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| 1 | Pink-color sign in esophageal squamous neoplasia, and speculation regarding the underlying mechanism显示文摘AIM:To investigate the reasons for the occurrence of the pink-color sign of iodine-unstained lesions. METHODS:In chromoendoscopy, the pink-color sign of iodine-unstained lesions is recognized as useful for the diagnosis of esophageal squamous cell carcinoma. Patients with superficial esophageal neoplasms treated by endoscopic resection were included in the study. Areas of mucosa with and without the pink-color sign were evaluated histologically. The following histologic features that were possibly associated with the pinkcolor sign were evaluated. The keratinous layer and basal cell layer were classified as present or absent. Cellular atypia was classified as high grade, moderate grade or low grade, based on nuclear irregularity, mitotic figures, loss of polarity, chromatin pattern and nuclear/cytoplasmic ratio. Vascular change was assessed based on dilatation, tortuosity, caliber change and variability in shape. Vessels with these four findings were classified as positive for vascular change. Endoscopic images of the lesions were captured immediately after iodine staining, 2-3 min after iodine staining and after complete fading of iodine staining. Quantitative analysis of color changes after iodine staining was also performed. RESULTS:A total of 61 superficial esophageal neoplasms in 54 patients were included in the study. The lesions were located in the cervical esophagus in one case, the upper thoracic esophagus in 10 cases, the mid-thoracic esophagus in 33 cases, and the lower thoracic esophagus in 17 cases. The median diameter of the lesions was 20 mm (range:2-74 mm). Of the 61 lesions, 28 were classified as pink-color sign positive and 33 as pink-color sign negative. The histologic diagnosis was high-grade intraepithelial neoplasia (HGIN) or cancer invading into the lamina propria in 26 of the 28 pink-color sign positive lesions. There was a significant association between pink-color sign positive epithelium and HGIN or invasive cancer (P = 0.0001). Univariate analyses found that absence of the keratinous layer and cellular atypia were significantly associated with the pink-color sign. After Bonferroni correction, there were no significant associations between the pink-color sign and presence of the basal membrane or vascular change. Multivariate analyses found that only absence of the keratinous layer was independently associated with the pink-color sign (OR = 58.8, 95%CI:5.5-632).Quantitative analysis was performed on 10 superficial esophageal neoplasms with both pink-color sign positive and negative areas in 10 patients. Pink-color sign positive mucosa had a lower mean color value in the late phase (pinkish color) than in the early phase (yellowish color), and had similar mean color values in the late and final phases. These findings suggest that pinkcolor positive mucosa underwent color fading from the color of the iodine (yellow) to the color of the mucosa (pink) within 2-3 min after iodine staining. Pink-color sign negative mucosa had similar mean color values in the late and early phases (yellowish color), and had a lower mean color value in the final phase (pinkish color) than in the late phase. These findings suggest that pink-color sign negative mucosa did not undergo color fading during the 2-3 min after iodine staining, and underwent color fading only after spraying of sodium thiosulfate. CONCLUSION:The pink-color sign was associated with absence of the keratinous layer. This sign may be caused by early fading of iodine staining. | Ryu Ishihara Hiromitsu Kanzaki Hiroyasu Iishi Kengo Nagai Fumi Matsui Takeshi Yamashina Noriko Matsuura Takashi Ito Mototsugu Fujii Sachiko Yamamoto Noboru Hanaoka Yoji Takeuchi Koji Higashino Noriya Uedo Masaharu Tatsuta Yasuhiko Tomita Shingo Ishiguro | 2013 | World Journal of Gastroenterology2013，19，27： | 10 |
| 2 | Increased Expression of Long Pentraxin PTX3 in Inflammatory Bowel Diseases显示文摘 | Shingo Kato Mitsuko Ochiai Tomoya Sakurada Shino Ohno Kyoko Miyamoto Mina Sagara Masataka Ito Kyoko Takeuchi Junko Imaki Kazuro Itoh Koji Yakabi | 2008 | Digestive Diseases and Sciences2008，，7： | 1 |
| 3 | Proteolytic Cleavage of High Mobility Group Box 1 Protein by Thrombin–Thrombomodulin Complexes显示文摘 | Takashi Ito Ko-ichi Kawahara Kohji Okamoto Shingo Yamada Minetsugu Yasuda Hitoshi Imaizumi Yuko Nawa Xiaojie Meng Binita Shrestha Teruto Hashiguchi Ikuro Maruyama | 2008 | Arteriosclerosis, Thrombosis, and Vascular Biology2008，，10： | 1 |
| 4 | Absence of the right coronary artery detected by 64-detector-row multislice computed tomography显示文摘 | Taeko Kunimasa Yuichi Sato Shingo Ito Takuro Takagi Tetsuo Lee Fumihiko Saeki Masao Moroi | 2006 | International Journal of Cardiology2006，，2： | 1 |
| 5 | Soluble interleukin‐6 receptor is a serum biomarker for the response of esophageal carcinoma to neoadjuvant chemoradiotherapy显示文摘 | Yosuke Makuuchi Kazufumi Honda Yoshiaki Osaka Ken Kato Takashi Kojima Hiroyuki Daiko Hiroyasu Igaki Yoshinori Ito Sumito Hoshino Shingo Tachibana Takafumi Watanabe Koh Furuta Shigeki Sekine Tomoko Umaki Yukio Watabe Nami Miura Masaya Ono Akihiko Tsuchida | 2013 | Cancer Sci2013，，8： | 1 |
| 6 | Chromoendoscopy with indigo carmine dye added to acetic acid in the diagnosis of gastric neoplasia: a prospective comparative study显示文摘 | Yuzo Sakai Reiko Eto Junji Kasanuki Fukuo Kondo Kazuki Kato Makoto Arai Takuto Suzuki Michiko Kobayashi Tomoaki Matsumura Dan Bekku Kenichi Ito Shingo Nakamoto Takeshi Tanaka Osamu Yokosuka | 2008 | Gastrointestinal Endoscopy2008，，4： | 1 |
| 7 | Plasmablastic lymphoma of the stomach in an HIV‐negative patient显示文摘 | Mitsuyoshi Hashimoto Shingo Inaguma Kenji Kasai Kyoko Kuwabara Nobuhiko Noda Masaya Hayakawa Masahiko Fujino Masafumi Ito Hiroshi Ikeda | 2012 | Pathology International2012，，11： | 1 |
| 8 | Expression and Clinical Significance of the erbB Family in Intrahepatic Cholangiocellular Carcinoma显示文摘 | Yasuhiro Ito Yasuhiro Ito Tsutomu Takeda Yo Sasaki Masato Sakon Terumasa Yamada Shingo Ishiguro Shingi Imaoka Masahiko Tsujimoto Shigeki Higashiyama Morito Monden Nariaki Matsuura | 2001 | Pathology - Research and Practice2001，，2： | 1 |
| 9 | Tyrosine-phosphorylation of the 12th armadillo-repeat of β-catenin isassociated with cadherin dysfunction in human cancer显示文摘 | Kohei Shomori Atsushi Ochiai Shingo Akimoto Yoshinori Ino Koyo Shudo Hisao Ito Setsuo Hirohashi | 2009 | International Journal of Oncology2009，，3： | 1 |
| 10 | Impact of comorbid renal dysfunction in patients with hepatocellular carcinoma on long-term outcomes after curative resection显示文摘BACKGROUND Hepatocellular carcinoma(HCC)is one of the most common malignancies worldwide.However,the number of patients with chronic kidney disease(CKD)is on the rise because of the increase in lifestyle-related diseases.AIM To establish a tailored management strategy for HCC patients,we evaluated the impact of comorbid renal dysfunction(RD),as stratified by using the estimated glomerular filtration rate(EGFR),and assessed the oncologic validity of hepatectomy for HCC patients with RD.METHODS We enrolled 800 HCC patients who underwent hepatectomy between 1997 and 2015 at our university hospital.We categorized patients into two(RD,EGFR<60 mL/min/1.73 m^(2);non-RD,EGFR≥60 mL/min/1.73 m^(2))and three groups(severe CKD,EGFR<30 mL/min/1.73 m^(2);mild CKD,30≤EGFR<60 mL/min/1.73 m2;control,EGFR≥60 mL/min/1.73 m^(2))according to renal function as defined by the EGFR.Overall survival(OS)and recurrence-free survival(RFS)were compared among these groups with the log-rank test,and we also analyzed survival by using a propensity score matching(PSM)model to exclude the influence of patient characteristics.The mean postoperative observation period was 64.7±53.0 mo.RESULTS The RD patients were significantly older and had lower serum total bilirubin,aspartate aminotransferase,and aspartate aminotransferase levels than the non-RD patients(P<0.0001,P<0.001,P<0.05,and P<0.01,respectively).No patient received maintenance hemodialysis after surgery.Although the overall postoperative complication rates were similar between the RD and non-RD patients,the proportions of postoperative bleeding and surgical site infection were significantly higher in the RD patients(5.5%vs 1.8%;P<0.05,3.9%vs 1.8%;P<0.05,respectively),and postoperative bleeding was the highest in the severe CKD group(P<0.05).Regardless of the degree of comorbid RD,OS and RFS were comparable,even after PSM between the RD and non-RD groups to exclude the influence of patient characteristics,liver function,and other causes of death.CONCLUSION Comorbid mild RD had a negligible impact on the prognosis of HCC patients who underwent curative hepatectomy with appropriate perioperative management,and close attention to severe CKD is necessary to prevent postoperative bleeding and surgical site infection. | Yuzuru Sakamoto Shingo Shimada Toshiya Kamiyama Ko Sugiyama Yoh Asahi Akihisa Nagatsu Tatsuya Orimo Tatsuhiko Kakisaka Hirofumi Kamachi Yoichi M Ito Akinobu Taketomi | 2022 | World Journal of Gastrointestinal Surgery2022，14，7： | 0 |
| 11 | S-Shaped Fused Azacorannulene Dimer:Structural and Redox Properties显示文摘Because of their unique structural and chemical properties,buckybowl molecules have attracted considerable attention in a wide range of scientific disciplines.The importance and utility of buckybowl molecules significantly increases once they acquire largerπ-surface area and/or heteroatoms.The fusion of buckybowl molecules has emerged as a new strategy to extend theπ-surface of polycyclic aromatic compounds;however,theπ-extension of heteroatom-embedded buckybowls by the fusion strategy is still rare.Here we report the synthesis and propeties of a fused azacorannulene dimer bearing a C62N2 core(1a),which can also be regarded as a double aza[5]helicene.Due to the steric repulsion between two azapentabenzocorannulene moieties,this molecule shows a rigid S-shaped structure where the two azacorannulene bowls face in opposite directions.Stepwise chemical oxidation of 1a resulted in the formation of the corresponding radical cation(1a^(+))and dication(1a^(2+)),providing an important insight into their aromaticity.The fusion of heteroatom-embedded buckybowls provides a powerful way to synthesizeπ-extended polycyclic aromatic molecules. | Weifan Wang Fiona Hanindita Richard D.Webster Shingo Ito | 2023 | CCS Chemistry2023，5，5： | 0 |
| 12 | Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses显示文摘Dear editor,Lung carcinoma is responsible for the highest fatal-ity rate among cancer-related deaths globally,with lung adenocarcinoma(LADC)emerging as the prevailing sub-type. | Kouya Shiraishi Atsushi Takahashi Yukihide Momozawa Yataro Daigo Syuzo Kaneko Takahisa Kawaguchi Hideo Kunitoh Shingo Matsumoto Hidehito Horinouchi Akiteru Goto Takayuki Honda Kimihiro Shimizu Masahiro Torasawa Daisuke Takayanagi Motonobu Saito Akira Saito Yuichiro Ohe Shun-ichi Watanabe Koichi Goto Masahiro Tsuboi Katsuya Tsuchihara Sadaaki Takata Tomomi Aoi Atsushi Takano Masashi Kobayashi Yohei Miyagi Kazumi Tanaka Hiroyuki Suzuki Daichi Maeda Takumi Yamaura Maiko Matsuda Yoko Shimada Takaaki Mizuno Hiromi Sakamoto Teruhiko Yoshida Yasushi Goto Tatsuya Yoshida Taiki Yamaji Makoto Sonobe Shinichi Toyooka Kazue Yoneda Katsuhiro Masago Fumihiro Tanaka Megumi Hara Nobuo Fuse Satoshi S.Nishizuka Noriko Motoi Norie Sawada Yuichiro Nishida Kazuki Kumada Kenji Takeuchi Kozo Tanno Yasushi Yatabe Kuniko Sunami Tomoyuki Hishida Yasunari Miyazaki Hidemi Ito Mitsuhiro Amemiya Hirohiko Totsuka Haruhiko Nakayama Tomoyuki Yokose Kazuyoshi Ishigaki Toshiteru Nagashima Yoichi Ohtaki Kazuhiro Imai Ken Takasawa Yoshihiro Minamiya Kazuma Kobayashi Kenichi Okubo Kenji Wakai Atsushi Shimizu Masayuki Yamamoto Motoki Iwasaki Koichi Matsuda Johji Inazawa Yuichi Shiraishi Hiroyoshi Nishikawa Yoshinori Murakami Michiaki Kubo Fumihiko Matsuda Yoichiro Kamatani Ryuji Hamamoto Keitaro Matsuo Takashi Kohno | 2024 | Cancer Communications2024，44，2： | 0 |
| 13 | Effect of the backbone structure of bidentate ligands in palladiumand nickel-catalyzed polar monomer copolymerization显示文摘Coordination-insertion copolymerization of non-polar olefins and polar monomers by late transition metal catalysts is a powerful method to synthesize functionalized polyolefins[1]. Seminal successes in this copolymerization have been achieved by using group-10 metal catalysts bearing a bidentate ligand such as phosphine-sulfonate and bisphosphine monoxide (BPMO)(Figure 1)[1]. These ligands typically consist of a strongσ-donor and a weakσ-donor and have an arylene linker between the two coordination sites (Figure 1,middle). Although a variety of coordination sites have thus far been investigated, less attention has been paid to the influence of the backbone structure. Recent papers shed light on this issue. | Shingo Ito | 2018 | Science China Chemistry2018，61，11： | 0 |
| 14 | Clinical efficacy of a combination of Percoll continuous density gradient and swim-up techniques for semen processing in HIV-1 serodiscordant couples显示文摘为了评估从 HIV-1 的精液为人的免疫不全病毒类型 1 的移动( HIV-1 )包括 Percoll 连续密度坡度和修改游泳起来技术的联合的一个过程的临床的功效,感染了男性, 129 的一个总数结合 HIV-1 积极男搭挡和 HIV-1 在在2002年1月和2012年4月之间的 Keio 大学医院被对待的否定女搭挡( serodiscordant 夫妇)被检查。从 129 HIV-1 的 183 精液的一个总数感染了男性被处理。在游泳起来以后,我们成功地在恢复收集了能动精子在 normozoospermia (126/126 精液) 的情况下象 100.0% 一样高的率, oligozoospermia (6/6 ) ,和 asthenozoospermia (36/36 ) 。oligoasthenozoospermia 的恢复率是 86.7%(13/15 ) 。在处理精液,仅仅四精液(4/181:2.2%) 在感染的男性的血显示出与那些一致的病毒的核苷酸序列。在使用这些精子以后,女病人的水平感染和新生儿的没有垂直感染都没被观察。而且,没有明显的不利效果在后代被观察。这个协议允许我们收集在高度的否定能动精子评估的 HIV-1,甚至在男因素盒子中。我们断定我们的协议为减少的 HIV-1 感染并且为产出一个健康孩子是临床上有效的。 | Osamu Inoue Naoaki Kuji Hiroe Ito Mitsutoshi Yamada Toshio Hamatani Aimi Oyadomari Shingo Kato Hideji Hanabusa Keiichi Isaka Mamoru Tanaka | 2017 | Asian Journal of Andrology2017，19，2： | 0 |
| 15 | Pyridine-Fused Azacorannulene:Fine-Tuning of the Structure and Properties of Nitrogen-Embedded Buckybowls显示文摘Heteroatom-embedded buckybowl molecules provide a fundamental molecular framework that has potential applications in various research fields.However,selective introduction of heteroatoms into buckybowls is challenging,and thus,studies investigating the effect of introduced heteroatoms have been limited.Here,we report the synthesis of pyridine-fused azacorannulene molecules.The influence of nitrogen atoms introduced into the peripheral positions on the structural,electronic,and optical properties is discussed. | Kimihiro Nakamura Kotaro Ochiai Ayaka Yubuta Dan He Daigo Miyajima Shingo Ito | 2023 | Precision Chemistry2023，1，1： | 0 |
| 16 | Molecular Dynamics Analysis on Tensile and Shearing Properties of Nitrogen-Containing Graphene显示文摘 | Shingo Okamoto Akihiko Ito | 2013 | 通讯和计算机(中英文版)2013，10，1： | 0 |
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