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| 1 | Total mercury in wild fish in Guizhou reservoirs, China显示文摘The health hazard of mercury (Hg) compounds is internationally recognized, and the main pathways for methylmercury (MeHg) intake in humans are through consumption of food, especially fish. Given the large releases of Hg to the environment in China, combined with the fast development of hydropower, this issue deserves attention. Provided similar mobilization pathways of Hg in China as seen in reservoirs in North America and Europe one should expect increased Hg contamination in relation to future hydropower reservoir construction in this country. This study presents total Hg (THg) concentrations in wild fish from six Guizhou reservoirs, China. The THg concentrations in fish were generally low despite high background levels in the bedrock and depositions from local point sources. The over all mean ± SD concentration of THg was (0.066 ± 0.078) μg/g (n = 235). After adjusting for among-reservoir variation in THg, there were significant differences in THg among functional groups of the fish, assumed to re?ect trophic levels. Predicted THg- concentration ratios, retrieved from a mixed linear model, between the functional groups were 9:4:4:1 for carnivorous, omnivorous, planktivorous and herbivorous fish. This result indicated that MeHg accumulation may prevail even under circumstances with short food chains as in this Chinese water system. No fish exceeded recommended maximum THg limit for human consumption set by World Health Organization and the Standardization Administration of China (0.5 μg/g fish wet weight (ww)). Only six fish (2.5%) exceeded the maximum THg limit set by US Environmental Protection Agency (0.3 μg/g fish ww). | Haiyu Yan Atle Rustadbakken Heng Yao Thorjorn Larssen Xinbin Feng Ting Liu Lihai Shang Thrond O. Haugen | 2010 | Journal of Environmental Sciences2010，22，8： | 6 |
| 2 | Comparison of the oncological,perioperative and functional outcomes of partial nephrectomy versus radical nephrectomy for clinical T1b renal cell carcinoma:A systematic review and metaanalysis of retrospective studies显示文摘Objective:To conduct a meta-analysis assessing the perioperative,functional and oncological outcomes of partial nephrectomy(PN)and radical nephrectomy(RN)for T1b tumours.The primary endpoints were the oncological outcomes.The secondary endpoints were the perioperative and functional outcomes.Methods:A systematic literature review was performed by searching multiple databases through February 2019 to identify eligible comparative studies according to the Preferred Reporting Items for Systematic Review and Meta-analysis statement.Identified reports were assessed according to the Newcastle-Ottawa Scale for nonrandomized controlled trials.Results:Overall,13 retrospective cohort studies were included in the analysis.Patients undergoing PN were younger(weighted mean difference[WMD]3.49 years,95%confidence interval[CI]5.16 to1.82;p<0.0001)and had smaller masses(WMD0.45 cm,95%CI0.59 to0.31;p<0.0001).There were no differences in the oncological outcome,which was demonstrated by progression-free survival(hazard ratio[HR]0.70;pZ0.22),cancerspecific mortality(HR 0.91;pZ0.57)and all-cause mortality(HR 1.01;pZ0.96).The two procedures were similar in estimated blood loss(WMD16.47 mL;pZ0.53)and postoperative complications(risk ratio[RR]1.32;pZ0.10),and PN provided better renal function preservation and was related to a lower likelihood of chronic kidney disease onset(RR 0.38;pZ0.006).Conclusion:PN is an effective treatment for T1b tumours because it offers similar surgical morbidity,equivalent cancer control,and better renal preservation compared to RN. | Yucong Zhang Gongwei Long Haojie Shang Beichen Ding Guoliang Sun Wei Ouyang Man Liu Yuan Chen Heng Li Hua Xu Zhangqun Ye | 2021 | Asian Journal of Urology2021，8，1： | 4 |
| 3 | Combined detection and subclass characteristics analysis of CTCs and CTECs by SE-iFISH in ovarian cancer显示文摘Objective:Hematogenous metastasis is essential for the progression of ovarian cancer(OC),and circulating tumor cells(CTCs)are part of the metastatic cascade.However,the detection rate of CTC is low due to the use of less sensitive detection methods.Therefore,this study aimed to detect CTCs and circulating tumorigenic endothelial cells(CTECs)in patients with OC using subtraction enrichment and immunostaining and fluorescence in situ hybridization(SE-iFISH).Methods:We enrolled a total of 56 subjects,including 20 OC patients and 36 ovarian benign tumor patients.CTCs and CTECs were captured by subtraction enrichment(SE)and counted and classified according to immunofluorescence staining of tumor markers(TMs)carbohydrate antigen 125(CA125)and human epididymis protein 4(HE4)combined with fluorescence in situ hybridization(iFISH)of chromosome 8(Chr8)aneuploidy.The diagnostic value and subtype characteristics of CTCs and CTECs were investigated.Results:The detection rate of CTCs by SE-iFISH was high.Compared with CA125 and HE4,Chr8 aneuploidy was the major identification feature of CTC.CTC counts in OC were statistically higher than those in benign groups.CTC and CTEC with≥pentaploidy were detected in both groups,illustrating the poor diagnostic value of CTC or CTEC.Distributions of triploid and tetraploid CTC subtypes were significantly different,and combined detection of triploid and tetraploid CTCs showed the best diagnostic value.In contrast,the distribution of CTECs in the OC and benign groups had no statistically significant difference.Small CTCs accounted for over 1/3 of the total CTC count.We also found that small CTCs and CTECs primarily comprised triploid cells,while large CTCs and CTECs mainly comprised pentaploidy and beyond.Conclusions:The application of SE-iFISH offered a more comprehensive understanding of heterogeneous CTCs and CTECs in OC.Analysis of subclass characteristics of the CTCs and CTECs according to Chr8 aneuploidy and cell size may broaden their potential clinical utility and deepen mechanistic studies in OC. | Hongyan Cheng Shang Wang Wenqing Luan Xue Ye Sha Dou Zhijian Tang Honglan Zhu Peter Ping Lin Yi Li Heng Cui Xiaohong Chang | 2021 | Chinese Journal of Cancer Research2021，33，2： | 3 |
| 4 | Genetic, hormonal, and environmental control of tillering in wheat显示文摘Tillering contributes greatly to grain yield in wheat.Investigating the mechanisms of tillering provides a theoretical foundation and genetic resources for the molecular breeding of wheat.The regulation of tillering is a complex molecular process that involves a multitude of factors.Little is known about the molecular mechanisms in the wheat genome,although progress has been made in rice.Here we review the developmental characteristics of tillers and summarize current knowledge of the roles of endogenous and environmental factors in wheat tillering.We propose directions for future studies and advanced technologies to be used for gene identification and functional studies. | Qiushuang Shang Yaping Wang Heng Tang Na Sui Xiansheng Zhang Fang Wang | 2021 | The Crop Journal2021，9，5： | 3 |
| 5 | Two-plane painting injection scheme for BRing of HIAF显示文摘The high-intensity heavy-ion accelerator facility(HIAF)is under design at the Institute of Modern Physics(IMP)and will provide an intense ion beam for nuclear physics,atomic mass measurement research,and other applications.As the main ring of HIAF,the BRing accumulates beams to high intensity and accelerates them to high energy.To achieve high intensities up to 1×10^(11)(^(238)U^(34+)),the injection gain of the BRing must be as high as 88.However,multiple multiturn injection supported by the electron cooling system takes a long time,causing substantial beam loss under a strong space charge effect.Hence,a two-plane painting injection scheme is proposed for beam accumulation in the BRing.This scheme uses a tilted injection septum and horizontal and vertical bump magnets to paint the beam into horizontal and vertical phase space simultaneously.In this paper,the two-plane painting injection parameters are optimized,and the resulting injection process is simulated using the Objective Ring Beam Injection and Tracking(ORBIT)code.An injection gain of up to 110.3 with a loss rate of 2:3%is achieved,meeting the requirements of BRing. | Guo-Feng Qu Wei-Ping Chai Jia-Wen Xia Jian-Cheng Yang Heng Du Zhong-Shan Li Wen-Wen Ge Wen-Heng Zheng Peng Shang | 2017 | Nuclear Science and Techniques2017，28，8： | 3 |
| 6 | Decoding Cortical Glial Cell Development显示文摘Mouse cortical radial glial cells(RGCs)are primary neural stem cells that give rise to cortical oligodendrocytes,astrocytes,and olfactory bulb(OB)GABAergic interneurons in late embryogenesis.There are fundamental gaps in understanding how these diverse cell subtypes are generated.Here,by combining single-cell RNA-Seq with intersectional lineage analyses,we show that beginning at around E16.5,neocortical RGCs start to generate ASCL1^(+)EGFR^(+)apical multipotent intermediate progenitors(MIPCs),which then differentiate into basal MIPCs that express ASCL1,EGFR,OLIG2,and MKI67.These basal MIPCs undergo several rounds of divisions to generate most of the cortical oligodendrocytes and astrocytes and a subpopulation of OB interneurons.Finally,single-cell ATAC-Seq supported our model for the genetic logic underlying the specification and differentiation of cortical glial cells and OB interneurons.Taken together,this work reveals the process of cortical radial glial cell lineage progression and the developmental origins of cortical astrocytes and oligodendrocytes. | Xiaosu Li Guoping Liu Lin Yang Zhenmeiyu Li Zhuangzhi Zhang Zhejun Xu Yuqun Cai Heng Du Zihao Su Ziwu Wang Yangyang Duan Haotian Chen Zicong Shang Yan You Qi Zhang Miao He Bin Chen Zhengang Yang | 2021 | Neuroscience Bulletin2021，37，4： | 2 |
| 7 | Comparison of two in vitro angiogenesis assays for evaluating the effects of netrin-1 on tube formation显示文摘Netrin-1 是也调整脉管的开发的神经指导暗示。然而,争论结果在 vivo 并且在 vitro 在脉管的开发有关 netrin-1 的角色被获得了。在现在的学习,二在 vitro angiogenesis 试金与相比评估藏匿由的 netrin-1 的效果 retrovirally 试管形成上的 transduced 黑瘤房间(Mel2a-netrin1 ) 。结果证明在调节媒介(厘米) 在 matrigel 试金从控制, Mel2a-netrin1 和 Mel2a 房间导致的试管形成没有明显的差别。在哪个 endothelial 房间然而与人的成纤维细胞是 co 有教养的,在 vitro 试金的另外一个的结果证明那 Mel2a-netrin1 厘米禁止了试管形成,据说通过堵住人的脐的静脉 endothelial 房间(HUVEC ) 的延伸和结合。这些结果证实 matrigel 试金不能表明 netrin-1 的 anti-angiogenic 角色。 | Hui Guo Yin Jia Min Shang Yuan Zhang Fu'an Xie Heng Wang Mingjing Yuan Li Yuan Jura Ye | 2014 | Acta Biochimica et Biophysica Sinica2014，46，9： | 1 |
| 8 | Pullout resistance of single and double nails in a model sand box显示文摘 | HONG yung shan WU chosen YANG shang heng | 2003 | Canadian Geotechnical Journal2003，40，5： | 1 |
| 9 | Reform Exploration for Safety Course System of Oil and Gas Storage and Transportation Facilities显示文摘In recent years,the safety of oil and gas storage and transportation facilities has been paid more attention by the state and enterprises due to frequent accidents.The oil and gas storage and transportation facilities safety courses in China University of Petroleum(Beijing)includes“Engineering mechanics”,“Strength design of pipelines and tanks”and“Safety and integrity management of oil and gas storage and transportation facilities”.The three courses lack relevance and the teaching mode is too rigid,resulting in students losing their initiative in learning.If students can’t use the knowledge flexibly,it will affect the achievement of the objectives of the training program.Therefore,oil and gas storage and transportation facilities safety courses are reformed,training plans are adjusted and teaching methods are improved.The practice shows that the reform enriches the teaching content,improves the teaching quality,stimulates classroom activity and gets a good evaluation of students.The reform of safety courses has a certain significance for cultivating compound talents who have the ability to solve practical problems in engineering. | Yanfei Chen Heng Ni Shang Ma Hong Zhang | 2021 | Review of Educational Theory2021，4，3： | 0 |
| 10 | Effects of A-Cation Mismatch σ~2 on Transport Properties of Manganese Doped Oxide Perovskites显示文摘Three factors control the transition from paramagnetic insulator to ferromagnetic metal. The first is the hole doping. The second factor is the average ionic radius of the A site cation rA. The last one concerns the ionic size mismatch σ2 at the A site. In order to study the effect of σ2, a series of samples were prepared with constant value of x and rA. The measurement of resistivity versus temperature dependence under magnetic field (0 and 5 T) indicates that the insulator-metal transition temperature moves towards the low temperature region with increasing σ2. The magnetoresistance of La 0.53 Sm 0.17 Sr 0.3 MnO3 obtains its maximum at room temperature. The experimental observation was discussed based on the measurement of the transport properties. | Shang Jinglin Yuan Songliu Cao Heng Wang Yongqiang Yin Shiyan | 2006 | Journal of Rare Earths2006，24，5： | 0 |
| 11 | Effect of Nitrogen and Sulfur Co‑Doped Graphene on the Electrochemical Hydrogen Storage Performance of Co_(0.9)Cu_(0.1)Si Alloy显示文摘Co_(0.9)Cu_(0.1)Si alloy was prepared by mechanical alloying method.Nitrogen-doped graphene(NG)and nitrogen–sulfur codoped graphene(NSG)were prepared by hydrothermal method.5 wt%graphene oxide,NG and NSG were doped into Co_(0.9)Cu_(0.1)Si alloy,respectively,by ball milling to improve the electrochemical hydrogen storage performance of the composite material.X-ray diffraction and scanning electron microscopy were used to characterize the structure and morphology of the composite material,and the LAND battery test system and three-electrode battery system were used to test the electrochemical performance of the composite material.The composite material showed better discharge capacity and better cycle stability than the pristine alloy.In addition,in order to study the optimal ratio of NSG,3%,5%,7%and 10%of NSG were doped into Co_(0.9)Cu_(0.1)Si alloy,respectively.Co_(0.9)Cu_(0.1)Si alloy doped with 5%NSG had the best performance among all the samples.The best discharge capacity was 580.1 mAh/g,and its highest capacity retention rate was 64.1%.The improvement in electrochemical hydrogen storage performance can be attributed to two aspects.On the one hand,the electrocatalytic performance of graphene is improved by co-doping nitrogen and sulfur,on the other hand,graphene has excellent electrical conductivity. | Wenhao Fan Jianxun Zhao Dayong Liu Qingcheng Liang Wanqiang Liu Qingshuang Wang Heng Liu Peng Chen Shang Gao Xinlong Bao Yong Cheng Xinwei Wang Xin Guo | 2023 | Acta Metallurgica Sinica(English Letters)2023，36，6： | 0 |
| 12 | Homeobox Gene Six3 is Required for the Differentiation of D2-Type Medium Spiny Neurons显示文摘Medium spiny neurons(MSNs)in the striatum,which can be divided into D1 and D2 MSNs,originate from the lateral ganglionic eminence(LGE).Previously,we reported that Six3 is a downstream target of Sp8/Sp9 in the transcriptional regulatory cascade of D2 MSN development and that conditionally knocking out Six3 leads to a severe loss of D2 MSNs.Here,we showed that Six3 mainly functions in D2 MSN precursor cells and gradually loses its function as D2 MSNs mature.Conditional deletion of Six3 had little effect on cell proliferation but blocked the differentiation of D2 MSN precursor cells.In addition,conditional overexpression of Six3 promoted the differentiation of precursor cells in the LGE.We measured an increase of apoptosis in the postnatal striatum of conditional Six3-knockout mice.This suggests that,in the absence of Six3,abnormally differentiated D2 MSNs are eliminated by programmed cell death.These results further identify Six3 as an important regulatory element during D2 MSN differentiation. | Xiaolei Song Haotian Chen Zicong Shang Heng Du Zhenmeiyu Li Yan Wen Guoping Liu Dashi Qi Yan You Zhengang Yang Zhuangzhi Zhang Zhejun Xu | 2021 | Neuroscience Bulletin2021，37，7： | 0 |
| 13 | Effect of Heredity of Raw Materials on Properties of Alumina-magnesia Refractory Castables显示文摘Regarding the morphology of alumina,effect of the heredity of raw materials on properties of aluminamagnesia refractory castables was investigated by adding platelet alumina as the specific template.In-situ spinel platelet formed derived from platelet alumina.By comparing phase evolution,apparent porosity,bulk density,permanent linear expansion and strength,it was demonstrated that the utilization of the microstructures' heredity of platelet alumina was a new alternative for controlling properties of alumina-magnesia refractory castables. | YUAN Wenjie CHEN Fan TANG Hai SHANG Heng ZHU Qingyou DENG Chengji ZHU Hongxi | 2016 | China's Refractories2016，25，4： | 0 |
| 14 | Over 18% binary organic solar cells enabled by isomerization of non-fullerene acceptors with alkylthiophene side chains显示文摘Side-chain engineering has been demonstrated as an effective method for fine-tuning the optical,electrical,and morphological properties of organic semiconductors toward efficient organic solar cells(OSCs).In this work,three isomeric non-fullerene small molecule acceptors(SMAs),named as BTP-4F-T2C8,BTP-4F-T2EH and BTP-4F-T3EH,with linear and branched alkyl chains substituted on the α or β positions of thiophene as the side chains,were synthesized and systematically investigated.The results demonstrate that the size and substitution position of alkyl side chains can greatly affect the electronic properties,molecular packing as well as crystallinity of the SMAs.After blending with donor polymer D18-Cl,the prominent device performance of 18.25% was achieved by the BTP-4F-T3EH-based solar cells,which is higher than those of the BTP-4F-T2EH-based(17.41%)and BTP-4F-T2C8-based(15.92%)ones.The enhanced performance of the BTP-4F-T3EH-based devices is attributed to its stronger crystallinity,higher electron mobility,suppressed bimolecular recombination,and the appropriate intermolecular interaction with the donor polymer.This work reveals that the side chain isomerization strategy can be a practical way in tuning the molecular packing and blend morphology for improving the performance of organic solar cells. | Ao Shang Siwei Luo Jianquan Zhang Heng Zhao Xinxin Xia Mingao Pan Chao Li Yuzhong Chen Jicheng Yi Xinhui Lu Wei Ma He Yan Huawei Hu | 2022 | Science China Chemistry2022，65，9： | 0 |
| 15 | Results of 23 yr of Pulsar Timing of PSR J1453-6413显示文摘In this paper,we presented the 23.3 yr of pulsar timing results of PSR J1456-6413 based on the observations of Parkes 64 m radio telescope.We detected two new glitches at MJD 57093(3)and 59060(12)and confirmed its first glitch at MJD 54554(10).The relative sizes(Δν/ν)of these two new glitches are 0.9×10^(-9)and 1.16×10^(-9),respectively.Using the“Cholesky”timing analysis method,we have determined its position,proper motion,and two-dimensional transverse velocities from the data segments before and after the second glitch,respectively.Furthermore,we detected exponential recovery behavior after the first glitch,with a recovery timescale of approximately 200 days and a corresponding exponential recovery factor Q of approximately 0.15(2),while no exponential recovery was detected for the other two glitches.More interestingly,we found that the leading component of the integral pulse profile after the second glitch became stronger,while the main component became weaker.Our results will expand the sample of pulsars with magnetosphere fluctuation triggered by the glitch event. | Wei Li Shi-Jun Dang Jian-Ping Yuan Lin Li Wei-Hua Wang Lun-Hua Shang Na Wang Qing-Ying Li Ji-Guang Lu Fei-Fei Kou Shuang-Qiang Wang Shuo Xiao Qi-Jun Zhi Yu-Lan Liu Ru-Shuang Zhao Ai-Jun Dong Bin Zhang Zi-Yi You Yan-Qing Cai Ya-Qin Yang Ying-Ying Ren Yu-Jia Liu Heng Xu | 2023 | Research in Astronomy and Astrophysics2023，23，10： | 0 |
| 16 | Impact of Real-Time Contrast-Enhanced Ultrasound-Guided Radiofrequency Ablation on Progression-Free Survival in Patients with Hepatocellular Carcinoma:a Retrospective Case-Control Study显示文摘Objective To compare the value of contrast-enhanced ultrasound(CEUS)and conventional ultrasound(US)during radiofrequency ablation(RFA)for the treatment of hepatocellular carcinoma(HCC)≥3.0 cm in diameter.Methods A total of 149 HCC patients treated with RFA guided by either CEUS or conventional US between January 2012 and June 2013 were retrospectively analyzed.Patients were divided into different groups based on the type of ultrasound guidance(CEUS or conventional US)and tumor volume(diameter<3.0 or≥3.0 cm).The progressionfree survival(PFS)and complete ablation rates were compared between groups,and risk factors for the PFS were investigated.Results Seventy four patients received CEUS-guided RFA,and conventional US was performed in 75 patients.Among patients with a tumor<3.0 cm,the PFS and complete ablation rates were similar.However,for patients with a tumor≥3.0 cm,those treated with CEUS had a significantly longer PFS(17.3 vs.3.1 months,HR=2.73;95%CI,1.28~5.81;P=0.007)and higher complete ablation rates at 6-and 12-month post-treatment(87.5%vs.57.7%,P=0.042;75.0%vs.38.5%,P=0.009,respectively)than those treated with conventional US-guided RFA.The type of treatment(P=0.024)and maximum tumour size(P=0.011)were both found to be independent factors associated with the PFS.Conclusion Compared with conventional US,CEUS is more effective for guiding RFA in patients with HCC≥3.0 cm.CEUS-guided RFA could target HCC more accurately,and its ability to immediately detect any residual tumor during RFA might contribute to an increase in complete ablation rates and reduced progression. | Xiao Shang Guang Yang Heng Jun Zhao Ming Zhang Guo Zhen Cui Jiu Wei Cui Nan Ya Wang | 2020 | Journal of Nutritional Oncology2020，5，3： | 0 |
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