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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial显示文摘 | Michael P Manns John G McHutchison Stuart C Gordon Vinod K Rustgi Mitchell Shiffman Robert Reindollar Zachary D Goodman Kenneth Koury Mei-Hsiu Ling Janice K Albrecht | 2001 | The Lancet2001，，9286： | 4 |
| 3 | Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial显示文摘 | Roger Stupp Monika E Hegi Warren P Mason Martin J van den Bent Martin JB Taphoorn Robert C Janzer Samuel K Ludwin Anouk Allgeier Barbara Fisher Karl Belanger Peter Hau Alba A Brandes Johanna Gijtenbeek Christine Marosi Charles J Vecht Karima Mokhtari Piet | 2009 | Lancet Oncology2009，，5： | 4 |
| 4 | Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial显示文摘 | Michael P Manns John G McHutchison Stuart C Gordon Vinod K Rustgi Mitchell Shiffman Robert Reindollar Zachary D Goodman Kenneth Koury Mei-Hsiu Ling Janice K Albrecht | 2001 | The Lancet . 2001 (9286)2001，，9286： | 4 |
| 5 | Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial显示文摘 | Michael P Manns John G McHutchison Stuart C Gordon Vinod K Rustgi Mitchell Shiffman Robert Reindollar Zachary D Goodman Kenneth Koury Mei-Hsiu Ling Janice K Albrecht | 2001 | 2001 (9286)2001，，9286： | 4 |
| 6 | Environmental magnetism: Principles and applications显示文摘 | Liu Qingsong Roberts Andrew P Larrasoa?a Juan C Banerjee Subir K Guyodo Yohan Tauxe Lisa Oldfield Frank | 2012 | EN2012，，4： | 3 |
| 7 | Reproducibility of the diagnosis of dysplasia in Barrett esophagus: A reaffirmation显示文摘 | Elizabeth Montgomery Mary P Bronner John R Goldblum Joel K Greenson Marian M Haber John Hart Laura W Lamps Gregory Y Lauwers Audrey J Lazenby David N Lewin Marie E Robert Alicia Y Toledano Yu Shyr Kay Washington | 2001 | Human Pathology2001，，4： | 3 |
| 8 | p53 protein overexpression in low grade dysplasia (LGD) in barrett’s esophagus: Immunohistochemical marker predictive of progression显示文摘 | Allan P Weston Sushanta K Banerjee Prateek Sharma Trang M Tran Robert Richards Rachel Cherian | 2001 | The American Journal of Gastroenterology2001，，5： | 2 |
| 9 | Emission of volatile organic compounds during composting of municipal solid wastes显示文摘 | Dimitris P Komilis Robert K Ham Jae K Park | 2004 | Water Research2004，，7： | 2 |
| 10 | Mechanical property characterization of mouse zona pellucida显示文摘 | Sun Y Wan K T Roberts K P | 2003 | IEEE Transactions on Nanobioscience2003，2，4： | 1 |
| 11 | The balanced scorecard measures that drive performance 显示文摘 | ROBERT S K DAVID P N | 1992 | Harvard Business Review1992，，： | 1 |
| 12 | A comparison of error metrics and constraints for multiple endmember spectral mixture analysis and spectral angle mapper显示文摘 | Dennison P E Halligan K Q Roberts D A | 2004 | Remote Sensing of Environment2004，93，3： | 1 |
| 13 | Tillage-induced increases in carbon dioxide loss from soil显示文摘 | Robert s W P Chan K Y | 1990 | Soil&Tillage Research1990，17，： | 1 |
| 14 | A new family of plant antifungal proteins 显示文摘 | Vigers A J Roberts W K Selitrennikoff C P | 1991 | Molecular Plant - Microbe Interaction1991，4，4： | 1 |
| 15 | Mechanical prop- erty characterization of mouse zona pellucida显示文摘 | SUN YU WAN K T ROBERTS K P | 2003 | IEEE Trans- actions on Micro-bioscience2003，2，4： | 1 |
| 16 | Disease progress, yield loss, and control of Xanthomonas fragariae on strawberry plants 显示文摘 | Roberts P D Jones J B Chandler C K | 1997 | Plant Disease1997，81，8： | 1 |
| 17 | Mathematical modeling of porosity formationin solidification 显示文摘 | Kimio K Robert D P | 1985 | Metallurgical Transactions1985，16，： | 1 |
| 18 | Experiments in short-term precipitation forecasting using artificial neural networks显示文摘 | ROBERT J K BARROS A P | 1998 | Mon Wea Rev1998，126，3： | 1 |
| 19 | Preclinical and clinical evaluations of ABX-EGF, a fully human anti-epidermal growth factor receptor antibody显示文摘 | Kenneth A Foon Xiao-Dong Yang Louis M Weiner Arie S Belldegrun Robert A Figlin Jeffrey Crawford Eric K Rowinsky Janice P Dutcher Nicholas J Vogelzang Jared Gollub John A Thompson Garry Schwartz Ronald M Bukowski Lorin K Roskos Gisela M Schwab | 2004 | International Journal of Radiation Oncology Biology Physics2004，，3： | 1 |
| 20 | The occurrence of selected pharmaceuticals in wastewater effluent and surface waters of the lower Tyne catchment 显示文摘 | Roberts P H Thomas K V | 2006 | Science Total Environment2006，356，13： | 1 |
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