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| 1 | Quantitative Analysis of Paleoatmospheric CO2 Level Based on Stomatal Characters of Fossil Ginkgo from Jurassic to Cretaceous in China显示文摘更好理论的 A 并且在地质的历史期间的在 paleo-CO_2 和气候之间的连接的实际理解是重要的提高现代人的社会的持续发展。自从 1980 年代,在植物生理学的开发导致了石块植物能为 paleoatmosphere 和 paleobiosphere 作为一个代理服务的实现。作为有进化壅滞的寡妇裸子植物,白果树很好适合 paleoenvironmental 重建。这篇论文用植物生理学的解剖数据在中国的北方从综合阶层分析石块白果树种类。用有气孔的参数,为 paleo-C0_2 水平的一个趋势在早中间的侏罗记和早白垩纪期间被获得,它与由 GEOCARB 的估计一致。趋势也类似于在地质的时间的吝啬的全球表面温度的。与三个另外的大气的 CO_2 集中参数相比, paleo-CO_2 水平的趋势基于从三个连续阶层的石块白果树标本的有气孔的参数是更多准确。 | SUN Bainian XIAO Liang XIE Sanping DENG Shenghui WANG Yongdong JIA Hui Susan Tumer | 2007 | Acta Geologica Sinica(English Edition)2007，81，6： | 23 |
| 2 | MdGSTF6,activated by MdMYB1,plays an essential role in anthocyanin accumulation in apple显示文摘Anthocyanins are biosynthesized on the cytosolic surface of the endoplasmic reticulum and then transported into the vacuole for storage.Glutathione S-transferases(GSTs)are considered to be responsible for the transport of anthocyanins into the vacuole.However,the regulatory mechanisms of GSTs in plants are still unclear.Here,we performed a genome-wide analysis and identified 69 GST genes in apple.The expression of MdGSTF6 was positively correlated with the anthocyanin content(r=0.949)during‘Yanfu 8’fruit development.The overexpression of MdGSTF6 in the Arabidopsis thaliana tt19 mutant resulted in seedlings of 35S::MdGSTF6-GFP/tt19 that could accumulate anthocyanin and rescue its phenotype,suggesting that MdGSTF6 was an anthocyanin transporter.The silencing of MdGSTF6 affected anthocyanin accumulation in apple fruit.Moreover,the knockdown of MdGSTF6 by RNA interference in cultured‘Gala’seedlings inhibited anthocyanin accumulation.The interaction experiments showed that MdMYB1 could bind directly to the MdGSTF6 promoter to transcriptionally activate its expression.Collectively,our results demonstrate that MdGSTF6 encodes an important GST transporter of anthocyanins in apple fruit and provide evidence for the associated regulatory mechanisms.Therefore,MdMYB1 can not only regulate anthocyanin synthesis,but also control the transport of anthocyanin in apples.This information may be useful for further clarifying the regulation of anthocyanin transport in apple. | Shenghui Jiang Min Chen Naibo He Xiaoliu Chen Nan Wang Qingguo Sun Tianliang Zhang Haifeng Xu Hongcheng Fang Yicheng Wang Zongying Zhang Shujing Wu Xuesen Chen | 2019 | Horticulture Research2019，6，1： | 16 |
| 3 | Malus sieversii: the origin, flavonoid synthesis mechanism, and breeding of red-skinned and red-fleshed apples显示文摘Flavonoids play essential roles in human health.Apple(Malus domestica Borkh.),one of the most widely produced and economically important fruit crops in temperate regions,is a significant source of flavonoids in the human diet and is among the top nutritionally rated and most widely consumed fruits worldwide.Epidemiological studies have shown that the consumption of apples,which are rich in a variety of free and easily absorbable flavonoids,is associated with a decreased risk of various diseases.However,apple production is challenged by serious inbreeding problems.The narrowing of the hereditary base has resulted in apples with poor nutritional quality and low flavonoid contents.Recently,there have been advances in our understanding of the roles that Malus sieversii(Ledeb.)M.Roem has played in the process of apple domestication and breeding.In this study,we review the origin of cultivated apples and red-fleshed apples,and discuss the genetic diversity and construction of the core collections of M.sieversii.We also discuss current research progress and breeding programs on red-skinned and red-fleshed apples and summarize the exploitation and utilization of M.sieversii in the breeding of high-flavonoid,and red-fleshed apples.This study highlights a valuable pattern of horticultural crop breeding using wild germplasm resources.The future challenges and directions of research on the molecular mechanisms of flavonoid accumulation and high-flavonoid apple breeding are discussed. | Nan Wang Shenghui Jiang Zongying Zhang Hongcheng Fang Haifeng Xu Yicheng Wang Xuesen Chen | 2018 | Horticulture Research2018，5，1： | 15 |
| 4 | Abscisic Acid Antagonizes Ethylene Production through the ABI4-Mediated Transcriptional Repression of ACS4 and ACS8 in Arabidopsis显示文摘增加的证据表明了 abscisic 酸(骆驼毛的织物) 否定地调制乙烯生合成,尽管内在的机制仍然保持不清楚。为了识别因素,包含了,我们在 Arabidopsis 与改变的乙烯生产为骆驼毛的织物感觉迟钝的异种进行了一幅屏幕。ABI4 的主导的等位基因, abi4-152,在 ABI4 的 C 终点与 16-amino-acid 截断生产通常认为的蛋白质,减少乙烯生产。由对比, ABI4 的二后退的猛烈等位基因, abi4-102 和 abi4-103,导致增加的乙烯进化,显示 ABI4 否定地调整乙烯生产。进一步的分析证明乙烯生合成基因 ACS4, ACS8,和 ACO2 的 thatexpression 显著地在 abi4-152 被减少,但是在猛烈异种增加了,与骆驼毛的织物上的部分依赖。染色质 immunoprecipitation 量的 PCR 试金证明 ABI4 直接绑这些乙烯生合成基因的倡导者,那件骆驼毛的织物提高这个相互作用。包含截断的 ABI4-152 肽的熔化蛋白质在转基因的植物比它的全身的对应物积累了到高水平,建议 ABI4 被它的 C 终点使动摇。因此,我们的结果证明那件骆驼毛的织物否定地在 Arabidopsis 通过乙烯生合成基因 ACS4 和 ACS8 的调停 ABI4 的 transcriptional 压抑调整乙烯生产。 | Zhijun Dong Yanwen Yu Shenghui Li Juan Wang Saijun Tang Rongfeng Huang | 2016 | Molecular Plant2016，9，1： | 9 |
| 5 | Determination of cloud-top height from stereoscopic observation显示文摘A new and accurate method is presented based on the cloud movement (height and position), the spherical and plane triangular relationships of the spacecraft, the center of the earth, the projected-cloud and the true-cloud for determination of cloud-top height and position. Synthetic stereo images that have spatial resolution of 1.25 km from a single satellite are used to test this method. It is demonstrated that the cloud-top structure can be determined from the stereoscopic measurements of geo-synchronous satellite with vertical accuracy of approximately 500 m. The vertical accuracy can be better with lower orbiters. | WANG Hongqing , LU Shenghui, ZHANG Yan and TAO Zuyu(Department of Atmospheric Science/School of Physics, Peking University, Beijing 100871, China) | 2002 | Progress in Natural Science:Materials International2002，12，9： | 9 |
| 6 | The computational fluid dynamic modeling of downwash flow field for a six-rotor UAV显示文摘The downwash flow field of the multi-rotor unmanned aerial vehicle(UAV), formed by propellers during operation, has a significant influence on the deposition, drift and distribution of droplets as well as the spray width of the UAV for plant protection. To study the general characteristics of the distribution of the downwash airflow and simulate the static wind field of multi-rotor UAVs in hovering state, a 3 D full-size physical model of JF01-10 six-rotor plant protection UAV was constructed using Solid Works. The entire flow field surrounding the UAV and the rotation flow fields around the six rotors were established in UG software. The physical model and flow fields were meshed using unstructured tetrahedral elements in ANSYS software.Finally, the downwash flow field of UAV was simulated.With an increased hovering height, the ground effect was reduced and the minimum current velocity increased initially and then decreased. In addition, the spatial proportion of the turbulence occupied decreased. Furthermore, the appropriate operational hovering height for the JF01-10 is considered to be 3 m. These results can be applied to six-rotor plant protection UAVs employed in pesticide spraying and spray width detection. | Yongjun ZHENG Shenghui YANG Xingxing LIU Jie WANG Tomas NORTON Jian CHEN Yu TAN | 2018 | Frontiers of Agricultural Science and Engineering2018，5，2： | 8 |
| 7 | Stratigraphy of the Triassic-Jurassic Boundary Successions of the Southern Margin of the Junggar Basin,Northwestern China显示文摘The Triassic-Jurassic(Tr-J) boundary marks a major extinction event,which(~200 Ma) resulted in global extinctions of fauna and flora both in the marine and terrestrial realms.There prevail great challenges in determining the exact location of the terrestrial Tr-J boundary,because of endemism of taxa and the scarcity of fossils in terrestrial settings leading to difficulties in linking marine and terrestrial sedimentary successions.Investigation based on palynology and bivalves has been carried out over a 1113 m thick section,which is subdivided into 132 beds,along the Haojiagou valley on the southern margin of the Junggar Basin of the northern Xinjiang,northwestern China.The terrestrial Lower Jurassic is conformably resting on the Upper Triassic strata.The Upper Triassic covers the Huangshanjie Formation overlaid by the Haojiagou Formation,while the Lower Jurassic comprises the Badaowan Formation followed by the Sangonghe Formation.Fifty six pollen and spore taxa and one algal taxon were identified from the sediments.Based on the key-species and abundance of spores and pollen,three zones were erected:the Late Triassic(Rhaetian) Aratrisporites-Alisporites Assemblage,the Early Jurassic(Hettangian) Perinopollenites-Pinuspollenites Assemblage,and the Sinemurian Perinopollenites-Cycadopites Assemblage.The Tr-J boundary is placed between bed 44 and 45 coincident with the boundary between the Haojiagou and Badaowan formations.Beds with Ferganoconcha(?),Unio-Ferganoconcha and Waagenoperna-Yananoconcha bivalve assemblages are recognized.The Ferganoconcha(?) bed is limited to the upper Haojiagou Formation, Unio-Ferganoconcha and Waagenoperna-Yananoconcha assemblages are present in the middle and upper members of the Badaowan Formation.The sedimentary succession is interpreted as terrestrial with two mainly lake deposit intervals within Haojiagou and Badaowan formations,yielding fresh water algae and bivalves.However,the presence of brackish water algae Tasmanites and the marine-littoral facies bivalve Waagenoperna from the Badaowan Formation indicate that the Junggar Basin was influenced by sea water caused by transgressions from the northern Tethys,during the Sinemurian. | SHA Jingeng Vivi VAJDA PAN Yanhong Linda LARSSON YAO Xiaogang ZHANG Xiaolin WANG Yaqiong CHENG Xiansheng JIANG Baoyu DENG Shenghui CHEN Siwei PENG Bo | 2011 | Acta Geologica Sinica(English Edition)2011，85，2： | 7 |
| 8 | MdMYB6 regulates anthocyanin formation in apple both through direct inhibition of the biosynthesis pathway and through substrate removal显示文摘Anthocyanin biosynthesis and sugar metabolism are important processes during plant growth,but the molecular interactions underlying these pathways are still unclear.In this work,we analyzed the anthocyanin and soluble sugar contents,as well as the transcript levels of transcription factors that are known to be related to the biosynthesis of anthocyanin in‘Hongcui 1’apple flesh during fruit development.Overexpression of MdMYB6 in red-fleshed calli was found to reduce anthocyanin content and result in downregulated expression of the MdANS and MdGSTF12 proteins.Yeast one-hybrid and electrophoretic mobility shift analyses showed that MdMYB6 could directly bind to the promoters of MdANS and MdGSTF12,indicating that MdMYB6 could inhibit anthocyanin biosynthesis by regulating MdANS and MdGSTF12.Overexpression of MdTMT1 in the Arabidopsis tmt1 mutant restored the glucose and fructose contents to the wild-type levels,while overexpression of MdTMT1 in red-fleshed calli increased the contents of glucose and fructose but reduced the contents of UDP-glucose,UDP-galactose,and anthocyanin.Using a GUS reporter system,yeast one-hybrid,chromatin immunoprecipitation-PCR and electrophoretic mobility shift analyses,we found that MdMYB6 could bind to the promoter of MdTMT1,resulting in increased promoter activity.Overexpression of MdMYB6 in calli overexpressing MdTMT1 increased the expression of MdTMT1,which led to reduced contents of UDP-glucose and UDP-galactose and decreased anthocyanin content compared to those of the calli that overexpressed MdTMT1.This finding suggested that MdMYB6 could also inhibit anthocyanin biosynthesis by regulating MdTMT1 to decrease the contents of UDP-glucose and UDP-galactose.Taken together,these results showed that MdMYB6 and MdTMT1 play key roles in both anthocyanin biosynthesis and sugar transport. | Haifeng Xu Qi Zou Guanxian Yang Shenghui Jiang Hongcheng Fang Yicheng Wang Jing Zhang Zongying Zhang Nan Wang Xuesen Chen | 2020 | Horticulture Research2020，7，1： | 6 |
| 9 | Sediment Transport in the Nearshore Area of Phoenix Island显示文摘Based on the measured data, suspended sediment concentration, surface sediment grain size, current and waves, the sediment transport mechanisms and pathways in the Phoenix Island area were analyzed using methods of flux decomposition and Grain Size Trend Analysis(GSTA). The results show that net suspended sediment is mainly transported by average current, Stokes drift, and gravitational circulation. The transport direction of suspended sediment is varying and basically following the direction of residual tidal currents. Surface sediment transport pathways are primarily parallel to the coastline along with two convergent centers. Waves and longshore currents have a significant influence on sediment transport, but the influence is limited due to a steep and deep underwater bank. Tidal current is the main controlling factor for sediment transport, especially in the deep water area. Neither suspended nor surface sediment is transported towards the southwest. The South Shandong Coastal Current(SSCC) has little effect on sediment transport processes in the nearshore area of Phoenix Island. | HU Rijun MA Fang WU Jianzheng ZHANG Wei JIANG Shenghui XU Yongchen ZHU Longhai WANG Nan LIU Aijiang | 2016 | Journal of Ocean University of China2016，15，5： | 4 |
| 10 | L-type calcium current in right ventricular outflow tract myocytes of rabbit heart显示文摘The mechanism of idiopathic ventricular tachycardia originating from the right ventricular outflow tract (RVOT) is not clear. Many clinical reports have suggested a mechanism of triggered activity. However, there are few studies investigating this because of the technical difficulties associated with examining this theory. The L-type calcium current (ICa-L), an important inward current of the action potential (AP), plays an important role in arrhythmogenesis. The aim of this study was to explore differences in the APs of right ventricular (RV) and RVOT cardiomyocytes, and differences in electrophysiological characteristics of the ICa-L in these myocytes. Rabbit RVOT and RV myocytes were isolated and their AP and ICa-L were investigated using the patch-clamp technique. RVOT cardiomyocytes had a wider range of AP duration (APD) than RV cardiomyocytes, with some markedly prolonged APDs and markedly shortened APDs. The markedly shortened APDs in RVOT myocytes were abolished by treatment with 4-AP, an inhibitor of the transient outward potassium current, but the markedly prolonged APDs remained, with some myocytes with a long AP plateau not repolarizing to resting potential. In addition, early afterdepolarization (EAD) and second plateau responses were seen in RVOT myocytes but not in RV myocytes. RVOT myocytes had a higher current density for ICa-L than RV myocytes (RVOT (13.16±0.87) pA pF-1, RV (8.59±1.97) pA pF-1; P<0.05). The ICa-L and the prolonged APD were reduced, and the EAD and second plateau response disappeared, after treatment with nifedipine (10 μmol L-1), which blocks the ICa-L. In conclusion, there was a wider range of APDs in RVOT myocytes than in RV myocytes, which is one of the basic factors involved in arrhythmogenesis. The higher current density for ICa-L is one of the factors causing prolongation of the APD in RVOT myocytes. The combination of EAD with prolonged APD may be one of the mechanisms of RVOT-VT generation. | LIANG ShengHui LIN ChenHui LI Yuan LIU TaiFeng WANG Yan | 2012 | Science China(Life Sciences)2012，55，1： | 3 |
| 11 | Beach Morphology and Coastline Evolution in the Southern Bohai Strait显示文摘The beach studied in this paper spans a length of 51 km and is one of several long sandy beaches in the southern Bohai Strait. Due to the obstruction of islands in the northeast and the influence of the underwater topography, the wave environment in the offshore area is complex; beach types and sediment transport characteristics vary along different coasts. The coastlines extracted from six aerial photographs in different years were compared to demonstrate the evolving features. Seven typical beach profiles were selected to study the lateral beach variation characteristics. Continuous wind and wave observation data from Beihuangcheng ocean station during 2009 were employed for the hindcast of the local wave environment using a regional spectral wave model. Then the results of the wave hindcast were incorporated into the LITDRIFT model to compute the sediment transport rates and directions along the coasts and analyze the longshore sand movement. The results show that the coastline evolution of sand beaches in the southern Bohai Strait has spatial and temporal variations and the coast can be divided into four typical regions. Region(I), the north coast of Qimudao, is a slightly eroded and dissipative beach with a large sediment transport rate; Region(II), the southwest coast of Gangluan Port, is a slightly deposited and dissipative beach with moderate sediment transport rate; Region(III), in the central area, is a beach that is gradually transformed from a slightly eroded dissipative beach to a moderately or slightly strong eroded bar-trough beach from west to east with a relatively moderate sediment transport rate. Region(IV), on the east coast, is a strongly eroded and reflective beach with a weak sediment transport rate. The wave conditions exhibit an increasing trend from west to east in the offshore area. The distribution of the wave-induced current inside the wave breaking region and the littoral sediment transport in the nearshore region exhibit a gradual weakening tendency from west to east, which is opposite to the trend of the wave conditions outside the breaking region. The presence of submerged shoal(Dengzhou Shoal), deep trough(Dengzhou Channel), islands and irregular topography influnces the wave climate, beach types, wave-induced current features, littoral sediment transport trends and coastline evolution patterns in the southern Bohai Strait. Human activities, such as the sand exploitation of Dengzhou Shoal and other coastal engineering projects, also influence the beach morphology and coastline evolution. | ZHANG Wei WU Jianzheng LI Weiran ZHU Longhai HU Rijun JIANG shenghui SUN Yonggen WANG Huijuan | 2015 | Journal of Ocean University of China2015，14，5： | 3 |
| 12 | Improvement in quality of life in depressed patients following verum acupuncture or electroacupuncture plus paroxetine:A randomized controlled study of 157 cases显示文摘Depressed patients with scores of 17 or more on the 17 items of the Hamilton Depression Rating Scale were treated with the antidepressant drug paroxetine. They also underwent verum acupuncture or electroacupuncture at Baihui (GV20) and Yintang (GV29). The World Health Organization Quality of Life Scale Brief Version showed a significant increase in the total scores of patients who underwent verum acupuncture and electroacupuncture for 6 weeks compared with those who were given paroxetine only; significantly increased physical domain and social relationship scores in verum acupuncture patients compared with paroxetine only; and significantly elevated psychological domain scores with electroacupuncture compared with paroxetine only. These results indicate that both verum acupuncture and electroacupuncture can improve quality of life in depressed patients undergoing paroxetine treatment. | Shenghui Ma Shanshan Qu Yong Huang Junqi Chen Renyong Lin Chongqi Wang Ganlong Li Canghuan Zhao Shenchang Guo Zhangjin Zhang | 2012 | Neural Regeneration Research2012，7，27： | 3 |
| 13 | Formation and evolution of intraplatform basin from the late Sinian to early Cambrian in Sichuan Basin,China显示文摘Based on the drilling,logging,seismic and outcrop data,the formation and evolution of the late Sinian to early Cambrian intraplatform basin in Sichuan Basin was studied.Through the analysis of the total residual thickness of Member 3+Member 4 of Dengying Formation,the total thickness of Maidiping Formation+Qiongzhusi Formation,and lithofacies characteristics of Maidiping Formation,the distribution of the intraplatform basin was defined and its controlling effect on natural gas distribution of Dengying Formation was revealed.The intraplatform basin was characterized by small total residual thickness of Member 3 and Member 4 of Dengying Formation,the large total thickness of Maidiping Formation and Qiongzhusi Formation,and the deep-water phosphorous-carbonaceous-siliceous mudstone in Maidiping Formation.Horizontally,the intraplatform basin was mainly distributed in Qingchuan-Ziyang-Yibin area,and experienced four evolution periods.During the period of Member 1 and Member 2 of Dengying Formation,the Sichuan Basinwas a rimmed carbonate platform with the well developed mounds and shoals on the platform margin and its interior.The intraplatform basin in western Sichuan Basin was initially formed due to the first episode of Tongwan movement.During the period of Member 3 and Member 4 of Dengying Formation,the depositional center was formed in Moxi,Changning and Zhengxiong area due to extension and rifting of the Upper Yangtze Craton,thereafter,the Sichuan Basin evolved into a rimmed carbonate platform with an intraplatform basin.The second episode of Tongwan movement between Sinian and Cambrian led to the overall uplift and exposure of Sichuan Basin characterized by weathering denudation at high position and downward fluid erosion at low position.During the period of Maidiping Formation,three lithofacies zones were developed horizontally,and the third episode of the Tongwan movement between Maidiping Formation and Qiongzhusi Formation modified the sedimentary geomorphology locally.During the period of Qiongzhusi Formation and Canglangpu Formation,continuous deposition made the Sichuan Basin evolve into a gentle siliciclastic ramp.The evolution of the intraplatform basin not only promoted formation of high-quality platform-margin dolomite reservoirs of Member 4 of Dengying Formation,but also controlled distribution of the high-quality source rocks of Maidiping Formation and Qiongzhusi Formation.The dolomite of Dengying Formation in the surrounding area of the intraplatform basin was the most favorable hydrocarbon exploration area because of its good source-reservoir configuration. | Hui Zhou Wei Li Baomin Zhang Jingjiang Liu Shenghui Deng Shiben Zhang Xiuqin Shan Jing Zhang Xiaobo Wang Hua Jiang | 2017 | Petroleum Research2017，2，1： | 2 |
| 14 | Animal exercise studies in cardiovascular research:Current knowledge and optimal design--A position paper of the Committee on Cardiac Rehabilitation,Chinese Medical Doctors’Association显示文摘Growing evidence has demonstrated exercise as an effective way to promote cardiovascular health and protect against cardiovascular diseases However,the underlying mechanisms of the beneficial effects of exercise have yet to be elucidated.Animal exercise studies are widely used to investigate the key mechanisms of exercise-induced cardiovascular protection.However,standardized procedures and well-established evaluation indicators for animal exercise models are needed to guide researchers in carrying out effective,high-quality animal studies using exercise to prevent and treat cardiovascular diseases.In our review,we present the commonly used animal exercise models in cardiovascular research and propose a set of standard procedures for exercise training,emphasizing the appropriate measurements and analysis in these chronic exercise models.We also provide recommendations for optimal design of animal exercise studies in cardiovascular research,including the choice of exercise models,control of exercise protocols,exercise at different stages of disease,and other considerations,such as age,sex,and genetic background.We hope that this position paper will promote basic research on exercise-induced cardiovascular protection and pave the way for successful translation of exercise studies from bench to bedside in the prevention and treatment of cardiovascular diseases. | Yihua Bei Lei Wang Rongjing Ding Lin Che Zhiqing Fan Wei Gao Qi Liang Shenghui Lin Suixin Liu Xiao Lu Yuqin Shen Guifu Wu Jian Yang Guolin Zhang Wei Zhao Lan Guo Junjie Xiao | 2021 | Journal of Sport and Health Science2021，10，6： | 2 |
| 15 | Morphology of the anterior mesorectum:a new predictor for local recurrence in patients with rectal cancer显示文摘Background:Pre-operative assessment with high-resolution magnetic resonance imaging(MRI)is useful for assessing the risk of local recurrence(LR)and survival in rectal cancer.However,few studies have explored the clinical importance of the morphology of the anterior mesorectum,especially in patients with anterior cancer.Hence,the study aimed to investigate the impact of the morphology of the anterior mesorectum on LR in patients with primary rectal cancer.Methods:A retrospective study was performed on 176 patients who underwent neoadjuvant treatment and curative-intent surgery.Patients were divided into two groups according to the morphology of the anterior mesorectum on sagittal MRI:(1)linear type:the anterior mesorectum was thin and linear;and(2)triangular type:the anterior mesorectum was thick and had a unique triangular shape.Clinicopathological and LR data were compared between patients with linear type anterior mesorectal morphology and patients with triangular type anterior mesorectal morphology.Results:Morphometric analysis showed that 90(51.1%)patients had linear type anterior mesorectal morphology,while 86(48.9%)had triangular type anterior mesorectal morphology.Compared to triangular type anterior mesorectal morphology,linear type anterior mesorectal morphology was more common in females and was associated with a higher risk of circumferential resection margin involvement measured by MRI(35.6%[32/90]vs.16.3%[14/86],P=0.004)and a higher 5-year LR rate(12.2%vs.3.5%,P=0.030).In addition,the combination of linear type anterior mesorectal morphology and anterior tumors was confirmed as an independent risk factor for LR(odds ratio=4.283,P=0.014).Conclusions:The classification established in this study was a simple way to describe morphological characteristics of the anterior mesorectum.The combination of linear type anterior mesorectal morphology and anterior tumors was an independent risk factor for LR and may act as a tool to assist with LR risk stratification and treatment selection. | Xiaojie Wang Zhifang Zheng Min Chen Jing Lin Xingrong Lu Ying Huang Shenghui Huang Pan Chi | 2022 | Chinese Medical Journal2022，135，20： | 2 |
| 16 | Role of senescence induction in cancer treatment显示文摘Cellular senescence is a form of permanent cell cycle arrest that can be triggered by a variety of cell-intrinsic and extrinsic stimuli, including telomere shortening,DNA damage, oxidative stress, and exposure to chemotherapeutic agents and ionizing radiation. Although the induction of apoptotic cell death is a desirable outcome in cancer therapy, mutations and/or deficiencies in the apoptotic signaling pathways have been frequently identified in many human cancer types,suggesting the importance of alternative apoptosis-independent therapeutic approaches for cancer treatment. A growing body of evidence has documented that senescence induction in tumor cells is a frequent response to many anticancer modalities including cyclin-dependent kinases 4/6 small molecule inhibitor-based targeted therapeutics and T helper-1 cytokine-mediated immunotherapy. This review discusses the recent advances and clinical relevance of therapy-induced senescence in cancer treatment. | Shenghui Qin Bradley A Schulte Gavin Y Wang | 2018 | World Journal of Clinical Oncology2018，9，8： | 2 |
| 17 | Nitrous oxide and nitric oxide emissions from an irrigated cotton field in Northern China显示文摘 | Chunyan Liu Xunhua Zheng Zaixing Zhou Shenghui Han Yinghong Wang Kai Wang Wangguo Liang Ming Li Deli Chen Zhiping Yang | 2010 | 2010 (1-2)2010，，1： | 2 |
| 18 | Prevalence of Salmonella on Raw Poultry at Retail Markets in China显示文摘 | Yang Baowei Xi Meili Wang Xin Cui Shenghui Yue Tianli Hao Hongshan Wang Yin Cui Yue Alali W Q Meng Jianghong Walls Isabel Wong D M Lo Fo Doyle M P | 2011 | Journal of Food Protection2011，，10： | 1 |
| 19 | Resveratrol ameliorates subacute intestinal ischemia-reperfusion injury显示文摘 | WenPeng Dong FanFan Li ZhiGuo Pan ShenXi Liu Hao Yu XianYue Wang ShengHui Bi WeiDa Zhang | 2013 | Journal of Surgical Research2013，，： | 1 |
| 20 | Synthesis and Characterization of a Silica-Based Drug Delivery System for Spinal Cord Injury Therapy显示文摘Acute inflammation is a central component in the progression of spinal cord injury(SCI).Anti-inflammatory drugs used in the clinic are often administered systemically at high doses,which can paradoxically increase inflammation and result in drug toxicity.A cluster-like mesoporous silica/arctigenin/CAQK composite(MSN-FC@ARCG)drug delivery system was designed to avoid systemic side effects of high-dose therapy by enabling site-specific drug delivery to the spinal cord.In this nanosystem,mesoporous silica was modified with the FITC fluorescent molecule and CAQK peptides that target brain injury and SCI sites.The size of the nanocarrier was kept at approximately 100 nm to enable penetration of the blood–brain barrier.Arctigenin,a Chinese herbal medicine,was loaded into the nanosystem to reduce inflammation.The in vivo results showed that MSN-FC@ARC-G could attenuate inflammation at the injury site.Behavior and morphology experiments suggested that MSN-FC@ARC-G could diminish local microenvironment damage,especially reducing the expression of interleukin-17(IL-17) and IL-17-related inflammatory factors,inhibiting the activation of astrocytes,thus protecting neurons and accelerating the recovery of SCI.Our study demonstrated that this novel,silica-based drug delivery system has promising potential for clinical application in SCI therapy. | Guodong Sun Shenghui Zeng Xu Liu Haishan Shi Renwen Zhang Baocheng Wang Changren Zhou Tao Yu | 2019 | Nano-Micro Letters2019，11，2： | 1 |
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