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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | 内侧固定平台单髁置换术后的冠状面下肢力线是翻修的影响因素显示文摘膝关节单髁置换术(unicompartmental knee arthroplasty,UKA)后患者冠状面的下肢力线被认为是影响手术长期疗效的一个重要因素,但关于最佳的UKA术后下肢力线还没有形成明确共识。一些研究主张术后下肢力线应保持在中立位,而另一些研究认为即使术后下肢力线存在10°的内翻也可获得良好的临床效果。 | Sean E Slaven John P Cody Robert A Sershon Henry Ho Robert H Hopper Jr Kevin B Fricka 李亚坤(整理) 张民(整理) | 2020 | 实用骨科杂志2020，26，12： | 15 |
| 3 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 4 | Quality in the technical performance of colonoscopy and the continuous quality improvement process for colonoscopy: recommendations of the U.S. Multi-Society Task Force on Colorectal Cancer显示文摘 | Douglas K Rex John H Bond Sidney Winawer Theodore R Levin Randall W Burt David A Johnson Lynne M Kirk Scott Litlin David A Lieberman Jerome D Waye James Church John B Marshall Robert H Riddell | 2002 | The American Journal of Gastroenterology2002，，6： | 3 |
| 5 | An analysis of multiple staging management strategies for carcinoma of the esophagus: computed tomography, endoscopic ultrasound, positron emission tomography, and thoracoscopy/laparoscopy显示文摘 | Michael B Wallace Paul J Nietert Craig Earle Mark J Krasna Robert H Hawes Brenda J Hoffman Carolyn E Reed | 2002 | The Annals of Thoracic Surgery2002，，4： | 2 |
| 6 | Diagnosis and management of splanchnic ischemia显示文摘Splanchnic or gastrointestinal ischemia is rare and randomized studies are absent. This review focuses on new developments in clinical presentation, diagnostic approaches, and treatments. Splanchnic ischemia can be caused by occlusions of arteries or veins and by physiological vasoconstriction during low-flow states. The prevalence of significant splanchnic arterial stenoses is high, but it remains mostly asymptomatic due to abundant collateral circulation. This is known as chronic splanchnic disease (CSD). Chronic splanchnic syndrome (CSS) occurs when ischemic symptoms develop. Ischemic symptoms are characterized by postprandial pain, fear of eating and weight loss. CSS is diagnosed by a test for actual ischemia. Recently, gastro-intestinal tonometry has been validated as a diagnostic test to detect splanchnic ischemia and to guide treatment. In single- vessel CSD, the complication rate is very low, but some patients have ischemic complaints, and can be treated successfully. In multi-vessel stenoses, the complication rate is considerable, while most have CSS and treatment should be strongly considered. CT and MR-based angiographic reconstruction techniques have emerged as alternatives for digital subtraction angiography for imaging of splanchnic vessels. Duplex ultrasound is still the first choice for screening purposes. The strengths and weaknesses of each modality will be discussed. CSS may be treated by minimally invasive endoscopic treatment of the celiac axis compression syndrome, endovascular antegrade stenting, or laparotomy-assisted retrograde endovascular recanalization and stenting.The treatment plan is highly individualized and is mainly based on precise vessel anatomy, body weight, co- morbidity and severity of ischemia. | Jeroen J Kolkman Marloes Bargeman Ad B Huisman Robert H Geelkerken | 2008 | World Journal of Gastroenterology2008，14，48： | 2 |
| 7 | New directions in management accounting research 显示文摘 | Atkinson A A Balakrishnan P B Cote J M Grout T M Roberts H Ulan E Wu A | | Journal of Management Accounting Research0，997，： | 1 |
| 8 | Underwater Bipedal Locomotion by Octopuses in Disguise显示文摘 | CHRISTINE L H FARNIS B ROBERT J F | 2005 | Science2005，307，： | 1 |
| 9 | Amyloid β-peptide impairs ion-motive ATPase activities:evidence for a role in loss of neuronal Ca^2+ Homeostasis and cell death显示文摘 | Robert J M Kenneth H Allan B | 1995 | J Neurosci1995，15，9： | 1 |
| 10 | Disregulated glyceroneogenesis:PCK1 as a candidate diabetes and obesity gene显示文摘 | Elmus G B Robert E H Bénédicte A | 2004 | Trens in Endocrinology and Metabolism2004，15，3： | 1 |
| 11 | Genetic variation of Japanese encephalitis virus in Nature 显示文摘 | WOAN R C ROBERT B T REBACA R R H | 1990 | J Gen Virol1990，71，2： | 1 |
| 12 | Multiple organ dysfunction after return of spontaneous circulation in postcardiac arrest syndrome显示文摘 | Roberts B W Kilgannon J H Chansky M E | 2013 | Crit Care Med2013，41，： | 1 |
| 13 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 14 | Predictors of survival for esophageal cancer patients with and without celiac axis lymphadenopathy: impact of staging endosonography显示文摘 | Mohamad A Eloubeidi Michael B Wallace Brenda J Hoffman Margaret B Leveen Annette Van Velse Robert H Hawes Carolyn E Reed | 2001 | The Annals of Thoracic Surgery2001，，1： | 1 |
| 15 | Polycomb repression of flowering during earlyplant development显示文摘 | Tetsu K John J H Robert B G | 2001 | Pro Natl Acad Sci USA2001，98，14： | 1 |
| 16 | Generationof potentially bioactive ergosterol-derived products following pulsedultraviolet light exposure of mushrooms (Agaricus bisporus)显示文摘 | MICHAEL D K ROBERT B B MICHAEL F H | 2012 | FoodChemistry2012，135，2： | 1 |
| 17 | A heuristic method for identifying modules for roduct architectures显示文摘 | Robert B Stone Kristin L Wood Richard H Crawford | | 0，，01： | 1 |
| 18 | The interactions between trading volume and volatility:Evidence from the equity options markets显示文摘 | Park T H Lorne N S Robert B | 1999 | Applied Finance Economics1999，9，6： | 1 |
| 19 | Control of chaos in a PWM current-mode H-bridge inverter using time-delayed feedback显示文摘 | Iu H H C Robert B | 2003 | IEEE Transactions on Circuits and Systems I:Fundamental Theory and Applications2003，50，8： | 1 |
| 20 | Metabolic syndrome and its components as predictors of incident type 2 diabetes mellitus in an Aboriginal community显示文摘 | Ley Sylvia H Harris Stewart B Mamakeesick Mary Noon Tina Fiddler Edith Gittelsohn Joel Wolever Thomas M S Connelly Philip W Hegele Robert A Zinman Bernard Hanley Anthony J G | 2009 | Canadian Medical Association. Journal2009，，6： | 1 |
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