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| 1 | An individualized immune signature of pretreatment biopsies predicts pathological complete response to neoadjuvant chemoradiotherapy and outcomes in patients with esophageal squamous cell carcinoma显示文摘No clinically available biomarkers can predict pathological complete response(pCR)for esophageal squamous cell carcinomas(ESCCs)with neoadjuvant chemoradiotherapy(nCRT).Considering that antitumor immunity status is an important determinant for nCRT,we performed an integrative analysis of immune-related gene profiles from pretreatment biopsies and constructed the first individualized immune signature for pCR and outcome prediction of ESCCs through a multicenter analysis.During the discovery phase,14 differentially expressed immune-related genes(DEIGs)with greater than a twofold change between pCRs and less than pCRs( | Chaoqi Zhang Guochao Zhang Nan Sun Zhen Zhang Liyan Xue Zhihui Zhang Haijun Yang Yuejun Luo Xiaoli Zheng Yonglei Zhang Yufen Yuan Ruixue Lei Zhaoyang Yang Bo Zheng Le Wang Yun Che Feng Wang Sihui Wang Shugeng Gao Qi Xue Yi Zhang Jie He | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 2 | Inactivation of Staphylococcus aureus and Enterococcus faecalis by a direct-current,cold atmospheric-pressure air plasma microjet显示文摘Objective:A direct-current,cold atmospheric-pressure air plasma microjet(PMJ)was performed to inactivate Staphylococcus aureus(S.aureus)and Enterococcus faecalis(E.faecalis)in air.The process of sterilization and morphology of bacteria was observed.We wish to know the possible inactivation mechanisms of PMJ and explore a potential application in dental and other temperature sensitive treatment.Methods:In this study,we employed a direct current,atmospheric pressure,cold air PMJ to inactivate bacterias.Scanning electron microscopy was employed to evaluate the morphology of S.aureus and showed rupture of cell walls after the plasma treatment and Optical emission spectrum(OES)were used to understand the possible inactivation mechanisms of PMJ.Results:The inactivation rates could reach 100%in 5 min.When the distance between the exit nozzle of the PMJ device and Petri dish was extended from 1 cm to 3 cm,effective inactivation was also observed with a similar inactivation curve.Conclusion:The inactivation of bacteria is attributed to the abundant reactive oxygen and nitrogen species,as well as ultroviolet radiation in the plasma.Different life spans and defensibilities of these killing agents may hold the key to understanding the different inactivation curves at different treatment distances. | Ye Tian Peng Sun Haiyan Wu Na Bai Ruixue Wang Weidong Zhu Jue Lnang Fuxiang Liu | 2010 | The Journal of Biomedical Research2010，24，4： | 2 |
| 3 | SARS-CoV-2 crosses the blood-brain barrier accompanied with basement membrane disruption without tight junctions alteration显示文摘SARS-CoV-2 has been reported to show a capacity for invading the brains of humans and model animals.However,it remains undear whether and how SARS-CoV-2 crosses the blood-brain barrier(BBB).Herein,SARS-CoV-2 RNA was occasionally detected in the vascular wall and perivascular space,as well as in brain microvascular endothelial cells(BMECs)in the infected K18-hACE2 transgenic mice.Moreover,the permeability of the infected vessel was in creased.Furthermore,disin tegrity of BBB was discovered in the infected hamsters by administration of Evans blue.Interestingly,the expression of claudin5,ZO-1,occludin and the ultrastructure of tight junctions(TJs)showed unchanged,whereas,the basement membrane was disrupted in the infected animals.Using an in vitro BBB model that comprises primary BMECs with astrocytes,SARS-CoV-2 was found to infect and cross through the BMECs.Consistent with in vivo experiments,the expression of MMP9 was increased and collagen IV was decreased while the markers for TJs were not altered in the SARS-CoV-2-infected BMECs.Besides,inflammatory responses including vasculitis,glial activation,and upregulated inflammatory factors occurred after SARS-CoV-2 infection.Overall,our results provide evidence supporting that SARS-CoV-2 can cross the BBB in a transcellular pathway accompanied with basement membrane disrupted without obvious alteration of TJs. | Ling Zhang Li Zhou Linlin Bao Jiangning Liu Hua Zhu Qi Lv Ruixue Liu Wei Chen Wei Tong Qiang Wei Yanfeng Xu Wei Deng-Hong Gao Jing Xue Zhiqi Song Pin Yu Yunlin Han Yu Zhang Xiuping Sun Xuan Yu Chuan Qin | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 2 |
| 4 | Synthesis of hexagonal and triangular Fe3O4 nanosheets via seed-mediated solvothermal growth显示文摘 | Chunhui Li Ruixue Wei Yanmin Xu Ailing Sun Liuhe Wei | 2014 | Nano Research2014，7，4： | 2 |
| 5 | The effects of repeated propofol anesthesia on spatial memory and long-term potentiation in infant rats under hypoxic conditions显示文摘Propofol is widely used as an intravenous drug for induction and maintenance in general anesthesia.Hypoxemia is a common complication during perianesthesia.We want to know the effect of propofol on spatial memory and LTP(Long-term potentiation)under hypoxic conditions.In this study,84 seven-day-old SpragueeDawley rats were randomly assigned into six groups(n Z 14)-four control groups:lipid emulsion solvent t 50%oxygen(CO),lipid emulsion solvent t room air(CA),lipid emulsion solvent t 18%oxygen(CH),and propofol t 50%oxygen(propofoleoxygen,PO);and two experiment groups:propofol t room air(propofol eair,PA),and propofol t 18%oxygen(propofolehypoxia,PH).After receiving propofol(50 mg/kg)or the same volume of intralipid intraperitoneal(5.0 ml/kg),injected once per day for seven consecutive days,the rats were exposed to 18%oxygen,50%oxygen and air,until recovery of the righting reflex.We found that the apoptotic index and activated caspase-3 increased in the PH group(P<0.05)compared with the PA group,fEPSP(field excitatory postsynaptic)potential and success induction rate of LTP reduced in all propofol groups(P<0.05).Compared with the PO group,the fEPSP and success induction rate of LTP reduced significantly in the PA and PH groups(P<0.05).Moreover,compared with CH group,the average time of escape latency was longer,and the number of platform location crossings was significantly reduced in the PH group(P<0.05).Thus,we believe that adequate oxygen is very important during propofol anesthesia. | Mang Sun Ruixue Yuan Hui Liu Jing Zhang Shengfen Tu | 2020 | Genes & Diseases2020，7，2： | 2 |
| 6 | RDFAdaptor:Efficient ETL Plugins for RDF Data Process显示文摘Purpose:The interdisciplinary nature and rapid development of the Semantic Web led to the mass publication of RDF data in a large number of widely accepted serialization formats,thus developing out the necessity for RDF data processing with specific purposes.The paper reports on an assessment of chief RDF data endpoint challenges and introduces the RDF Adaptor,a set of plugins for RDF data processing which covers the whole life-cycle with high efficiency.Design/methodology/approach:The RDFAdaptor is designed based on the prominent ETL tool—Pentaho Data Integration—which provides a user-friendly and intuitive interface and allows connect to various data sources and formats,and reuses the Java framework RDF4J as middleware that realizes access to data repositories,SPARQL endpoints and all leading RDF database solutions with SPARQL 1.1 support.It can support effortless services with various configuration templates in multi-scenario applications,and help extend data process tasks in other services or tools to complement missing functions.Findings:The proposed comprehensive RDF ETL solution—RDFAdaptor—provides an easy-to-use and intuitive interface,supports data integration and federation over multi-source heterogeneous repositories or endpoints,as well as manage linked data in hybrid storage mode.Research limitations:The plugin set can support several application scenarios of RDF data process,but error detection/check and interaction with other graph repositories remain to be improved.Practical implications:The plugin set can provide user interface and configuration templates which enable its usability in various applications of RDF data generation,multi-format data conversion,remote RDF data migration,and RDF graph update in semantic query process.Originality/value:This is the first attempt to develop components instead of systems that can include extract,consolidate,and store RDF data on the basis of an ecologically mature data warehousing environment. | Jiao Li Guojian Xian Ruixue Zhao Yongwen Huang Yuantao Kou Tingting Luo Tan Sun | 2021 | Journal of Data and Information Science2021，6，3： | 2 |
| 7 | A four-miRNA signature identified from genome-wide serum miRNA profiling predicts survival in patients with nasopharyngeal carcinoma显示文摘 | LIU Na CUI Ruixue SUN Ying | 2014 | Ant J Cancer2014，134，6： | 1 |
| 8 | Advances in Researches on Genetic Diversity of Lepidoptera Insects显示文摘This paper reviewed advances in researches on genetic diversity of Lepidoptera insects from chromosome polymorphism,protein polymorphism,and DNA polymorphism,and stated that DNA sequence variation will become main points of researches about genetic diversity. | Yuting WANG Ruixue LI Fan SUN Wei WANG Taichu WANG | 2017 | Asian Agricultural Research2017，9，4： | 1 |
| 9 | Recent progress on the fabrication of hollow microspheres 显示文摘 | WANG Aijuan LU Yupeng SUN Ruixue | 2007 | Materials Science and Engineering2007，1，6： | 1 |
| 10 | Fabrication and characterization of porous hydroxyapatite microspheres by spray-drying method 显示文摘 | SUN Ruixue LU Yupeng | 2008 | Front Mater Sci China2008，2，1： | 1 |
| 11 | Controlled synthesis and thermal stability of hydroxyapatite hierarchical microstructures显示文摘 | SUN Ruixue CHEN Kezheng LIAO Zhongmiao | 2013 | Mater Res Bull2013，48，11： | 1 |
| 12 | On-site dielectric testing of GIS: Theoretical and practical considerations显示文摘 | Sun Ruixue Eriksson Andrew | 1991 | IEEE Transactions on Power Delivery1991，6，2： | 1 |
| 13 | Dual-parameter shaping regularized full waveform inversion in frequency domain显示文摘The regularization contributes to the resolution and stability in geophysical inversion. The authors apply dual-parameter shaping regularization to full waveform inversion,aiming at two points:( 1) improving the boundary resolution,and( 2) increasing convergence. Firstly,the forward modeling is done,and the inversion is processed with the optimal solution. Compared with classical Tikhonov regularization scheme,the method reflects better resolution and stronger convergence. Then,Marmousi model is experimented and inversed,and the deep structure has a sharper outline. The phase residual comparison illustrates weaker cycle-slipping. And a choice scheme of parameter is applied in FWI. | SUN Ruixue HAN Liguo SUN Eryan | 2015 | Global Geology2015，18，4： | 1 |
| 14 | Hydroxyl radical production by abiotic oxidation of pyrite under estuarine conditions:The effects of aging,seawater anions and illumination显示文摘Pyrite is widely distributed in estuarine sediments as an inexpensive natural Fenton-like reagent,however,the mechanism on the hydroxyl radical(HO^(·))production by pyrite under estuarine environmental conditions is still poorly understood.The batch experiments were performed to investigate the effects of estuarine conditions including aging(in air,in water),seawater anions(Cl^(-),Br^(-)and HCO_(3)^(-))and light on the HO^(·)production by pyrite oxidation.The one-electron transfer dominated the process from O_(2) to HO^(·)induced by oxidation of pyrite.The Fe(oxyhydr)oxide coatings on the surface of pyrite aged in air and water consumed hydrogen peroxide while mediating the electron transfer,and the combined effect of the two resulted in a suppression of HO^(·)production in the early stage of aging and a promotion of HO^(·)production in the later stage of aging.Corrosion of the surface oxide layers by aggressive anions was the main reason for the inhibition of HO^(·)production by Cl^(-)and Br^(-),and the generation of Cl^(·)and Br^(·)may also play a role in the scavenging of HO^(·).HCO_(3)^(-)increased the average rate of HO^(·)production through surface-CO_(2) complexes formed by adsorption on the surface of pyrite.The significant enhancement of HO^(·)production under light was attributed to the formation of photoelectrons induced by photochemical reactions on pyrite and its surface oxide layers.These findings provide new insights into the environmental chemical behavior of pyrite in the estuary and enrich the understanding of natural remediation of estuarine environments. | Ruixue Liu Yinshun Dai Yucheng Feng Shiwen Sun Xiaodong Zhang Chunjiang An Shan Zhao | 2024 | Journal of Environmental Sciences2024，，1： | 1 |
| 15 | Research on intelligent judgment method of natural gas hydrate drilling risk显示文摘There are many emergency risks in the process of natural gas hydrate(NGH)drilling.In order to ensure the safe and efficient exploitation of NGH,it is urgent to establish an intelligent judgment method for the risks in the process of NGH drilling.In this paper,the response relationship between monitoring parameters and risk categories of NGH while drilling is established.Based on fuzzy analytic hierarchy process(FAHP),the comprehensive weights of 10 risk monitoring parameters are obtained,including gas production,wellbore instability,hydrate ice barrier,drill string fracture,sticking,bit balling,drilling tool piercement,gas seepage,seabed subsidence and seabed landslide.Besides,the comprehensive judgment weight matrix is constructed,and the reasonable fluctuation range of monitoring parameters is formed.Thus,the intelligent judgment method of NGH drilling risk is established.The intelligent judgment and alarm of NGH drilling risks can be realized quickly and accurately by this method,namely,it can monitor the risks in the process of operation and guarantee the construction safety of NGH drilling. | Haitao Li Zhaolong Ge Na Wei Wantong Sun Yao Zhang Jin Xue Lin Jiang Jun Pei Bing Liao Hongliang Cao Ruixu Zhang Shuangli Li Qixia Lu Jinyan Luo | 2021 | Petroleum2021，7，4： | 1 |
| 16 | Covalent Triazine Frameworks(CTFs) for Photocatalytic Applications显示文摘Covalent triazine frameworks(CTFs) as a new type of porous organic polymers(POPs) with nitrogen-rich content, high chemical stability, visible light sensitive, metal-free and fully conjugated structure, have gained considerable attention in the last ten years owing to their great potential in extensive applications, especially for photocatalysis systems. In this review, we propose to provide current progress in the design and synthesis of CTFs, along with an emphasis on their photocatalytic applications. Firstly, a brief background including the development of photocatalytic areas is provided. Then, synthetic strategies of CTFs are described and compared. Furthermore, the evolution of CTF materials in photocatalysis fields and strategies for enhancing photocatalytic performance is presented. Finally, some perspectives and challenges on synthesizing high crystalline CTFs and designing excellent catalytic performance of CTF materials are discussed, inspiring the development of CTF materials in photocatalytic applications. | SUN Ruixue TAN Bien | 2022 | Chemical Research in Chinese Universities2022，38，2： | 0 |
| 17 | Light-harvesting Complex Ⅱ Sensitized Oxide Photoanodes with Organic Acceptor Molecule as Electron Transfer Mediator显示文摘Dye sensitized solar cell(DSSC) is a promising thin film solar cell that has been widely investigated after its birth because of its advantages,such as flexibility,low-cost,easyfabrication and so on[1-3].For DSSCs,sensitizers play a core role due to their responsibility for the generation of the photo carriers resulted from light absorption and the transfer of the photo-generated electrons into semiconductor photoanodes[4]. | DONG Wenjing ZHANG Tianning LIU Kun SUN Ruixue HUANG Chanyan SUN Yan LIU Cheng CHEN Xin YANG Guoqiang YANG Chunhong DAI Ning | 2014 | Chemical Research in Chinese Universities2014，30，2： | 0 |
| 18 | Crystalline covalent triazine frameworks manipulated by aliphatic amine modulator显示文摘Crystallization is an unsolved challenge in the chemistry of covalent triazine frameworks(CTFs) due to the poorly controlled simultaneous polymerization and crystallization processes. Herein, the synthesis of crystalline CTFs via the introduction of aliphatic amine as a dynamic modulator is reported. By optimizing the amount of aliphatic amine, the crystallization process can be controlled in an open system, resulting in the synthesis of crystalline CTFs. These crystalline CTFs exhibit much better photocatalytic hydrogen evolution performance, with highly ordered CTF-1-C3 demonstrating superior performance(10 mmol g^(-1)h^(-1)) compared with most reported CTF-1. This approach also allows for the preparation of various crystalline CTFs. | Xunliang Hu Yantong Guo Ruixue Sun Xiaoyan Wang Bien Tan | 2023 | Science China Chemistry2023，66，9： | 0 |
| 19 | The synergistic effects of PRDX5 and Nrf2 on lung cancer progression and drug resistance under oxidative stress in the zebrafish models显示文摘Previous studies have shown that PRDX5 and Nrf2 are antioxidant proteins related to abnormal reactive oxidative species(ROS).PRDX5 and Nrf2 play a critical role in the progression of inflammations and tumors.The combination of PRDX5 and Nrf2 was examined by Co-immunoprecipitation,western blotting and Immunohistochemistry.H2O2 was applied to affect the production of ROS and induced multi-resistant protein 1(MRP1)expression in NSCLC cells.The zebrafish models mainly investigated the synergistic effects of PRDX5 and Nrf2 on lung cancer drug resistance under oxidative stress.We showed that PRDX5 and Nrf2 form a complex and significantly increase the NSCLC tissues compared to adjacent tissues.The oxidative stress improved the combination of PRDX5 and Nrf2.We demonstrated that the synergy between PRDX5 and Nrf2 is positively related to the proliferation and drug resistance of NSCLC cells in the zebrafish models.In conclusion,our data indicated that PRDX5 could bind to Nrf2 and has a synergistic effect with Nrf2.Meanwhile,in the zebrafish models,PRDX5 and Nrf2 have significant regulatory impacts on lung cancer progression and drug resistance activities under oxidative stress. | SITONG QIAN YING FANG CHENGYUN YAO YONGSHENG WANG ZHI ZHANG XIAOHUA WANG JIN GAO YONG FENG LEI SUN RUNYUE ZOU GUOREN ZHOU JINJUN YE RUIXUE XIA HONGPING XIA | 2022 | Oncology Research2022，30，2： | 0 |
| 20 | Genome-wide meta-analysis identifies ten new psoriasis susceptibility loci in the Chinese population显示文摘Psoriasis is caused by many factors and is characterized by excessive proliferation of the epidermis and erythema with silver scales on the surface of the skin and concomitant with a variety of diseases(Griffiths et al., 2021). Despite the unclear aetiology,increasing evidence has demonstrated that genetic factors play key roles in the pathogenesis of psoriasis. | Weiwei Chen Wenjun Wang Liang Yong Qi Zhen Yafen Yu Huiyao Ge Yiwen Mao Lu Cao Ruixue Zhang Xia Hu Zhuo Li Yirui Wang Wencheng Fan Qiongqiong Xu Hui Zhang Shirui Chen Jing Wu Liangdan Sun | 2022 | Journal of Genetics and Genomics2022，49，2： | 0 |
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