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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Landscape of DILI-related adverse drug reaction in China Mainland显示文摘Drug-induced liver injury(DILI)is a type of bizarre adverse drug reaction(ADR)damaging liver(L-ADR)which may lead to substantial hospitalizations and mortality.Due to the general low incidence,detection of L-ADR remains an unsolved public health challenge.Therefore,we used the data of 6.673 million of ADR reports from January 1st,2012 to December 31st,2016 in China National ADR Monitoring System to establish a new database of L-ADR reports for future investigation.Results showed that totally 114,357 ADR reports were retrieved by keywords searching of liver-related injuries from the original heterogeneous system.By cleaning and standardizing the data fields by the dictionary of synonyms and English translation,we resulted 94,593 ADR records reported to liver injury and then created a new database ready for computer mining.The reporting status of L-ADR showed a persistent 1.62-fold change over the past five years.The national population-adjusted reporting numbers of L-ADR manifested an upward trend with age increasing and more evident in men.The annual reporting rate of L-ADR in age group over 80 years old strikingly exceeded the annual DILI incidence rate in general population,despite known underreporting situation in spontaneous ADR reporting system.The percentage of herbal and traditional medicines(H/TM)L-ADR reports in the whole number was 4.5%,while 80.60%of the H/TM reports were new findings.There was great geographical disparity of reported agents,i.e.more cardiovascular and antineoplastic agents were reported in higher socio-demographic index(SDI)regions and more antimicrobials,especially antitubercular agents,were reported in lower SDI regions.In conclusion,this study presented a large-scale,unbiased,unified,and computer-minable L-ADR database for further investigation.Age-,sex-and SDI-related risks of L-ADR incidence warrant to emphasize the precise pharmacovigilance policies within China or other regions in the world. | Jiabo Wang Haibo Song Feilin Ge Peng Xiong Jing Jing Tingting He Yuming Guo Zhuo Shi Chao Zhou Zixin Han Yanzhong Han Ming Niu Zhaofang Bai Guangbin Luo Chuanyong Shen Xiaohe Xiao | 2022 | Acta Pharmaceutica Sinica B2022，12，12： | 12 |
| 3 | Discrete chaos in Banach spaces显示文摘This paper is concerned with chaos in discrete dynamical systems governed by continuously Frechet differentiable maps in Banach spaces. A criterion of chaos induced by a regular nondegenerate homoclinic orbit is established. Chaos of discrete dynamical systems in the n-dimensional real space is also discussed, with two criteria derived for chaos induced by nondegenerate snap-back repellers, one of which is a modified version of Marotto's theorem. In particular, a necessary and sufficient condition is obtained for an expanding fixed point of a differentiable map in a general Banach space and in an n-dimensional real space, respectively. It completely solves a long-standing puzzle about the relationship between the expansion of a continuously differentiable map near a fixed point in an n-dimensional real space and the eigenvalues of the Jacobi matrix of the map at the fixed point. | SHI Yuming CHEN Guanrong | 2005 | Science China Mathematics2005，48，2： | 7 |
| 4 | Size fractionated biomass and productivity of phytoplankton and new production in the Prydz Bay and the adjacent Indian sector of the Southern Ocean during the austral summer 1998/1999显示文摘The paper deals with the studies on the cell abundance, the composition of dominant species, size fractionated biomass and productivity of phytoplankton, new production, the environmentally restricted mechanism in the Prydz Bay and the adjacent Indian sector of the Southern Ocean during the austral summer 1998/1999. The results showed that there was marked feature of spatial zonation in the sea areas investigated. In the Prydz Bay and its adjacent continental shelf, the biomass and productivity of phytoplankton were high; those of continental slope and open ocean area were obviously low. The nutrient concentration had opposite distribution trend, due to the consumption of phytoplankton. It mainly affected by the vertical stability of water column, grazing pressure of zooplankton, temperature and light etc.The results of size-fractionation showed that the average contribution of netplankton to total chlorophyll a in studied sea areas was 52.2%, those of nano- and picoplankton were 29.4% and 18.4%, respectively. The average contribution of netplankton to total primary production was 52.4%, those of nano- and picoplankton were 28.7% and 18.9%, separately. It is same as previous conclusion that the contribution of picoplankton to productivity is slightly larger than that to biomass of phytoplankton communities. The average new production and f-ratio were 230.6 mg/(m2·d) and 0.43, respectively. | Cai Yuming 1,3, Ning Xiuren 1,2,3, Zhu Genghai3, Shi Junxian3 1. Key Laborary of Submarine Geosciences of State Oceanic Administration,Hangzhou 310012,China. 2. Key Laborary of Ocean Dynamic Processes and Satellite Oceanography of State Oceanic Administration,Hangzhou 310012,China 3. Second Institute of Oceanography of State Oceanic Administration, Hangzhou 310012,China | 2003 | Acta Oceanologica Sinica2003，22，4： | 5 |
| 5 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 6 | Bacterioplankton production in dilution zone of the Changjiang (Yangtze) Estuary显示文摘The bacterioplankton production and bacterioplankton abundance were surveyed in dilution zone of the Changjiang Estuary and a mesocosm experimental device for enriched phosphate experiment and oil contaminated experiment was placed in the waters nearby Luhua Island during October 1997 and May 1998. The results showed that the average bacterioplankton production in spring was higher than that in autumn, the production at the surface water was higher than that at the bottom in the surveyed area; the higher values appeared in the middle of the area. The results from mesocosm experiment with adding phosphate and oil contaminated showed that the bacterioplankton production increased rising trend day by day during the experiment period. | Liu Zilin 1,2 , Koshikawa Hiroshi 3, Ning Xiuren 1,2 , Shi Junxian 2, Cai Yuming 1,21.KeyLaboratoryofSubmarineGeosciences,StateOceanicAdministration,China2.SecondInstituteofOceanography,StateOceanicAdministration,Hangzhou310012,China3.Nationa | 2001 | Acta Oceanologica Sinica2001，20，1： | 3 |
| 7 | Study on co-occurrence character networks from Chinese essays in different periods显示文摘Co-occurrence networks of Chinese characters are constructed from collections of essays in different periods of China:the ancient Chinese language,the Chinese language in Wei,Jin,and Southern-Northern Dynasties,the recent Chinese language,and the modern Chinese language,and their statistical parameters are studied.It has been found that 99.6% networks have the scale-free feature and 95.0% networks have the smallworld e?ect.This study reveals some commonalities and di?erences among articles in different periods of China from a complex network perspective.There has been a controversial question as to whether the literatures in Wei,Jin,and Southern-Northern Dynasties should belong to the ancient Chinese language or the recent Chinese language in the linguistic study.Our work shows that the statistical parameters of networks in Wei,Jin,and Southern-Northern Dynasties are clearly different from those of networks in the other periods of China,and it seems more reasonable that the literatures in Wei,Jin,and Southern-Northern Dynasties belong to the recent Chinese language. | LIANG Wei SHI YuMing TSE Chi K WANG YanLi | 2012 | Science China(Information Sciences)2012，55，11： | 2 |
| 8 | Study of relationship between wave transport and sea surface temperature anomaly(SSTA) in the tropical Pacific显示文摘Large-scale water transport is one of the key factors that affect sea surface temperature anomaly(SSTA) in the eastern equatorial Pacific(EEP).The relationship between the wave transport in the tropical Pacific and the SSTA in the EEP is examined by different methods,including band-pass filtering,period analysis,correlation analysis,significant analysis,and empirical orthogonal function(EOF) analysis.We have found that the eastward shift of the wave transport anomaly in the tropical Pacific,with a period of 2 a and enhancing the transport of warm waters from the western Pacific warm pool,precedes the increase of sea surface temperature(SST) in the EEP.The wave transport and the SSTA in the EEP have a maximum correlation of 0.65 with a time-lag of 6 months(transport variation precedes the temperature).The major periods(3.7 a and 2.45 a) of the wave transport variability,as revealed by the EOF analysis,appear to be consistent with the SSTA oscillation cycle in the EEP.Based on the first occurrence of a significant SSTA in the Ni?o 3 region(5°S–5°N,90°–150°W),two types of warm events are defined.The wave transport anomalies in two types present predominantly the west anomaly in the tropical Pacific,it is that the wave transport continues transport warm water from west to east before the onset of the warm event.The impact of wave-induced water transport on the SSTA in the EEP is confirmed by the heat flux of the wave transport.The wave transport exerts significant effect on the SSTA variability in the EEP and thus is not neglectable in the further studies. | SHI Yongfang WU Kejian ZHU Xianye YANG Fan ZHANG Yuming | 2016 | Acta Oceanologica Sinica2016，35，9： | 2 |
| 9 | Effect of zinc addition on catalytic properties of PtSnK/γ-Al 2 O 3 catalyst for isobutane dehydrogenation显示文摘 | Yiwei Zhang Yuming Zhou Junjun Shi Xiaoli Sheng Yongzheng Duan Shijian Zhou Zewu Zhang | 2012 | Fuel Processing Technology2012，，： | 1 |
| 10 | Effect of znic ad- dition on catalytic properties of Pt - Sn - K/y - AI203 catalyst for isobutane dehydrogenation 显示文摘 | Zhang Yiwei Zhou Yuming Shi Junjun | 2012 | Fuel Processing Technology2012，93，96： | 1 |
| 11 | Spectral theory of second order vector difference equations显示文摘 | Shi Yuming Chen Shaozhu | 1999 | J Math Anal Appl1999，239，2： | 1 |
| 12 | Analysis of metal transfer and correlated influence in dual bypass GMAW of alumi- num显示文摘 | Shi Yu Liu Xiaopei Zhang Yuming | 2008 | Welding Journal2008，87，9： | 1 |
| 13 | Stability of the boundary solution of a nonau- tonomous predator-prey system with the Beddington-DeAngelis functional response显示文摘 | Chen Fengde Chen Yuming Shi Jinlin | 2008 | J Math Anal Appl2008，344，2： | 1 |
| 14 | β - carotene in Golden Rice is as good as b - car- otene in oil at providing vitamin A to children显示文摘 | Guangwen Tang Yuming Hu Shi - an Yin Yin Wang | 2012 | The American Journal of Clinical Nutrition2012，，96： | 1 |
| 15 | Chaotifica- tion of nonautonomous discrete dynamical systems 显示文摘 | Huang Qiuling Shi Yuming Zhang Lijuan | 2011 | International Journal of Bifurcation and Chaos2011，21，11： | 1 |
| 16 | Chaos in nonautonomous discrete dynamical systems approached by their induced systems 显示文摘 | Shi Yuming | 2012 | Inter- national Journal of Bifurcation and Chaos2012，22，11： | 1 |
| 17 | Self-adjoint extensions for singular linear Hamihonian systems 显示文摘 | Sun Huaqing Shi Yuming | 2011 | Math Nachr2011，284，56： | 1 |
| 18 | A Comparative Study About the Neuroprotective Effects of EPA-Enriched Phosphoethanolamine Plasmalogen and Phosphatidylethanolamine Against Oxidative Damage in Primary Hippocampal Neurons显示文摘s Oxidative stress is involved in the progression of neurodegenerative diseases.Previous evidences showed that plasma-logens could improve neurodegenerative diseases.In this study,we investigated the function of phosphoethanolamine plasmalogens enriched with EPA(EPA-pPE)and phosphatidylethanolamine enriched with EPA(EPA-PE)on oxidative damage prevention after hy-drogen peroxide(H2O2)and tert-butylhydroperoxide(t-BHP)challenge in primary hippocampal neurons.Results showed that neurons pretreated with EPA-pPE and EPA-PE demonstrated the ability to alleviate oxidative damage,which was proved by the in-creased cell viability.Moreover,the shape and number of neurons were more similar to those of the control group.Antioxidant acti-vity,apoptosis,as well as TrkB/ERK/CREB signaling pathway were investigated to explore the mechanisms.The results suggested that EPA-PE was superior to EPA-pPE in regulating mitochondrial apoptosis.EPA-pPE was more prominent than EPA-PE in upre-gulating TrkB/ERK/CREB signaling pathway.Phospholipids with EPA exerted neuroprotective effects via inhibiting oxidative stress,suppressing apoptosis,and regulating TrkB/ERK/CREB signaling pathway.Therefore,the results provide a scientific basis for utili-zation of phospholipids enriched with EPA on the treatment of neurodegenerative disease. | ZHU Yunfang ZHANG Tiantian DING Lin SHI Haohao XUE Changhu XIE Wancui CHE Hongxia WANG Yuming | 2021 | Journal of Ocean University of China2021，20，5： | 1 |
| 19 | Standing stock of phytoplankton and primary productivity in Penaeus orientalis larval multiplication releasing area of the Xiangshan Bay显示文摘The standing stock of phytoplankton (phy. ) and primary productivity (pp) in the Xiangshan Bay were observed in 1992. The results showed higher biological parameters in the bay. The average chlorophyll a (chl a) concentration was (3. 50 5. 93 ) mg/m3 and the primary productivity (444. 5 871. 0) mg/(m2 d). The distribution of chl a and productivity showed distinct spatial and temporal patterns in the bay. The continent influence was Obvious at the top of the bay, lower seawater exchange and higher stability led to higher standing stock of phytoplankton and productivity. At the bay mouth, seawater exchanged continuously with adjacent waters by rapid currents, resulting in fast and unstable exchange and lower standing stock of phytoplankton and primary productivity. The seasonal characters of those parameters were pronounced, in the sequence of spring, summer, autumn and winter. The results of size--fractionated showed that the average contribution of the nano--and picoplankton (< 20pm) to total chl a and productivity were 75 % and 87%, respectively, indicating their importance in phytoplankton community biomass and productivity of the Xiangshan Bay. | Liu Zilin Cai Yuming Shi Junxiang Ning Xiuren (1. Second Institute of Oceanography, State Oceanic Administration, Hangzhou 310012, China) | 2000 | Acta Oceanologica Sinica2000，19，1： | 1 |
| 20 | Dietary Supplementation with Sea Cucumber Saponins and Exercise Can Significantly Suppress Adipose Accumulation in Mice Fed with High-Fat Diet显示文摘Dietary supplementation with sea cucumber saponins(SCS)and exercise have been confirmed to be effective in pre-venting the development of obesity and its related diseases.However,the combined effectiveness of these interventions has not been explored.Here,we studied whether the beneficial influences of exercise could be further enhanced by dietary supplementation with SCS in high-fat diet-fed KM(Kunming)mice.Mice were randomly divided into four groups,including the high-fat diet group(HF),the SCS group(HF-S),the exercise group(HF-E),and the combination of dietary SCS and exercise group(HF-S+E).There were eight mice in every group.The results demonstrated that the combination of dietary SCS and exercise could synergistically reduce fat accumulation.In particular,white adipose tissue decreased by 63%in the HF-S+E group compared with that in the HF group.SCS supplementation with exercise also improved peripheral markers,such as serum parameters and hepatic TG levels.Further mechani-cal testing indicated that the combined effects of dietary SCS and exercise on inhibiting fat accumulation might be attributed to the inhibition of lipid synthesis in the liver and the activation of lipolysis in white adipose tissue to increase energy consumption. | LI Rong MENG Jing SHI Haohao WANG Chengcheng LI Zhaojie XUE Changhu WANG Yuming ZHANG Tiantian | 2021 | Journal of Ocean University of China2021，20，3： | 1 |
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