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| 1 | NEDD9 promotes cancer stemness by recruiting myeloid-derived suppressor cells via CXCL8 in esophageal squamous cell carcinoma显示文摘Objective:Esophageal squamous cell carcinoma(ESCC)has high morbidity and mortality rates worldwide.Cancer stem cells(CSCs)may cause tumor initiation,metastasis,and recurrence and are also responsible for chemotherapy and radiotherapy failures.Myeloid-derived suppressor cells(MDSCs),in contrast,are known to be involved in mediating immunosuppression.Here,we aimed to investigate the mechanisms of interaction of CSCs and MDSCs in the tumor microenvironment.Methods:ESCC tissues and cell lines were evaluated.Neural precursor cell expressed,developmentally downregulated 9(NEDD9)was knocked down and overexpressed by lentiviral transfection.Quantitative PCR,Western blot,immunohistochemistry,cell invasion,flow cytometry,cell sorting,multiplex chemokine profiling,and tumor growth analyses were performed.Results:Microarray analysis revealed 10 upregulated genes in esophageal CSCs.Only NEDD9 was upregulated in CSCs using the sphere-forming method.NEDD9 expression was correlated with tumor invasion(P=0.0218),differentiation(P=0.0153),and poor prognosis(P=0.0373).Additionally,NEDD9 was required to maintain the stem-like phenotype.Screening of chemokine expression in ESCC cells with NEDD9 overexpression and knockdown showed that NEDD9 regulated C-X-C motif chemokine ligand 8(CXCL8)expression via the ERK pathway.CXCL8 mediated the recruitment of MDSCs induced by NEDD9 in vitro and in vivo.MDSCs promoted the stemness of ESCC cells through NEDD9 via the Notch pathway.Conclusions:As a marker of ESCC,NEDD9 maintained the stemness of ESCC cells and regulated CXCL8 through the ERK pathway to recruit MDSCs into the tumor,suggesting NEDD9 as a therapeutic target and novel prognostic marker for ESCC. | Dongli Yue Shasha Liu Tengfei Zhang Yong Wang Guohui Qin Xinfeng Chen Huanyu Zhang Dong Wang Lan Huang Feng Wang Liping Wang Song Zhao Yi Zhang | 2021 | Cancer Biology & Medicine2021，18，3： | 4 |
| 2 | Association oftransforming growth factor-β1 gene variants with risk of coal workers'pneumoconiosis显示文摘Objective:The aim of this case-control study was to explore whether five tagging single nucleotide polymorphisms(tSNPs)within the transforming growth factor-β1(TGF-β1)gene were involved in manifestation of inflammatory and fibrotic processes associated with coal workers'pneumoconiosis(CWP).Methods:The study included 508 CWP patients and 526 controls who were underground coal miners from Xuzhou Mining Business Group.Five tSNPs were selected from the HapMap and detected by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)method.Results:The single SNP analysis showed that the genotype frequencies of SNP2(rs1800470,+869T/C,extron 1)and SNP5(rs11466345,intron 5)in CWP cases were sig- nificantly different from those in controls.Multivariate logistic regression analysis revealed that SNP2(rs1800470) CC genotype was associated with decreased risk of CWP(OR=0.50,95%CI=0.32-0.78),which was evident among subgroups of those never smoke(OR=0.40,95%CI=0.24-0.66),cases with stageⅡ(OR=0.41,95%CI =0.22-0.76)and exposure period(<28 y:OR=0.54,95%CI=0.31-0.95;≥28 y:OR=0.52,95%CI=0.32-0.96). However,the SNP5(rs11466345)GG genotype was associated with an increased risk of CWP(OR=2.5,95%CI =1.36-4.57),and further stratification analysis showed that the risk of CWP was increased in both smoking and nonsmoking groups,shorter and longer exposure groups,while the risk of CWP was only increased in patients with stageⅠandⅡ.Conclusion:This study suggests that TGF-β1 polymorphisms may contribute to susceptibility of CWP. | Haiyang Qian Zhifang Song Meilin Wang Xiaomin Jia Aiping Li Ye Yang Lianlian Shen Shasha Wang Chunhui Ni Jianwei Zhou | 2010 | The Journal of Biomedical Research2010，24，4： | 3 |
| 3 | Research on the risk-based model for regional emergency resource allocation for ship-source oil spill显示文摘The key point for rational allocation of emergency resources is to match the oil spill response capacity with the risk of oil spill. This paper proposes an innovative risk-based model for quantitative regional emergency resource allocation, which comprehensively analyzes the factors such as oil spill probability, hazard consequences, oil properties, weathering process and operation efficiency, etc. The model calculates three major resources, i.e.,mechanical recovery, dispersion and absorption, according to the results of risk assessment. In a field application in Xiaohu Port, Guangzhou, China, and the model achieved scientific and rational allocation of emergency resources by matching the assessed risk with the regional capacity, and allocating emergency resources according to capability target. The model is considered to be beneficial to enhancing the resource efficiency and may contribute to the planning of capacity-building programs in high-risk areas. | ZHANG Chunchang AN Wei XIONG Deqi LIU Baozhan SONG Shasha | 2018 | Acta Oceanologica Sinica2018，37，11： | 2 |
| 4 | Sequential immunizations confer cross-protection against variants of SARS-CoV-2,including Omicron in Rhesus macaques显示文摘Variants of concern(VOCs)like Delta and Omicron,harbor a high number of mutations,which aid these viruses in escaping a majority of known SARS-CoV-2 neutralizing antibodies(NAbs).In this study,Rhesus macaques immunized with 2-dose inactivated vaccines(Coronavac)were boosted with an additional dose of homologous vaccine or an RBD-subunit vaccine,or a bivalent inactivated vaccine(Beta and Delta)to determine the effectiveness of sequential immunization.The booster vaccination significantly enhanced the duration and levels of neutralizing antibody titers against wild-type. | Wei Deng Qi Lv Fengdi Li Jiangning Liu Zhiqi Song Feifei Qi Qiang Wei Pin Yu Mingya Liu Shasha Zhou Yaqing Zhang Hong Gao Nan Wang Zijing Jia Kai Gao Jiayi Liu Chong Xiao Haiquan Shang Xiangxi Wang Linlin Bao Chuan Qin | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 2 |
| 5 | Analysis of impacting factors on polarimetric SAR oil spill detection显示文摘Polarimetric synthetic aperture radar(SAR) oil spill detection parameters conformity coefficient(μ), Muller matrix parameters(|C|, B_0), the eigenvalues of simplified coherency matrix(λ_(nos)) and the influence of SAR observing parameters, ocean environment and noise level are investigated. Radarsat-2 data are used to make systematic analysis of polarimetric parameters for different incidences, wind speeds, noise levels and the ocean phenomena(oil slick and look likes). The influence of the SAR observing parameters, the ocean environment and the noise level on the typical polarimetric SAR parameter conformity coefficient has been analyzed. The results indicate that conformity coefficient cannot be simply used for oil spill detection, which represents the image signal to the noise level to some extent. When the signals are below the noise level for the oil slick and the look likes, the conformity coefficients are negative; while the signals above the noise level corresponds to positive conformity coefficients. For dark patches(low wind and biogenic slick) with the signal below the noise,polarization features such as conformity coefficient cannot separate them with oil slick. For the signal above the noise, the oil slick, the look likes(low wind and biogenic slick) and clean sea all have positive conformity coefficients, among which, the oil slick has the smallest conformity coefficient, the look likes the second, and the clean sea the largest value. For polarimetric SAR data oil spill detection, the noise plays a significant role. So the polarimetric SAR data oil spill detection should be carried out on the basis of noise consideration. | SONG Shasha ZHAO Chaofang AN Wei LI Xiaofeng WANG Chen | 2018 | Acta Oceanologica Sinica2018，37，11： | 2 |
| 6 | Reduced salinity interacts with ultraviolet radiation to alter photosystem Ⅱ function in diatom Skeletonema costatum显示文摘To investigate the effect of reduced salinity on diatoms’ capacity to cope with changing ultraviolet radiation(U VR) and photosynthetically active radiation(PAR),Skeletonema costatum was grown in a range of salinity(15,25,and 35).The photo system Ⅱ(PSⅡ) function was analyzed by increasing PAR and UVR to mimic a mixing event in turbulent waters.The re sults show that high UVR exposure significantly reduced PSII activity,especially in cells grown at low salinity.UVR,but not salinity,stimulated the ’removal’ rate of PSII protein PsbA.Salinity alone,in the range of 15 to 35,did not regulate PSⅡ acceptor region;however,the low salinity+UVR treatment decreased the energy flux for electron transport per PSⅡ reaction center in S.costatum.It showed that low salinity exacerbated the damaging effect of UVR on PSⅡ function in S.costatum by suppressing Psb A protein synthe sis and modifying the photochemistry of PSⅡ.Although higher catalase(CAT) activity and NPQs were induced,they were unable to prevent the combined damage effect of low salinity+UVR.Our findings indicate that reduced salinity and increased UVR potentially affect the abundance and distribution of S.costatum with the escalation of climate disturbances. | Shasha ZANG Fang YAN Daode YU Jingjing SONG Lei WANG Zhiguang XU Hongyan WU | 2022 | Journal of Oceanology and Limnology2022，40，4： | 1 |
| 7 | Cores and stable set of extension of convex fuzzy cooperative game显示文摘 | YANG Shasha GAO Zuofeng SONG Shasha | 2013 | Joumal of Liaoning Technical University(Natural Science)2013，32，2： | 1 |
| 8 | L1CAM overexpression promotes tumor progression through recruitment of regulatory T cells in esophageal carcinoma显示文摘Objective:L1 cell adhesion molecule(L1 CAM)exhibits oncogenic activity in tumors.However,the link between L1 CAM and the tumor microenvironment remains poorly understood in patients with esophageal squamous cell carcinoma(ESCC).In this study,we investigated how L1 CAM expression in ESCC affects the oncogenic characteristics of tumor cells and the tumor microenvironment.Methods:Human ESCC samples were collected,and the m RNA and protein levels of L1 CAM were examined by real-time PCR and immunohistochemistry.Overexpression and knockdown gene expression assays were used for mechanistic studies.The cell proliferation and cell cycle were measured with CCK-8 assays and flow cytometry.Cell migration and invasion ability were measured with Transwell assays.Multiplex bead-based assays were performed to identity the factors downstream of L1 CAM.Xenograft studies were performed in nude mice to evaluate the effects of L1 CAM on tumor growth and regulatory T cell(Treg)recruitment.Results:L1 CAM expression was significantly elevated in ESCC tissues(P<0.001)and correlated with poorer prognosis(P<0.05).Ablation of L1 CAM in ESCC cells inhibited tumor growth and migration,and increased tumor cell apoptosis(P<0.05).In the tumor microenvironment,L1 CAM expression correlated with Treg infiltration in ESCC by affecting CCL22 secretion.Mechanistically,L1 CAM facilitated CCL22 expression by activating the PI3 K/Akt/NF-κB signaling pathway.Furthermore,CCL22 promoted Treg recruitment to the tumor site;the Tregs then secreted TGF-β,which in turn promoted L1 CAM expression via Smad2/3 in a positive feedback loop.Conclusions:Our findings provide new insight into the mechanism of immune evasion mediated by L1 CAM,suggesting that targeting L1 CAM-CCL22-TGF-βcrosstalk between tumor cells and Tregs may offer a unique means to improve treatment of patients with ESCC. | Xuan Zhao Shasha Liu Xinfeng Chen Jianyi Zhao Feng Li Qitai Zhao Tan Xie Lan Huang Zhen Zhang Yu Qi Yang Yang Song Zhao Yi Zhang | 2021 | Cancer Biology & Medicine2021，18，2： | 1 |
| 9 | Seeding Performance Simulations and Experiments for a Spoon- Wheel Type Precision Cottonseed-Metering Device Based on EDEM显示文摘To study the effects of seed metering on seeding performance under different motion parameters,a simulation model for a spoonwheel type seeder was established.A seed meter was tested by using EDEM(Engineering Discrete Element Method)software to simulate its working process at different speeds and tilt angles.The trajectories of individual cottonseeds in the seed-metering device were obtained,concurrently,the stress trend in the grain group was determined as a function of time.The simulation results suggest that at larger speeds,the metering index of the seed meter gradually decreases,while the index and the missing index gradually increase.As the tilt angle increased,the multiples index and missing index gradually decreased,while the multiples index gradually increased.When the seed meter speed reached 50 r/min and the tilt angle was 15°,the seed meter had a relatively good working performance with a seed spacing acceptance index of 92.59%,a multiples index of 1.85%,and a missing rate index of 5.56%.The seed meter was tested on a bench by using a JPS-12 performance-tester bench.At the aforementioned speed and angle,the coefficient of variation for the cottonseed spacing was 2.1%.The field trial results indicated that the multiples and the missing rates were higher than those for the tester bench but still met a passing rate of more than 90%.The coefficient of variation for the seed spacing was less than 10%,suggesting that the design could be used for field sowing.The resulting seeding uniformity was higher under these conditions,which indicates that the seed meter has a better working performance and the bench has a good seeding effect. | Yudao LI Shulun XING Shasha LI Li LIU Xiaohui ZHANG Zhanhua SONG Fade LI | 2020 | Mechanical Engineering Science2020，2，1： | 1 |
| 10 | Characteristics of shale gas reservoirs in Wufeng Formation and Longmaxi Formation in Well WX2,northeast Chongqing显示文摘To further understand shale reservoir characteristics of Wufeng Formation and Longmaxi Formation in the Wuxi area,northeast Chongqing,based on drilling data of Well WX2,and taking the graptolite biostratigraphy as the standard marker of stratigraphic division and comparison,the geochemistry,petrology,reservoir space and properties of organic-rich black shale were well investigated,and its gasbearing capacity and controlling factors were also analyzed.The result shows that in the Wufeng Formation and Longmaxi Formation of Well WX2,the organic-rich shale is 89.8 m thick and is characterized by good kerogen type,high organic abundance,moderate maturity and favorable hydrocarbongeneration condition,and the graptolite sequence is developed completely and continuously;the organic abundance is influenced by depositional rate,and the slow depositional rate is favorable for accumulation of organic matter in the black graptolite shale;from top to bottom,content of siliceous minerals increases and content of clay minerals decrease,therefore the brittleness increases;the organicrich siliceous shale and clay siliceous shale are favorable lithofacies for development of shale reservoirs;the nanopore is dominated by the parallel-plate pore with four open sides and has good connectivity;the pore size distribution curve has the multimodal characteristic,and the pore diameter mainly is in the range of 0.42e0.62 nm and the range of 3e5 nm;organic pores and interlayer pores of clay minerals make the greatest contribution to the total pore volume,while pores of brittle minerals have the least contribution;from top to bottom,organic pores gradually increase while interlayer pores of clay minerals gradually decrease;the on-site core gas content exceeds 8 m3/t,and the gas-bearing capacity is jointly controlled by hydrocarbon generation,reservoir and preservation conditions;and the WF2-LM6 biozone of the Katian to the early Aeronian is the high-quality shale reservoir,where the LM1 biozone of the Hirnantian was the best“sweet spot”which is the target of horizontal well drilling. | Jin Wu Feng Liang Wen Lin Hongyan Wang Wenhua Bai Chao Ma Shasha Sun Qun Zhao Xiaojiang Song Rongze Yu | 2017 | Petroleum Research2017，2，4： | 1 |
| 11 | Silver ions/ovalbumin films layer-by-layer self-assembled polyacrylonitrile nanofibrous mats and their antibacterial activity显示文摘 | Rukun Song Jinjiao Yan Shasha Xu Yuntao Wang Ting Ye Jing Chang Hongbing Deng Bin Li | 2013 | Colloids and Surfaces B: Biointerfaces2013，，： | 1 |
| 12 | Study on a Comprehensive Assessment System for Wood-Frame Building Environment显示文摘 | Song shasha Wang xiaohuan Yang feng Fei benhua | 2013 | Wood Research2013，58，3： | 1 |
| 13 | Enhancing the cycling stability of Na-ion batteries by bonding MoS2 on assembled carbon-based materials显示文摘Room temperature Na-ion batteries(SIBs) show great potential for use as renewable energy storage systems.However, the large-scale application of SIBs has been hindered by the lack of an ideal SIBs anode material. We synthesized MoS2 on carbonized graphene-chitosan(G-C) using the hydrothermal method. The strong interaction between the MoS2 and the G-C greatly improved the electron transport rate and maintained the structural stability of the electrode, which lead to both an excellent rate capability and long cycle stability. The G-C monolith was proven to enhance the electrical conductivity of the composites and served as a matrix for uniformly dispersing active MoS2 nanosheets(NSs), as well as being a buffer material to adapt to changes in volume during the cycle.Serving as an anode material for SIBs, the MoS2-G-C electrode showed good cycling stability(527.3mAh g-1 at100 m A g-1 after 200 cycles), excellent rate capability, and a long cycle life(439.1 m Ah g-1 at 1 A g-1 after 200 cycles). | Pin Song Jun Di Lixing Kang Manzhang Xu Bijun Tang Jun Xiong Jiewu Cui Qingsheng Zeng Jiadong Zhou Yongmin He Qundong Fu Juan Peng Shasha Guo Bo Lin Jingyu Zhang Peng Meng Zheng Liu | 2019 | Nano Materials Science2019，1，4： | 0 |
| 14 | The First Crested Duck Genome Reveals Clues to Genetic Compensation and Crest Cushion Formation显示文摘The Chinese crested(CC)duck is a unique indigenous waterfowl breed,which has a crest cushion that affects its survival rate.Therefore,the CC duck is an ideal model to investigate the genetic compensation response to maintain genetic stability.In the present study,we first generated a chromosome-level genome of CC ducks.Comparative genomics revealed that genes related to tissue repair,immune function,and tumors were under strong positive selection,indicating that these adaptive changes might enhance cancer resistance and immune response to maintain the genetic stability of CC ducks.We also assembled a Chinese spot-billed(Csp-b)duck genome,and detected the structural variations(SVs)in the genome assemblies of three ducks(i.e.,CC duck,Csp-b duck,and Peking duck).Functional analysis revealed that several SVs were related to the immune system of CC ducks,further strongly suggesting that genetic compensation in the anti-tumor and immune systems supports the survival of CC ducks.Moreover,we confirmed that the CC duck originated from the mallard ducks.Finally,we revealed the physiological and genetic basis of crest traits and identified a causative mutation in TAS2R40 that leads to crest formation.Overall,the findings of this study provide new insights into the role of genetic compensation in adaptive evolution. | Guobin Chang Xiaoya Yuan Qixin Guo Hao Bai Xiaofang Cao Meng Liu Zhixiu Wang Bichun Li Shasha Wang Yong Jiang Zhiquan Wang Yang Zhang Qi Xu Qianqian Song Rui Pan Lingling Qiu Tiantian Gu Xinsheng Wu Yulin Bi Zhengfeng Cao Yu Zhang Yang Chen Hong Li Jianfeng Liu Wangcheng Dai Guohong Chen | 2023 | Genomics, Proteomics & Bioinformatics2023，21，3： | 0 |
| 15 | Unsaturated bi-heterometal clusters in metal-vacancy sites of 2D MoS2 for efficient hydrogen evolution显示文摘The valence states and coordination structures of doped heterometal atoms in two-dimensional(2D)nanomaterials lack predictable regulation strategies.Hence,a robust method is proposed to form unsaturated heteroatom clusters via the metal-vacancy restraint mechanism,which can precisely regulate the bonding and valence state of heterometal atoms doped in 2D molybdenum disulfide.The unsaturated valence state of heterometal Pt and Ru cluster atoms form a spatial coordination structure with Pt–S and Ru–O–S as catalytically active sites.Among them,the strong binding energy of negatively charged suspended S and O sites for H+,as well as the weak adsorption of positively charged unsaturated heterometal atoms for H*,reduces the energy barrier of the hydrogen evolution reaction proved by theoretical calculation.Whereupon,the electrocatalytic hydrogen evolution performance is markedly improved by the ensemble effect of unsaturated heterometal atoms and highlighted with an overpotential of 84 mV and Tafel slope of 68.5 mV dec^(−1).In brief,this metal vacancy-induced valence state regulation of heterometal can manipulate the coordination structure and catalytic activity of heterometal atoms doped in the 2D atomic lattice but not limited to 2D nanomaterials. | Gonglei Shao Jie Xu Shasha Gao Zhang Zhang Song Liu Xu Zhang Zhen Zhou | 2024 | Carbon Energy2024，6，3： | 0 |
| 16 | FPGA-based Digital Implementation of Flexible Power Control for Three-phase to Single-phase MMC-based Advanced Co-phase Traction Power Supply System显示文摘A three-phase to single-phase modular multilevel converter based advanced co-phase traction power supply(MMC-ACTPS) system is an effective structure to address the concerns of phase splitting and poor power quality of the conventional electrified railway. Due to the large number of MMCACTPS system modules, I/O resources and computing speed have high requirements on processors. Moreover, the module capacitor balance is challenging because the sorting time is too long when the traditional sorting algorithm for voltage balance is used. To solve the above issues, a digital implementation scheme of flexible power control strategy for three-phase to single-phase MMC-ACTPS system based on field programmable gate array(FPGA), which has sufficient I/O resources, has been proposed. Due to the parallel execution characteristics of the FPGA, the execution time of the controller and the modulator can be greatly reduced compared with a digital signal processor(DSP) + FPGA or DSpace. In addition, an improved sorting algorithm is proposed to reduce the sorting time and the implementation steps are analyzed. Finally, simulation and experimental results are presented to demonstrate the effectiveness and correctness of the proposed control strategy. | Jiangpeng Yang Hongjian Lin Haotian Zhu Zeliang Shu Lan Ma Changsong Cai Pengcheng Zhang Li He Ruoyu Li Shasha Song Josep M.Guerrero | 2023 | Journal of Modern Power Systems and Clean Energy2023，11，6： | 0 |
| 17 | The Dynamics of Dopamine D_(2) Receptor-Expressing Striatal Neurons and the Downstream Circuit Underlying L-Dopa-Induced Dyskinesia in Rats显示文摘L-dopa(l-3,4-dihydroxyphenylalanine)-induced dyskinesia(LID)is a debilitating complication of dopamine replacement therapy for Parkinson’s disease.The potential contribution of striatal D_(2) receptor(D2R)-positive neurons and downstream circuits in the pathophysiology of LID remains unclear.In this study,we investigated the role of striatal D_(2)R+neurons and downstream globus pallidus externa(GPe)neurons in a rat model of LID.Intrastriatal administration of raclopride,a D_(2)R antagonist,significantly inhibited dyskinetic behavior,while intrastriatal administration of pramipexole,a D_(2)-like receptor agonist,yielded aggravation of dyskinesia in LID rats.Fiber photometry revealed the overinhibition of striatal D_(2)R+neurons and hyperactivity of downstream GPe neurons during the dyskinetic phase of LID rats.In contrast,the striatal D2R+neurons showed intermittent synchronized overactivity in the decay phase of dyskinesia.Consistent with the above findings,optogenetic activation of striatal D_(2)R+neurons or their projections in the GPe was adequate to suppress most of the dyskinetic behaviors of LID rats.Our data demonstrate that the aberrant activity of striatal D_(2)R+neurons and downstream GPe neurons is a decisive mechanism mediating dyskinetic symptoms in LID rats. | Kuncheng Liu Miaomiao Song Shasha Gao Lu Yao Li Zhang Jie Feng Ling Wang Rui Gao Yong Wang | 2023 | Neuroscience Bulletin2023，39，9： | 0 |
| 18 | Temperature determines the shift of thermal neutral zone and influences thermogenic capacity in striped hamsters显示文摘The thermoneutral zone(TNZ)reflects the adaptation of mammals to their natural habitat.However,it remains unclear how TNZ shifts in response to variations in ambient temperature.To test the hypothesis that ambient temperature plays a key role in determining TNZ variations between seasons,we measured metabolic rate,body temperature,and cytochrome c oxidase(COX)activity of several visceral organs in striped hamsters(Cricetulus barabensis)either acclimated to semi-natural conditions over a year,or subjected to a gradual decrease in mean temperature from 30±1°C to-15±1°C.The TNZ range in striped hamsters differed seasonally,with a wider TNZ and a lower lower-critical temperature in winter compared to summer.The hamsters showed a consider-able leftward shift of lower-critical temperature from 30°C to 20°C after the ambient temperature of acclimation from 30°C down to-15°C,whereas the upper-critical temperature of TNZ remainedfixed at 32.5°C.The rest-ing metabolic rate in thermoneutral zone(RMRt),nonshivering thermogenesis(NST),and COX activity of brown adipose tissue,liver,skeletal muscle,brain,and kidneys,increased significantly in hamsters acclimated at lower ambient temperatures.Following acute exposure to 5°C and-15°C,hamsters acclimated to 32.5°C had signifi-cantly lower maximal NST and lower serum thyroid tri-iodothyronine(T3)levels compared to those kept at 23°C.Thesefindings suggest that acclimation to the upper-critical temperature of TNZ impairs the hamsters’thermo-genic capacity to cope with extreme cold temperature.Reduced ambient temperature was mainly responsible for the leftward shift of TNZ in striped hamsters,which reflects the adaptation to cold environments. | Shasha LIAO Song TAN Meizhi JIANG Jing WEN Jinsong LIU Jing CAO Ming LI Zhijun ZHAO | 2023 | Integrative Zoology2023，18，2： | 0 |
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