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| 1 | Experimental and Numerical Studies of Vitiated Air Effects on Hydrogen-fueled Supersonic Combustor Performance显示文摘This paper deals with the vitiation effects of test air on the scramjet performance in the ground combustion heated facilities. The primary goal is to evaluate the effects of H2O and CO2, the two major vitiated species generated by combustion heater, on hydrogen-fueled supersonic combustor performance with experimental and numerical approaches. The comparative experiments in the clean air and vitiated air are conducted by using the resistance heated direct-connected facility, with the typical Mach 4 flight conditions simulated. The H2O and CO2 species with accurately controlled contents are added to the high enthalpy clean air from resistance heater, to synthesize the vitiated air of a combustion-type heater. Typically, the contents of H2O species can be varied within the range of 3.5%-30% by mole, and 3.0%-10% for CO2 species. The total temperature, total pressure, Mach number and O2 mole fraction at the combustor entrance are well-matched between the clean air and vitiated air. The combustion experiments are completed at the fuel equivalence ratios of 0.53 and 0.42 respectively. Furthermore, three-dimensional (3D) reacting flow simulations of combustor flowpath are performed to provide insight into flow field structures and combustion chemistry details that cannot resolved by experimental instruments available. Finally, the experimental data, combined with computational results, are employed to analyze the effects of H2O and CO2 vitiated air on supersonic combustion characteristics and performance. It is concluded that H2O and CO2 contaminants can significantly inhibit the combustion induced pressure rise measured from combustor wall, and the pressure profile decreases with the increasing H2O and CO2 contents in nonlinear trend; simulation results agree well with experimental data and the overall vitiation effects are captured; direct extrapolation of the results from vitiated air to predict the performance of actual flight conditions could result in over-fueling the combustor, possible inlet un-start and inappropriate combustion mode transition. The detailed analysis and discussion are presented and the research conclusions are summarized. | LUO Feiteng SONG Wenyan ZHANG Zhiqiang LI Weiqiang LI Jianping | 2012 | Chinese Journal of Aeronautics2012，25，2： | 5 |
| 2 | Influences of Geometric Parameters upon Nozzle Performances in Scramjets显示文摘这篇文章调查并且介绍在它的嘴表演之上施加的一个超音速冲压式喷气发动机的几何参数的影响。这些参数包括分叉的角度,全部的长度,高度比率,在长度,和在角度。在超音速冲压式喷气发动机嘴以内的流动地被与联合含蓄的解答者和一个 RNG k- 骚乱模型联合使用 CFD softwareFLUENT 数字地模仿。 | Li Jianping Song Wenyan Xing Ying Luo Feiteng | 2008 | Chinese Journal of Aeronautics2008，21，6： | 4 |
| 3 | Carrier-free highly drug-loaded biomimetic nanosuspensions encapsulated by cancer cell membrane based on homology and active targeting for the treatment of glioma显示文摘Nanosuspensions,as a new drug delivery system for insoluble drugs,are only composed of a drug and a small amount of stabilizer,which is dispersed in an aqueous solution with high drug-loading,small particle size,high dispersion,and large specific surface area.It can significantly improve the dissolution,bioavailability,and efficacy of insoluble drugs.In this study,paclitaxel nanosuspensions((PTX)NS)were prepared by an ultrasonic precipitation method,with the characteristics of simple preparation and easy repetition.With the help of a homologous targeting mechanism,a kind of glioma C6 cancer cell membrane(CCM)-coated(PTX)NS was developed and modified with DWSW peptide to obtain DWSW-CCM-(PTX)NS with the functions of BBB penetration and tumor targeting.The results showed that the cancer cell membrane could effectively camouflage the nanosuspensions so that it was not cleared by the immune system and could cross the blood-brain-barrier(BBB)and selectively target tumor tissues.Cell uptake experiments and in vivo imaging confirmed that the uptake of DWSW-CCM-(PTX)NS by tumor cells and the distribution in intracranial gliomas increased.Cytotoxicity test and in vivo anti-glioma studies showed that DWSW-CCM-(PTX)NS could significantly inhibit the growth of glioma cells and significantly prolong the survival time of glioma-bearing mice.Finally,the cancer cell membrane coating endowed the nanosuspensions with the biological properties of homologous adhesion and immune escape.This study provides an integrated solution for improving the targeting of nanosuspensions and demonstrates the encouraging potential of biomimetic nanosuspensions applicable to tumor therapy. | Yueyue Fan Yuexin Cui Wenyan Hao Mengyu Chen Qianqian Liu Yuli Wang Meiyan Yang Zhiping Li Wei Gong Shiyong Song Yang Yang Chunsheng Gao | 2021 | Bioactive Materials2021，6，12： | 3 |
| 4 | Phosphorus does not alleviate the negative effect of nitrogen enrichment on legume performance in an alpine grassland显示文摘Aims Nitrogen(N)-fixing legumes,despite being highly phosphorus(P)-demanding,constitute an important plant functional group and play key roles in N-poor ecosystems such as alpine grasslands.However,legume performance,including biomass,abundance and species richness,is expected to change,because anthropogenic activities have drastically increased soil N and P availability world-wide.We conducted a field experiment to assess the effects of N and P addition,alone and in combination,on legume performance in an alpine grassland,and identified and clarified the mechanisms underlying these changes.Methods A three year field experiment of N addition(10 g N m−2 year−1),P addition(5 g P m−2 year−1),and N+P combined addition(both N and P,same amounts as solo treatments)was conducted in an alpine grassland on the tibetan Plateau in china from 2011 to 2013.Effects of nutrient addition were assessed at the community level(above-ground net primary production(ANPP),height and light intensity),functional group level(biomass,species richness,relative height,relative coverage and relative density of legumes)and species level(foliar N,P concentration of two legumes).Important findings Overall,adding N alone significantly increased ANPP by 20.82%,but adding P alone did not;whereas,addition of N and P together resulted in a large increase in ANPP(+37.03%)than addition of either alone,indicating potential co-limitation of alpine grasslands.In contrast,adding P alone significantly promoted legume perfor-mance as measured by 65.22%increase in biomass and 58.45%increase in relative abundance,while adding N alone reduced leg-ume performance as measured by 39.54%decrease in biomass and 50.36%in relative abundance.combining P and N addition did not mitigate the negative effect of N addition on legume performance and,surprisingly,suppressed legume biomass by 53.14%and relative abundance by 63.51%.N and P addition altered the balance of light competition between grasses and legumes as indicated by the changes in light levels,plant heights and litter accumulation.However,there were no obvious changes in legume species richness in response to N and P within our experimental timeframe.this study provides further evidence of the importance of P as a co-limiting nutrient in alpine grasslands,contrary to the traditional view that N limitation predominates in such regions.the contrasting effects of N and P addition on legume performance provide important insights into potential changes in legume performance in nutrient-limited grasslands following N and P enrichment under climate change,with implications for nutrient management in alpine grasslands. | Fei Ren Weimin Song Litong Chen Zhaorong Mi Zhenhua Zhang Wenyan Zhu Huakun Zhou Guangmin Cao Jin-Sheng He | 2017 | Journal of Plant Ecology2017，10，5： | 3 |
| 5 | SETD8 induces stemness and epithelial–mesenchymal transition of pancreatic cancer cells by regulating ROR1 expression显示文摘Pancreatic cancer(PC)is one of the most deadly diseases,and its incidence is increasing year by year.The methyltransferase SETD8 has been demonstrated to play an important role in tumor cell proliferation and metastasis.However,little is known about whether SETD8 could affect the invasion and metastasis of PC and the mechanism underlying the regulation.Based on our previous report,here,we further found that SETD8 could promote the invasion and migration of PC cells by inducing the expression of receptor tyrosine kinase-like orphan receptor 1(ROR1).ROR1 was predominantly upregulated in PC tissues and was correlated with lymph node metastasis and worse prognosis.Mechanistically,SETD8 mediated ROR1 activity and regulated PC cells invasion and migration,although promoting the expression of stemness and epithelial–mesenchymal transition-related molecules.This promotion effect disappeared when the catalytically inactive mutant SETD8 was overexpressed,which could be counteracted by the SETD8-specific methyltransferase inhibitor UNC0379.Collectively,our results demonstrate that SETD8 may be a novel prognostic factor and a therapeutic target of PC. | Mengqi Liu Yihua Shi Qiangsheng Hu Yi Qin Shunrong Ji Wensheng Liu Qifeng Zhuo Guixiong Fan Zeng Ye Changfeng Song Xianjun Yu Xiaowu Xu Wenyan Xu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，12： | 2 |
| 6 | Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells显示文摘Neutrophil extracellular traps(NETs)can capture and kill viruses,such as influenza viruses,human immunodeficiency virus(HIV),and respiratory syncytial virus(RSV),thus contributing to host defense.Contrary to our expectation,we show here that the histones released by NETosis enhance the infectivity of SARS-CoV-2,as found by using live SARS-CoV-2 and two pseudovirus systems as well as a mouse model.The histone H3 or H4 selectively binds to subunit 2 of the spike(S)protein,as shown by a biochemical binding assay,surface plasmon resonance and binding energy calculation as well as the construction of a mutant S protein by replacing four acidic amino acids.Sialic acid on the host cell surface is the key molecule to which histones bridge subunit 2 of the S protein.Moreover,histones enhance cell-cell fusion.Finally,treatment with an inhibitor of NETosis,histone H3 or H4,or sialic acid notably affected the levels of sgRNA copies and the number of apoptotic cells in a mouse model.These findings suggest that SARS-CoV-2 could hijack histones from neutrophil NETosis to promote its host cell attachment and entry process and may be important in exploring pathogenesis and possible strategies to develop new effective therapies for COVID-19. | Weiqi Hong Jingyun Yang Jun Zou Zhenfei Bi Cai He Hong Lei Xuemei He Xue Li Aqu Alu Wenyan Ren Zeng Wang Xiaohua Jiang Kunhong Zhong Guowen Jia Yun Yang Wenhai Yu Qing Huang Mengli Yang Yanan Zhou Yuan Zhao Dexuan Kuang Junbin Wang Haixuan Wang Siyuan Chen Min Luo Ziqi Zhang Tiangi Lu Li Chen Haiying Que Zhiyao He Qiu Sun Wei Wang Guobo Shen Guangwen Lu Zhiwei Zhao Li Yang Jinliang Yang Zhenling Wang Jiong Li Xiangrong Song Lunzhi Dai Chong Chen Jia Geng Maling Gou Lu Chen Haohao Dong Yong Peng Canhua Huang Zhiyong Qian Wei Cheng Changfa Fan Yuquan Wei Zhaoming Su Aiping Tong Shuaiyao Lu Xiaozhong Peng Xiawei Wei | 2022 | Cellular & Molecular Immunology2022，19，5： | 2 |
| 7 | Selective adsorption of phosphate in water using lanthanum-based nanomaterials:A critical review显示文摘In recent years,lanthanum-based nanomaterials(La-NMs)are selected as an efficient nano-adsorbent for phosphate removal because La3+has a strong affinity with oxygen-donor atoms from phosphate.Additionally,there are a broad interest and literature base for the effect of different synthesis optimization and environmental parameters on the adsorption performance of La-NMs.A considerable amount of research has also investigated the regeneration and application of La-NMs to real wastewater in a laboratory scale.Based on the literature survey,it was found that La-NMs are often produced via co-precipitation and hydrothermal methods.Moreover,phosphate’s adsorption process and behavior onto La-NMs are described well with the pseudo-second-order model and Langmuir model.The interaction mechanism between phosphate and La-NMs are dominated by ligand exchange,surface complexation and electrostatic attraction.Furthermore,phosphate could easily desorb from La-NMs due to the weak H-bonding interaction between phosphate and the H-bond acceptor groups on the surface of La-NMs.Despite the wealth of literature available in this area,there is a lack of systematic review to evaluate the gaps in the use of La-NMs to eliminate phosphate in water.In this review,we mainly summarize and discuss the role and the effect of the synthesis techniques on the physicochemical properties and the adsorption behavior of La-NMs.The possible adsorption mechanism,regeneration efficiency,and the application of La-NMs to the real environmental samples are also presented and highlighted. | Mamitiana Roger Razanajatovo Wenyan Gao Yaran Song Xuan Zhao Qina Sun Qingrui Zhang | 2021 | Chinese Chemical Letters2021，32，9： | 2 |
| 8 | Hyperactive PI3Kδ predisposes naive T cells to activation via aerobic glycolysis programs显示文摘Activated phosphoinositide 3-kinaseδsyndrome(APDS)is an autosomal-dominant combined immunodeficiency disorder resulting from pathogenic gain-of-function(GOF)mutations in the PIK3CD gene.Patients with APDS display abnormal T cell homeostasis.However,the mechanisms by which PIK3CD GOF contributes to this feature remain unknown.Here,with a cohort of children with PIK3CD GOF mutations from multiple regions of China and a corresponding CRISPR/Cas9 gene-edited mouse model,we reported that hyperactive PI3Kδdisrupted TNaive cell homeostasis in the periphery by intrinsically promoting the growth,proliferation,and activation of TNaive cells.Our results showed that PIK3CD GOF resulted in loss of the quiescence-associated gene expression profile in naive T cells and promoted naive T cells to overgrow,hyperproliferate and acquire an activated functional status.Naive PIK3CD GOF T cells exhibited an enhanced glycolytic capacity and reduced mitochondrial respiration in the resting or activated state.Blocking glycolysis abrogated the abnormal splenic T cell pool and reversed the overactivated phenotype induced by PIK3CD GOF in vivo and in vitro.These results suggest that enhanced aerobic glycolysis is required for PIK3CD GOF-induced overactivation of naive T cells and provide a potential therapeutic approach for targeting glycolysis to treat patients with APDS as well as other immune disorders. | Yanjun Jia Qiuyun Yang Yanping Wang Wenyan Li Xuemei Chen Tao Xu Zhirui Tian Minxuan Feng Liang Zhang Wenjing Tang Na Tian Lina Zhou Wenxia Song Xiaodong Zhao | 2021 | Cellular & Molecular Immunology2021，18，7： | 2 |
| 9 | Power allocation and mode selection methods for cooperative communication in the rectangular tunnel显示文摘For the multipath fading on electromagnetic waves of wireless communication in the confined areas,the rectangular tunnel cooperative communication system was established based on the multimode channel model and the channel capacity formula derivation was obtained.On the optimal criterion of the channel capacity,the power allocation methods of both amplifying and forwarding(AF) and decoding and forwarding(DF) cooperative communication systems were proposed in the limitation of the total power to maximize the channel capacity.The mode selection methods of single input single output(SISO) and single input multiple output(SIMO) models in the rectangular tunnel,through which the higher channel capacity can be obtained,were put forward as well.The theoretical analysis and simulation comparison show that,channel capacity of the wireless communication system in the rectangular tunnel can be effectively enhanced through the cooperative technology;channel capacity of the rectangular tunnel under complicated conditions is maximized through the proposed power allocation methods,and the optimal cooperative mode of the channel capacity can be chosen according to the cooperative mode selection methods given in the paper. | Zhai Wenyan Sun Yanjing Xu Zhao Li Song | 2015 | International Journal of Mining Science and Technology2015，25，2： | 2 |
| 10 | An integrated rough number-based approach to design concept evaluation under subjective environments显示文摘 | Wenyan Song Xingguo Ming Zhenyong Wu | 2013 | Journal of Engineering Design2013，，5： | 1 |
| 11 | Fail-ure modes and effects analysis using integrated weight- based fuzzy TOPSIS显示文摘 | Song Wenyan Ming Xinguo Wu Zhenyong | 2013 | International Journal of Com- puter Integrated Manufacturing2013，26，12： | 1 |
| 12 | A Rough TOPSIS Approach for Failure Mode and Effects Analysis in Uncertain Environments 显示文摘 | Song Wenyan Ming Xinguo Wu Zhenrong | 2013 | Quality and Reliablity Engineering International2013，30，： | 1 |
| 13 | Failure Modes and Effects Analysis Using Inte- grated Weight-based Fuzzy TOPSIS显示文摘 | Song Wenyan Ming Xinguo Wu Zhenyong | 2013 | Interna- tional Journal of Computer Intergrated Manufac- turing2013，26，12： | 1 |
| 14 | Risk evaluation of customer integration in new product development under uncertainty显示文摘 | Wenyan Song Xinguo Ming Zhitao Xu | 2013 | Computers & Industrial Engineering2013，，3： | 1 |
| 15 | A rough TOPSIS approach for failure mode and effects analysis in uncertain environments 显示文摘 | SONG Wenyan MING Xinguo WU Zhenyong | 2014 | Quality and Reliability Engineering International2014，30，4： | 1 |
| 16 | Redefining the Age of the Cenozoic Shanwang Formation in Shanwang Basin显示文摘Objective The Shanwang Basin is a small Cenozoic sedimentary basin located in Linqu county,Shandong province.The Shanwang Formation,especially the diatomaceous shale member,contains diverse and finely preserved flora and fauna fossils(Fig.1).Previous paleontological study and radiometric dating show that it was formed in the Miocene.However,on the precise age of the formation,there are such different opinions as Late Miocene。 | YU Jifeng ZHAO Xiangguang PANG Xinlong JASON Hilton FU Wenzhao ZHAO Xiuli SONG Zhaojun HU Jialiang LU Lei ZHANG Hongjun YANG Ziqun QIAO Wenyan SHI Suo | 2017 | Acta Geologica Sinica(English Edition)2017，91，4： | 1 |
| 17 | Tillage effects on soil carbon fractionsin the Sanjiang Plain, Northeast China显示文摘 | Zhang J Song C Wenyan Y | 2007 | Soil and tillage Research2007，93，1： | 1 |
| 18 | A reduced graphene oxide–nanoporous magnetic oxide iron hybrid as an improved anode material for lithium ion batteries显示文摘 | Xianjun Zhu Wenyan Wu Zhen Liu Liang Li Jing Hu Huaili Dai Lei Ding Kun Zhou Chunya Wang Xuegang Song | 2013 | Electrochimica Acta2013，，： | 1 |
| 19 | Intranasal administration of a recombinant RBD vaccine induces long-term immunity against Omicron-included SARS-CoV-2 variants显示文摘The outbreak of coronavirus disease 2019(COVID-19)has posed great threats to global health and economy.Several effective vaccines are available now,but additional booster immunization is required to retain or increase the immune responses owing to waning immunity and the emergency of new variant strains.The deficiency of intramuscularly delivered vaccines to induce mucosal immunity urged the development of mucosal vaccines.Here,we developed an adjuvanted intranasal RBD vaccine and monitored its long-term immunogenicity against both wild-type and mutant strains of severe acute respiratory syndrome coronavirus-2(SARSCoV-2),including Omicron variants,in mice.Three-dose intranasal immunization with this vaccine induced and maintained high levels of neutralizing IgG antibodies in the sera for at least 1 year.Strong mucosal immunity was also provoked,including mucosal secretory IgA and lung-resident memory T cells(TRM).We also demonstrated that the long-term persistence of lung TRM cells is a consequence of local T-cell proliferation,rather than T-cell migration from lymph nodes.Our data suggested that the adjuvanted intranasal RBD vaccine is a promising vaccine candidate to establish robust,long-lasting,and broad protective immunity against SARS-CoV-2 both systemically and locally. | Hong Lei Aqu Alu Jingyun Yang Wenyan Ren Cai He Tianxia Lan Xuemei He Li Yang Jiong Li Zhenling Wang Xiangrong Song Wei Wang Guangwen Lu Xiawei Wei | 2022 | Signal Transduction and Targeted Therapy2022，7，6： | 1 |
| 20 | Cold season CH4,CO2 and N2O fluxes from freshwater marshes in northeast China显示文摘 | ZHANG Jinbo SONG Changchun YANG Wenyan | 2005 | Chemosphere2005，59，11： | 1 |
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