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| 1 | Deep Structural Framework and Genetic Analysis of Gold Concentration Areas in the Northwestern Jiaodong Peninsula, China: A New Understanding based on High-Resolution Reflective Seismic Survey显示文摘The gold concentration areas in the northwestern Jiaodong Peninsula constituted an important gold metallogenetic region in Eastern China during the Mesozoic. The deep geological bodies' texture characteristic is important for exploring the resources thoroughly and understanding the metallogenic process. The detailed textures were revealed using high-resolution seismic profiles through the three major ore-controlling structures-Sanshandao fault zone, Jiaojia fault zone and Zhaoping fault zone. This study aims to establish a deep structural framework of this area. Based on their formation mechanism, the fault structures developed in the area can be divided into regional and local fault structures. The structural styles are characterised by superimposing their compressional, strike-slip and extensional multi-stage activities. The crust is cut by vertical structures corresponding to a left-lateral strike-slip fault system on the surface. Nearby these structures are the arc-shape structures formed by multi-stage magma intrusions into the upper crust. Bounded by the Tancheng–Lujiang and Muping–Jimo fault zones, the current Jiaodong block, developed a series of NE-trending strike-slip fault systems, was probably formed by the assemblage of several obliquely aligned blocks. The intensive magmatism and hydrothermal activity between the blocks induced large-scale mineralisation. It provides a new angle of view for understanding the cratonic destruction and large ore-concentration formed during the Mesozoic. | YU Xuefeng SHAN Wei XIONG Yuxin GENG Ke SUN Yuqin CHI Naijie GUO Baokui LI Dapeng LI Hongkui SONG Yingxin YANG Deping | 2018 | Acta Geologica Sinica(English Edition)2018，92，5： | 19 |
| 2 | Recurrent gain-of-function USP8 mutations in Cushing's disease显示文摘库欣的疾病,引起过量皮质醇生产的也已知的同样促肾上腺皮质的荷尔蒙(ACTH )-secreting 垂体腺瘤(舞步) ,占多达 85%corticotrophin 依赖的库欣的症候群盒子。然而,在这疾病的基因改变是不清楚的。这里,我们执行了从 12 秘密 ACTH 舞步导出并且匹配血样品的 DNA 定序的 whole-exome,它在候选人基因揭示了体的变化的三种类型, USP8 (编码 ubiquitin 特定的朊酶 8 ) ,专门在 exon 14 在 12 秘密 ACTH 舞步中的 8 个。我们进一步评估了体的 USP8 变化在另外由定序的 Sanger 的 258 舞步。进一步定序指向在 108 秘密 ACTH 舞步(62.04%) 中的 67 个识别了 USP8 变体的 17 种类型的一个总数。然而,任何一个都没在舞步的另外的类型这些变化被检测(n = 150 ) 。这些变化在 USP8 的 14-3-3 绑定主题以内聚集并且破坏在 USP8 和 14-3-3 蛋白质之间的相互作用,导致保护 EGFR 免受 lysosomal 降级的伤害的一个提高的能力。因此,有 EGFR 表示,提高的 EGFR 蛋白质丰富和 mRNA 表示的更高的发生 POMC 铺平的变异的 USP8 显示的舞步,它编码 ACTH 的先锋。有变异的 USP8 的舞步在尺寸是显著地更小的并且比野类型的舞步有更高的 ACTH 生产。在里面通过手术 resected 主要变异 USP8 的肿瘤房间, USP8 击倒或堵住的 EGFR 有效地稀释 ACTH 分泌物。一起拿,体的 gain-of-function USP8 变化是普通的并且在库欣的疾病贡献 ACTH 生产过剩。USP8 或 EGFR 的抑制为对待变异 USP8 的 corticotrophin 腺瘤是有希望的。我们的学习在库欣的疾病加亮潜在地功能的变异的基因并且提供卓见进这疾病的治疗学。 | Zeng-Yi Ma Zhi-Jian Song Jian-Hua Chen Yong-Fei Wang Shi-Qi Li Liang-Fu Zhou Ying Mao Yi-Ming Li Rong-Gui Hu Zhao-Yun Zhang Hong-Ying Ye Ming Shen Xue-Fei Shou Zhi-Qiang Li Hong Peng Qing-Zhong Wang Dai-Zhan Zhou Xiao-Lan Qin Jue Ji Jie Zheng Hong Chen Yin Wang Dao-Ying Geng Wei-Jun Tang Chao-Wei Fu Zhi-Feng Shi Yi-Chao Zhang Zhao Ye Wen-Qiang He Qi-Lin Zhang Qi-Sheng Tang Rong Xie Jia-Wei Shen Zu-Jia Wen Juan Zhou Tao Wang Shan Huang Hui-Jia Qiu Ni-Dan Qiao Yi Zhang Li Pan Wei-Min Bao Ying-Chao Liu Chuan-Xin Huang Yong-Yong Shi Yao Zhao | 2015 | Cell Research2015，25，3： | 16 |
| 3 | Ginsenoside Rg1 enhances the resistance of hematopoietic stem/progenitor cells to radiation- induced aging in mice显示文摘 | Cui CHEN Xin-yi MU Yue ZHOU Ke SHUN Shan GENG Jun LIU Jian-wei WANG Jie CHEN Tin-yu LI Ya-ping WANG | 2014 | Acta Pharmacologica Sinica2014，35，1： | 15 |
| 4 | Identification of mecciRNAs and their roles in the mitochondrial entry of proteins显示文摘Mammalian mitochondria have small genomes encoding very limited numbers of proteins.Over one thousand proteins and noncoding RNAs encoded by the nuclear genome must be imported from the cytosol into the mitochondria.Here,we report the identification of hundreds of circular RNAs(mecciRNAs)encoded by the mitochondrial genome.We provide both in vitro and in vivo evidence to show that mecciRNAs facilitate the mitochondrial entry of nuclear-encoded proteins by serving as molecular chaperones in the folding of imported proteins.Known components involved in mitochondrial protein and RNA importation,such as TOM40 and PNPASE,interact with mecciRNAs and regulate protein entry.The expression of mecciRNAs is regulated,and these transcripts are critical for the adaption of mitochondria to physiological conditions and diseases such as stresses and cancers by modulating mitochondrial protein importation.mecciRNAs and their associated physiological roles add categories and functions to the known eukaryotic circular RNAs and shed novel light on the communication between mitochondria and the nucleus. | Xu Liu Xiaolin Wang Jingxin Li Shanshan Hu Yuqi Deng Hao Yin Xichen Bao Qiangfeng Cliff Zhang Geng Wang Baolong Wang Qinghua Shi Ge Shan | 2020 | Science China(Life Sciences)2020，63，10： | 15 |
| 5 | Slit-Robo signaling induces malignant transformation through Hakai-mediated E-cadherin degradation during colorectal epithelial cell carcinogenesis显示文摘指导暗示的裂缝家庭绑在环岛(Robo ) 受体并且调制房间移植。我们这里报导 Slit2 的那宫外的表情和上皮的癌房间招募了的表示 Robo1 colorectal 的 Robo1 或 recombinant Slit2 处理为 E-cadherin (电子恶棍) ubiquitination 和 lysosomal 降级,上皮间充质的转变(EMT ) ,和肿瘤生长和肝转移的 ubiquitin ligase Hakai,它被救由 Hakai 击倒。相反,内长的 Robo1 或对 Robo1 有约束力的 Slit2 的特定的封锁击倒阻止的电子恶棍降级和颠倒的 EMT,导致减少的肿瘤生长和肝转移。Robo1 的宫外的表示也在 Slit2 积极的人的胚胎的肾触发了恶意的转变 293 个房间。重要地, Slit2 和 Robo1 的表示显著地在 colorectal 癌病人与增加的变形风险和更差的全面幸存被联系。我们断定由 Slit2 的 Robo1 的那个约会在 colorectal 期间通过调停 Hakai 的电子恶棍 ubiquitination 和 lysosomal 降级导致恶意的转变上皮的房间 carcinogenesis。 | Wei-Jie Zhou Zhen H Geng Shan Chi Wenli Zhang Xiao-Feng Niu Shu-Jue Lan Li Ma Xuesong Yang Li-Jing Wang Yan-Qing Ding Jian-Guo Geng | 2011 | Cell Research2011，21，4： | 14 |
| 6 | Seroepidemiological Investigation of Lyme Disease and Human Granulocytic Anaplasmosis among People Living in Forest Areas of Eight Provinces in China显示文摘Objective Lyme disease and Human granulocytic anaplasmosis are tick‐borne diseases caused by Borrelia burgdorferi and Anaplasma phagocytophilum respectively. We have investigated infection and co-infection of the two diseases in the population of forest areas of eight provinces in China by measuring seroprevalence of antibodies against B. burgdorferi and A. phagocytophilum. Methods Forest areas in 8 provinces were chosen for investigation using whole sampling and questionnaire survey methods. 3 669 serum samples from people in the forest areas were tested for the presence of antibodies by indirect immunofluorescent assay (IFA). Results Seroprevalence against B. burgdorferi was 3% to 15% and against A. phagocytophilum was 2% to 18% in the study sites in the 8 provinces in China. We also found co-infection of B. burgdorferi and A. phagocytophilum in 7 of the 8 provinces (the exception being the Miyun area in Beijing). The seroprevalence for both B. burgdorferi and A. phagocytophilum was significantly higher among people exposed to ticks than among people who were not exposed to ticks. Conclusion We conclude that both pathogens are endemic in the forest areas in the eight provinces, but the prevalence of B. burgdorferi and A. phagocytophilum differs between the provinces. | HAO Qin GENG Zhen HOU Xue Xia TIAN Zhen YANG Xiu Jun JIANG Wei Jia SHI Yan ZHAN Zhi Fei LI Guo Hua YU De Shan WANG Hua Yong XU Jian Guo WAN Kang Lin | 2013 | Biomedical and Environmental Sciences2013，26，3： | 13 |
| 7 | Long-term outcomes after hepatectomy of huge hepatocellular carcinoma: A single-center experience in China显示文摘Background: Currently, hepatectomy remains the first-line therapy for hepatocellular carcinoma(HCC). However, surgery for patients with huge( > 10 cm) HCCs is controversial. This retrospective study aimed to explore long-term survival after hepatectomy for patients with huge HCC. Methods: The records of 188 patients with pathologically confirmed HCC who underwent curative hepatectomy between 2007 and 2017 were reviewed;patients were divided into three groups according to tumor size: huge( > 10 cm;n = 84), large(5–10 cm;n = 51) and small( < 5 cm;n = 53) HCC. Kaplan-Meier analysis was used to assess overall survival(OS) and disease-free survival(DFS), and log-rank analysis was performed for pairwise comparisons among the three groups. Risk factors for survival and recurrence were analyzed using the Cox proportional hazard model. Results: The median follow-up period was 20 months. Although the prognosis of small HCC was better than that of huge and large HCC, OS and DFS were not significantly different between huge and large HCC( P = 0.099 and P = 0.831, respectively). A family history of HCC, poor Child-Pugh class, vascular invasion, diolame, pathologically positive margins, and operative time ≥240 min were identified as independent risk factors for OS and DFS in a multivariate model. Tumor size( > 10 cm) had significant effect on OS, and postoperative antiviral therapy and postoperative complications also had significant effects on DFS. Conclusions: Huge HCC is not a contraindication of hepatectomy. Although most of these patients experienced recurrence after surgery, OS and DFS were not significantly different from those of patients with large HCC after resection. | Qiang Fang Qing-Song Xie Jiang-Ming Chen Shen-Liang Shan Kun Xie Xiao-Ping Geng Fu-Bao Liu | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，6： | 10 |
| 8 | Nature:研究鉴定出蛋白Nlrp9b抵抗轮状病毒感染机制显示文摘轮状病毒(rotavirus)是婴儿和儿童罹患肠胃炎和腹泻的一种最为常见的原因,每年导致全世界大约21.5万人死亡。它是高度传染性的和潜在致命性的。这种病毒特异性地感染宿主小肠中的肠上皮细胞,并且已进化出抵抗干扰素和NF-KB信号的策略来躲避免疫系统,这就提出一个问题:其他的宿主因子是否参与肠道粘膜中的抗病毒反应。不过,针对体内(特别是通过NLR炎性体)检测和限制肠道病毒的机制,人们知之甚少。 | Shu Zhu, Zheng Wei, Noah W. Palm, Yi Yang, Hua Yu, Hua-Bing Li, Geng Wang, Xuqiu Lei, Marcel R. de Zoete, Jun Zhao, Yunjiang Zheng, Haiwei Chen, Liang Shan, Richard A. Flavell Siyuan Ding, Ningguo Feng, Harry B. Greenberg Siyuan Ding, Harry B. Greenberg Penghua Wang, Yujiao Zhao Wen Pan, Jun Lu Jun Zhao, Yuval Kluger Kellie A. Jurado, Clara Abraham, Erol Fikrig Erol Fikrig, Richard A. Flavell | 2017 | 现代生物医学进展2017，17，27： | 10 |
| 9 | Risk of gestational diabetes recurrence and the development of type 2 diabetes among women with a history of gestational diabetes and risk factors: a study among 18 clinical centers in China显示文摘Background:Gestational diabetes mellitus(GDM)brings health issues for both mothers and offspring,and GDM prevention is as important as GDM management.It was shown that a history of GDM was significantly associated with a higher maternal risk for GDM recurrence.The incidence of GDM recurrence was unclear because of the incidence of second-child was low before 2016 in China.We aim to investigate the prevalence of GDM recurrence and its associated high-risk factors which may be useful for the prediction of GDM recurrence in China.Methods:A retrospective study was conducted which enrolled participants who underwent regular prenatal examination and delivered twice in the same hospital of 18 research centers.All participants were enrolled from January 2018 to October 2018,where they delivered the second baby during this period.A total of 6204 women were enrolled in this study,and 1002 women with a history of GDM were analyzed further.All participants enrolled in the study had an oral glucose tolerance test(OGTT)result at 24 to 28 weeks and were diagnosed as GDM in the first pregnancy according to the OGTT value(when any one of the following values is met or exceeded to the 75-g OGTT:0 h[fasting],≥5.10 mmol/L;1 h,≥10.00 mmol/L;and 2 h,≥8.50 mmol/L).The prevalence of GDM recurrence and development of type 2 diabetes mellitus were calculated,and its related risk factors were analyzed.Results:In 6204 participants,there are 1002 women(1002/6204,16.15%)with a history of GDM and 5202 women(5202/6204,83.85%)without a history of GDM.There are significant differences in age(32.43±4.03 years vs.33.00±3.34 years vs.32.19±3.37 years,P<0.001),pregnancy interval(4.06±1.44 years vs.3.52±1.43 years vs.3.38±1.35 years,P=0.004),prepregnancy body mass index(BMI)(27.40±4.62 kg/m^(2)vs.23.50±3.52 kg/m^(2)vs.22.55±3.47 kg/m^(2),P<0.001),history of delivered macrosomia(22.7%vs.11.0%vs.6.2%,P<0.001)among the development of diabetes mellitus(DM),recurrence of GDM,and normal women.Moreover,it seems so important in the degree of abnormal glucose metabolism in the first pregnancy to the recurrence of GDM and the development of DM.There are significant differences in OGTT levels of the first pregnancy such as area under the curve of OGTT value(18.31±1.90 mmol/L vs.16.27±1.93 mmol/L vs.15.55±1.92 mmol/L,P<0.001),OGTT fasting value(5.43±0.48 mmol/L vs.5.16±0.49 mmol/L vs.5.02±0.47 mmol/L,P<0.001),OGTT 1-hour value(10.93±1.34 mmol/L vs.9.69±1.53 mmol/L vs.9.15±1.58 mmol/L,P<0.001),OGTT 2-hour value(9.30±1.66 mmol/L vs.8.01±1.32 mmol/L vs.7.79±1.38 mmol/L,P<0.001),incidence of impaired fasting glucose(IFG)(fasting plasma glucose≥5.6 mmol/L)(31.3%vs.14.6%vs.8.8%,P<0.001),and incidence of two or more abnormal OGTT values(68.8%vs.39.7%vs.23.9%,P<0.001)among the three groups.Using multivariate analysis,the factors,such as age(1.07[1.02-1.12],P=0.006),prepregnancy BMI(1.07[1.02,1.12],P=0.003),and area under the curve of OGTT in the first pregnancy(1.14[1.02,1.26],P=0.02),have an effect on maternal GDM recurrence;the factors,such as age(1.28[1.01-1.61],P=0.04),pre-pregnancy BMI(1.26[1.04,1.53],P=0.02),and area under the curve of OGTT in the first pregnancy(1.65[1.04,2.62],P=0.03),have an effect on maternal DM developed further.Conclusions:The history of GDM was significantly associated with a higher maternal risk for GDM recurrence during follow-up after the first pregnancy.The associated risk factors for GDM recurrence or development of DM include age,high pre-pregnancy BMI,history of delivered macrosomia,the OGTT level in the first pregnancy,such as the high area under the curve of OGTT,IFG,and two or more abnormal OGTT values.To prevent GDM recurrence,women with a history of GDM should do the preconception counseling before preparing next pregnancy. | Yumei Wei Juan Juan Rina Su Geng Song Xu Chen Ruiqin Shan Ying Li Shihong Cui Shangrong Fan Ling Feng Zishan You Haixia Meng Yan Cai Cuilin Zhang Huixia Yang | 2022 | Chinese Medical Journal2022，，6： | 7 |
| 10 | Antibiotic resistance and molecular characterization of diarrheagenic Escherichia coli and non-typhoidal Salmonella strains isolated from infections in Southwest China显示文摘Background:Bacterial diarrhea is one of the most common causes for medical consultations,mortality and morbidity in the world.Diarrheagenic Escherichia coli(DEC)and non-typhoidal Salmonella(NTS)are major intestinal pathogens in developing countries,and the indiscriminate use of antibiotics has greatly contributed to resistant strains.Hence,the aim of the present study is to identify the antimicrobial resistance patterns and the molecular characteristics of DEC and NTS in southwest,China.Methods:1121 diarrheal patients and 319 non-diarrheal subjects across all age groups were recruited from four sentinel hospitals from June 2014 to July 2015 in Kunming City,Yunnan Province.Each stool specimen was collected to detect DEC and NTS with standard microbiological and molecular methods.Antimicrobial resistance testing was performed with the Kirby-Bauer disk diffusion method,and the standards for antimicrobial susceptibility testing complied with the Clinical and Laboratory Standards Institute(CLSI).Molecular characterization of strains was carried out using pulsed-field gel electrophoresis(PFGE).A structured questionnaire was used to record basic epidemiological data(e.g.sex,age,residence,season,etc.).Data were analyzed using Chi-square or Fisher’s exact test.Results:DEC was detected in 127(11.33%)diarrhea cases and 9(2.82%)non-diarrheal cases(χ^(2)=20.69,P<0.001,OR=4.36,95%CI:2.19-8.65),and the prevalence of NTS isolated from diarrhea cases was higher than that of non-diarrheal cases across all age groups(n=42,3.75%,n=1,0.31%,χ^(2)=10.10,P=0.002,OR=12.38,95%CI:1.70-90.29).The rates of resistance to ten antibiotics of DEC and NTS showed significant differences(χ^(2)=386.77,P<0.001;χ^(2)=191.16,P<0.001).The rates of resistance to Amoxicillin and Clavulafiate(AMC),Cephalothin(CEP),Gentamicin(GEN)and Sulfamethoxazole-Trimethoprim(SXT)of DEC isolated from diarrhea cases were higher than those of NTS isolated from diarrhea patients(37.01%vs 14.29%,χ^(2)=7.57,P=0.006;29.92%vs 11.90%,χ^(2)=5.40,P=0.02;37.01%vs 11.90%,χ^(2)=5.80,P=0.016;62.20%vs 26.19%,χ^(2)=16.44,P<0.001;respectively).Ciprofloxacin(CIP)was the most sensitive antibiotic for DEC and NTS strains isolated from diarrhea cases.Resistance rates of DEC isolates from cases and controls to more than three kinds antimicrobials(multidrug resistance,MDR)showed no significant differences(81.10%vs 88.89%,P=0.33).Pulsotype patterns of DEC strains were highly diverse;however,the pulsotype pattern of NTS strains was closely related to the serotype.The pattern of S.enteritidis was highly similar,but the S.enterica Typhimurium strain was discrete.Conclusions:Antibiotic resistance of Enterobacteriaceae is of great concern.The societal effects of antibiotic use justify strict monitoring to combat increases in antimicrobial resistance.Molecular epidemiology and systematic epidemiological investigation can provide accurate evidence for tracking the infection source. | Shun-Xian Zhang Yong-Ming Zhou Li-Guang Tian Jia-Xu Chen Rita Tinoco-Torres Emmanuel Serrano Shi-Zhu Li Shao-Hong Chen Lin Ai Jun-Hu Chen Shang Xia Yan Lu Shan Lv Xue-Jiao Teng Wen Xu Wen-Peng Gu Si-Tang Gong Xiao-Nong Zhou Lan-Lan Geng Wei Hu | 2018 | Infectious Diseases of Poverty2018，7，1： | 7 |
| 11 | Quasi-Static and Dynamic Behaviors of Helical Gear System with Manufacturing Errors显示文摘Time?varying mesh stiffness(TVMS) and gear errors include short?term and long?term components are the two main internal dynamic excitations for gear transmission. The coupling relationship between the two factors is usually neglected in the traditional quasi-static and dynamic behaviors analysis of gear system. This paper investigates the influence of short?term and long?term components of manufacturing errors on quasi?static and dynamic behaviors of helical gear system considering the coupling relationship between TVMS and gear errors. The TVMS, loaded static transmission error(LSTE) and loaded composite mesh error(LCMS) are determined using an improved loaded tooth contact analysis(LTCA) model. Considering the structure of shaft, as well as the direction of power flow and bearing location, a precise generalized finite element dynamic model of helical gear system is developed, and the dynamic responses of the system are obtained by numerical integration method. The results suggest that lighter loading conditions result in smaller mesh stiffness and stronger vibration, and the corresponding resonance speeds of the system become lower. Long?term components of manufacturing errors lead to the appearance of sideband frequency components in frequency spectrum of dynamic responses. The sideband frequency components are predominant under light loading conditions. With the increase of output torque, the mesh frequency and its harmonics components tend to be enhanced relative to sideband frequency components. This study can provide effective reference for low noise design of gear transmission. | Bing Yuan Shan Chang Geng Liu Li-Yan Wu | 2018 | Chinese Journal of Mechanical Engineering2018，31，2： | 6 |
| 12 | Effect of acid density of HZSM-5 on the oligomerization of ethylene in FCC dry gas显示文摘The oligomerization of ethylene in FCC dry gas over HZSM-5 catalyst with different Si/Al2 ratios was studied. The effect of acid density of catalyst on the oligomerization of ethylene was discussed. By increasing the acid density of catalyst, ethylene conversion showed a linear increase, while the yields of olefins decreased when the acid density of catalyst exceeded 0.14 mmolNH3/g owing to a promotion of hydrogen transfer reaction. Through comparing the average distance between acid sites on catalyst with kinetic diameters of olefins, it was found that the dimerization of ethylene was not restrained by the sparse distribution of acid sites, while the hydrogen transfer reaction of C3 and C4 olefins was limited. On these bases, a conclusion is proposed that the dimerization of ethylene proceeded via Eley-Rideal mechanism, while the hydrogen transfer reaction of C3 and C4 olefins followed the Langmuir-Hinshelwood mechanism. | Xue Ding Shan Geng Chunyi Li Chaohe Yang Guohui Wang | 2009 | Journal of Natural Gas Chemistry2009，18，2： | 5 |
| 13 | Human colorectal cancer cells frequently express IgG and display unique Ig repertoire显示文摘BACKGROUND There is growing evidence proving that many human carcinomas, including colon cancer, can overexpress immunoglobulin(Ig); the non B cancer cell-derived Ig usually displayed unique V(D)J rearrangement pattern that are distinct from B cell-derived Ig. Especially, the cancer-derived Ig plays important roles in cancer initiation, progression, and metastasis. However, it still remains unclear if the colon cancer-derived Ig can display unique V(D)J pattern and sequencing, which can be used as novel target for colon cancer therapy.AIM To investigate the Ig repertoire features expressed in human colon cancer cells.METHODS Seven cancerous tissue samples of colon adenocarcinoma and corresponding noncancerous tissue samples were sorted by fluorescence-activated cell sorting using epithelial cell adhesion molecule as a marker for epithelial cells. Ig repertoire sequencing was used to analyze the expression profiles of all 5 classes of Ig heavy chains(IgH) and the Ig repertoire in colon cancer cells and corresponding normal epithelial cells.RESULTS We found that all 5 IgH classes can be expressed in both colon cancer cells and normal epithelial cells. Surprisingly, unlike the normal colonic epithelial cells that expressed 5 Ig classes, our results suggested that cancer cells most prominently express IgG. Next, we found that the usage of Ig in cancer cells caused the expression of some unique Ig repertoires compared to normal cells. Some VH segments, such as VH3-7, have been used in cancer cells, and VH3-74 was frequently present in normal epithelial cells. Moreover, compared to the normal cell-derived Ig, most cancer cell-derived Ig showed unique VHDJH patterns.Importantly, even if the same VHDJH pattern was seen in cancer cells and normal cells, cancer cell-derived IgH always displayed distinct hypermutation hot points.CONCLUSION We found that colon cancer cells could frequently express IgG and unique IgH repertoires, which may be involved in carcinogenesis of colon cancer. The unique IgH repertoire has the potential to be used as a novel target in immune therapy for colon cancer. | Zi-Han Geng Chun-Xiang Ye Yan Huang Hong-Peng Jiang Ying-Jiang Ye Shan Wang Yuan Zhou Zhan-Long Shen Xiao-Yan Qiu | 2019 | World Journal of Gastrointestinal Oncology2019，11，3： | 4 |
| 14 | Deep gold mineralization features of Jiaojia metallogenic belt,Jiaodong gold Province:Based on the breakthrough of 3000 m exploration drilling显示文摘Recently,continuous breakthroughs have been made about deep gold prospecting in the Jiaodong gold province area of China.Approximately 5000 t of cumulative gold resources have been explored in Jiaodong,which has thus become an internationally noteworthy gold ore cluster.The gold exploration depth has been increased to about 2000 m from the previous<1000 m.To further explore the mineralization potential of the Jiaodong area at a depth of about 3000 m,the Shandong Institute of Geological Sciences has drilled an exploratory drillhole named“Deep drillhole ZK01”to a depth of 3266 m.Hence,as reported herein,the mineralization characteristics of the Jiaojia metallogenic belt have been successfully documented.ZK01 is,to date,the deepest borehole with an gold intersect in China,and constitutes a significant advance in deep gold prospecting in China.The findings of this study further indicate that the depth interval of 2000 m to 4000 m below the ground surface in the Wuyi Village area incorporates 912 t of inferred gold resources,while the depth interval of 2000 m to 4000 m below the surface across the Jiaodong area possesses about 4000 t of inferred gold resources.The Jiaojia Fault Belt tends to gently dip downward,having dip angles of about 25°and about 20°at vertical depths of 2000 m and 2850 m,respectively.The deep part of the Jiaojia metallogenic belt differs from the shallow and moderately deep parts about fracturing,alteration,mineralization,and tectonic type.The deep zones can generally be categorized from inside outward as cataclastic granite,granitic cataclasite,weakly beresitized granitic cataclasite,beresitized cataclasite,and gouge.These zones exhibit a gradual transitional relation or occur alternately and repeatedly.The mineralization degree of the pyritized cataclastic granite-type ore in the deep part of the Jiaojia metallogenic belt is closely related to the degree of pyrite vein development;that is,the higher the pyrite content,the wider the veins and the higher the gold grade.Compared to the shallow gold ores,the deep-seated gold ores have higher fineness and contain joseite,tetradymite,and native bismuth,suggesting that the deep gold mineralization temperature is higher and that mantle-sourced material may have contributed to this mineralization.ZK01 has also revealed that the deep-seated ore bodies in the Jiaojia metallogenic belt are principally situated above the main fracture plane(gouge)and hosted within the Linglong Granite,contradicting previous findings indicating that the moderately shallow gold ore bodies are usually hosted in the contact zone between the Linglong Granite and Jiaodong Group or meta-gabbro.These new discoveries are particularly significant because they can help correct mineralization prospecting models,determine favorable positions for deep prospecting,and improve metallogenic prediction and resource potential evaluation. | Xue-feng Yu Da-peng Li Jing-xiang Tian De-ping Yang Wei Shan Ke Geng Yu-xin Xiong Nai-jie Chi Peng-fei Wei Peng-rui Liu | 2020 | China Geology2020，3，3： | 2 |
| 15 | Structural basis for gating mechanism of Pannexin 1 channel显示文摘Dear Editor,Pannexin 1(PANX1)plays extensive physiological roles across diverse fields of biology,including cell death,1,2 inflammation,3 cancer progression,4 and neurological disorders.5 As suggested by biochemical analysis,PANX1 forms an oligomeric channel for the facilitated diffusion of ions and large molecules across the plasma membrane upon activation.6 However,the underlying molecular gating mechanism of PANX1 and the structure of human PANX1 are still elusive.In the current study,we report the cryo-EM structures of full-length and carboxyl-terminal(CT)tail-cleaved human PANX1.Combined with single-channel electrophysiological study,we identified the key residues involved in the gating of PANX1. | Luqiu Mou Meng Ke Mengxiao Song Yuanyue Shan Qingjie Xiao Qingting Liu Jialu Li Ke Sun Lei Pu Li Guo Jia Geng Jianping Wu Dong Deng | 2020 | Cell Research2020，30，5： | 2 |
| 16 | Complete genome sequence of Bacillus thuringiensis Bt185, a potential soil insect biocontrol agent显示文摘Bacillus thuringiensis Bt185 and its insecticidal spectrum-expanded engineering strains are considered as potential biocontrol agents to soil insect Holotrichia parallela,Holotrichia oblita or Anomala corpulenta.Here we reported the complete genome of strain Bt185,it harbors eight plasmids,and plasmid p BT1850294 carries three cry8 genes. | LI Yan-qiu SHU Chang-long SHAN Yue-ming GENG Li-li SONG Fu-ping ZHANG Jie | 2017 | Journal of Integrative Agriculture2017，16，3： | 2 |
| 17 | Clinical outcomes of serolimus-eluting stents versus bare metal stents in ST-segment elevation myocardial infarction patients: a meta-analysis显示文摘背景 sirolimus-eluting stent (SES ) 的好处和安全系统地没在圣片断举起在不同试用被确定心肌的梗塞(STEMI ) 病人与主要或救经皮的冠的干预(一种总线标准) 。比较 SES 和赤裸金属的 stent (BMS ) 的 randomised 试用的元分析被执行。系统的文学搜索被进行识别所有使随机化的临床的试用的方法。主要结果是主要不利心脏的事件(权标) 的率。第二等的结果包括了死亡,周期性的心肌的梗塞,周期性的 revascularization,和 stent 血栓。完全结果, 1973 个 STEMI 病人在把 SES 与 BMS 作比较的七合格使随机化的试用被注册。主要不利心脏的事件的分享的率比在 BMS 组在 SES 组是显著地更低的(9.7% 对 20.3% ,或 2.45, 95% Cl 1.88-3.19, P < 0.00001 ) 。在死亡的所有原因的重要差别都没在 SES 和 BMS 组之间被发现,以及在分享的周期性的心肌的梗塞评价。分享的周期性的 revascularization 率比在 BMS 组在 SES 组是显著地更低的(5.1% 对 14.8% ,或 3.30, 95%Cl 2.37-4.60, P < 0.00001 ) 。没有重要差别在 stent 血栓的分享的率之间被发现(1.2% 在 SES 组织, 2.0% 在 BMS 组织,或 1.61, 95%Cl 0.79-3.26, P=0.19 ) 。结论 SES 被 thegreater 减小在 STEMI 病人在重复 revascularization 与 BMS 相比与主要不利心脏的事件的减少的风险联系。更大的试用与更长列在后面在上面被保证到 betterdefine 在 STEMI 的 SES 的角色。 | PAN Xiao-hong ZHONG Wen-zhao XIANG Mei-xiang XU Geng SHAN Jiang WANG Jian-an | 2009 | Chinese Medical Journal2009，，1： | 1 |
| 18 | Induction of jasmonate signalling regulators MaMYC2s and their physical interactions with MaICE1 in methyl jasmonate‐induced chilling tolerance in banana fruit显示文摘 | MING‐LEI ZHAO JUN‐NING WANG WEI SHAN JIA‐GENG FAN JIAN‐FEI KUANG KE‐QIANG WU XUE‐PING LI WEI‐XIN CHEN FANG‐YUAN HE JIAN‐YE CHEN WANG‐JIN LU | 2012 | Plant Cell & Environment2012，，1： | 1 |
| 19 | Prevalence of diabetic retinopathy in mainland china: a meta-analysis 显示文摘 | Liu L Wu X Liu L Geng J Yuan Z Shan Z | 2012 | PloS One2012，7，45： | 1 |
| 20 | Effect of Temperature and H<sub>2</sub>S Concentration on Corrosion of X52 Pipeline Steel in Acidic Solutions显示文摘 | Rong Shan Wang Li Kui Weng Yan Wei Zhang Jian Qiao Geng Chen Xi Du Er Wei Liu | 2013 | Materials Science Forum2013，，743： | 1 |
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