chang Yiong-Huak Chan Barry Halliwell Christopher P. Chen | 2009 | Atherosclerosis2009，，1： | 1 |
| 7 | Intrathoracic Impedance Monitoring in Patients With Heart Failure: Correlation With Fluid Status and Feasibility of Early Warning Preceding Hospitalization显示文摘 | Cheuk-Man Yu Li Wang Elaine Chau Raymond Hon-Wah Chan Shun-Ling Kong Man-Oi Tang Jill Christensen Robert W. Stadler Chu-Pak Lau | 2005 | Circulation2005，，： | 1 |
| 8 | Quality of colonoscopy withdrawal technique and variability in adenoma detection rates (with videos)显示文摘 | Robert H. Lee Raymond S. Tang V. Raman Muthusamy Samuel B. Ho Nimeesh K. Shah Laura Wetzel Andrew S. Bain Erin E. Mackintosh Aeri M. Paek Ana Maria Crissien Lida Jafari Saraf Denise M. Kalmaz Thomas J. Savides | 2011 | Gastrointestinal Endoscopy2011，，： | 1 |
| 9 | Activities of fresh juice of Scutellaria barbata and warmed water extractof Radix Sophorae Tonkinensis on anti-proliferation and apoptosis of human cancercell lines显示文摘 | Chung Chui Fung Lau Johnny Tang Kin Kan Gregory Cheng Raymond Wong Stanton Kok Paul Lai Rocky Ho Roberto Gambari Albert Chan | 2005 | International Journal of Molecular Medicine2005，，2： | 1 |
| 10 | Is uric acid protective or deleterious in acute ischemic stroke? A prospective cohort study显示文摘 | Raymond C.S. Seet Katherine Kasiman Jan Gruber Soon-Yew Tang Meng-Cheong Wong Hui-Meng Chang Yiong-Huak Chan Barry Halliwell Christopher P. Chen | 2009 | Atherosclerosis2009，，1： | 1 |
| 11 | Multimodal analgesia for hip arthroplasty 显示文摘 | Raymond Tang Holly Evans Alan Chaput | 2009 | Orthop Clin N Am2009，40，3： | 1 |
| 12 | A 3-year prospective study of neurological soft signs in first-episode schizophrenia显示文摘 | Eric Yu-Hai Chen Christy Lai-Ming Hui Raymond Chor-Kiu Chan Eva Lai-Wah Dunn May Yin-King Miao Wai-Song Yeung Chi-Keung Wong Wah-Fat Chan Wai-Nang Tang | 2004 | Schizophrenia Research2004，，1： | 1 |
| 13 | MR-seq:measuring a single cell's transcriptome repeatedly by RNA-seq显示文摘We described a novel single-cell RNA-seq technique called MR-seq(measure a single-cell transcriptome repeatedly),which permits statistically assessing the technical variation and identifying the differentially expressed genes between just two single cells by measuring each single cell twice. We demonstrated that MR-seq gave sensitivity and reproducibility similar to the standard single-cell RNA-seq and increased the positive predicate value. Application of MR-seq to early mouse embryos identified hundreds of candidate intra-embryonic heterogeneous genes among mouse 2-,4-and 8-cell stage embryos. MR-seq should be useful for detecting differentially expressed genes among a small number of cells. | Lu Yang Zhaochun Ma Chen Cao Yuhao Zhang Xinglong Wu Raymond Lee Boqiang Hu Lu Wen Hao Ge Yanyi Huang Kaiqin Lao Fuchou Tang | 2017 | Science Bulletin2017，62，6： | 1 |
| 14 | IN VIVO NEAR-INFRAREDFLUORESCENCEIMAGING OF HUMANCOLONADENOCARCINOMABY SPECIFIC IMMUNOTARGETINGOFA TUMOR-ASSOCIATEDMUCIN显示文摘Background and Aims: Accurate endoscopic detection of premalignant lesions and earlycancers in the colon is essential for cure, since prognosis is closely related to lesion size andstage. Although it has great clinical potential, autofluorescence endoscopy has limited tumorto-normal tissue image contrast for detecting small preneoplastic lesions. We have developed amolecularly specific, near-infrared fluorescent monoclonal antibody (CC49) bioconjugate whichtargets tumor-associated glycoprotein 72 (TAG72), as a contrast agent to improve fluorescencebased endoscopy of colon cancer. Methods: The fluorescent anti-TAG72 conjugate was evaluated in vitro and in vivo in athymic nude mice bearing human colon adenocarcinoma (LS174T)subcutaneous tumors. Autofluorescence, a fluorescent but irrelevant antibody and the free fluorescent dye served as controls. Fluorescent agents were injected intravenously, and in vivowhole body fluorescence imaging was performed at various time points to determine pharmacokinetics, followed by ex vivo tissue analysis by confocal fluorescence microscopy and histology Results: Fluorescence microscopy and histology confirmed specific LS174T cell membrane targeting of labeled CC49 in vitro and ex vivo. In vivo fluorescence imaging demonstrated significant tumor-to-normal tissue contrast enhancement with labeled-CC49 at three hours postinjection, with maximum contrast after 48 h. Accumulation of tumor fluorescence demonstratedthat modification of CC49 antibodies did not alter their specific tumor-localizing properties, andwas antibody-dependent since controls did not produce detectable tumor fluorescence. Conclusions: These results show proof-of-principle that our near-infrared fluorescent-antibody probetargeting a tumor-associated mucin detects colonic tumors at the molecular level in real time,and offer a basis for future improvement of image contrast during clinical fluorescence endoscopy. | RALPH S.DACOSTA YING TANG TUULA KALLIOMAKI RAYMOND M.REILLY ROBERT WEERSINK ALISHA R.ELFORD NORMAN E.MARCON BRIAN C.WILSON | 2009 | Journal of Innovative Optical Health Sciences2009，2，4： | 0 |
| 15 | 城市绽放——BRAUN BUFFEL旗舰店显示文摘项目是Spacemen为Braun Buffel设计的最新旗舰店,是一系列名为“城市绽放”的概念空间中的第一个项目。设计案例对立在森林中的一棵活树进行抽象诠释,通过一个具有视觉冲击力的概念来吸引人们进入零售店。项目的设计避开了传统的奢华概念,转而采用极简主义方法,空间的核心是对一棵树从地板发芽到天花板的过程演绎,就像在科幻实验室中生长一样,覆盖着苔藓的装置与商店的开放式布局形成对比,旨在将建筑与装置融为一体,赋予空间独特的个性。 | Edward Tan Edward Chan Raymond Tang Phyllis Zhang Kuma Ni Alvin Zhou 舒禹(编译) David Yeow Photograph(摄影) | 2022 | 现代装饰2022，，6： | 0 |
| 16 | 爱搽显示文摘在第三个店铺的设计前期,业主考察团队曾进到一个"画中"的茶园,并深深地沉浸在茶园的"宁静"氛围中。他们想要把这种"氛围"作为店铺的特色体验。SPACEMEN从大自然中汲取灵感,通过一系列黄铜色调的"波浪链面",抽象化地在餐厅空间设计中表达了茶园的标志性地形。餐厅位于上海新开发的露天购物中心"丰盛里",本餐厅将成为该品牌的新旗舰店。 | Edward Tan Kyan Foo Raymond Tang Ed Chan Simon Liu | 2018 | 现代装饰2018，0，11： | 0 |
| 17 | The Hong Kong consensus recommendations on the diagnosis and management of pancreatic cystic lesions显示文摘Background:The finding of pancreatic cystic lesions(PCL)on incidental imaging is becoming increasingly common.International studies report a prevalence of 2.2-44.7%depending on the population,imaging modality and indication for imaging,and the prevalence increases with age.Patients with PCL are at risk of developing pancreatic cancer,a disease with a poor prognosis.This publication summarizes recommendations for the diagnosis and management of PCL and post-operative pancreatic exocrine insufficiency(PEI)from a group of local specialists.Methods:Clinical evidence was consolidated from narrative reviews and consensus statements formulated during two online meetings in March 2022.The expert panel included gastroenterologists,hepatobiliary surgeons,oncologists,radiologists,and endocrinologists.Results:Patients with PCL require careful investigation and follow-up due to the risk of malignant transformation of these lesions.They should undergo clinical investigation and pancreas-specific imaging to classify lesions and understand the risk profile of the patient.Where indicated,patients should undergo pancreatectomy to excise PCL.Following pancreatectomy,patients are at risk of PEI,leading to gastrointestinal dysfunction and malnutrition.Therefore,such patients should be monitored for symptoms of PEI,and promptly treated with pancreatic enzyme replacement therapy(PERT).Patients with poor response to PERT may require increases in dose,addition of a proton pump inhibitor,and/or further investigation,including tests for pancreatic function.Patients are also at risk of new-onset diabetes mellitus after pancreatectomy;they should be screened and treated with insulin if indicated.Conclusions:These statements are an accurate summary of our approach to the diagnosis and management of patients with PCL and will be of assistance to clinicians treating these patients in a similar clinical landscape. | Tan-To Cheung Yuk Tong Lee Raymond Shing-Yan Tang Wong Hoi She Kai Chi Cheng Chin Cheung Cheung Keith Wan Hang Chiu Kenneth Siu Ho Chok Wing Sun Chow Tak Wing Lai Wai-Kay Seto Thomas Yau | 2023 | Hepatobiliary Surgery and Nutrition2023，12，5： | 0 |
| 18 | Low-temperature caproate production,microbial diversity,and metabolic pathway in xylose anaerobic fermentation显示文摘Mixed culture fermentation(MCF)is challenged by the unqualified activity of enriched bacteria and unwanted methane dissolution under low temperatures.In this work,caproate production from xylose was investigated by MCF at a low temperature(20°C).The results showed that a 9 d long hydraulic retention time(HRT)in a continuously stirred tank reactor was necessary for caproate production(~0.3 g/L,equal to 0.6 g COD/L)from xylose(10 g/L).The caproate concentration in the batch mode was further increased to 1.6 g/L.However,changing the substrate to ethanol did not promote caproate production,resulting in~1.0 g/L after 45 d of operation.Four genera,Bifidobacterium,Caproiciproducens,Actinomyces,and Clostridium_sensu_stricto_12,were identified as the enriched caproate-producing bacteria.The enzymes in the fatty acid biosynthesis(FAB)pathway for caproate production were identified via metagenomic analysis.The enzymes for the conversion of(C_(n+2))-2,3-Dehydroxyacyl-CoA to(C_(n+2))-Acyl-CoA(i.e.,EC 1.3.1.8 and EC 1.3.1.38)in the reverseβ-oxidation(RBO)pathway were not identified.These results could extend the understanding of low-temperature caproate production. | Qingting Wang Kun Dai Jie Tang Sidi Hong Sijie Zheng Ting Sun Raymond Jianxiong Zeng Fang Zhang | 2023 | Frontiers of Environmental Science & Engineering2023，17，3： | 0 |
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