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| 1 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 2 | 96-Week Treatment of Tenofovir Amibufenamide and Tenofovir Disoproxil Fumarate in Chronic Hepatitis B Patients显示文摘Background and Aims:Tenofovir amibufenamide(TMF)is a novel phosphoramidated prodrug of tenofovir with nonin-ferior efficacy and better bone and renal safety to tenofovir disoproxil fumarate(TDF)in 48 weeks of treatment.Here,we update 96-week comparison results.Methods:Patients with chronic hepatitis B were assigned(2:1)to receive either 25 mg TMF or 300 mg TDF with matching placebo for 96 weeks.The virological suppression was defined as HBV DNA levels<20 IU/mL at week 96.Safety was evaluated thoroughly with focusing on bone,renal,and metabolic pa-rameters.Results:Virological suppression rates at week 96 were similar between TMF and TDF group in both HBeAg-positive and HBeAg-negative populations.Noninferior efficacy was maintained in the pooled population,while it was first achieved in patients with HBV DNA≥7 or 8 log10 IU/mL at baseline.Non-indexed estimated glomerular filtration rate for renal safety assessment was adopted,while a smaller decline of which was seen in the TMF group than in the TDF group(p=0.01).For bone mineral density,patients receiv-ing TMF displayed significantly lower reduction levels in the densities of spine,hip,and femur neck at week 96 than those receiving TDF.In addition,the lipid parameters were stable after week 48 in all groups while weight change still showed the opposite trend.Conclusions:TMF maintained similar efficacy at week 96 compared with TDF with continued superior bone and renal safety profiles(NCT03903796). | Zhihong Liu Qinglong Jin Yuexin Zhang Guozhong Gong Guicheng Wu Lvfeng Yao Xiaofeng Wen Zhiliang Gao Yan Huang Daokun Yang Enqiang Chen Qing Mao Shide Lin Jia Shang Huanyu Gong Lihua Zhong Huafa Yin Fengmei Wang Peng Hu Qiong Wu Chao Pan Wen Jia Chuan Li Chang’an Sun Junqi Niu Jinlin Hou TMF Study Group | 2023 | Journal of Clinical and Translational Hepatology2023，11，3： | 3 |
| 3 | Regulating bifunctional flower-like NiFe_(2)O_(4)/graphene for green EMI shielding and lithium ion storage显示文摘Environment and energy are the eternal hot topics in the world,multiloculated microscale materials have attracted great attention in the field of electromagnetic interference(EMI)shielding and lithium ions storage.Herein,a novel flower-like NiFe_(2)O_(4)/graphene composite with adjustable structure was fabricated as EMI shielding material and anode material of lithium-ion batteries.NiFe_(2)O_(4)/graphene composite is a potential green EMI shielding material.The EMI shielding effectiveness(SE)increases with the increase of graphene content in NiFe_(2)O_(4)/graphene composite,and the total EMI SE of NiFe_(2)O_(4)/graphene with 73.6 wt.%graphene increases from 26.5 to 40.6 d B with the increase of frequency in 2–18 GHz.Furthermore,it exhibits long-life and large capacity lithium storage performance at high current density.The capacity reaches 732.79 m Ah g^(-1)after 100 cycles at 0.1 A g^(-1),recovering to more than 139%from the minimum capacity value.After 300 cycles at 0.5 A g^(-1),the capacity increases to 688.5 mAh g^(-1).The initial capacities at 2 and 5 A g^(-1)are 704.9 and 717.8 mAh g^(-1),and remain 297.9 and 203.2 m Ah g^(-1)after 1000 cycles.The distinguished EMI shielding performance and electrochemical performance are mainly ascribed to the structure regulation of NiFe_(2)O_(4)/graphene composite,as well as the synergistic effect of graphene and NiFe_(2)O_(4).This research opens up infinite opportunities for the application of multifunctional and interdisciplinary materials. | Lihua Yao Wenqiang Cao Jianguo Zhao Qi Zheng Yuchang Wang Shang Jiang Qiliang Pan Jie Song Youqi Zhu Maosheng Cao | 2022 | Journal of Materials Science & Technology2022，，32： | 2 |
| 4 | Highly ordered mesoporous carbons-based glucose/O 2 biofuel cell显示文摘 | Ming Zhou Liu Deng Dan Wen Li Shang Lihua Jin Shaojun Dong | 2009 | Biosensors and Bioelectronics2009，，9： | 1 |
| 5 | Controlled synthesis of ZnO branched nanorod arrays by hierarchical solu- tion growth and application in dye-sensitized solar cells 显示文摘 | Fang Xiaoming Peng Lihua Shang Xiaoying | 2011 | Thin Solid Films2011，519，19： | 1 |
| 6 | Variation of peroxidase isoenzyme and biofilm of Phanerochaete chrysosporium in continuous membrane bioreactor for Reactive Brilliant Red X3-B treatment显示文摘The inuence of a Reactive Brilliant Red X-3B (RBR X-3B) dye on the peroxidase isoenzyme of Phanerochaete chrysosporium was determined, and the biofilm structure in a white rot fungal continuous membrane bioreactor (MBR) was also investigated by scanning electron microscope (SEM). The variation of peroxidase isoenzyme and the decolorization rate in the continuous MBR were evaluated. The results showed that the 100 mg/L RBR X-3B could stimulate the production of the peroxidase isoenzyme in the shaking-ask culture. In addition, two new peroxidase isoenzyme bands with relative mobility (Rf) value of 0.27 and 0.28 appeared, but the activity was lower than the blank control of 11 d. In the continuous MBR, the system worked stably during the first 60 d, the main peroxidase isoenzyme bands existed and three new bands with Rf value of 0.10, 0.27, and 0.28 appeared. Meanwhile, the biofilm grew well and the average decolorization rate could reach 90.6%. But the bands of peroxidase isoenzyme decreased rapidly at day 65, only two bands with Rf value 0.24 and 0.26 existed, and the decolorization rate decreased to 78.3%. Therefore, 5 bottles of P. chrysosporium mycelial pellet were added into the MBR, and then the activity of the peroxidase isoenzyme and the decolorization rate had a slight recovery. Finally, the decolorization rate finally decreased to 75.2%. These results contribute to a comprehensive understanding of the variation of peroxidase isoenzyme and biofilm in continuous MBR by white rot fungi. | GAO Shang, CHEN Cheng, TAO Fang, HUANG Minsheng, MA Lihua, WANG Zhonghua, WU Linhui School of Resource and Environment Science, East China Normal University, Shanghai 200062, China. | 2009 | Journal of Environmental Sciences2009，21，7： | 1 |
| 7 | Astragaloside IV inhibits adenovirus replication and apoptosis in A549 cells in vitro显示文摘 | Lei Shang Zhangyi Qu Lihua Sun | 2011 | J Pharm Pharmacol2011，，63： | 1 |
| 8 | A self-adaptive correction method for perspective distortions of image显示文摘Frequently, the shooting angles available to photograph an object are limited, and the resultant images contain perspective distortions. These distortions make more difficult to perform subsequent tasks like feature extraction and information identification. This paper suggested a perspective correction method that extracts automatically distortion features through edge detection. Results showed that this method is powerful in correcting images with perspective distortions. The corrected image has virtually little information missing, clear features and high recovery rate. | Lihua WU Qinghua SHANG Yupeng SUN Xu BAI | 2019 | Frontiers of Computer Science2019，13，3： | 1 |
| 9 | Left Ventricular Tachycardia Originating Near the Left Main Coronary Artery显示文摘 | Dayi Hu Chenjun Guo Jianjun Yang Lihua Shang Yuyun Xu Kenneth A. Ellenbogen Richard K. Shepard Mark A. Wood | 2000 | Journal of Interventional Cardiac Electrophysiology2000，，2： | 1 |
| 10 | Efficacy and safety of acupoint application for allergic rhinitis: a systematic review and Meta-analysis of randomized controlled trials显示文摘OBJECTIVE: To use evidence-based medicine to explore the efficacy of acupoint application(AA) for allergic rhinitis(AR) at different time points and its safety. METHODS: We searched 7 databases(Pub Med, Cochrane, Embase, China National Knowledge Infrastructure, Wanfang Database, China Science and Technology Journal Database, and China Biology Medicine disc) as well as the international clinical trial registration platform from January 2010 to March 2020 for randomized controlled trials(RCTs) comparing the efficacy of AA versus placebo, Western Medicine or other alternative therapies on AR. Risk of bias was assessed according to the Cochrane handbook, and statistical analysis was performed using Rev Man 5.3. Outcomes included the total effective rate, recurrence rate, total nasal symptom score(TNSS), visual analogue scale(VAS), quality of life measured by the Rhinitis Quality of Life Questionnaire(RQLQ) or Short Form-36(SF-36), adverse events, and biomarkers including immunoglobulin E(Ig E), peripheral blood eosinophil count(EOS), interleukin-4(IL-4), and interferon gamma(INF-γ). RESULTS: Twenty-eight RCTs involving 3282 participants were included. The short-term and long-term efficacy of AA was significantly better than placebo, including better total effective rate [RR: 3.05, 95%CI(1.84, 5.07), after treatment;RR: 9.29, 95%CI(2.57, 33.66), at 6 months], lower recurrence rate [RR: 0.55, 95%CI(0.45, 0.66), at 6 months;RR: 0.65, 95%CI(0.57, 0.74), at 1 year], lower TNSS [MD:-3.09, 95%CI(-3.58,-2.61), after treatment], and lower RQLQ [MD:-14.79, 95%CI(-21.49,-8.10), after treatment;MD:-11.92, 95%CI(-17.40,-6.45), at 4-6 months]. Compared with Western Medicine, AA had better long-term total effective rate [RR: 1.33, 95%CI(1.05, 1.69), at 3 months;RR: 1.49, 95%CI 1.22 to 1.81, at 1 year) and lower recurrence rate [RR: 0.48, 95%CI(0.39, 0.58), at 6 months;RR: 0.45, 95%CI(0.33, 0.60), at 1 year]. AA had better long-term total effective rate versus acupuncture [RR: 2.06, 95% CI(1.28, 3.31), at 1 year] or oral Chinese medicine [RR: 1.21, 95% CI(1.09, 1.34), ≥ 6 months]. Both AA and Western Medicine can reduce serum levels of Ig E, EOS, and IL-4 after treatment. The main adverse event of AA was local skin reaction without systemic side effects. CONCLUSIONS: The short-term(within one month) and long-term(at 3 months, 6 months and 1 year) efficacy of acupoint application on AR was better than that of placebo. The long-term efficacy of acupoint application was superior to that of Western Medicine(at 3 months, 6 months and 1 year), oral Chinese medicine(at more than 6 months) and acupuncture(at 1 year). AA can reduce serum Ig E, EOS, and IL-4 level of AR patients in a short run. Acupoint application is safe, but severe skin reactions can reduce patient compliance. | SHEN Mengxia SHANG Wenfang WU Jiangxia YU Zelin XUAN Lihua | 2022 | Journal of Traditional Chinese Medicine2022，42，6： | 0 |
| 11 | Preparation and evaluation of controllable drug delivery system:A light responsive nanosphere based on β-cyclodextrin/mesoporous silica显示文摘A novel light responsive nanosphere was constructed,and it was used as a drug carrier to investigate the loading and release properties of the Quercetin(QU).In this paper,mesoporous silica nanoparticles(MSN)were used as a substrate,and 3-aminopropyl triethyoxysilane was used as a surface modification agent to introduce—NH_(2),and the azobenzene-4,4’-dicarboxylic acid(AZO)was used as light responsive agent to introduce the group of—N=N—,and thenβ-cyclodextrin(β-CD)was combined with AZO through host-guest interaction to construct light responsive nanoparticles(MSN@β-CD).The structure and properties of the carrier were analyzed by FTIR,BET,XPS,TGA,XRD,SEM and TEM.In vitro drug release studies showed the release rate of QU@MSN@β-CD(dark)was 12.19%within 72 h,but the release rate of QU@MSN@β-CD(light 10 min)was 26.09%,exhibiting a light-responsive property.The CCK8 tests demonstrated that MSN@β-CD could significantly decrease the toxicity of QU.Therefore,the controllable light-responsive drug delivery system has great application prospects. | Yi Wu Hongzhou Shang Shisheng Lai Yali Di Xiaoran Sun Ning Qiao Lihua Han Zheng Zhao Yujin Lu | 2023 | Chinese Journal of Chemical Engineering2023，62，10： | 0 |
| 12 | Global model of plasma-activated water over long time scale:Pulsed discharge and afterglow显示文摘Plasma-activated water(PAW)has been utilised in various application fields,and a deep understanding on the plasma chemistry is the foundation of application-orientated optimisation.In this paper,a global model is built to study the chemical properties of PAW produced by a dielectric barrier discharge that is powered by nanosecond voltage pulses.The applied voltage is firstly repeated with 10 kHz frequency for 100 s,and then shut down for 200 s afterglow,providing a long-term evolution regarding the production and consumption of some typical reactive oxygen/nitrogen species(RONS)in PAW.The calculated results agree principally with experimental measurements from literature.During the pulsed discharge,the water gradually acidises,and the long-lived species accumulate;while in the afterglow,most of the aqueous RONS decay rapidly,except for O_(3aq),NO_(3aq)^(−),H_(2)O_(2aq)and N_(2)O_(aq),which might be the main sources to sustain long-term effects.Furthermore,the effects of applied voltage and gap distance on RONS are investigated.Correlation analyses from Pearson correlation coefficient indicate that gaseous RONS are more sensitive to the gap distance,while the aqueous ones are more sensitive to the voltage amplitude,suggesting the possibility to independently regulating the gaseous and aqueous chemistry. | Wenjun Ning Hao Shang Yiwei Ji Ronghui Li Lihua Zhao Xiaolong Huang Shenli Jia | 2023 | High Voltage2023，8，2： | 0 |
| 13 | Coronary artery anomalies: the left main coronary artery or left anterior descending coronary artery originating from the proximal of right coronary artery显示文摘Coronary artery anomalies (CAAs) are present at birth,but are usually asymptomatic and are found during coronary angiography or multi-slice computed tomography (MSCT) examinations.Their prevalence is less than 1.3% based published series.1,2 The most common coronary anomaly is separate origin of the left anterior descending coronary artery (LAD) and left circumflex coronary artery (LCX) from the left sinus of the Valsalva.The second most common anomaly is the origin of the LCX artery from the right coronary artery (RCA) or right sinus of the Valsalva.We present two cases of coronary artery anomalies:one is the left main coronary artery (LMCA) arising from the proximal RCA,the other is the LAD originating from the proximal RCA. | Xiong Weiguo He Dongyong Lu Chunpeng Qin Xuguang Li Hongliang Xu Xinhua Shang Lihua | 2014 | Chinese Medical Journal2014，，12： | 0 |
| 14 | Optimization of the Ethanol Extraction Method of Monoester Alkaloids from Radix Aconiti Preparata Based on HPLC-MS and Orthogonal Test显示文摘[Objectives] This study was conducted to optimize the ethanol extraction technology of monoester alkaloids from Radix Aconiti Preparata. [Methods]On the basis of defined extraction times,ethanol concentration,ethanol times and extraction time were investigated by HPLC-MS combined with orthogonal test to optimize extraction process using the content of monoester alkaloids( the sum of benzoyl neoaconitine,benzoyl hypoaconitine and benzoyl aconitine) as an index.[Results]The optimum ethanol extraction technology was as follows: 75% ethanol,ethanol amount 25 times of the medicinal material,and each extraction for 1. 5 h.[Conclusions] The optimal extraction technology is simple,feasible,stable and reliable. It can provide reference for the industrial production and quality control of monoester alkaloids from Radix Aconiti Preparata. | Changkai ZHOU Rui ZHANG Xiuling SHANG Lihua ZHOU Zukang ZHANG Jing GAO Hongxia YU Hongyan JI Xiaomin XING Qie GUO Donghua LIU Fangang MENG Jingchun YAO Na ZHANG Yongjun LIU Fanbo JING | 2020 | Agricultural Biotechnology2020，9，3： | 0 |
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