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| 1 | Assessment of metastatic liver disease in patients with primary extrahepatic tumors by contrast-enhanced sonography versus CT and MRI显示文摘瞄准:与已知的额外的肝的原发性瘤对包括 CT, MRI 和临床 / 组织学的数据的联合标准答案在病人在肝转移的察觉用 SonoVue 评估提高对比的 ultrasonography (CEUS ) 。方法:它是一国际多集中学习,并且有 12 个中心和 125 个病人(64 男性, 61 女性,变老 59+/-11 年) 包含,与 102 个病人一起每协议。原发性瘤是在 35% 表面的颜色,在 27% 的胸,在 17% 胰腺并且其它在 21% 。用 SonoVue 的 CEUS 用西门子 Elegra, Philips HDI 5000 和 Acuson 红杉与一种 low-mechanical-index 技术和对比特定的软件被采用;为至少五分钟的连续扫描。结果:有 SonoVue 的 CEUS 显著地增加了检测的焦点的肝损害对 unenhanced sonography 的数字。在 31.4% 病人,更多的损害在对比改进以后被发现。检测的损害的全部的数字与 CEUS (55 ) 是可比较的,三倍阶段的螺线 CT (61 ) 和有一个肝特定的对比代理人(53 ) 的 MRI。变形疾病的察觉的精确性(即至少一变形损害) 比为 unenhanced sonography (81.4%) 为 CEUS (91.2%) 是显著地更高的并且类似于三倍阶段的螺线 CT (89.2%) 的。在其 CEUS 检查否定的 53 个病人,后续考试 3-6 瞬间以后在 50 个病人(94.4%) 证实了变形损害的缺席。结论:CEUS 被证明在在有已知的额外的肝的原发性瘤的病人的肝转移的察觉可靠并且怀疑肝损害。 | Christoph F Dietrich Wolfgang Kratzer Deike Strobel Etienne Danse Robert Fessl Alfred Bunk Udo Vossas Karlheinz Hauenstein Wilhelm Koch Wolfgang Blank Matthijs Oudkerk Dietbert Hahn Christian Greis | 2006 | World Journal of Gastroenterology2006，12，11： | 39 |
| 2 | Efficacy of SpyGlass^(TM)-directed biopsy compared to brush cytology in obtaining adequate tissue for diagnosis in patients with biliary strictures显示文摘AIM: To evaluate the diagnostic yield(inflammatory activity) and efficiency(size of the biopsy specimen) of SpyGlassTM-guided biopsy vs standard brush cytology in patients with and without primary sclerosing cholangitis(PSC).METHODS: At the University Medical Center Mainz, Germany, 35 consecutive patients with unclear biliarylesions(16 patients) or long-standing PSC(19 patients) were screened for the study. All patients underwent a physical examination, lab analyses, and abdominal ultrasound. Thirty-one patients with non-PSC strictures or with PSC were scheduled to undergo endoscopic retrograde cholangiography(ERC) and subsequent per-oral cholangioscopy(POC). Standard ERC was initially performed, and any lesions or strictures were localized. POC was performed later during the same session. The Boston Scientific SpyGlass SystemTM(Natick, MA, United States) was used for choledochoscopy. The biliary tree was visualized, and suspected lesions or strictures were biopsied, followed by brush cytology of the same area. The study endpoints(for both techniques) were the degree of inflammation, tissue specimen size, and the patient populations(PSC vs non-PSC). Inflammatory changes were divided into three categories: none, low activity, and high activity. The specimen quantity was rated as low, moderate, or sufficient.RESULTS: SpyGlassTM imaging and brush cytology with material retrieval were performed in 29 of 31(93.5%) patients(23 of the 29 patients were male). The median patient age was 45 years(min, 20 years; max, 76 years). Nineteen patients had known PSC, and 10 showed non-PSC strictures. No procedure-related complications were encountered. However, for both methods, tissues could only be retrieved from 29 pa-tients. In cases of inflammation of the biliary tract, the diagnostic yield of the SpyGlassTM-directed biopsies was greater than that using brush cytology. More tissue material was obtained for the biopsy method than for the brush cytology method(P = 0.021). The biopsies showed significantly more inflammatory characteristics and greater inflammatory activity compared to the cy-tological investigation(P = 0.014). The greater quantity of tissue samples proved useful for both PSC and non-PSC patients.CONCLUSION: SpyGlassTM imaging can be recom-mended for proper inflammatory diagnosis in PSC pa-tients. However, its value in diagnosing dysplasia wasnot addressed in this study and requires further investi-gation. | Johannes Wilhelm Rey Torsten Hansen Sebastian Dümcke Achim Tresch Katja Kramer Peter Robert Galle Martin Goetz Marcus Schuchmann Ralf Kiesslich Arthur Hoffman | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，4： | 2 |
| 3 | Fuadamentals of polarimetric remote sensing 显示文摘 | WILHELM S ROBERT J | 2009 | Remote Sensing SPIE2009，1，： | 1 |
| 4 | Flexible tools for specifying design variation显示文摘 | Pasupathy Trichy Zhao Xiaoping Wilhelm Robert | 2006 | Int J Adv Manuf Technol2006，28，： | 1 |
| 5 | One size does not fit all: The emerging frontier in large-scale marine conservation显示文摘 | Robert J. Toonen T. ‘Aulani Wilhelm Sara M. Maxwell Daniel Wagner Brian W. Bowen Charles R.C. Sheppard Sue M. Taei Tukabu Teroroko Russell Moffitt Carlos F. Gaymer Lance Morgan Nai‘a Lewis Anne L.S. Sheppard John Parks Alan M. Friedlander | 2013 | Marine Pollution Bulletin . 2013 (1-2)2013，，1： | 1 |
| 6 | Registration and integration of multiple laser scanned data for reverse engineering of complex 3D models 显示文摘 | Hong Tzong Yan Chun Yam Chen Robert Wilhelm | 2000 | International Journal of Production Research2000，38，2： | 1 |
| 7 | Mesenchymal stem cells transmigrate over the endothelial barrier显示文摘 | Annette Schmidt Dennis Ladage Caroline Steingen Klara Brixius Timo Schink?the Franz-Josef Klinz Robert H.G. Schwinger Uwe Mehlhorn Wilhelm Bloch | 2006 | European Journal of Cell Biology2006，，11： | 1 |
| 8 | An integrated Tomographic Gamma Scanning system for non-destructive assay of radioactive waste显示文摘 | Ramkumar Venkataraman Marcel Villani Stephen Croft Patricia McClay Robert McElroy Susan Kane Wilhelm Mueller Robert Estep | 2007 | and Methods in Physics Research, A2007，，1： | 1 |
| 9 | Diversity in octadecanoid-induced gene expression of tomato显示文摘 | Claus Wasternack Birgit Ortel Otto Miersch Robert Kramell Michael Beale Friedemann Greulich Ivo Feussner Bettina Hause Thomas Krumm Wilhelm Boland Benno Parthier | 1998 | Journal of Plant Physiology1998，，2： | 1 |
| 10 | Leaching and differential recrystallization of metamict zircon under experimental hydrothermal conditions显示文摘 | Thorsten Geisler Marcus Ulonska Helmut Schleicher Robert T. Pidgeon Wilhelm van Bronswijk | 2001 | Contributions to Mineralogy and Petrology2001，，1： | 1 |
| 11 | Registration and integration of multiple laser scanned data for reverse engineering of complex 3D models显示文摘 | Yau Hong Tzong Chen Chun Yan Wilhelm Robert G | 2000 | International Journal of Production Research2000，38，2： | 1 |
| 12 | Biodiversity and endemism mapping as a tool for regional conservation planning case study of the Pleurothallidinae (Orchidaceae) of the Andean rain forests in Bolivia显示文摘 | Robert M Christoph N Wilhelm B Pierre L I | 2003 | Biodiversity and Conservation2003，12，： | 1 |
| 13 | Registratian and integration of multiple laser scanned data for reverse engineering of complex 3 D models显示文摘 | HONG-TZONG YAU CHUN-YAN CHEN ROBERT G WILHELM | 2000 | International Journal of Production Research2000，38，2： | 1 |
| 14 | 1,3,4-Trisubstituted piperidine derivatives from Mannich bases显示文摘 | John T Plati Robert A Schmidt Wilhelm Wenner | 1949 | J Org Chem1949，14，5： | 1 |
| 15 | Material-specific high-resolution table-top extreme ultraviolet microscopy显示文摘Microscopy with extreme ultraviolet(EUV)radiation holds promise for high-resolution imaging with excellent material contrast,due to the short wavelength and numerous element-specific absorption edges available in this spectral range.At the same time,EUV radiation has significantly larger penetration depths than electrons.It thus enables a nano-scale view into complex three-dimensional structures that are important for material science,semiconductor metrology,and next-generation nano-devices.Here,we present high-resolution and material-specific microscopy at 13.5 nm wavelength.We combine a highly stable,high photon-flux,table-top EUV source with an interferometrically stabilized ptychography setup.By utilizing structured EUV illumination,we overcome the limitations of conventional EUV focusing optics and demonstrate high-resolution microscopy at a half-pitch lateral resolution of 16 nm.Moreover,we propose mixed-state orthogonal probe relaxation ptychography,enabling robust phase-contrast imaging over wide fields of view and long acquisition times.In this way,the complex transmission of an integrated circuit is precisely reconstructed,allowing for the classification of the material composition of mesoscopic semiconductor systems. | Wilhelm Eschen Lars Loetgering Vittoria Schuster Robert Klas Alexander Kirsche Lutz Berthold Michael Steinert Thomas Pertsch Herbert Gross Michael Krause Jens Limpert Jan Rothhardt | 2022 | Light(Science & Applications)2022，11，5： | 0 |
| 16 | Intraprocedural bowel cleansing with the Jet Prep cleansing system improves adenoma detection显示文摘AIM: To investigate the impact of Jet Prep cleansing on adenoma detection rates.METHODS: In this prospective,randomized,crossover trial,patients were blindly randomized to an intervention arm or a control arm.In accordance with the risk profile for the development of colorectal carcinoma,the study participants were divided into high-risk and low-risk groups.Individuals with just one criterion(age > 70 years,adenoma in medical history,and first-degree relative with colorectal cancer) were regarded as high-risk patients.Bowel preparation was performed in a standardized manner one day before the procedure.Participants in the intervention arm underwent an initial colonoscopy with standard bowel cleansing using a 250-m L syringe followed by a second colonoscopy that included irrigation by the use of the Jet Prep cleansing system.The reverse sequence was used in the control arm.The study participants were divided into a high-risk group and a low-risk group according to their respective risk profiles for the development of colorectal carcinoma.RESULTS: A total of 64 patients(34 men and 30 women) were included in the study; 22 were included in the high-risk group.After randomization,30 patients were assigned to the control group(group A) and 34 to the intervention group(group B).The average Boston Bowel Preparation Scale score was 5.15 ± 2.04.The withdrawal time needed for the first step was significantly longer in group A using the Jet Prep system(9.41 ± 3.34 min) compared to group B(7.5 ± 1.92 min).A total of 163 polyps were discovered in 64 study participants who underwent both investigation steps.In group A,49.4% of the polyps were detected during the step of standard bowel cleansing while the miss rate constituted 50.7%.Group B underwent cleansing with the Jet Prep system during the first examination step,and as many as 73.9% of polyps were identified during this step.Thus,the miss rate in group B was a mere 26.1%(P < 0.001).When considering only the right side of the colon,the miss rate in group A during the first examination was 60.6%,in contrast to a miss rate of 26.4% in group B(P < 0.001).CONCLUSION: Jet Prep is recommended for use during colonoscopy because a better prepared bowel enables a better adenoma detection,particularly in the proximal colon. | Arthur Hoffman Sanjay Murthy Lena Pompetzki Johannes Wilhelm Rey Martin Goetz Achim Tresch Peter Robert Galle Ralf Kiesslich | 2015 | World Journal of Gastroenterology2015，21，26： | 0 |
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