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| 1 | Elevation of tumor necrosis factor-α,interleukin-1β and interleukin-6 levels in aortic intima of Chinese Guizhou minipigs with streptozotocin-induced diabetes显示文摘有调停毒素的胰腺的损坏的背景大动物模型关于糖尿病 mellitus 和心血管的糖尿病的复杂并发症在研究广泛地被使用了。试图证实有 streptozotocin ( STZ )的中国贵州 minipig 模型导致了糖尿病并且描绘动物的现在的学习由在大动脉的墙中分析煽动性的 cytokine 层次当模特儿,例如肿瘤坏死因素( TNF ), interleukin-1 ( IL-1 )和 interleukin-6 ( IL-6 ) .Methods 22 男中国贵州 minipigs (变老, 4~6 个月;重量, 20 kg 到 30 kg ) 被划分成导致 STZ 的糖尿病的组(n=12 ) 和控制组(n=10 ) 。STZ (125 mg/kg ) 被管理导致多糖症,以后,胰岛素被用来在 10 mmol/L 下面控制 fasting 血葡萄糖层次。口头的葡萄糖忍耐测试(OGTT ) 以前被执行并且在 STZ 管理和丙氨酸 transaminase,天门冬素 transaminase,白朊,血脲氮, creatinine,类脂化合物和白色的浆液集中以后的一个月血房间计数以前并且六个月以后被测量。在六个月和胰为小岛房间 immunohistochemically 被检验以后,在两个组的动物是 euthanized。糖尿病的 minipigs 和控制的大动脉的 intima 在由西方的污点中等的调节的组织为 TNF- 水平被分析。在大动脉的 intima 的 TNF- , IL-1 和 IL-6 mRNA 层次是由反向的抄写和聚合酶链反应(RT-PCR ).Results 的 assayed 在浆液葡萄糖层次的重要举起被观察在 STZ 正式就职(P0.001 ) 和显著地增加的 OGTT 价值以后的一个月和六个月被注意,与基线数据相比。正常的胰有许多不规则的大小的小岛和小岛房间的小簇,当在糖尿病的 minipigs 的胰小岛房间几乎消失了时。没有统计差别以前在生物化学的考试的浆液集中被通知并且在 STZ 以后的六个月感应。西方的污点证明在 aotic intima 的戏剧性地增加的TNF-水平调节了TNF-, IL-1 和 IL-6 的中等、重要的举起 mRNA 层次被现在的学习建立了的 RT-PCR.Conclusions 揭示有 导致STZ 的 diabetes.Inflammatory cytokines 的中国贵州 minipig 模型(TNF-, IL-1 和 IL-6 )显著地在糖尿病的 minipigs 的大动脉的 intima 提高了。 | LU Lin ZHANG Qi PU Li-jin XU Xue-wei ZHANG Rui-yan ZHANG Jian-sheng HU Jian YANG Zheng-kun LU An-kang DING Feng-hua SHEN Jie CHEN Qiu-jin LOU Sheng FANG Dan-hong SHEN Wei-feng | 2007 | Chinese Medical Journal2007，，6： | 43 |
| 2 | Design and engineering implementation of non-supplementary fired compressed air energy storage system: TICC-500显示文摘The integration and accommodation of the wind and solar energy pose great challenges on today’s power system operation due to the intermittent nature and volatility of the wind and solar resources.High efficient large-scale electrical energy storage is one of the most effective and economical solutions to those problems.After the comprehensive review of the existing storage technologies,this paper proposes an overall design scheme for the Non-supplementary Fired Compressed Air Energy Storage(NFCAES)system,including system design,modeling and efficiency assessment,as well as protection and control.Especially,the design principles of the multistage regenerative,i.e.heat recovery system which is used to fully recycle and utilize the waste heat from compression are provided,so as the overall system efficiency evaluation method.This paper theoretically ascertains the storage decoupling rules in the potential and internal energy of molecular compressed air and reveals the conversion mechanism of gas,heat,power,electricity and other forms of energy.On this basis,a 500-k W physical simulation system of CAES system(TICC-500,Tsinghua-IPCCAS-CEPRI-CAES)is built,which passed a system-wide 420-k W load power generation test with less pollution and zero carbon emissions.Besides,the multi-form energy conversion of multi-stage regenerative CAES and storage efficiency is verified,especially its incomparable superiority in solving the uncertainty problem in wind and solar power generation.Finally,the propaganda and application scenario of the CAES system in China is introduced. | MEI Sheng Wei WANG Jun Jie TIAN Fang CHEN Lai Jun XUE Xiao Dai LU Qiang ZHOU Yuan ZHOU Xiao Xin | 2015 | Science China(Technological Sciences)2015，58，4： | 37 |
| 3 | Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients显示文摘Human infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)causes coronavirus disease 2019(COVID-19)and there is no cure currently.The 3CL protease(3CLpro)is a highly conserved protease which is indispensable for CoVs replication,and is a promising target for development of broad-spectrum antiviral drugs.In this study we investigated the anti-SARS-CoV-2 potential of Shuanghuanglian preparation,a Chinese traditional patent medicine with a long history for treating respiratory tract infection in China.We showed that either the oral liquid of Shuanghuanglian,the lyophilized powder of Shuanghuanglian for injection or their bioactive components dose-dependently inhibited SARS-CoV-23CLpro as well as the replication of SARS-CoV-2 in Vero E6 cells.Baicalin and baicalein,two ingredients of Shuanghuanglian,were characterized as the first noncovalent,nonpeptidomimetic inhibitors of SARS-CoV-23CLpro and exhibited potent antiviral activities in a cell-based system.Remarkably,the binding mode of baicalein with SARS-CoV-23CLpro determined by X-ray protein crystallography was distinctly different from those of known 3CLpro inhibitors.Baicalein was productively ensconced in the core of the substrate-binding pocket by interacting with two catalytic residues,the crucial S1/S2 subsites and the oxyanion loop,acting as a“shield”in front of the catalytic dyad to effectively prevent substrate access to the catalytic dyad within the active site.Overall,this study provides an example for exploring the in vitro potency of Chinese traditional patent medicines and effectively identifying bioactive ingredients toward a specific target,and gains evidence supporting the in vivo studies of Shuanghuanglian oral liquid as well as two natural products for COVID-19 treatment. | Hai-xia Su Sheng Yao Wen-feng Zhao Min-jun Li Jia Liu Wei-juan Shang Hang Xie Chang-qiang Ke Hang-chen Hu Mei-na Gao Kun-qian Yu Hong Liu Jing-shan Shen Wei Tang Lei-ke Zhang Geng-fu Xiao Li Ni Dao-wen Wang Jian-ping Zuo Hua-liang Jiang Fang Bai Yan Wu Yang Ye Ye-chun Xu | 2020 | Acta Pharmacologica Sinica2020，41，9： | 32 |
| 4 | Clinical and experimental study on regional administration of phosphorus32 glassmicrospheres in treating hepatic carcinoma显示文摘AIM To study the therapeutical effectiveness, dosage range and toxic adverse effects of domestic phosphorus 32 glass microsphere and evaluate its clinical significance. METHODS Ⅰ. Fifty two BALB/*!c tumor bearing male nude mice were allocated into treatment group( n =38) and control group( n =14). In the former group different doses of 32 P GMS were injected into the tumor mass, while in the latter 31 P GMS or no treatment was given. The experimental animals were sacrificed in batches, and then the tumors and their nearby tissues were examined by light and electron microscopy. Ⅱ. Through selective catheterization of hepatic artery, 32 P GMS was infused to 5 healthy domestic pigs in a dosage equivalent to the therapeutic dose for human being, and 31 P GMS was infused to another 5 healthy domestic pigs. Two pigs infused with contrast medium served as whole course blank controls. One pig from each group was surrendered to euthanasia at week 1, 4, 8 and 16 respectively. The ultrastructural histopath ological changes in liver tissues taken from different sites were evaluated semiquan titatively. Ⅲ. One hundred and twenty seven times of 32 P GMS intrahepatic artery interventional therapies were performed on 93 patients with hepatic carcinoma, including 79 cases of primary hepatic carcinoma and 14 cases of secondary hepatic carcinoma. 32 P GMS ( n =30), and group B, 32 P GMS and half dose of trans hepatic artery embolization (TAE) ( n =49) , and 18 patients with HCC by TAE only as control group C. Fourteen patients with secondary hepatic carcinoma were treated in the same way as group B or C. RESULTS Ⅰ. Comparing with the control group, the treatment group of tumor bearing nude mice attained the tumor inhibition rates of 59 7%-93 7% ( F =579 62, P <0 01) at 14*!d . At an absorbed dose of 7320Gy, the tumor cells were completely destroyed. When the absorbed doses ranged from 1830Gy to 3660Gy, most of the tumor cells showed the evidences of injury or necrosis, but there appeared some well differentiated tumor cells and enhanced effect of the autoimmunocytes. At an absorbed dose of 366Gy or less, some tumor cells still remained active proliferative ability. The definite anticancer effect appeared as early as 3d after intratumoral injection of 32 P GMS. Ⅱ. The cumulative amount of 32 P GMS in the target tissue after trans hepatic artery instillation attained more than 90% of the total dose administrated. Semiquantitative analysis of ultrastructral morphology in the experimental group showed no statistical difference between the nuclear abnormality (N abn ) and mitochondrial variability (M var ) at week 1 or 2, but revealed prominent difference (χ 2=6 70-9 68, P <0 01 , χ 2=65 09-115 09, P <0 001 ) as compared with those in the other groups. In the experimental group the N abn in tissues showed no significant difference between week 8 and week 16. No apparent changes were found in the stomach, spleen, kidney and lung tissues of the experimental pigs. Ⅲ. The therapeutical results of HCC patients in group A were closely approximated to those of group C, no hematological toxic side effects were noted, and the systemic reaction was mild. In some patients 2*!mos - 3*!mos after treatment some secondary foci appeared around the periphery of the primary lesion. In general better effectiveness was obtained in patients with small lesion. After analyzing by RIDIT method, the therapeutic result in group B was significantly better than that in group C, and secondary foci around the original lesion were rarely seen at 3*!mos after treatment. In group C the collateral circulation was reestablished along the periphery of primary foci and the secondary foci appeared more frequently, and required to undergo several courses of treatment. In group B, 4 cases of HCC were treated surgically as their mass decreased in size after 32 P GMS treatment. | LIU Lu, JIANG Zao, TENG Gao Jun, SONG Ji Zhi, ZHANG Dong Sheng, GUO Qing Ming, FANG Wen, HE Shi Cheng and GUO Jin He | 1999 | World Journal of Gastroenterology1999，5，6： | 21 |
| 5 | Climate and litter C/N ratio constrain soil organic carbon accumulation显示文摘Soil organic carbon(SOC) plays critical roles in stabilizing atmospheric CO2 concentration, but the mechanistic controls on the amount and distribution of SOC on global scales are not well understood. In turn, this has hampered the ability to model global C budgets and to find measures to mitigate climate change. Here, based on the data from a large field survey campaign with 2600 plots across China’s forest ecosystems and a global collection of published data from forested land, we find that a low litter carbon-to-nitrogen ratio(C/N) and high wetness index(P/PET, precipitation-to-potentialevapotranspiration ratio) are the two factors that promote SOC accumulation, with only minor contributions of litter quantity and soil texture. The field survey data demonstrated that high plant diversity decreased litter C/N and thus indirectly promoted SOC accumulation by increasing the litter quality. We conclude that any changes in plant-community composition, plant-species richness and environmental factors that can reduce the litter C/N ratio, or climatic changes that increase wetness index, may promote SOC accumulation. The study provides a guideline for modeling the carbon cycle of various ecosystem scales and formulates the principle for land-based actions for mitigating the rising atmospheric CO2 concentration. | Guoyi Zhou Shan Xu Philippe Ciais Stefano Manzoni Jingyun Fang Guirui Yu Xuli Tang Ping Zhou Wantong Wang Junhua Yan Gengxu Wang Keping Ma Shenggong Li Sheng Du Shijie Han Youxin Ma Deqiang Zhang Juxiu Liu Shizhong Liu Guowei Chu Qianmei Zhang Yuelin Li Wenjuan Huang Hai Ren Xiankai Lu Xiuzhi Chen | 2019 | National Science Review2019，6，4： | 21 |
| 6 | Identification,localization and morphology of APUD cells in gastroenteropancreatic system of stomach-containing teleosts显示文摘AIM To identify the type localization andmorphology of APUD endocrine cells in thegastroenteropancreatic(GEP)system ofstomach-containing teleosts,and study APUDendocrine system in the stomach,intestine andpancreas of fish species.METHODS Two kinds of immunocytochemical(ICC)techniques of the streptavidin biotin-peroxidase complex(SABC)and streptavidin-peroxidase(S-P)method were used.Theidentification,localization and morphology ofAPUD endocrine cells scattered in the mucosa ofdigestive tract,intermuscular nerve plexus andglandular body of northern snakehead(Channaargus),ricefield eel(Monopterus albus),yellow catfish(Pelteobagrus fulvidraco),mandarinfish(Siniperca chuatsi),largemouthbass(Micropterus salmoides),orientalsheatfish(Silurus asotus),freshwater pomfret(Colossoma brachypomum)and nile tilapia(Tilapia nilotica)were investigated with 8 kindsof antisera.RESULTS The positive reaction of 5-hydroxytryptamine(5-HT)immunoreactiveendocrine(IRE)cells was found in the digestive tract and glandular body of 8 fish species indifferent degree.Only a few gastrin(GAS)-IREcells were seen in C.argus,M.albus and P.fulvidraco.Glucagon(GLU)-IRE cells were notfound in the digestive tract and glandular bodybut existed in pancreatic island of most fishspecies.The positive reaction of growthhormone(GH)-IRE cells was found only inpancreatic island of S.Chuatsi and S.Asotus,no positive reaction in the other 6 fish species.Somatostatin(SOM)-,calcitonin(CAL)-,neurofilament(NF)-and insulin(INS)-IRE cellsin the stomach,intestine and pancreas of 8 kindsof fish were different in distribution and types.The distribution of all 8 APUD cells was the mostin gastrointestinal epithelium mucosa and then indigestive glands.The positive reaction of SOM-and 5-HT-IRE cells was found in intermuscularnerve plexus of intestine of P.fulvidraco andS.chuatsi.Only GH-IRE cells were denselyscattered in the pancreatic islands of S.chuatsiand S.asotus,and odd distribution in thepancreas of S.asotus,SOM-IRE cells weredistributed in the pancreatic islands of S.asotus,C.Brachypomum and T.nilotica.There were INS-IRE cells in the pancreaticislands of S.chuatsi and S.asolus.Eightkinds of APUD cells had longer cell body andcytoplasmic process when they were located inthe gastrointestinal epithelium,and had shortercell body and cytoplasmic process in the gastricgland,and irregular shape in the esophagus andpancreatic island.CONCLUSION Eight kinds of IRE cells were identified in the GEP system of stomach-containing teleosts. These endocrine cells were scattered in gastrointestinal mucosa, intermuscular nerve plexus, gland body, pancreatic gland and islands under APUD system. CAL- and GH-IRE cells in the pancreatic islands of fishes showed functional diversity for these two hormones. Their morphological feature provides evidence of endocrine-paracrine and endocrine-exocrine acting mode. This research can morphologically prove that the GEP endocrine system of fish ( the lowest vertebrate) is almost the same as of mammal and human. | Qian Sheng Pan Zhi Ping Fang Feng Jie Huang | 2000 | World Journal of Gastroenterology2000，6，6： | 20 |
| 7 | Patterns and driving factors of WUE and NUE in natural forest ecosystems along the North-South Transect of Eastern China显示文摘从 2008 年 7 月,到 2008 年 8 月,从 22 种类的 72 件叶样品和在九天赋的 81 件土壤样品,森林生态系统对沿着东方中国(NSTEC ) 的纵贯的横断的南方镇定,从北方。把样品基于这些,我们学习了蔬菜水使用效率(WUE ) 和氮使用效率(NUE ) 的地理分发模式,并且分析了他们与环境因素的关系。蔬菜 WUE 和 NUE 分别地通过叶的 13C 的测量和占优势的种类的 C/N 被计算。结果出现了:(1 ) 蔬菜 WUE,从 2.13 ~ 28.67 mg C g1 H2O ,当蔬菜 NUE 显示出一个相反的趋势时,沿着 NSTEC 在代表性的森林生态系统从南方线性地增加了到北方,从北方增加到南方,从 12.92 ~ 29.60 g C g1 N 。(2 ) 蔬菜 WUE 和 NUE 被气候主导地驾驶并且显著地由土壤营养素因素影响。基于集中为 WUE 的 75.5% 变化正在回答的多重逐步的回归分析,吝啬的年度温度,土壤磷集中,和土壤氮(p < 0.001 ) 。当时,吝啬的年度降水和土壤磷集中能在蔬菜 NUE 解释 65.7% 变化(p < 0.001 ) 。而且,蔬菜 WUE 和 NUE 将被大气的氮免职严重也在氮影响浸透的生态系统。(3 ) 在沿着 NSTEC 的典型森林生态系统在蔬菜 WUE 和 NUE 之间有一种重要交易关系(p < 0.001 ) ,沿着 NSTEC 在自然森林生态系统在资源利用为植被显示平衡策略。这研究建议那个全球变化将影响森林生态系统的资源使用效率。然而,当减少时,植被能由增加缺乏资源的使用效率适应那些变化相对宽大的。但是极端影响例如重氮免职,将打破这交易机制并且把戏剧的骚乱给生态系统 biogeochemical 周期。 | SHENG Wenping REN Shujie YU Guirui FANG Huajun JIANG Chunming ZHANG Mi | 2011 | Journal of Geographical Sciences2011，21，4： | 19 |
| 8 | The first year follow-up after colorectal adenoma polypectomyis important: A multiple-center study in symptomatichospital-based individuals in China显示文摘The recurrence of colorectal adenoma(CRA)is high.Although there are guidelines for colonoscopy surveillance after polypectomy in other countries,little is known about its recurrence rate and recurrence peak,especially in China.The aim of the present research is to investigate how long after polypectomy follow-up should take and to analyze risk factors of recurrence.1208 patients who received polypectomies fromfive clinical research centers in four regions of China(Shanghai,Guangzhou,Nanjing and Beijing)were included.They were divided into 4 groups:group A(follow-up≤1 year after poly-pectomy),group B(follow-up 2–3 years after polypect-omy),group C(follow-up 4–5 years after polypectomy),and group D(follow-up>5 years after polypectomy).The sex,age,adenoma location,size,number,and pathological characteristics were compared.On the whole,the recur-rence rate was 59.46%in group A,61.09%in group B,78.07%in group C,and 87.12%in group D,which indicated an increased tendency with a prolonged follow-up duration.There was a significant difference between group A and C or D,and between group B and C or D(P<0.01),but there was no statistical difference between group A and B.Additionally,the recurrent patients in thefirst year had a recurrence rate of 97.33%in thefirst three years(59.46/61.09),which means that the peak of recurrence was almost entirely concentrated in thefirst year.The recurrence rate was higher in males and the elder.The risk factors included multiple numbers,villous feature,high-grade dysplasia of medium or smaller size and location in the distal colon.In conclusion,the peak of recurrence was almost totally concentrated in thefirst year;meanwhile,thefirst year follow-up is of critical importance in China.It may not be necessary to do the follow-up examination during the second and third years,but after three years,another colonoscopy should be undertaken. | Qin-Yan GAO Hui-Min CHEN Jian-Qiu SHENG Ping ZHENG Cheng-Gong YU Bo JIANG Jing-Yuan FANG | 2010 | Frontiers of Medicine2010，4，4： | 17 |
| 9 | Analysis of soft tissue sarcomas in 1118 cases显示文摘背景分析并且周期性地比较软组织肉瘤以便更新发生,临床的诊断,治疗,和进行中的研究是重要的。现在的学习被进行决定软织物肉瘤的每种类型的相对频率。在 1993 年 1 月和 2006 年 12 月之间对待的主要软织物肉瘤的 1118 个盒子全部的方法 A 在回顾的分析被评估。根据病理学的组织结果,有最高的比例的疾病是恶意的含纤维的 histiocytomas (35.24%) , synovial 肉瘤(17.08%) , liposarcomas (16.28%) ,和 rhabdomyosarcomas (12.61%) 。软织物肉瘤在每个年龄组被检测并且发生在身体的所有部分。盒子的数字多年以来逐渐地增加了。结论恶意的含纤维的 histiocytomas 在软织物肉瘤之中有最高的频率。盒子的数字多年以来逐渐地增加了。 | FANG Zhi-wei CHEN Jing TENG Sheng CHEN Yong XUE Rui-feng | 2009 | Chinese Medical Journal2009，，1： | 16 |
| 10 | Report on Childhood Obesity in China (10): Association of Sleep Duration with Obesity显示文摘Objectives To explore the association of sleep duration with obesity among children in urban areas of China.Methods A total of 6 576 children(3 293 boys and 3 283 girls) aged 7-11 years were randomly selected from 36 primary schools in 6 metropolitan cities in China.A 7-day Physical Activity Recall was used to assess the sleep duration and physical activity level.The height,weight,waist circumference(WC) and percentage of body fat(%BF,as determined by bioelectrical impedance analysis technique) were measured by following the standardized operation procedures.The information on demography,lifestyle and eating habits was collected with a self-administered questionnaire from participants and their parents.Results The average sleep duration per night in the children was 9.7 h with the decreasing trends along with the increase of age(P<0.05).The sleep duration was negatively associated with body mass index(BMI) and WC in both boys and girls after adjustment for confounders(β value-0.23 and-0.82 for boys,-0.24 and-0.91 for girls,respectively,P<0.01).However,no significant association of sleep duration with %BF was found.Children who slept less than 9.0 h per night had a higher risk for overweight and obesity(OR=1.29,95% CI:1.01,1.64) and abdominal obesity(OR=1.38,95% CI:1.04,1.83) as compared with those who slept for 10.0-10.9 h.Conclusions Short sleep duration is associated with obesity.It is important to ensure adequate sleep duration of children and foster their healthy lifestyle at an early stage of life. | MENG Li Ping LIUAi Ling HU Xiao Qi ZHANG Qian DU Song Ming FANG Hong Yun MA Jun XU Gui Fa LI Ying GUO Hong Wei DU Lin MA Guan Sheng | 2012 | Biomedical and Environmental Sciences2012，25，2： | 16 |
| 11 | Microsatellite instability,MMR gene expression and proliferation kinetics in colorectal cancer with famillial predisposition显示文摘INTRODUCTIONGenetic instability is a conunon property of manyhuman cancers,including those of HNPCC.A novel form of genetic instability involving somaticalterations,such as deletions and insertions insimple repeated sequences,has been found.Microsatellitcs are relatively short runs of tandemlyrepeated sequences scattered throughout | Bao Ping Wu Ya Li Zhang Dian Yuan Zhou Chun Fang Gao Zhuo Sheng Lai | 2000 | World Journal of Gastroenterology2000，6，6： | 14 |
| 12 | Multi-objective Optimization of a Parallel Ankle Rehabilitation Robot Using Modified Differential Evolution Algorithm显示文摘Dimensional synthesis is one of the most difficult issues in the field of parallel robots with actuation redundancy. To deal with the optimal design of a redundantly actuated parallel robot used for ankle rehabilitation, a methodology of dimensional synthesis based on multi-objective optimization is presented. First, the dimensional synthesis of the redundant parallel robot is formulated as a nonlinear constrained multi-objective optimization problem. Then four objective functions, separately reflecting occupied space, input/output transmission and torque performances, and multi-criteria constraints, such as dimension, interference and kinematics, are defined. In consideration of the passive exercise of plantar/dorsiflexion requiring large output moment, a torque index is proposed. To cope with the actuation redundancy of the parallel robot, a new output transmission index is defined as well. The multi-objective optimization problem is solved by using a modified Differential Evolution(DE) algorithm, which is characterized by new selection and mutation strategies. Meanwhile, a special penalty method is presented to tackle the multi-criteria constraints. Finally, numerical experiments for different optimization algorithms are implemented. The computation results show that the proposed indices of output transmission and torque, and constraint handling are effective for the redundant parallel robot; the modified DE algorithm is superior to the other tested algorithms, in terms of the ability of global search and the number of non-dominated solutions. The proposed methodology of multi-objective optimization can be also applied to the dimensional synthesis of other redundantly actuated parallel robots only with rotational movements. | WANG Congzhe FANG Yuefa GUO Sheng | 2015 | Chinese Journal of Mechanical Engineering2015，28，4： | 13 |
| 13 | A multicenter,retrospective.epidemiologic survey of the clinical features and management of bone metastatic disease in China显示文摘Background:Bone metastases are common in patients with advanced cancer.Bisphosphonates(BPs) could prevent or delay the development of skeleton-related events(SREs).The present study aimed to identify the clinical features of and treatment strategies for Chinese patients with bone metastases.Methods:Consecutive cancer patients who had bone metastases and received BP treatment were enrolled.A questionnaire was developed to collect the patients' clinical data,as well as information on the diagnosis and management of bone metastases.Physicians' awareness of the guidelines and knowledge of the application of BP were also assessed.Results:A total of 3223 patients with lung cancer(36.5%),breast cancer(30.9%),prostate cancer(8.5%),and gastrointestinal cancer(5.7%) were included in this study.The sites of bone metastases were the thoracic spine(56.0%),lumbar spine(47.1%),ribs(32.6%),and pelvis(23.2%).The SRE frequency was the highest in patients with multiple myeloma(36.6%),followed by those with lung cancer(25.9%),breast cancer(20.2%),prostate cancer(18.2%),and gastrointestinal cancer(17.3%).Irradiation to the bone was the most frequent SRE(58%in lung cancer patients,45%in breast cancer patients,and 48%in prostate cancer patients).Our survey also showed that 45.5%of patients received BP within 3 months after their diagnosis of bone metastases,whereas the remaining 54.5%of patients did not receive BP treatment until at least 3 months after their diagnosis of bone metastases.The SRE frequency in the former group was significantly lower than that in the latter group(4.0%vs.42.3%,P < 0.05).In patients with more than 6 months of continuous BP treatment,the mean time to the first SRE was significantly longer than that in patients with less than 6 months of continuous BP treatment(7.2 vs.3.4 months,P < 0.05).In addition,12.2%of the physicians were not aware of the efficacy of BP in preventing and delaying SRE.Only half(52.3%) of the physicians agreed that the BP treatment should persist for at least 6 months unless it was intolerable.Conclusions:Our study suggested that prompt and persistent BP treatment was associated with a reduced risk of SREs.However,our survey also revealed that the proper application of BP was not as common as expected in China. | Yunpeng Yang Yuxiang Ma Jin Sheng Yan Huang Yuanyuan Zhao Wenfeng Fang Shaodong Hong Ying Tian Cong Xue Li Zhang | 2016 | Chinese Journal of Cancer2016，35，5： | 13 |
| 14 | Caffeine is responsible for the bloodglucose-lowering effects of green tea and Puer tea extractsin BALB/c mice显示文摘The present study was designed to determine the effects of Puer tea and green tea on blood glucose level. Male BALB/c mice were administered green tea extract(GTE) or Puer tea extract(PTE), either intragastrically or in their drinking water. The major components of these teas are epigallocatechin gallate(EGCG) and caffeine, respectively. Blood glucose measurement results showed that mice fed intragastrically or mice that drank GTE, PTE or caffeine showed significantly lower blood glucose levels compared to the control group. However, EGCG exhibited no influence on the blood glucose levels. When caffeine was eliminated from the GTE and PTE, the effect on the blood glucose levels was abolished, but the effect was recovered when caffeine was re-introduced into the extracts. Evaluation of hematological and biochemical indices at the time of the greatest caffeine-induced decrease in blood glucose levels showed that the effect of caffeine was specific. Microarray analyses were performed in 3T3-L1 preadipocytes and mature adipocytes treated with 0.1 mg·m L-1 caffeine to identify factors that might be involved in the mechanisms underlying these effects. The results showed that few genes were changed after caffeine treatment in adipocytes, and of them only phospholipid transfer protein(PLTP) may be ralated to blood glucose. In conclusion, this study indicates that caffeine may be the key constituent of tea that decreases blood glucose levels, and it may be used to treat type 2 diabetes. | FANG Chong-Ye WANG Xuan-Jun HUANG Ye-Wei HAO Shu-Mei SHENG Jun | 2015 | Chinese Journal of Natural Medicines2015，13，8： | 12 |
| 15 | Reconfigurable parallel mechanisms with planar five-bar metamorphic linkages显示文摘This paper presents the idea of constructing reconfigurable limbs by integrating metamorphic linkages as subchains.The planar five-bar metamorphic linkages that have three phases resulting from locking of motors are considered.Under the assumption that the constraint exerted by the reconfigurable limb can switch between no constraint,a constraint force,and a constraint couple,the output motions of the metamorphic linkage in its two planar four-bar linkage phases are identified.By adding an appropriate joint to planar four-bar linkages with translational output,four planar five-bar linkages that can be employed in the construction of reconfigurable limbs are enumerated.Serial chains that can provide a constraint couple and a constraint force are synthesized based on screw theory.Reconfigurable limbs that have three configurations associated with the three distinct phases of the metamorphic linkages are assembled with planar five-bar metamorphic linkages and serial chains with four degrees of freedom.A class of reconfigurable parallel mechanisms are constructed by connecting a moving platform and a base with three identical reconfigurable limbs.The degrees of freedom of the reconfigurable parallel mechanism in different configurations with the metamorphic linkages in different phases are given.Finally,the actuation scheme for this kind of mechanisms is addressed. | YE Wei FANG YueFa GUO Sheng | 2014 | Science China(Technological Sciences)2014，57，1： | 12 |
| 16 | Antibiotic Resistance Genes in the Human-Impacted Environment:A One Health Perspective显示文摘Antibiotic resistance and its environmental component are gaining more attention as part of combating the growing healthcare crisis. The One Health framework, promulgated by many global health agencies, recognizes that antimicrobial resistance is a truly inter-domain problem in which human health, animal agriculture, and the environment are the core and interrelated components.This prospectus presents the status and issues relevant to the environmental component of antibiotic resistance, namely, the needs for advancing surveillance methodology: the environmental reservoirs and sources of resistance, namely, urban wastewater treatment plants, aquaculture production systems, soil receiving manure and biosolid, and the atmosphere which includes longer range dispersal.Recently, much work has been done describing antibiotic resistance genes in various environments;now quantitative, mechanistic,and hypothesis-driven studies are needed to identify practices that reduce real risks and maintain the effectiveness of our current antibiotics as long as possible. Advanced deployable detection methods for antibiotic resistance in diverse environmental samples are needed in order to provide the surveillance information to identify risks and define barriers that can reduce risks. Also needed are practices that reduce antibiotic use and thereby reduce selection for resistance, as well as practices that limit the dispersal of or destroy antibiotic-resistant bacteria or their resistance genes that are feasible for these varied environmental domains. | James M. TIEDJE WANG Fang Celia M. MANAIA Marko VIRTA SHENG Hongjie MA Liping ZHANG Tong Edward TOPP | 2019 | Pedosphere2019，29，3： | 11 |
| 17 | An overview of design for CSNS/RCS and beam transport显示文摘The China Spallation Neutron Source (CSNS) is the first accelerator-based pulsed neutron source in China. Its accelerators are made up of an 80 MeV H- linac, a Rapid Cycling Synchrotron (RCS) and two beam transport lines. RCS accumulates and accelerates protons to the design energy of 1.6 GeV, and extracts high energy beam to strike the target. The overview of RCS is presented, and the key problems of the physics design are discussed. The two beam transport lines, from linac to RCS and from RCS to the target, are also introduced. | WANG Sheng AN YuWen FANG ShouXian HUANG Nan LIU WeiBin LIU YuDong QIN Qing QIU Jing WANG Na XU Gang XU ShouYan YU ChengHui | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，S2： | 11 |
| 18 | Diagnosis and surgical treatment of pancreatic endocrine tumors in 36 patients:a single-center report显示文摘背景胰腺的内分泌的肿瘤(宠物) 是稀罕的,他们的外科的治疗经常被辩论。这回顾的研究的目的是分析诊断和从1980年5月工作和非工作的 PETs.Methods 到2006年3月的外科的策略,有在浙江大学的第二所隶属于的医院的胰腺的内分泌的肿瘤的 36 个病人是回顾地在 36 个病人,之中的 studied.Results (81%) 29 让了工作肿瘤,并且(19%) 7 有 nonfunctioning 肿瘤。百分之 92 insulinomas 是良性的,而(57%) 4 nonfunctioning 宠物是恶意的。工作肿瘤的尺寸是(2. | LIU Hong ZHANG Su-zhan WU Yu-lian FANG He-qing LI Jiang-tao SHENG Hong-wei WANG Yong | 2007 | Chinese Medical Journal2007，，17： | 11 |
| 19 | Optimization of the Assembly Efficiency for Lidamycin Chromophore Bound to its Apoprotein:A Case Study using Orthogonal Array显示文摘Objective Lidamycin (LDM) can be dissociated to an apoprotein (LDP) and an active enediyne chromophore (AE).The detached AE can reassemble with its LDP‐containing fusion protein to endow the latter with potent antitumor activity.However,the reassembly of AE with LDP is affected by several factors.Our aim was to optimize the assembly efficiency of the AE with a LDP‐containing fusion protein and investigate the influence of several factors on the assembly efficacy.Methods A method based on RP‐HPLC was developed to analyze the assembly rate,and an orthogonal experimental design L9 (3 4 ) was used to investigate the effects of temperature,assembly time,pH and molecular ratio of LDP‐containing fusion protein to AE on the assembly rate.Furthermore,the determined optimum conditions for the assembly rate of the LDP‐containing fusion protein with AE were applied and evaluated.Results A calibration curve based on the LDM micromolar concentration against the peak‐area of AE by HPLC was obtained.The order in which individual factors in the orthogonal experiment affected the assembly rate were temperature>time>pH>molar ratio of AE to protein and all were statistically significant (P<0.01).The optimal assembly conditions were temperature at 10°C,time of 12 h,pH 7.0,and the molar ratio of AE: protein of 5:1.The assembly rate of AE with a LDP‐containing fusion protein was improved by 23% after condition optimization.Conclusion The assembly rate of chromophore of lidamycin with its LDP‐containing fusion protein was improved after condition optimization by orthogonal design,and the optimal conditions described herein should prove useful for the development of this type of LDP‐containing fusion protein. | ZHONG Gen Shen GUO Xiao Fang ZHANG Sheng Hua ZHEN Yong Su | 2011 | Biomedical and Environmental Sciences2011，24，6： | 9 |
| 20 | Risk analysis for the highly pathogenic avian influenza in China's Mainland using meta-modeling显示文摘A logistic model was employed to correlate the outbreak of highly pathogenic avian influenza (HPAI) with related environmental factors and the migration of birds. Based on MODIS data of the normalized difference vegetation index, environmental factors were considered in generating a probability map with the aid of logistic regression. A Bayesian maximum entropy model was employed to explore the spatial and temporal correlations of HPAI incidence. The results show that proximity to water bodies and national highways was statistically relevant to the occurrence of HPAI. Migratory birds, mainly waterfowl, were important infection sources in HPAI transmission. In addition, the HPAI outbreaks had high spatiotemporal autocorrelation. This epidemic spatial range fluctuated 45 km owing to different distribution patterns of cities and water bodies. Furthermore, two outbreaks were likely to occur with a period of 22 d. The potential risk of occurrence of HPAI in China's Mainland for the period from January 23 to February 17, 2004 was simulated based on these findings, providing a useful meta-model framework for the application of environmental factors in the prediction of HPAI risk. | CAO ChunXiang XU Min CHANG ChaoYi XUE Yong ZHONG ShaoBo FANG LiQun CAO WuChun ZHANG Hao GAO MengXu HE QiSheng ZHAO Jian CHEN Wei ZHENG Sheng LI XiaoWen | 2010 | Chinese Science Bulletin2010，55，36： | 9 |
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