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| 1 | Management of gastric and duodenal neuroendocrine tumors显示文摘Gastrointestinal neuroendocrine tumors(GI-NETs) are rare neoplasms, like all NETs. However, the incidence of GI-NETS has been increasing in recent years. Gastric NETs(G-NETs) and duodenal NETs(D-NETs) are the common types of upper GI-NETs based on tumor location. G-NETs are classified into three distinct subgroups: type?Ⅰ, Ⅱ, and Ⅲ. Type?Ⅰ?G-NETs, which are the most common subtype(70%-80% of all G-NETs), are associated with chronic atrophic gastritis, including autoimmune gastritis and Helicobacter pylori associated atrophic gastritis. Type Ⅱ G-NETs(5%-6%) are associated with multiple endocrine neoplasia type 1 and Zollinger-Ellison syndrome(MEN1-ZES). Both type?Ⅰ?and Ⅱ G-NETs are related to hypergastrinemia, are small in size, occur in multiple numbers, and are generally benign. In contrast, type Ⅲ G-NETs(10%-15%) are not associated with hypergastrinemia, are large-sized single tumors, and are usually malignant. Therefore, surgical resection and chemotherapy are generally necessary for type Ⅲ G-NETs, while endoscopic resection and followup, which are acceptable for the treatment of most type?Ⅰ?and Ⅱ G-NETs, are only acceptable for small and well differentiated type Ⅲ G-NETs. D-NETs include gastrinomas(50%-60%), somatostatin-producing tumors(15%), nonfunctional serotonin-containing tumors(20%), poorly differentiated neuroendocrine carcinomas(< 3%), and gangliocytic paragangliomas(< 2%). Most D-NETs are located in the first or second part of the duodenum, with 20% occurring in the periampullary region. Therapy for D-NETs is based on tumor size, location, histological grade, stage, and tumor type. While endoscopic resection may be considered for small nonfunctional D-NETs(G1) located in the higher papilla region, surgical resection is necessary for most other D-NETs. However, there is no consensus regarding the ideal treatment of D-NETs. | Yuichi Sato Satoru Hashimoto Ken-ichi Mizuno Manabu Takeuchi Shuji Terai | 2016 | World Journal of Gastroenterology2016，22，30： | 10 |
| 2 | Magnifying Narrowband Imaging Is More Accurate Than Conventional White-Light Imaging in Diagnosis of Gastric Mucosal Cancer显示文摘 | Yasumasa Ezoe Manabu Muto Noriya Uedo Hisashi Doyama Kenshi Yao Ichiro Oda Kazuhiro Kaneko Yoshiro Kawahara Chizu Yokoi Yasushi Sugiura Hideki Ishikawa Yoji Takeuchi Yoshibumi Kaneko Yutaka Saito | 2011 | Gastroenterology2011，，6： | 4 |
| 3 | Esophageal diverticulum: New perspectives in the era of minimally invasive endoscopic treatment显示文摘Esophageal diverticula are rare conditions that cause esophageal symptoms, such as dysphagia, regurgitation, and chest pain. They are classified according to their location and characteristic pathophysiology into three types: epiphrenic diverticulum, Zenker's diverticulum, and Rokitansky diverticulum. The former two disorders take the form of protrusions, and symptomatic cases require interventional treatment. However, the esophageal anatomy presents distinct challenges to surgical resection of the diverticulum, particularly when it is located closer to the oral orifice. Since the condition itself is not malignant,minimally invasive endoscopic approaches have been developed with a focus on alleviation of symptoms. Several types of endoscopic devices and techniques are currently employed, including peroral endoscopic myotomy(POEM). However,the use of minimally invasive endoscopic approaches, like POEM, has allowed the development of new disorder called iatrogenic esophageal diverticula. In this paper, we review the pathophysiology of each type of diverticulum and the current state-of-the-art treatment based on our experience. | Hiroki Sato Manabu Takeuchi Satoru Hashimoto Ken-ichi Mizuno Koichi Furukawa Akito Sato Junji Yokoyama Shuji Terai | 2019 | World Journal of Gastroenterology2019，25，12： | 3 |
| 4 | The efficacy of endoscopic triamcinolone injection for the prevention of esophageal stricture after endoscopic submucosal dissection显示文摘 | Satoru Hashimoto Masaaki Kobayashi Manabu Takeuchi Yuichi Sato Rintaro Narisawa Yutaka Aoyagi | 2011 | Gastrointestinal Endoscopy2011，，6： | 3 |
| 5 | Surveillance and treatment for second primary cancer in the gastric tube after radical esophagectomy显示文摘 | Takeo Bamba Shin-ichi Kosugi Manabu Takeuchi Masaaki Kobayashi Tatsuo Kanda Atsushi Matsuki Katsuyoshi Hatakeyama | 2010 | Surgical Endoscopy2010，，6： | 2 |
| 6 | Granulocytapheresis for the Treatment of Severe Alcoholic Hepatitis: A Case Series and Literature Review显示文摘 | Kenya Kamimura Michitaka Imai Akira Sakamaki Shigeki Mori Masaaki Kobayashi Ken-ichi Mizuno Manabu Takeuchi Takeshi Suda Minoru Nomoto Yutaka Aoyagi | 2014 | Digestive Diseases and Sciences2014，，2： | 2 |
| 7 | The deep-space multi-object orbit determination system and its application to Hayabusa2’s asteroid proximity operations显示文摘The deep-space multi-object orbit determination system(DMOODS)and its application in the asteroid proximity operation of the Hayabusa2 mission are described.DMOODS was developed by the Japan Aerospace Exploration Agency(JAXA)for the primary purpose of determining the trajectory of deep-space spacecraft for JAXA’s planetary missions.The weighted least-squares batch filter is used for the orbit estimator of DMOODS.The orbit estimator supports more than 10 data types,some of which are used for relative trajectory measurements between multiple space objects including natural satellites and small bodies.This system consists of a set of computer programs running on Linux-based consumer PCs on the ground,which are used for orbit determination and the generation of radiometric tracking data,such as delta differential one-way ranging and doppler tracking data.During the asteroid proximity phase of Hayabusa2,this system played an essential role in operations that had very strict navigation requirements or operations in which few optical data were obtained owing to special constraints on the spacecraft attitude or distance from the asteroid.One example is orbit determination during the solar conjunction phase,in which the navigation accuracy is degraded by the effect of the solar corona.The large range bias caused by the solar corona was accurately estimated with DMOODS by combining light detection and ranging(LIDAR)and ranging measurements in the superior solar conjunction phase of Hayabusa2.For the orbiting operations of target markers and the MINERVA-II2 rover,the simultaneous estimation of six trajectories of four artificial objects and a natural object was made by DMOODS.This type of simultaneous orbit determination of multi-artificial objects in deep-space has never been accomplished before. | Hiroshi Takeuchi Kent Yoshikawa Yuto Takei Yusuke Oki Shota Kikuchi Hitoshi Ikeda Stefania Soldini Naoko Ogawa Yuya Mimasu Go Ono Fuyuto Terui Naoya Sakatani Manabu Yamada Toru Kouyama Shingo Kameda Takanao Saiki Yuichi Tsuda | 2020 | Astrodynamics2020，4，4： | 2 |
| 8 | Paracrine Receptor Activation by Microenvironment Triggers Bypass Survival Signals and ALK Inhibitor Resistance in EML4-ALK Lung Cancer Cells显示文摘 | Tadaaki Yamada Shinji Takeuchi Junya Nakade Kenji Kita Takayuki Nakagawa Shigeki Nanjo Takahiro Nakamura Kunio Matsumoto Manabu Soda Hiroyuki Mano Toshimitsu Uenaka Seiji Yano | 2012 | Clinical Cancer Research2012，，13： | 1 |
| 9 | Surveillance and treatment for second primary cancer in the gastric tube after radical esophagectomy显示文摘 | Takeo Bamba Shin-ichi Kosugi Manabu Takeuchi Masaaki Kobayashi Tatsuo Kanda Atsushi Matsuki Katsuyoshi Hatakeyama | 2010 | Surgical Endoscopy2010，，6： | 1 |
| 10 | Development of Karman Vortex Probe for Measuring the Velocily of Molten Metal Flow Marterial Transactions 显示文摘 | Manabu Iguchi Masamichi Takeuchi Hirotoshi Kawabata | 1994 | JIM1994，35，10： | 1 |
| 11 | A mouse model for EML4-ALK-positive lung cancer显示文摘 | Manabu Soda Shuji Takada Kengo Takeuchi | 2008 | National Academy of Sciences of the USA2008，105，19： | 1 |
| 12 | An efficient diagnostic strategy for small, depressed early gastric cancer with magnifying narrow-band imaging: a post-hoc analysis of a prospective randomized controlled trial显示文摘 | Shinya Yamada Hisashi Doyama Kenshi Yao Noriya Uedo Yasumasa Ezoe Ichiro Oda Kazuhiro Kaneko Yoshiro Kawahara Chizu Yokoi Yasushi Sugiura Hideki Ishikawa Yoji Takeuchi Yutaka Saito Manabu Muto | 2013 | Gastrointestinal Endoscopy2013，，： | 1 |
| 13 | The efficacy of endoscopic triamcinolone injection for the prevention of esophageal stricture after endoscopic submucosal dissection显示文摘 | Satoru Hashimoto Masaaki Kobayashi Manabu Takeuchi Yuichi Sato Rintaro Narisawa Yutaka Aoyagi | 2011 | Gastrointestinal Endoscopy2011，，6： | 1 |
| 14 | EML4-ALK Fusion Is Linked to Histological Characteristics in a Subset of Lung Cancers显示文摘 | Kentaro Inamura Kengo Takeuchi Yuki Togashi Kimie Nomura Hironori Ninomiya Michiyo Okui Yukitoshi Satoh Sakae Okumura Ken Nakagawa Manabu Soda Young Lim Choi Toshiro Niki Hiroyuki Mano Yuichi Ishikawa | 2008 | Journal of Thoracic Oncology2008，，1： | 1 |
| 15 | Case of severe alcoholic hepatitis treated with granulocytapheresis显示文摘Severe alcoholic hepatitis(AH) has a high mortality,and it is associated with encephalopathy,acute renal failure,sepsis,gastrointestinal bleeding,and endotoxemia.The 28-d mortality remains poor(34%-40%),because no effective treatment has been established.Recently,corticosteroids(CS) have been considered effective for significantly improving the prognosis of those with AH,as it prevents the production of pro-inflammatory cytokines.However,CS are not always appropriate as an initial therapeutic option,such as in cases with an infection or resistance to CS.We describe a patient with severe AH complicated by a severe infection caused by the multidrug resistance bacteria(Pseudomonas aeruginosa),and was successfully treated with granulocytapheresis monotherapy without using CS.The experience of this case will provide understanding of the disease and information treating cases without using CS. | Yukari Watanabe Kenya Kamimura Tomohiro Iwasaki Hiroyuki Abe Shunsaku Takahashi Ken-ichi Mizuno Manabu Takeuchi Atsushi Eino Ichiei Narita Shuji Terai | 2016 | World Journal of Clinical Cases2016，4，11： | 1 |
| 16 | Malignant change secondary to fibrous dysplasia显示文摘 | Manabu Hoshi Seiichi Matsumoto Jun Manabe Taisuke Tanizawa Toshio Shigemitsu Naohiro Izawa Takeuchi Kengo Noriyoshi Kawaguchi | 2006 | International Journal of Clinical Oncology2006，，3： | 1 |
| 17 | Transcatheter arterial embolization of ruptured hepatocellular carcinoma associated with liver cirrhosis显示文摘 | Toshihiko Nouchi MD Masanobu Nishimura MD Manabu Maeda MD Testutaro Funatsu MD Yasushi Hasumura MD Professor Jugoro Takeuchi MD | 1984 | Digestive Diseases and Sciences1984，，12： | 1 |
| 18 | Morphological characteristics of perylene-doped phthalocyanine thin films and their photovoltaic effect显示文摘 | RUDIONO FUJIO KANEKO MANABU TAKEUCHI | 1999 | Applied Surface Science1999，142，： | 1 |
| 19 | Tribocharging mechanism of mono-component irregular and spherical toners in an electrographic development system显示文摘 | Koji Takagi D S P Castle Manabu Takeuchi | 2003 | Powder Technology2003，，135136： | 1 |
| 20 | Tu1588 Usefulness of Japan Esophageal Society Classification of Magnified Endoscopy for the Diagnosis of Superficial Esophageal Squamous Cell Carcinoma显示文摘 | Tsuneo Oyama Ryu Ishihara Manabu Takeuchi Dai Hirasawa Miwako Arima Haruhiro Inoue Kenichi Goda Akihisa Tomori Kumiko Momma | 2012 | Gastrointestinal Endoscopy2012，，4： | 1 |
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