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| 1 | Report on Childhood Obesity in China (9): Sugar-sweetened Beverages Consumption and Obesity显示文摘Objective To explore the associations between sugar-sweetened beverage (SSB) consumption and obesity as well as obesity-related cardiometabolic disorders among children in China. Methods A total of 6974 (boys 3558, girls 3412) children aged 6-13 years participated in the study. Each participant's height, weight, waist circumference, fasting glucose, triglycerides, total cholesterol, high- density lipoprotein cholesterol, and low-density lipoprotein cholesterol were measured. The type of beverage consumption was determined using a self-administered questionnaire. Results SSBs were consumed regularly by 46.1% of the children. The prevalence [adjusted odds ratio (95% confidence internal (CI)] of obesity was 7.6% [as the reference group (ref.)], 10.1% [1.36(1.07, 1.74)], and 11.6% [1.46(1.21, 1.75)], among children who regularly drank milk, other beverages and SSBs, respectively. Regularly drinking SSBs elevated the likelihood of abdominal obesity [adjusted odds ratio (95% CI): 1.36 (1.17, 1.59)]. The prevalence [adjusted odds ratio (95% CI)] of obesity among children who regularly drank sports/caloric beverages, carbonated beverages, sweet tea, and plant protein beverages was 16.8% [2.00(1.31, 3.07)], 12.7% [1.52(1.23, 1.88)], 11.5% [1.52(1.18, 1.95)], and 10.4% [1.41(1.03, 1.94)], respectively, which was higher than that of regular milk drinkers [7.6 % (ref.)]. The prevalence [adjusted odds ratio (95% CI)] of abdominal obesity among children who regularly drank sweet tea, fruit/vegetable juices, and carbonated beverages was 17.7% [1.55(1.26, 1.90)], 16.2% [1.36(1.09, 1.70)], and 15.3% [1.24(1.03, 1.50)], respectively, which was much higher than that of regular milk drinkers [12.8% (ref.)]. Conclusions Regular SSB consumption was positively related to obesity and abdominal obesity. This relationship should be investigated further using a longitudinal study design. | SHANG Xian Wen LIU Ai Ling ZHANG Qian HU Xiao Qi DU Song Ming MA Jun XU Gui Fa LI Ying GUO Hong Wei DU Lin LI Ting Yu MA Guan Sheng | 2012 | Biomedical and Environmental Sciences2012，25，2： | 23 |
| 2 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 3 | A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30显示文摘Mitochondrial 熔化是为正常 mitochondrial 功能和 mitochondrial DNA 继承混合并且统一 mitochondrial 分隔空间的一个高度协调的过程。Dysregulated mitochondrial 熔化原因 mitochondrial 破碎,反常 mitochondrial 生理学和继承,并且有原因地与很多 neuronal 疾病被连接了。这里,我们识别了 potently 导致了 mitochondrial 熔化在在 Mfn1 或 Mfn2 是缺乏的房间恢复 mitochondrial 网络和氧化呼吸的 diterpenoid 衍生物 15-oxospiramilactone (S3 ) 。线粒体局部性的 deubiquitinase USP30 是 S3 的一个目标。由 S3 的 USP30 的抑制导致 Mfn1/2 的 non-degradative ubiquitination 的增加,它提高 Mfn1 和 Mfn2 活动并且支持 mitochondrial 熔化。通过 USP30 的一个禁止者的使用,因此,我们的学习揭开在支持 mitochondrial 的 Mfns 的 non-degradative ubiquitination 的异乎寻常的功能熔化。 | Wen Yue Ziheng Chen HaiYang Li Chen Yan Ming Chen Du Feng Chaojun Yan Hao Wu Lei Du Yueying Wang Jinhua Liu Xiaohu Huang Laixin Xia Lei Liu Xiaohui Wang Haijing Jin Jun Wang Zhiyin Song Xiaojiang Hao Quan Chen | 2014 | Cell Research2014，24，4： | 18 |
| 4 | Report on Childhood Obesity in China (10): Association of Sleep Duration with Obesity显示文摘Objectives To explore the association of sleep duration with obesity among children in urban areas of China.Methods A total of 6 576 children(3 293 boys and 3 283 girls) aged 7-11 years were randomly selected from 36 primary schools in 6 metropolitan cities in China.A 7-day Physical Activity Recall was used to assess the sleep duration and physical activity level.The height,weight,waist circumference(WC) and percentage of body fat(%BF,as determined by bioelectrical impedance analysis technique) were measured by following the standardized operation procedures.The information on demography,lifestyle and eating habits was collected with a self-administered questionnaire from participants and their parents.Results The average sleep duration per night in the children was 9.7 h with the decreasing trends along with the increase of age(P<0.05).The sleep duration was negatively associated with body mass index(BMI) and WC in both boys and girls after adjustment for confounders(β value-0.23 and-0.82 for boys,-0.24 and-0.91 for girls,respectively,P<0.01).However,no significant association of sleep duration with %BF was found.Children who slept less than 9.0 h per night had a higher risk for overweight and obesity(OR=1.29,95% CI:1.01,1.64) and abdominal obesity(OR=1.38,95% CI:1.04,1.83) as compared with those who slept for 10.0-10.9 h.Conclusions Short sleep duration is associated with obesity.It is important to ensure adequate sleep duration of children and foster their healthy lifestyle at an early stage of life. | MENG Li Ping LIUAi Ling HU Xiao Qi ZHANG Qian DU Song Ming FANG Hong Yun MA Jun XU Gui Fa LI Ying GUO Hong Wei DU Lin MA Guan Sheng | 2012 | Biomedical and Environmental Sciences2012，25，2： | 16 |
| 5 | Analysis of Genetic Diversity of Processing Apple Varieties显示文摘Genetic diversity of 18 processing apple varieties and two fresh varieties were evaluated using 12 simple sequence repeats (SSR) primer pairs previously identified in Malus domestica Borkh. A total of 87 alleles in 10 loci were detected using 10 polymorphic SSR markers selected within the range of 5-14 alleles per locus. All the 20 varieties could be distinguished using two primer pairs and they were divided into four groups using cluster analysis. The genetic similarity (GS) of groups analyzed using cluster analysis varied from 0.14 to 0.83. High acid variety Avrolles separated from other varieties with GS less than 0.42. The second group contained Longfeng and Dolgo from Northeast of China, the inherited genes of Chinese crab apple. The five cider varieties with high tannin contents, namely, Dabinette, Frequin rouge, Kermerrien, M.Menard, and D.Coetligne were clustered into the third group. The fourth group was mainly composed of 12 juice and fresh varieties. Principal coordinate analysis (PCO) also divided all the varieties into four groups. Juice and fresh apple varieties, Longfeng and Dolgo were clustered together, respectively, using both the analyses. Both the analyses showed there was much difference between cider and juice varieties, cider and fresh varieties, as well as Chinese crab apple and western European crab apple, whereas juice varieties and fresh varieties had a similar genetic background. The genetic diversity and differentiation could be sufficiently reflected by combining the two analytical methods. | SONG Ye ZHAI Heng YAO Yu-xin LI Ming DU Yuan-peng | 2006 | Agricultural Sciences in China2006，5，10： | 10 |
| 6 | A fundamental theorem for eco-environmental surface modelling and its applications显示文摘We propose a fundamental theorem for eco-environmental surface modelling(FTEEM) in order to apply it into the fields of ecology and environmental science more easily after the fundamental theorem for Earth’s surface system modeling(FTESM). The Beijing-Tianjin-Hebei(BTH) region is taken as a case area to conduct empirical studies of algorithms for spatial upscaling, spatial downscaling, spatial interpolation, data fusion and model-data assimilation, which are based on high accuracy surface modelling(HASM), corresponding with corollaries of FTEEM. The case studies demonstrate how eco-environmental surface modelling is substantially improved when both extrinsic and intrinsic information are used along with an appropriate method of HASM. Compared with classic algorithms, the HASM-based algorithm for spatial upscaling reduced the root-meansquare error of the BTH elevation surface by 9 m. The HASM-based algorithm for spatial downscaling reduced the relative error of future scenarios of annual mean temperature by 16%. The HASM-based algorithm for spatial interpolation reduced the relative error of change trend of annual mean precipitation by 0.2%. The HASM-based algorithm for data fusion reduced the relative error of change trend of annual mean temperature by 70%. The HASM-based algorithm for model-data assimilation reduced the relative error of carbon stocks by 40%. We propose five theoretical challenges and three application problems of HASM that need to be addressed to improve FTEEM. | Tianxiang YUE Na ZHAO Yu LIU Yifu WANG Bin ZHANG Zhengping DU Zemeng FAN Wenjiao SHI Chuanfa CHEN Mingwei ZHAO Dunjiang SONG Shihai WANG Yinjun SONG Changqing YAN Qiquan LI Xiaofang SUN Lili ZHANG Yongzhong TIAN Wei WANG Ying’an WANG Shengnan MA Hongsheng HUANG Yimin LU Qing WANG Chenliang WANG Yuzhu WANG Ming LU Wei ZHOU Yi LIU Xiaozhe YIN Zong WANG Zhengyi BAO Miaomiao ZHAO Yapeng ZHAO Yimeng JIAO Ufra NASEER Bin FAN Saibo LI Yang YANG John PWILSON | 2020 | Science China Earth Sciences2020，63，8： | 7 |
| 7 | Application of a novel porous tantalum implant in rabbit anterior lumbar spine fusion model:in vitro and in vivo experiments显示文摘Background Some porous materials have been developed to enhance biologic fusion of the implants to bone in spine fusion surgeries.However,there are several inherent limitations.In this study,a novel biomedical porous tantalum was applied to in vitro and in vivo experiments to test its biocompatibility and osteocompatibility.Methods Bone marrow-derived mesenchymal stem cells (BMSCs) were cultured on porous tantalum implant.Scanning electron microscope (SEM) and Cell Counting Kit-8 assay were used to evaluate the cell toxicity and biocompatibility.Twenty-four rabbits were performed discectomy only (control group),discectomy with autologous bone implanted (autograft group),and discectomy with porous tantalum implanted (tantalum group) at 3 levels:L3–L4,L4–L5,and L5–L6 in random order.All the 24 rabbits were randomly sacrificed at the different post-operative times (2,4,6,and 12 months;n = 6 at each time point).Histologic examination and micro-computed tomography scans were done to evaluate the fusion process.Comparison of fusion index scores between groups was analyzed using one-way analysis of variance.Other comparisons of numerical variables between groups were made by Student t test.Results All rabbits survived and recovered without any symptoms of nerve injury.Radiographic fusion index scores at 12 months post-operatively between autograft and tantalum groups showed no significant difference (2.89 ± 0.32 vs.2.83 ± 0.38, F= 244.60, P = 0.709).Cell Counting Kit-8 assay showed no significant difference of absorbance values between the leaching liquor group and control group (1.25 ± 0.06 vs.1.23 ± 0.04, t = –0.644, P = 0.545),which indicated the BMSC proliferation without toxicity.SEM images showed that these cells had irregular shapes with long spindles adhered to the surface of tantalum implant.No implant degradation,wear debris,or osteolysis was observed.Histologic results showed solid fusion in the porous tantalum and autologous bone implanted intervertebral spaces.Conclusion This novel porous tantalum implant showed a good biocompatibility and osteocompatibility,which could be a valid biomaterial for interbody fusion cages. | Ming Lu Song Xu Zi-Xiong Lei Dong LU Wei Cao Marko Huttula Chang-He Hou Shao-Hua Du Wei Chen Shuang-Wu Dai Hao-Miao Li Da-Di Jin | 2019 | Chinese Medical Journal2019，，1： | 7 |
| 8 | Influence of plastic film mulching and planting density on yield,leaf anatomy,and root characteristics of maize on the Loess Plateau显示文摘In rainfed areas of northwestern China,maize production is constrained mainly by low temperature during early growth and water limitation during the entire growth period.Plastic film mulching is commonly used to increase maize yield in this area,because it increases topsoil temperature and moisture content as well as water use efficiency.However,the physiological and anatomical bases of maize yield improvement with plastic film mulching are not well understood.The effects of plastic film mulching and planting density on maize yield,photosynthetic characteristics,respiration,leaf anatomy,and root growth were studied in a two-year field experiment conducted on the Loess Plateau of China in 2017 and 2018.The experiment used a split-split plot design with two mulching treatments(plastic film mulching and no mulching),two planting densities(7.5×104 and10.5×104 plants ha-1),and two maize cultivars,Zhengdan 958 and Xianyu 335.Compared with no mulching,plastic film mulching increased maize yields by 31.1%–46.4%in 2017 and3.6%–34.7%in 2018.Compared with low planting density,high planting density significantly increased and slightly reduced yields of both cultivars in the dry year 2017 and the rainy year 2018,respectively.Plastic film mulching increased photosynthesis and respiration as well as leaf stomatal density and aperture.Photosynthetic rate,dark respiration,and stomatal conductance and aperture were lower at high planting than at low planting density.Maize yield was positively correlated with photosynthesis,dark respiration,and stomatal aperture.Mulching increased root dry weight and length in the 0–20 cm soil layer and root activity at maturity.Overall,the changes in root growth and leaf anatomy resulted in increased photosynthesis and dark respiration,and the increased photosynthesis contributed to the increase in grain yield and biomass production under plastic film mulching conditions.Our results increase understanding of the physiological mechanisms by which plastic film mulching increases maize yield in water-and temperature-limited areas. | Li Niu Yanyan Yan Peng Hou Wenbo Bai Rulang Zhao Yonghong Wang Shaokun Li Taisheng Du Ming Zhao Jiqing Song Wenbin Zhou | 2020 | The Crop Journal2020，8，4： | 6 |
| 9 | Real world effectiveness of PCSK-9 inhibitors combined with statins versus statins-based therapy among patients with very high risk of atherosclerotic cardiovascular disease in China(RWE-PCSK study)显示文摘BACKGROUND The efficacy and safety of proprotein convertase subtilisin/kexin type 9(PCSK-9) inhibitors were confirmed by several clinical trials, but its effectiveness in routine clinical practice in China has not been evaluated. This study aims to describe the real world effectiveness of PCSK-9 inhibitors combined with statins compared with statins-based therapy among patients with very high risk of atherosclerotic cardiovascular disease(ASCVD).METHODS This is a multi-center observational study, enrolled patients from 32 hospitals who underwent percutaneous coronary intervention(PCI) from January to June in 2019. There are 453 patients treated with PCSK-9 inhibitors combined with statins in PCSK-9 inhibitor group and 2,610 patients treated with statins-based lipid lowering therapies in statins-based group. The lipid control rate and incidence of major adverse cardiovascular events(MACE) over six months were compared between two groups.A propensity score-matched(PSM) analysis was used to balance two groups on confounding factors. Survival analysis using Kaplan-Meier methods was applied for MACE.RESULTS In a total of 3,063 patients, 89.91% of patients had received moderate or high-intensity statins-based therapy before PCI, but only 9.47% of patients had low-density lipoprotein cholesterol(LDL-C) levels below 1.4 mmol/L at baseline. In the PSM selected patients, LDL-C level was reduced by 42.57% in PCSK-9 inhibitor group and 30.81%(P < 0.001) in statins-based group after six months. The proportion of LDL-C ≤ 1.0 mmol/L increased from 5.29% to 29.26% in PCSK-9 inhibitor group and 0.23% to 6.11% in statins-based group, and the proportion of LDL-C ≤ 1.4 mmol/L increased from 10.36% to 47.69% in PCSK-9 inhibitor group and 2.99% to 18.43% in statins-based group(P < 0.001 for both). There was no significant difference between PCSK-9 inhibitor and statins-based treatment in reducing the risk of MACE(hazard ratio = 2.52, 95% CI: 0.49-12.97, P = 0.250).CONCLUSIONS In the real world, PCSK-9 inhibitors combined with statins could significantly reduce LDL-C levels among patients with very high risk of ASCVD in China. The long-term clinical benefits for patients received PCSK-9 inhibitor to reduce the risk of MACE is still unclear and requires further study. | Yu-Qi LIU Dan-Dan LI Meng CHAI Hong-Liang CONG Xiao-Qiang CONG Jun DAI Rong-Pin DU Ming GAO Jin-Cheng GUO Yan-Qing GUO Xiao-Jian HONG Rong-Chong HUANG Feng-Shun JIA Jia-Yu LI Qing LI Jia-Mei LIU Xin-Ping LIU Yu-Guo LIU Hong-Gang NIE Bing SHAO Xiao-Yu SHEN Hai-Qing SONG Yi-Jun SONG Li-Jun WANG Shuo WANG Dong-Mei WU Jing XIA Zhi-Yong YANG Hong-Ying YU Hui ZHANG Tie-Mei ZHANG Ji-Yi ZHAO Liang-Chen ZHAO Ming-Qi ZHENG Yun-Dai CHEN | 2021 | Journal of Geriatric Cardiology2021，18，4： | 5 |
| 10 | The recruitment of exogenous endothelial progenitor cells in lung tumor model of nude mice显示文摘Background and Objective: Endothelial progenitor cells (EPCs) play an important role in hypoxia-triggered tumor vasculogenesis. However, the homing of exogenous EPCs in tumors is still unclear. In this study, we investigated the recruitment of exogenous EPCs in human lung adenocarcinoma model of nude mice. Methods: EPCs labeled with green fluorescence protein (GFP) were transplanted into nude mice bearing human lung adenocarcinoma. The growth of tumor was observed. After the mice were killed, GFP-EPCs in different tissues were examined by fluorescence. The tumor tissues were stained for CD133, hypoxia-inducible factor-1alpha (HIF-1α), stromal cell-derived factor-1α (SDF-1α), and vascular endothelial growth factor receptor (KDR). Real-time polymerase chain reaction of CD133, HIF-1α, SDF-1α, and VEGF-1 were also performed. Results: The growth of tumor in EPC group was significantly faster than that in saline solution group (P < 0.05). Under fluorescence microscope, GFP-EPCs were strongly expressed in both tumor and bone marrow. EPCs were recruited to the tumor periphery to participate in tumor vasculogenesis. The expression of CD133, HIF-1α, and SDF-1 mRNA in tumor and bone marrow were significantly higher than that in the liver, spleen, and skin (P < 0.05). Conclusions: Exogenous EPCs can be recruited to tumor and accelerate tumor growth. Except tumor, bone marrow can also recruit EPCs. | Qiang Peng Ming Liu Shu-Min Song Xian-Hua Li Yi-Hua Du Yong Zhi Min-Yong Wang | 2010 | Chinese Journal of Cancer2010，29，11： | 4 |
| 11 | MicroRNA-145 plays a role in mitochondrial dysfunction in alveolar epithelial cells in lipopolysaccharide-induced acute respiratory distress syndrome显示文摘BACKGROUND: Acute respiratory distress syndrome (ARDS) causes substantial mortalities.Alveolar epithelium is one of the main sites of cell injuries in ARDS. As an important kind of microRNAs(miRNAs), microRNA-145 (miR-145) has been studied in various diseases, while its role in ARDS has notbeen investigated.METHODS: Lipopolysaccharide (LPS) was intratracheally instilled to establish a rat ARDS model.Cytokines from bronchoalveolar lavage fl uid (BALF) were measured using rat tumor necrosis factor-α andinterleukin-6 enzyme-linked immunosorbent assay kits (R&D Systems), and the pathological structureswere evaluated using hematoxylin and eosin (H&E) staining and transmission electron microscope;thelung miR-145 messenger RNA (mRNA) was detected using quantitative polymerase chain reaction.Bioinformatics focused on the target genes and possible pathways of gene regulation.RESULTS: A rat model of LPS-induced ARDS was successfully established. The miR-145was down-regulated in the LPS-induced ARDS lung, and mitochondrial dysfunction was observedin alveolar epithelial cells, most obviously at 72 hours after LPS. TargetScan and miRDB databaseswere used to predict the target genes of miR-145. A total of 428 overlapping genes were identifi ed,seven genes were associated with mitochondrial function, and Ogt, Camk2d, Slc8a3, and Slc25a25were verifi ed. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were enriched in themitogen-activated protein kinase (MAPK) signaling pathway, and Gene Ontology (GO) biologicalprocess was mainly enriched in signal transduction and transcription regulation.CONCLUSIONS: The miR-145 is down-regulated in LPS-induced ARDS, and affects itsdownstream genes targeting mitochondrial functions. | Yi Han Su-cheng Mu Jian-li Wang Wei Wei Ming Zhu Shi-lin Du Min Min Yun-jie Xu Zhen-ju Song Chao-yang Tong | 2021 | World Journal of Emergency Medicine2021，12，1： | 3 |
| 12 | Revised Super-long Down-regulation Protocol Improves the Outcome of Infertile Patients with Repeated Implantation Failure in IVF/ICSI-ET显示文摘Objective To investigate the outcome of revised super-long down-regulation protocol(RSDP) for in vitro fertilization / intracytoplasmic sperm injection-embryo transfer(IVF/ICSI-ET) in the special infertile patients with repeated implantation failure(RIF).Methods Patients with RIF were divided into RSDP group and routine long downregulation protocol(RLDP) group. In RSDP group, gonadotropin releasing hormone agonist(GnRHa) was injected intramuscularly by 2.5 mg in mid-luteal phase for the first time and 1.25 mg after 28 d; gonadotropin(Gn) was started 14 d later after the second GnRHa dose. IVF/ICSI-ET was performed according to the routine procedure. The clinical outcomes of RSDP group were compared with those of RLDP group.Results In RSDP group, the number of retrieved oocytes and valid embryos was significantly lower(P<0.05); there were no significant differences about fertilization rate(P>0.05); both good-quality embryo rate and implantation rate were significantly increased(P<0.005); clinical pregnancy rate was obviously improved(P<0.05), as compared with RLDP group.Conclusion RSDP can improve the IVF outcomes significantly in RIF patients. | Min-feng SHI Tie ZHOU Ying WANG Guang-hua CHEN Ming ZHU Jun OU Hui DU Tao-fei YAN Di SONG Ju-fen ZHENG Hui-qin ZHANG Ning HUI Ying-hao SUN | 2014 | Journal of Reproduction and Contraception2014，25，2： | 2 |
| 13 | The first data release(DR1) of the LAMOST regular survey显示文摘The Large sky Area Multi-Object Fiber Spectroscopic Telescope(LAMOST) general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio(SNR) ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters: late A,FGK-type stars with high quality spectra(1 061 918 entries), A-type stars(100 073 entries), and M-type stars(121 522 entries). This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided. | A-Li Luo Yong-Heng Zhao Gang Zhao Li-Cai Deng Xiao-Wei Liu Yi-Peng Jing Gang Wang Hao-Tong Zhang Jian-Rong Shi Xiang-Qun Cui Yao-Quan Chu Guo-Ping Li Zhong-Rui Bai Yue Wu Yan Cai Shu-Yun Cao Zi-Huang Cao Jeffrey L.Carlin Hai-Yuan Chen Jian-Jun Chen Kun-Xin Chen Li Chen Xue-Lei Chen Xiao-Yan Chen Ying Chen Norbert Christlieb Jia-Ru Chu Chen-Zhou Cui Yi-Qiao Dong Bing Du Dong-Wei Fan Lei Feng Jian-Ning Fu Peng Gao Xue-Fei Gong Bo-Zhong Gu Yan-Xin Guo Zhan-Wen Han Bo-Liang He Jin-Liang Hou Yong-Hui Hou Wen Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Zhi-Ying Huo Lei Jia Fang-Hua Jiang Xiang Jiang Zhi-Bo Jiang Ge Jin Xiao Kong Xu Kong Ya-Juan Lei Ai-Hua Li Chang-Hua Li Guang-Wei Li Hai-Ning Li Jian Li Qi Li Shuang Li Sha-Sha Li Xin-Nan Li Yan Li Yin-Bi Li Ye-Ping Li Yuan Liang Chien-Cheng Lin Chao Liu Gen-Rong Liu Guan-Qun Liu Zhi-Gang Liu Wen-Zhi Lu Yu Luo Yin-Dun Mao Heidi Newberg Ji-Jun Ni Zhao-Xiang Qi Yong-Jun Qi Shi-Yin Shen Huo-Ming Shi Jing Song Yi-Han Song Ding-Qiang Su Hong-Jun Su Zheng-Hong Tang Qing-Sheng Tao Yuan Tian Dan Wang Da-Qi Wang Feng-Fei Wang Guo-Min Wang Hai Wang Hong-Chi Wang Jian Wang Jia-Ning Wang Jian-Ling Wang Jian-Ping Wang Jun-Xian Wang Lei Wang Meng-Xin Wang Shou-Guan Wang Shu-Qing Wang Xia Wang Ya-Nan Wang You Wang Yue-Fei Wang You-Fen Wang Peng Wei Ming-Zhi Wei Hong Wu Ke-Fei Wu Xue-Bing Wu Yu-Zhong Wu Xiao-Zheng Xing Ling-Zhe Xu Xin-Qi Xu Yan Xu Tai-Sheng Yan De-Hua Yang Hai-Feng Yang Hui-Qin Yang Ming Yang Zheng-Qiu Yao Yong Yu Hui Yuan Hai-Bo Yuan Hai-Long Yuan Wei-Min Yuan Chao Zhai En-Peng Zhang Hua-Wei Zhang Jian-Nan Zhang Li-Pin Zhang Wei Zhang Yong Zhang Yan-Xia Zhang Zheng-Chao Zhang Ming Zhao Fang Zhou Xu Zhou Jie Zhu Yong-Tian Zhu Si-Cheng Zou Fang Zuo | 2015 | Research in Astronomy and Astrophysics2015，15，8： | 2 |
| 14 | Clinical Value of Human Papillomavirus E6/E7 mRNA Testing in Patients with Atypical Squamous Cells of Undetermined Significance and Low-Grade Squamous Intraepithelial Lesion显示文摘Objective:To explore the clinical significance of the quantitative detection of human papillomavirus(HPV)E6/E7mRNA in triage of patients with atypical squamous cells of undetermined significance(ASC-US)and low-grade squamous intraepithelial lesion(LSIL).Methods:A cross-sectional screening study was conducted among women who underwent outpatient gynecological screening at the Obstetrics and Gynecology Hospital of Fudan University from September 2015 to July 2016.A total of 500 patients from our hospital with ASC-US or LSIL based on cytology testing were subjected to HPV DNA and HPV E6/E7 mRNA quantitative analysis.Results:The specificity of the HPV E6/E7 mRNA test for detecting≥high-grade squamous intraepithelial lesion(HSIL+)was statistically higher than that of the HPV DNA test(61.3%vs.40.0%,P<0.05),whereas there was no significant difference in the sensitivity of HPV E6/E7 mRNA test and HPV DNA test(90.0%vs.95.0%,P>0.05).The positive rates of HPV in the participants tested by HPV E6/E7 mRNA and HPV DNA were,respectively,42.8%(214/500)and 62.8%(314/500),with statistical significance(P<0.05).Conclusions:The HPV E6/E7 mRNA test was slightly less sensitivity than that of the HPV DNA test for diagnosing HSIL+in patients with ASC-US and LSIL,but the difference was not significant,although the specificity of the former was significantly higher.HPV E6/E7 mRNA detection can effectively reduce overdiagnosis and overtreatment of patients with ASC-US and LSIL and has important clinical value in triage of patients with ASC-US and LSIL. | Qing Wang Cai-Ying Zhu Li-Mei Chen Shu-Jun Gao Ming Du Hong-Wei Zhang Hua Feng Yu Song Wen-Jing Diao Yan-Yun Li Long Sui | 2018 | Reproductive and Developmental Medicine2018，2，3： | 2 |
| 15 | A simple inorganic-solvent-thermal route to nanocrystalline niobium diboride显示文摘 | Jianhua Ma Yihong Du Meining Wu Guoxing Li Zhiqing Feng Ming Guo Yixiu Sun Weihua Song Mingjin Lin Xule Guo | 2008 | Journal of Alloys and Compounds2008，，： | 1 |
| 16 | Data release of the LAMOST pilot survey显示文摘This paper describes the data release of the LAMOST pilot survey, which includes data reduction, calibration, spectral analysis, data products and data access. The accuracy of the released data and the information about the FITS headers of spectra are also introduced. The released data set includes 319 000 spectra and a catalog of these objects. | A-Li Luo Hao-Tong Zhang Yong-Heng Zhao Gang Zhao Xiang-Qun Cui Guo-Ping Li Yao-Quan Chu Jian-Rong Shi Gang Wang Jian-Nan Zhang Zhong-Rui Bai Xiao-Yan Chen Feng-Fei Wang Yan-Xin Guo Jian-Jun Chen Bing Du Xiao Kong Ya-Juan Lei Yin-Bi Li Yi-Han Song Yue Wu Yan-Xia Zhang Xin-Lin Zhou Fang Zuo Peng Du Lin He Wen Hou Yi-Qiao Dong Jian Li Guang-Wei Li Shuang Li Jing Song Yuan Tian Meng-Xin Wang Yong-Hui Hou Zhi-Ying Huo Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Lei Jia Fang-Hua Jiang Xiang Jiang Zi-Bo Jiang Ge Jin Ai-Hua Li Qi Li Yin-Dun Mao Zheng-Hong Tang Qing-Sheng Tao Liang-Ping Tu Da-Qing Wang Dan Wang Jian-Ping Wang Lei Wang Shou-Guan Wang Shu-Qing Wang Ya-Nan Wang You Wang Yue-Fei Wang Ming-Zhi Wei Xiang-Xiang Xue Xiao-Zheng Xing Ling-Zhe Xu Xin-Qi Xu Yan Xu De-Hua Yang Shi-Hai Yang Zheng-Qiu Yao Yong Yu Hui Yuan Chao Zhai En-Peng Zhang Jing Zhang Li-Ping Zhang WeiZhang Yong Zhang Zhen-Chao Zhang Ming Zhao Fang Zhou Yong-Tian Zhu Jie Zhu Si-Cheng Zou | 2012 | Research in Astronomy and Astrophysics2012，12，9： | 1 |
| 17 | LncRNA CFAR promotes cardiac fibrosis via the miR-449a-5p/LOXL3/mTOR axis显示文摘Cardiac fibrosis is one of the crucial pathological factors in the heart,and various cardiac conditions associated with excessive fibrosis can eventually lead to heart failure.However,the exact molecular mechanism of cardiac fibrosis remains unclear.In the present study,we show that a novel lnc RNA that we named cardiac fibrosis-associated regulator(CFAR)is a profibrotic factor in the heart.CFAR was upregulated in cardiac fibrosis and its knockdown attenuated the expression of fibrotic marker genes and the proliferation of cardiac fibroblasts,thereby ameliorating cardiac fibrosis.Moreover,CFAR acted as a ce RNA sponge for mi R-449a-5p and derepressed the expression of LOXL3,which we experimentally established as a target gene of mi R-449a-5p.In contrast to CFAR,mi R-449a-5p was found to be significantly downregulated in cardiac fibrosis,and artificial knockdown of mi R-449a-5p exacerbated fibrogenesis,whereas overexpression of mi R-449a-5p impeded fibrogenesis.Furthermore,we found that LOXL3 mimicked the fibrotic factor TGF-β1 to promote cardiac fibrosis by activating m TOR.Collectively,our study established CFAR as a new profibrotic factor acting through a novel mi R-449a-5p/LOXL3/m TOR axis in the heart and therefore might be considered as a potential molecular target for the treatment of cardiac fibrosis and associated heart diseases. | Mingyu Zhang Bowen Zhang Xiaohan Wang Jiahang Song Ming Tong Zheng Dong Jiaonan Xu Meng Liu Yuan Jiang Ning Wang Ying Wang Zhimin Du Yanyan Liu Rong Zhang Chaoqian Xu | 2023 | Science China(Life Sciences)2023，66，4： | 1 |
| 18 | Numerical Simulation of Bohai Oil Spill in the Winter Sea Ice Period显示文摘The Bohai Sea is a seasonal icy sea area that has the lowest latitude of any sea experiencing icing in the northern hemisphere, and simulation studies on oil spills during its sea ice period are the key to analyzing winter oil spill accidents. This study applied the three-dimensional free surface to establish a high-resolution hydrodynamic model and simulate tidal distributions in the Bohai Sea. Then, the oil spill model of the open sea area and thermodynamic model were combined to establish a numerical model for the Bohai oil spill during the winter sea ice period. The hydrodynamic model and sea ice growth and melting model were verified, and the parameters were adjusted based on the measured values, which indicate that the numerical model established in this paper is of high accuracy,stability and ubiquity. Finally, after checking the calculations repeatedly, the diffusion coefficient for the Bohai Sea was determined to be 1.0×10^(–7 )m^2/s. It is better that the comprehensive weathering attenuation coefficient is lower than that of a non-winter oil spill, with 1.3×10^(–7 )m^2/s being the most appropriate coefficient. This study can provide the reliable technical support for the operational safety and reduction in losses caused by winter oil spill accidents for the petroleum industry. | WANG Kun DU Jing LIU Ming WU Jin-hao JIANG Heng-zhi JIN Sheng SONG Lun | 2019 | China Ocean Engineering2019，33，2： | 1 |
| 19 | Corrugated rGO-supported Pd composite on carbon paper for efficient cathode of Mg-H_(2)O_(2)semi-fuel cell显示文摘A corrugated reduced graphene oxide(rGO)-supported Pd composite on carbon paper(Pd/rGO/CP)is prepared via a simple chemical reduction process combined with electrodeposition.The micros tructure,morphology,and surface chemical state of the composite and its performance in H_(2)O_(2)reduction in an acidic medium are investigated.An rGO film with ample corrugated wrinkles coated closely on CP is prepared,and Pd nanoparticles are evenly decorated on the surface of rGO/CP.The Pd/rGO/CP electrode has a low Pd loading and high catalytic performance for H_(2)O_(2)reduction in acidic media compared to Pd/CP.An excellent mass normalized activity(11,783 A·g_(Pd)^(-1))of the Pd/rGO/CP electrode for H_(2)O_(2)reduction is achieved at 0 V due to the corresponding low Pd loadings.Mg-H_(2)O_(2)semi-fuel cells using Pd/rGO/CP electrode as the cathode exhibits a peak power density of215 mW·cm^(-2)at 60℃and perfect stability during a 50-h discharge.The rGO interlayer forms a microscopic threedimensional(3 D)structure on the surface of CP,thereby improving the utilization of precious metals and the specific surface area,as well as providing more Pd sites due to the transfer of electrons to Pd.Consequently,the performance of the electrode is improved. | Feng-Chun Wen Su.-Ri.-Gu.-Ga.Li Yan Chen Xi-Hua Du Hua Tan Ya-Jiao Song Ming Song Li-Mei Sun | 2022 | Rare Metals2022，41，8： | 1 |
| 20 | Cardiomyocyte peroxisome proliferator-activated receptor α prevents septic cardiomyopathy via improving mitochondrial function显示文摘Clinically, cardiac dysfunction is a key component of sepsis-induced multi-organ failure. Mitochondria are essential for cardiomyocyte homeostasis, as disruption of mitochondrial dynamics enhances mitophagy and apoptosis. However, therapies targeted to improve mitochondrial function in septic patients have not been explored. Transcriptomic data analysis revealed that the peroxisome proliferator-activated receptor (PPAR) signaling pathway in the heart was the most significantly decreased in the cecal ligation puncture-treated mouse heart model, and PPARα was the most notably decreased among the three PPAR family members. Male Pparafl/fl (wild-type), cardiomyocyte-specific Ppara-deficient (PparaΔCM), and myeloid-specific Ppara-deficient (PparaΔMac) mice were injected intraperitoneally with lipopolysaccharide (LPS) to induce endotoxic cardiac dysfunction. PPARα signaling was decreased in LPS-treated wild-type mouse hearts. To determine the cell type in which PPARα signaling was suppressed, the cell type-specific Ppara-null mice were examined. Cardiomyocyte- but not myeloid-specific Ppara deficiency resulted in exacerbated LPS-induced cardiac dysfunction. Ppara disruption in cardiomyocytes augmented mitochondrial dysfunction, as revealed by damaged mitochondria, lowered ATP contents, decreased mitochondrial complex activities, and increased DRP1/MFN1 protein levels. RNA sequencing results further showed that cardiomyocyte Ppara deficiency potentiated the impairment of fatty acid metabolism in LPS-treated heart tissue. Disruption of mitochondrial dynamics resulted in increased mitophagy and mitochondrial-dependent apoptosis in Ppara△CM mice. Moreover, mitochondrial dysfunction caused an increase of reactive oxygen species, leading to increased IL-6/STAT3/NF-κB signaling. 3-Methyladenine (3-MA, an autophagosome formation inhibitor) alleviated cardiomyocyte Ppara disruption-induced mitochondrial dysfunction and cardiomyopathy. Finally, pre-treatment with the PPARα agonist WY14643 lowered mitochondrial dysfunction-induced cardiomyopathy in hearts from LPS-treated mice. Thus, cardiomyocyte but not myeloid PPARα protects against septic cardiomyopathy by improving fatty acid metabolism and mitochondrial dysfunction, thus highlighting that cardiomyocyte PPARα may be a therapeutic target for the treatment of cardiac disease. | Xin-xin Zhu Xia Wang Shi-yu Jiao Ye Liu Li Shi Qing Xu Jing-jing Wang Yun-er Chen Qi Zhang Yan-ting Song Ming Wei Bao-qi Yu Jens Fielitz Frank J.Gonzalez Jie Du Ai-juan Qu | 2023 | Acta Pharmacologica Sinica2023，44，11： | 1 |
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