|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Exercise training in the management of patients with resistant hypertension显示文摘Hypertension is a very prevalent risk factor for cardiovascular disease. The prevalence of resistant hypertension, i.e., uncontrolled hypertension with 3 or more antihypertensive agents including 1 diuretic, is between 5% and 30% in the hypertensive population. The causes of resistant hypertension are multifactorial and include behavioral and biological factors, such as nonadherence to pharmacological treatment. All current treatment guidelines highlight the positive role of physical exercise as a non-pharmacological tool in the treatment of hypertension. This paper draws attention to the possible role of physical exercise as an adjunct non-pharmacological tool in the management of resistant hypertension. A few studies have investigated it, employing different methodologies, and taken together they have shown promising results. In summary, the available evidence suggests that aerobic physical exercise could be a valuable addition to the optimal pharmacological treatment of patients with resistant hypertension. | Fernando Ribeiro Rui Costa José Mesquita-Bastos | 2015 | World Journal of Cardiology2015，7，2： | 6 |
| 2 | Association between EGF +61A/G polymorphism and gastric cancer in Caucasians显示文摘AIM: To investigate the association between epidermal growth factor (EGF) +61A/G polymorphism and susceptibility to gastric cancer, through a cross-sectional study. METHODS: Polymerase chain reaction resctriction fragment lenght polymorphism analyses were used to genotype EGF +61 in 207 patients with gastric lesions (162 patients with gastric adenocarcinomas, 45 with atrophy or intestinal metaplasia) and 984 controls. All subjects were Caucasian. RESULTS: Genotype distribution was 23.5% for GG and 76.5% for GA/AA in the control group, 18.4% for GG and 68.6% for GA/AA in the entire group with gastric lesions and 17.9% for GG and 82.1% for GA/AA in the group with gastric adenocarcinoma. No statistically significant associations were found between EGF +61 variants and risk for developing gastric cancer [odds ratios (OR) = 1.41, 95% confidence intervals (CI): 0.90-2.21, P = 0.116]. However, the stratification of individuals by gender revealed that males carrying A alleles (EGF +61A/G or AA) had an increased risk for developing gastric cancer as compared to GG homozygous males (OR = 1.55, 95% CI: 1.05-2.28, P = 0.021). CONCLUSION: In summary, we found that males who were A carriers for EGF +61 had an increased risk for developing gastric cancer. This result may be explained by the suggestion that women secrete less gastric acid than men. | Ana Paula Araújo Bruno M Costa Ana L Pinto-Correia Maria Fragoso Paula Ferreira Mário Dinis-Ribeiro Sandra Costa Rui M Reis Rui Medeiros | 2011 | World Journal of Gastroenterology2011，17，4： | 3 |
| 3 | Biodiesel compatibility with carbon steel and HDPE parts显示文摘 | Marcia Marie Maru Marcia Maria Lucchese Cristiano Legnani Welber Gianini Quirino Andrea Balbo Isabele Bulh?es Aranha Lílian Terezinha Costa Cecília Vilani Lídia ágata de Sena Jailton Carreteiro Damasceno Talita dos Santos Cruz Leandro Reis Lidízio Rui Fer | 2009 | Fuel Processing Technology2009，，9： | 1 |
| 4 | Validation and clinical application of an UHPLC method for simultaneous analysis of total homocysteine and cysteine in human plasma显示文摘 | Ana Valente Maria Rosário Bronze Manuel Bicho Rui Duarte Helena Soares Costa | 2012 | Science2012，，24： | 1 |
| 5 | Sleep‐wake abnormalities in patients with cirrhosis显示文摘 | Sara Montagnese Cristiano De Pittà Michele De Rui Michela Corrias Matteo Turco Carlo Merkel Piero Amodio Rodolfo Costa Debra J. Skene Angelo Gatta | 2014 | Hepatology2014，，2： | 1 |
| 6 | Fenton oxidation of cork cooking wastewater—overall kinetic analysis显示文摘 | Anabela M.F.M. Guedes Luis M.P. Madeira Rui A.R. Boaventura Carlos A.V. Costa | 2003 | Water Research2003，，13： | 1 |
| 7 | Plasma-assisted catalytic oxidation of methane: On the influence of plasma energy deposition and feed composition 显示文摘 | Rui Marquesa Stephanie Da Costab Patrick Da Costa | 2008 | Applied CatalysisB: Environmental2008，82，12： | 1 |
| 8 | Recombinant human erythropoietin treatment protects the cardio-renal axis in a model of moderate chronic renal failure显示文摘 | Ana Margarida Teixeira Patrícia Garrido Paulo Santos Rui Alves Belmiro Parada Elísio Costa Anabela Almeida Edite Teixeira-Lemos José Sereno Rui Pinto Luís Belo Alice Santos-Silva Frederico Teixeira Flávio Reis | 2010 | Renal Failure2010，，9： | 1 |
| 9 | DNA repair polymorphisms might contribute differentially on familial and sporadic breast cancer susceptibility: a study on a Portuguese population显示文摘 | Sandra Costa Daniela Pinto Deolinda Pereira Helena Rodrigues Jorge Cameselle-Teijeiro Rui Medeiros Fernando Schmitt | 2007 | Breast Cancer Research and Treatment2007，，2： | 1 |
| 10 | Methane oxidation by NO and O 2 from reverse spillover on alumina supported palladium catalysts显示文摘 | Rui Marques Sandra Capela Stéphanie Da Costa Franck Delacroix Gérald Djéga-Mariadassou Patrick Da Costa | 2008 | Catalysis Communications2008，，8： | 1 |
| 11 | Learning and memory deficits in Notch mutant mice显示文摘 | Rui M Costa Tasuku Honjo Alcino J Silva | 2003 | Curr Biol2003，13，15： | 1 |
| 12 | Determination of Fe (Ⅲ) and total Fe in wines by sequential injection analysis and flame atomic absorption spectrometry 显示文摘 | Rui Cerdeira de Campos Costa Alberto Nova Araujo | 2001 | Analytica Chimica Acta2001，438，12： | 1 |
| 13 | Influence of brine salting prior to pickle salting in the manufacturing of various salted-dried fish species显示文摘 | Ana Br6s Rui Costa | 2010 | Journal of Food Engineering2010，100，3： | 1 |
| 14 | Effect of cooking methods on fatty acids, conjugated isomers of linoleic acid and nutritional quality of beef intramuscular fat显示文摘 | Cristina M.M. Alfaia Susana P. Alves Anabela F. Lopes Maria J.E. Fernandes Ana S.H. Costa Carlos M.G.A. Fontes Matilde L.F. Castro Rui J.B. Bessa José A.M. Prates | 2009 | Meat Science2009，，4： | 1 |
| 15 | Apoptosis and Bcl-2 expression in the livers of patients with steatohepatitis显示文摘 | Rita M. Ramalho Helena Cortez-Pinto Rui E. Castro Susana Solá Adília Costa Miguel C. Moura Maria E. Camilo Cecília M.P. Rodrigues | 2006 | European Journal of Gastroenterology & Hepatology2006，，1： | 1 |
| 16 | Plasma-assisted catalytic oxidation of methane on the influence of plasma energy deposition and feed composition显示文摘 | Rui Marques Stephanie Da Costa Patrick | 2008 | Applied Catalysis B: Environmental2008，82，： | 1 |
| 17 | Current advances in solid free-form techniques for osteochondral tissue engineering显示文摘 | Joao Bebiano Costa Joana Silva-Correia Rui Luis Reis Joaquim Miguel Oliveira | 2018 | Bio-Design and Manufacturing2018，1，3： | 1 |
| 18 | Septic shock 3.0 criteria application in severe COVID-19 patients:An unattended sepsis population with high mortality risk显示文摘BACKGROUND Coronavirus disease 2019(COVID-19)can be associated with life-threatening organ dysfunction due to septic shock,frequently requiring intensive care unit(ICU)admission,respi-ratory and vasopressor support.There-fore,clear clinical criteria are pivotal for early recognition of patients more likely to need prompt organ support.Although most patients with severe COVID-19 meet the Sepsis-3.0 criteria for septic shock,it has been increasingly recognized that hyperlactatemia is frequently absent,possibly leading to an underestimation of illness severity and mortality risk.AIM To identify the proportion of severe COVID-19 patients with vasopressor support requirements,with and without hyperlactatemia,and describe their clinical outcomes and mortality METHODS We performed a single-center prospective cohort study.All adult patients admitted to the ICU with COVID-19 were included in the analysis and were further divided into three groups:Sepsis group,without both criteria;Vasoplegic Shock group,with persistent hypotension and vasopressor support without hyperlactatemia;and Septic Shock 3.0 group,with both criteria.COVID-19 was diagnosed using clinical and radiologic criteria with a severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)positive RT-PCR test.RESULTS 118 patients(mean age 63 years,87%males)were included in the analysis(n=51 Sepsis group,n=26 Vasoplegic Shock group,and n=41 Septic Shock 3.0 group).SOFA score at ICU admission and ICU length of stay were different between the groups(P<0.001).Mortality was significantly higher in the Vasoplegic Shock and Septic Shock 3.0 groups when compared with the Sepsis group(P<0.001)without a significant difference between the former two groups(P=0.713).The log rank tests of Kaplan-Meier survival curves were also different(P=0.007).Ventilator-free days and vasopressor-free days were different between the Sepsis vs Vasoplegic Shock and Septic Shock 3.0 groups(both P<0.001),and similar in the last two groups(P=0.128 and P=0.133,respectively).Logistic regression identified the maximum dose of vasopressor therapy used(AOR 1.046;95%CI:1.012-1.082,P=0.008)and serum lactate level(AOR 1.542;95%CI:1.055-2.255,P=0.02)as the major explanatory variables of mortality rates(R20.79).CONCLUSION In severe COVID-19 patients,the Sepsis 3.0 criteria of septic shock may exclude approximately one third of patients with a similarly high risk of a poor outcome and mortality rate,which should be equally addressed. | JoséPedro Cidade LM Coelho Vasco Costa Rui Morais Patrícia Moniz Luís Morais Pedro Fidalgo António Tralhão Carolina Paulino David Nora Bernardino Valério Vítor Mendes Camila Tapadinhas Pedro Povoa | 2022 | World Journal of Critical Care Medicine2022，11，4： | 0 |
| 19 | 经自然腔道取标本手术(NOSES)治疗胃癌的国际共识(2019)显示文摘At present,natural orifice specimen extraction surgery(NOSES)has attracted more and more attention worldwide,because of its great advantages including minimal cutaneous trauma and post-operative pain,fast post-operative recovery,short hospital stay,and positive psychological impact.However,NOSES for the treatment of gastric cancer(GC)is still in its infancy,and there is great potential to improve its theoretical system and clinical practice.Especially,several key points including oncological outcomes,bacteriological concerns,indication selection,and standardized surgical procedures are raised with this innovative technique.Therefore,it is necessary to achieve an international consensus to regulate the implementation of GC-NOSES,which is of great significance for healthy and orderly development of NOSES worldwide. | Xu Guan Zheng Liu Amjad Parvaiz Antonio Longo Avanish Saklani Ali AShafik Jian-Chun Cai Charles Ternent Lin Chen Cuneyt Kayaalp Fatih Sumer Fernanda Nogueira Feng Gao Fang-Hai Han Qing-Si He Ho-Kyung Chun Chang-Ming Huang Hai-Yang Huang Rui Huang Zhi-Wei Jiang Jim S Khan Joaquim Manuel da Costa Pereira JosephWNunoo-Mensah Jung Tack Son Liang Kang Keisuke Uehara Ping Lan Le-Ping Li Han Liang Bing-Rong Liu Juan Liu Dan Ma Ming-Yin Shen Mohammad Rashidul Islam Narimantas Evaldas Samalavicius Kai Pan Petr Tsarkov Xin-Yu Qin Ricardo Escalante Sergey Efetov Seung Kyu Jeong Suk-Hwan Lee Dong-Hui Sun Li Sun Tatiana Garmanova Yan-Tao Tian Gui-Yu Wang Guo-Jun Wang Guo-Rong Wang Xiao-Qiang Wang William Tzu-Liang Chen Woo Yong Lee Su Yan Zu-Li Yang Gang Yu Pei-Wu Yu Dan Zhao Yun-Shi Zhong Jian-Ping Wang Xi-Shan Wang The International Alliance of NOSES | 2020 | Gastroenterology Report2020，8，1： | 0 |
| 20 | What we have learned from urinary bladder cancer models显示文摘Urinary bladder cancer(UBC)is a heterogeneous disease with highly variable clinical outcomes and responses to chemotherapy.Despite some advances in the molecular understanding of UBC,this knowledge still has not been translated to the clinic in terms of improvements in the prognosis and treatment of patients.Suitable urinary bladder tumor models representative of the human disease in terms of histology and behavior are needed to study factors involved in tumor initiation,progression and metastasis.Further,accurate model systems would facilitate identification of new therapeutic targets and predictive markers that could lead to optimization of existing therapies and development of new ones.Many established cancer cell lines derived from human urinary bladder tumors representing different grades and stages have been used as experimental models for UBC study.These cell lines reflect some of the genetic and morphologic alterations observed in human urothelial carcinoma and serve as simplified models to study the behavior of cancer cells in vitro.However,their translational potential is limited due to the artificial conditions,in which the cells are maintained,grown and tested.Animal models offer a more complex and realistic model for the establishment,development,and progression of tumors as well as to evaluate new therapeutic approaches.Over the years,the authors'group has worked with several UBC cell lines,established and characterized chemically induced UBC models,and patient-derived xenografts models.In this study,the authors will provide a summary of the UBC models developed by their group,analyze their translational potential and weaknesses,and define areas that remain to be explored. | Carina Bernardo Céu Costa Carlos Palmeira Rosário Pinto-Leite Paula Oliveira Rui Freitas Francisco Amado Lúcio L.Santos | 2016 | Journal of Cancer Metastasis and Treatment2016，2，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员