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| 1 | aunalysis of the Genome Sequence of the Medicinal Plant Salvia miltiorrhiza显示文摘 | Haibin Xu Jingyuan Song Hongmei Luo Yujun Zhang Qiushi Li Yingjie Zhu Jiang Xu Ying Li Chi Song Bo Wang Wei Sun Guoan Shen Xin Zhang Jun Qian Aijia Ji Zhichao Xu Xiang Luo Liu He Chuyuan Li Chao Sun Haixia Yah Guanghong Cui Xiwen Li Xian 'en Li Jianhe Wei Juyan Liu Yitao Wang Alice Hayward David Nelson Zemin Ning Reuben J. Peters Xiaoquan Qi Shilin Chen | 2016 | Molecular Plant2016，9，6： | 70 |
| 2 | Klf7 modulates the differentiation and proliferation of chicken preadipocyte显示文摘Kr? | Zhiwei Zhang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，4： | 34 |
| 3 | Environmental connections of novel avian-origin H7N9 influenza virus infection and virus adaptation to the human显示文摘A novel H7N9 influenza A virus has been discovered as the causative identity of the emerging acute respiratory infection cases in Shanghai,China.This virus has also been identified in cases of infection in the neighboring area Hangzhou City in Zhejiang Province.In this study,epidemiologic,clinical,and virological data from three patients in Hangzhou who were confirmed to be infected by the novel H7N9 influenza A virus were collected and analyzed.Human respiratory specimens and chicken feces from a contacted free market were tested for influenza virus by real-time reverse transcription PCR(RT-PCR) and sequencing.The clinical features of the three cases were similar featured with high fever and severe respiratory symptoms;however,only one of the patients died.A certain degree of diversity was observed among the three Hangzhou viruses sequenced from human samples compared with other reported H7N9 influenza A viruses.The sequences of the novel avian-origin H7N9 influenza viruses from Hangzhou City contained important amino acid substitutions related to human adaptation.One of the Hangzhou viruses had gained a novel amino acid substitution(Q226I) in the receptor binding region of hemagglutinin.More importantly,the virus sequenced from the chicken feces had a 627E substitution in the PB2 protein instead of the mammalian-adapted 627K substitution that was found in the PB2 proteins from the Hangzhou viruses from the three patients.Therefore,the newly-emerging H7N9 virus might be under adaptation pressure that will help it 'jump' from avian to human hosts.The significance of these substitutions needs further exploration,with both laboratory experiments and extensive field surveillance. | LI Jun YU XinFen PU XiaoYing XIE Li SUN YongXiang XIAO HaiXia WANG FenJuan DIN Hua WU Ying LIU Di ZHAO GuoQiu LIU Jun PAN JingCao | 2013 | Science China(Life Sciences)2013，56，6： | 32 |
| 4 | 2016 Chinese expert consensus and guidelines for the diagnosis and treatment of papillary thyroid microcarcinoma显示文摘The incidence of papillary thyroid carcinoma(PTC)has exponentially increased in recent years.Papillary thyroid microcarcinoma(PTMC)accounts for the majority of the reported cases of PTC.The debates and crucial issues in PTMC management have received researchers'attention.To further improve the clinical management of PTMC in China, | Ming Gao Minghua Ge Qinghai Ji Ruochuan Cheng Hankui Lu Haixia Guan Li Gao Zhuming Guo Tao Huang Xiaoming Huang Xiaoming Li Yansong Lin Qinjiang Liu Xin Ni Yi Pan Jianwu Qin Zhongyan Shan Hui Sun Xudong Wang Zhengang Xu Yang Yu Daiwei Zhao Naisong Zhang ShengZhang Ying Zheng Jingqiang Zhu Dapeng Li Xiangqian Zheng 无 | 2017 | Cancer Biology & Medicine2017，14，3： | 23 |
| 5 | Low-frequency wide-band hybrid energy harvester based on piezoelectric and triboelectric mechanism显示文摘Recently,hybrid energy harvester has been considered as an attractive potential approach to response the worldwide energy crisis due to the combination of advantages from different harvesting mechanism.In this paper,a novel low-frequency wide-band hybrid energy harvester based on piezoelectric and triboelectric mechanism is presented and systematically studied including structural design,fabrication process,working principle simulation and measurement.With a vibrational excitation,the polyvinylidene fluoride(PVDF) cantilevers will vibrate and impact the polydimethylsiloxane(PDMS) film on the substrate,producing a piezoelectric output as well as a triboelectric output.The structural parameters of each cantilever are optimized using finite element simulation,and the well-designed PVDF cantilevers with controllable PDMS mass not only reduce the device working frequency but also enlarge the bandwidth.Under a sweep-frequency test,three voltage peaks induced by the piezoelectric part are observed at 15,32.5 and 47.5 Hz,with the value of 320,288 and 264 mV,respectively.With the combined triboelectric part,a 20 V peak-peak voltage is generated at 15 Hz.The electrical driving ability of this hybrid energy harvester also has been demonstrated by lighting up a commercial light emitting diode(LED). | HAN MengDi ZHANG XiaoSheng LIU Wen SUN XuMing PENG XuHua ZHANG HaiXia | 2013 | Science China(Technological Sciences)2013，56，8： | 17 |
| 6 | Effect of acupotomy on nitric oxide synthase and beta-endorphin in third lumbar vertebrae transverse process syndrome model rats显示文摘OBJECTIVE: To explore the long-term effects and pain relief mechanism of acupotomy by observing changes in nitric oxide synthase(NOS) and beta-endorphin(β-EP) in the hypothalamus, spinal cord,and peripheral blood of rats with third lumbar vertebrae(L3) transverse process syndrome.METHODS:Twenty-eight SD rats were randomly assigned to normal, model, electroacupuncture(EA),and acupotomy group. The last three groups were put through an operation to emulate L3transverse process syndrome. Fourteen days after the simulation operation, EA and acupotomy treatments were applied to the respective groups. Fifty-six days afterthe simulation operation, biochemistry tests and enzyme-linked immunosorbent assay were used to measure NOS and β-EP in the hypothalamus, spinal cord, and peripheral blood.RESULTS: Rats with the simulation operation showed significantly higher levels of NOS and β-EP in the hypothalamus, spinal cord, and peripheral blood than those in the normal group. The EA and acupotomy groups had significantly lower levels of NOS and β-EP than those in the model group.There was no statistical difference between the EA and acupotomy groups.CONCLUSION: EA and acupotomy treatments significantly lowered NOS and β-EP levels in the hypothalamus, spinal cord, and peripheral blood and alleviated L3transverse process syndrome. | Changqing Guo Naigang Liu Xiaohong Li Hongmei Sun Bo Hu Jing Lu Yan Guo Chuxi Liang Hong Xu Haixia Wu | 2014 | Journal of Traditional Chinese Medicine2014，34，2： | 15 |
| 7 | Low frequency wide bandwidth MEMS energy harvester based on spiral-shaped PVDF cantilever显示文摘In this paper,a piezoelectric energy harvester based on spiral-shaped polyvinylidene fluoride(PVDF)cantilever is designed and fabricated for harvesting low frequency vibration energy in the environment.In this design,the spiral-shaped PVDF cantilever is major for lowering the resonant frequency by increasing the length of the cantilever;Copper and silicon proof masses on both sides are working on further decreasing the resonant frequency and widen its bandwidth.Due to the high flexibility of the PVDF cantilever,this device is extremely sensitive to vibration and can harvest weak vibration energy.Both simulation and experimental results have approved that this device can operate at very low frequency which is about 20 Hz and can effectively harvest energy from 15–50 Hz.The peak of the output voltage can reach 1.8 V with the acceleration of 0.2 g.This is a promising harvester for powering the wireless sensors in the future. | LIU Wen HAN MengDi MENG Bo SUN XuMing HUANG XianLiang ZHANG HaiXia | 2014 | Science China(Technological Sciences)2014，57，6： | 13 |
| 8 | Responses of rice growth to copper stress under free-air CO_2 enrichment (FACE)显示文摘The responses of rice to the second degree contamination of copper were studied by pot experiments under free-air CO2 enrichment (FACE) with 570 μmol·mol-1 of CO2. The results showed that the content of copper in rice leaves was reduced with the CO2 concentration reaching 570 μmol·mol-1 and this happened more significantly under the second degree contamination of copper. Under FACE, activities of superoxide dismutase (SOD) enzyme in rice leaves treated by copper contamination were induced, whereas the contents of glutathione (GSH) and glutathione disulfide (GSSG) had no significant difference from the control. In the presence of ambient CO2, activities of SOD enzyme treated by copper pollution were suppressed during the whole rice growth, however, the contents of GSH and GSSG were induced at tillering and jointing stages, and then restored to the control levels in later growth under the second degree contamination of copper. With the rice growing, the content of malondialdehyde (MDA) rises continuously, but there had been no significant difference between the treatments at the same growth stage. Further studies are needed on the response mechanism of rice to Cu stress under elevated CO2. | JIA HaiXia GUO HongYan YIN Ying WANG Qiang SUN Qin WANG XiaoRong ZHU JianGuo | 2007 | Chinese Science Bulletin2007，52，19： | 10 |
| 9 | Use of Xinfeng capsule to treat abarticular pathologic changes in patients with rheumatoid arthritis显示文摘OBJECTIVE: To observe the influence of Xinfengcapsule(XFC) on abarticular pathologic changes(APCs) and other indices of patients with rheumatoid arthritis(RA) and explore the mechanism of action of XFC in improving such changes.METHODS: Three-hundred RA patients were divided randomly into a treatment group(n=150) and control group(n=150). A normal control(NC)group(n=90) was also created. Changes in cardiac function, pulmonary function, anemia indices and platelet parameters of RA patients were measured.Curative effects of the two groups were compared,and comparison carried out with the NC group.RESULTS: In 300 RA patients, late diastolic peak flow velocity(A peak) was much higher(P<0.01)and early diastolic peak flow velocity(E peak), E/A,and left ventricular fraction shortening much lower(P<0.01) than those in the NC group. Vital capacity(VC), forced vital capacity in one second, forced vital capacity(FVC), maximal voluntary ventilation(MVV), maximal expiratory flow in 50% of VC(FEF50) and FEF75 were lowered remarkably(P<0.05 or P<0.01). Platelet count(PLT), plateletcrit(PCT) and mean platelet volume(MPV) increased markedly(P<0.05 or P<0.01), and hemoglobin(Hb)level decreased significantly(P<0.05). After XFC treatment, the A peak and PLT and PCT were much lower(P<0.05), and E/A and the number of red blood cells as well as Hb level were much higher(P<0.05), as were FVC, MVV and FEF50(P<0.05 or P<0.01), in the treatment group than those in the NC group. Total score of pain and swelling in joints,uric-acid level and high-sensitivity C-reactive protein level were much lower, and superoxide dismutase level as well as the number of CD4 +CD25+ regulation T cells(Treg) and CD4+CD25+CD127- Treg were much higher(P<0.05 or P<0.01)in the treatment group than those in the NC group.CONCLUSION: RA patients with pathologic changes in joints also suffer from lower cardiac and pulmonary functions and from parameters of anemia and platelet factors. XFC can improve the symptoms of RA patients, ameliorate their cardiac and pulmonary functions and reduce the parameters of anemia and platelet factors. XFC lowers the immune inflammatory reaction to improve APCs in RA patients. | Jian Liu Yunxiang Cao Chuanbing Huang Yuan Wang Xi Chen Wandong Zhang Guizhen Wang Haixia Fan Yao Ge Ruilian Chen Ruikai Zong Yajun Qi Yue Sun Yifei Liu Fang Wang | 2014 | Journal of Traditional Chinese Medicine2014，34，5： | 10 |
| 10 | Amino acid substitutions of GLY98,LEU245 and GLU543 in COI1 distinctively affect jasmonate-regulated male fertility in Arabidopsis显示文摘 | HUANG Huang WANG CuiLi TIAN HaiXia SUN Yu XIE DaoXin SONG SuSheng | 2014 | Science China(Life Sciences)2014，57，1： | 6 |
| 11 | Phase field modeling of multiple dendrite growth of Al-Si binary alloy under isothermal solidification显示文摘Phase field method offers the prospect of being able to perform realistic numerical experiments on dendrite growth in metallic systems.In this study,the growth process of multiple dendrites in Al-2-mole-%-Si binary alloy under isothermal solidification was simulated using phase field model.The simulation results showed the impingement of arbitrarily oriented crystals and the competitive growth among the grains during solidification.With the increase of growing time,the grains begin to coalesce and impinge the adjacent grains.When the dendrites start to impinge,the dendrite growth is obviously inhibited. | Sun Qiang Zhang Yutuo Cui Haixia Wang Chengzhi | 2008 | China Foundry2008，5，4： | 6 |
| 12 | Arsenic trioxide alleviates acute graft-versus-host disease by modulating macrophage polarization显示文摘This study aimed to explore macrophage polarization in acute graft-versus-host disease after hematopoietic stem cell transplantation, and investigated if arsenic trioxide(ATO) could correct this imbalance. In the colon of GVHD mice, we found that the number of F4/80+iNOS+ cells as well as the expression intensity of TNF-α and IL-1β was greater in the GVHD group than in the BM group, whereas the number of F4/80+CD206+ cells and the expression intensity of IL-10 and TGF-β was greater in the BM group than in the GVHD group. We investigated the effect of ATO on GVHD mice, and found that ATO treatment clearly improved the survival of the mice and reduced the severity of GVHD. In addition, ATO reduced the number of F4/80+iNOS+ cells, and increased the number of F4/80+CD206+ cells in the colon of GVHD mice. Furthermore, ATO sharply decreased CD86 and CD80 expression, and increased CD163 and CD206 expression in macrophages induced from aGVHD patients. Therefore,ATO can modulate the M1 and M2 phenotype in GVHD mice or in macrophages from aGVHD patients. Our data suggest that macrophage polarization is involved in the pathogenesis of aGVHD, and ATO treatment modulates macrophage polarization toward an M2 phenotype. | Xiao Liu Yan Su Xueyan Sun Haixia Fu Qiusha Huang Qi Chen Xiaodong Mo Meng Lv Yuan Kong Lanping Xu Xiaojun Huang Xiaohui Zhang | 2020 | Science China(Life Sciences)2020，63，11： | 6 |
| 13 | Gut microbiome alterations and its link to corticosteroid resistance in immune thrombocytopenia显示文摘Quantitative metagenomic studies have linked the gut microbiota to autoimmune disorders.Here,we performed deep shotgun metagenomic sequencing of fecal samples from 99 immune thrombocytopenia(ITP)patients and 52 healthy controls.Dysbiosis in the gut microbiome of ITP was detected phylogenetically and functionally,and classifier based on species markers distinguished individuals with ITP from healthy controls.In particular,the abundance of Ruminococcus gnavus,Bifidobacterium longum and Akkermansia muciniphila was markedly increased in treatment-na?ve ITP patients,and the alterations of microbial species were correlated with clinical indices.Functionally,the secondary bile acid biosynthesis and flagellar assembly were depleted in the gut microbiota of ITP,which may contribute to the onset of ITP by affecting the immune system.Furthermore,we found that corticosteroid treatment affected the gut microbiome of ITP.Compared with corticosteroid-sensitive ITP patients,we identified that the corticosteroid-resistant ITP patients displayed a distinct gut microbiome,which was different from that of the treatment-na?ve ITP patients.Together,we provided support for the critical role of gut microbiota in the development of ITP and established a foundation for further research characterizing gut microbiota in relation to corticosteroid resistance of ITP. | Yanan Wang Fengqi Liu Gaochao Zhang Yan Su Xueyan Sun Qi Chen Chencong Wang Haixia Fu Yun He Xiaolu Zhu Xiao Liu Meng Lv Xiangyu Zhao Xiaosu Zhao Yueying Li Qianfei Wang Xiaojun Huang Xiaohui Zhang | 2021 | Science China(Life Sciences)2021，64，5： | 6 |
| 14 | Sensitive electrochemical DNA sensor for the detection of HIV based on a polyaniline/graphene nanocomposite显示文摘A nanocomposite of polyaniline/graphene(PAN/GN)was prepared using reverse-phase polymerization.The nanocomposite material was dropcast onto a glassy carbon electrode(GCE).Then,a single-stranded DNA(ssDNA)probe for HIV-1 gene detection was immobilized on the modified electrode,and the negative charged phosphate backbone of the HIV-1 was bound to the modified electrode surface via p-p*stacking interactions.The hybridization between the ssDNA probe and the target HIV-1 formed doublestranded DNA(dsDNA),and the electron transfer resistance of the electrode was measured using impedimetric studies with a[Fe(CN)6]^(3-/4-)redox couple.Under the optimized experimental conditions,the change of the impedance value was linearly related to the logarithm of the concentration of HIV genes in the range from 5.0×10^(-16)M to 1.0×10^(-10)M(R=0.9930),and the HIV sensor exhibited a lower detection limit of 1.0×10^(-16)M(S/N=3).The results show that this biosensor presented wonderful selectivity,sensitivity and specificity for HIV-1 gene detection.Thus,this biosensor provides a new method for the detection of HIV gene fragments. | Qiaojuan Gong Haixia Han Haiying Yang Meiling Zhang Xiaoling Sun Yunxia Liang Zhaorong Liu Wenchan Zhang Jinli Qiao | 2019 | Journal of Materiomics2019，5，2： | 5 |
| 15 | Rare-earth element geochemistry reveals the provenance of sediments on the southwestern margin of the Challenger Deep显示文摘The hadal zone represents one of the last great frontiers in modern marine science,and deciphering the provenance of sediment that is supplied to these trench settings remains a largely unanswered question.Here,we examine the mineralogical and geochemical composition of a sediment core(core CD-1)that was recovered from the southwestern margin of the Challenger Deep within the Mariana Trench.Major element abundances and rare-earth element patterns from these sediments require inputs from both terrigenous dust and locally sourced volcanic debris.We exploit a two-endmember mixing model to demonstrate that locally sourced volcanic material dominates the sediment supply to the Challenger Deep(averaging^72%).The remainder,however,is supplied by aeolian dust(averaging^28%),which is consistent with adjacent studies that utilized Sr-Nd isotopic data.Building on a growing database,we strengthen our understanding of Asian aeolian dust input into the northwestern Pacific,which ultimately improves our appreciation of sedimentation in,and around,the hadal zone. | JIANG Zuzhou SUN Zhilei LIU Zhaoqing CAO Hong GENG Wei XU Haixia WANG Lisheng WANG Libo | 2019 | Journal of Oceanology and Limnology2019，37，3： | 5 |
| 16 | Highly efficient catalytic scavenging of oxygen free radicals with graphene-encapsulated metal nanoshields显示文摘 | Junying Wang Xiaoju Cui Haobo Li Jianping Xiao Jiang Yang Xiaoyu Mu Haixia Liu Yuan-Ming Sun Xuhui Xue Changlong Liu Xiao-Dong Zhang Dehui Deng Xinhe Bao | 2018 | Nano Research2018，11，5： | 4 |
| 17 | Ablation of Akt2 and AMPKα2 rescues high fat diet-induced obesity and hepatic steatosis through Parkin-mediated mitophagy显示文摘Given the opposing effects of Akt and AMP-activated protein kinase(AMPK)on metabolic homeostasis,this study examined the effects of deletion of Akt2 and AMPKα2 on fat diet-induced hepatic steatosis.Akt2–Ampkα2 double knockout(DKO)mice were placed on high fat diet for 5 months.Glucose metabolism,energy homeostasis,cardiac function,lipid accumulation,and hepatic steatosis were examined.DKO mice were lean without anthropometric defects.High fat intake led to adiposity and decreased respiratory exchange ratio(RER)in wild-type(WT)mice,which were ablated in DKO but not Akt2^(-/-) and Ampkα2^(-/-) mice.High fat intake increased blood and hepatic triglycerides and cholesterol,promoted hepatic steatosis and injury in WT mice.These effects were eliminated in DKO but not Akt2^(-/-) and Ampkα2^(-/-) mice.Fat diet promoted fat accumulation,and enlarged adipocyte size,the effect was negated in DKO mice.Fat intake elevated fatty acid synthase(FAS),carbohydrate-responsive element-binding protein(CHREBP),sterol regulatory element-binding protein 1(SREBP1),peroxisome proliferator-activated receptor gamma coactivator 1-alpha(PGC-1α),peroxisome proliferator-activated receptor-α(PPARα),PPARγ,stearoyl-CoA desaturase 1(SCD-1),phosphoenolpyruvate carboxykinase(PEPCK),glucose 6-phosphatase(G6Pase),and diglyceride O-acyltransferase 1(DGAT1),the effect was absent in DKO but not Akt2^(-/-) and Ampkα2^(-/-) mice.Fat diet dampened mitophagy,promoted inflammation and phosphorylation of forkhead box protein O1(FoxO1)and AMPKα1(Ser^(485)),the effects were eradicated by DKO.Deletion of Parkin effectively nullified DKO-induced metabolic benefits against high fat intake.Liver samples from obese humans displayed lowered microtubule-associated proteins 1A/1B light chain 3B(LC3B),Pink1,Parkin,as well as enhanced phosphorylation of Akt,AMPK(Ser^(485)),and FoxO1,which were consolidated by RNA sequencing(RNAseq)and mass spectrometry analyses from rodent and human livers.These data suggest that concurrent deletion of Akt2 and AMPKα2 offers resilience to fat diet-induced obesity and hepatic steatosis,possibly through preservation of Parkin-mediated mitophagy and lipid metabolism. | Shuyi Wang Jun Tao Huaguo Chen Machender R.Kandadi Mingming Sun Haixia Xu Gary D.Lopaschuk Yan Lu Junmeng Zheng Hu Peng Jun Ren | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 4 |
| 18 | Solution processed inorganic V20x as interfacial function materials for inverted planar-heterojunction perovskite solar cells with enhanced efficiency显示文摘 | Haitao Peng Weihai Sun Yunlong Li Senyun Ye Haixia Rao Weibo Yan Huanping Zhou Zuqiang Bian Chunhui Huang | 2016 | Nano Research2016，9，10： | 4 |
| 19 | 2017 Chinese expert consensus on the clinical application ofserum marker for thyroid cancer显示文摘In recent years, the clinical incidence of thyroid cancer has been increasing year by year, and its risk assessment and clinical management methods have also been accordingly modified and constantly improved. There are great differences between the clinical diagnostic and therapeutic modes and disease management of thyroid cancer employed by various medical institutions in China, particularly with regard to the clinical application of serum marker of thyroid cancer. To this end, the China Anti-Cancer Association Thyroid Cancer Specialized Committee Chinese Association of Thyroid Oncology organized this compilation of ExpertConsensus on Clinical Application of Serum Marker of Thyroid Cancer to help and impel relevant clinical institutions and professionals to standardize clinical diagnosis, treatment, and long-term management of thyroid cancer, and to properly utilize the serum marker for scientific auxiliary clinical diagnosis and assessment of thyroid cancer before and after operation. | Ming Gao Minghua Ge Qinghai Ji Ruochuan Cheng Hankui Lu Haixia Guan Wei Cui Li Gao Zairong Gao Lin Guo Zhuming Guo Tao Huang Xiaoming Huang Yansong Lin Qinjiang Liu Xin Ni Jianwu Qin Li Ren Zhongyan Shan Hui Sun Xudong Wang Zhengang Xu Yang Yu Bin Zhang DaiweiZhao Ying Zheng Jingqiang Zhu Xiangqian Zheng 无 | 2018 | Cancer Biology & Medicine2018，15，4： | 3 |
| 20 | SARS coronavirus without reservoir originated from an unnatural evolution, experienced the reverse evolution, and finally disappeared in the world显示文摘Severe acute respiratory syndrome (SARS) first emerged in Guangdong on November 16,2002,and subsequently spread to Hong Kong,Beijing,Taiwan,and other areas.According to WHO,8 098 cases were reported in 29 countries.1,2 Although researchers around the world have been carrying out extensive studies for 10 years,the reservoir of SARS coronavirus (CoV) has not been found.1。 | Xu Dezhong Sun Huimin Su Haixia Zhang Lei Zhang Jingxia Wang Bo Xu Rui | 2014 | Chinese Medical Journal2014，，13： | 2 |
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