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| 1 | Wnt/b-catenin signaling plays an ever-expanding role in stem cell self-renewal,tumorigenesis and cancer chemoresistance显示文摘Wnt signaling transduces evolutionarily conserved pathways which play important roles in initiating and regulating a diverse range of cellular activities,including cell proliferation,calcium homeostasis,and cell polarity.The role of Wnt signaling in controlling cell proliferation and stem cell self-renewal is primarily carried out through the canonical pathway,which is the best-characterized the multiple Wnt signaling branches.The past 10 years has seen a rapid expansion in our understanding of the complexity of this pathway,as many new components of Wnt signaling have been identified and linked to signaling regulation,stem cell functions,and adult tissue homeostasis.Additionally,a substantial body of evidence links Wnt signaling to tumorigenesis of cancer types and implicates it in the development of cancer drug resistance.Thus,a better understanding of the mechanisms by which dysregulation of Wnt signaling precedes the development and progression of human cancer may hasten the development of pathway inhibitors to augment current therapy.This review summarizes and synthesizes our current knowledge of the canonical Wnt pathway in development and disease.We begin with an overview of the components of the canonical Wnt signaling pathway and delve into the role this pathway has been shown to play in stemness,tumorigenesis,and cancer drug resistance.Ultimately,we hope to present an organized collection of evidence implicating Wnt signaling in tumorigenesis and chemoresistance to facilitate the pursuit of Wnt pathway modulators that may improve outcomes of cancers in which Wnt signaling contributes to aggressive disease and/or treatment resistance. | Maryam K.Mohammed Connie Shao Jing Wang Qiang Wei Xin Wang Zachary Collier Shengli Tang Hao Liu Fugui Zhang Jiayi Huang Dan Guo Minpeng Lu Feng Liu Jianxiang Liu Chao Ma Lewis L.Shi Aravind Athiviraham Tong-Chuan He Michael J.Lee | 2016 | Genes & Diseases2016，3，1： | 70 |
| 2 | Endovascular therapy for Acute ischemic Stroke Trial (EAST): study protocol for a prospective, multicentre control trial in China显示文摘Background and purpose:5 recent trials have shown the benefit of endovascular treatment for acute ischaemic stroke(AIS)due to large vessel occlusion of the anterior circulation.This study aims to evaluate the safety and efficacy of Solitaire thrombectomy in patients with moderate-to-severe stroke in the Chinese population,which has a high prevalence of intracranial atherosclerosis.Methods and analysis:This multicentre prospective control study will involve 17 stroke centres in China,and plans to recruit 150 patients in the intervention group,and 150 patients in the medical group,in which patients meet enrolment criteria but refuse intervention.Patients with AIS due to large vessel occlusion indicated for treatment with Solitaire stent retriever within 12 hours of symptom onset,and who meet the inclusion and exclusion criteria,will be enrolled in this study.The primary efficacy endpoint is functional independence as defined by a modified Rankin Scale(mRS)score≤2 at 90 days or by functional improvement as defined by mRS,using shift analysis.The procedural efficacy endpoint is arterial recanalisation of the occluded target vessel measured by a modified Thrombolysis in Cerebral Infarction(mTICI)score equal or superior to 2b right following the use of the study device.The primary safety endpoint is symptomatic intracranial haemorrhage(sICH)within 24±3 hours postprocedure.Ethics and dissemination:The protocol was approved by the Ethics Committee at the coordinating centre and by the local Institutional Review Board of each participating centre.Trial registration number:NCT02350283. | Zhongrong Miao Xiaochuan Huo Feng Gao Xiaoling Liao Chunjuan Wang Ya Peng Yibin Cao Shengli Chen Meng Zhang Changchun Jiang Xiaoxiang Peng Cunfeng Song Liping Wei Qiyi Zhu Zaiyu Guo Li Liu Hang Lin Hua Yang Wei Wu Hui Liang Anding Xu Kangning Chen Xingquan Zhao Yuesong Pan Hao Li Liping Liu Yilong Wang Yongjun Wang EAST investigators | 2016 | Stroke & Vascular Neurology2016，1，2： | 8 |
| 3 | 乙肝病毒X蛋白对肝细胞生物钟基因的影响及其意义(英文)显示文摘Objective:The aim of this study was to investigate the influence of hepatitis B virus X protein (HBx) on the clock genes in LO2 cells and its significance.Methods:A cell line LO2-HBx,Stably transfected with HBx gene,was established.The levels of mRNA and protein expression of CLOCK and BMAL1 were detected by real-time PCR and western blot.Results:The expression of CLOCK mRNA and protein were increased in cell line LO2-HBx (P<0.05),while the expression of BMAL1 mRNA and protein were decreased in cell line LO2-HBx (P<0.05).Conclusion:The expressions of core clock gene CLOCK and BMAL1 have been changed by HBx,which breaks down the previous circadian rhythm of liver cells.This maybe one of the reasons leads to the formation of liver cancer. | Shengli Yang Xiaoli Pan Zhifan Xiong Bo Wei Hongyi Yao | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，8： | 6 |
| 4 | Cobalt(Ⅱ) coordination polymers built on isomeric dipyridyl triazole ligands with pyromellitic acid:Synthesis,characterization and their effects on the thermal decomposition of ammonium perchlorate显示文摘Three new cobalt(Ⅱ) coordination compounds,[Co(3,3'-Hbpt)2(H2pm)(H2O)2]·2H2O(1),[Co(4,4'-Hbpt)(pm)0.5(H2O)]·3H2O (2) and [Co(3,4'-Hbpt)(pm) 0.5 (H2O)3]·2H2O(3)(3,3'-Hbpt=3,5-bis(3-pyridyl)-1H-1,2,4-triazole;4,4'-bpt=3,5-bis(4-pyridyl)1H-1,2,4-triazole,3,4'-Hbpt=3-(3-pyridyl)-5-(4'-pyridyl)-1H-1,2,4-triazole and H4pm=pyromellitic acid) have been synthesized by hydrothermal reactions.Single-crystal X-ray diffraction reveals that compound 1 has a one-dimensional (1D) chain network,2 exhibits a four-connected three-dimensional (3D) structure with 1D open channels encapsulated by water molecules,while 3 displays a regular two-dimensional (2D) architecture connected through 1D metal helical chains.In addition,the efficacy of compounds 1-3 as additives to promote the thermal decomposition of ammonium perchlorate (AP) is explored by differential scanning calorimetry (DSC). | XIE Gang LI Bing CHEN SanPing YANG Qi WEI Wei GAO ShengLi | 2012 | Science China Chemistry2012，55，3： | 5 |
| 5 | Photo-controlled degradation of PLGA/Ti3C2 hybrid coating on Mg-Sr alloy using near infrared light显示文摘A PLGA/Ti_(3)C_(2) hybrid coating was successfully deposited on the surface of magnesium-strontium(Mg-Sr)alloys.Compared with the corrosion current density(icorr)of the Mg-Sr alloy(7.13×10^−5 A/cm^2),the modified samples(Mg/PLGA/Ti_(3)C_(2))was lower by approximately four orders of magnitude(7.65×10^−9 A/cm^2).After near infrared 808 nm laser irradiation,the icorr of the modified samples increased to 3.48×10^−7 A/cm^2.The mechanism is that the local hyperthermia induced the free volume expansion of PLGA,and the increase in intermolecular gap enhanced the penetration of electrolytes.Meanwhile,the cytotoxicity study showed that the hybrid coating endowed the Mg-Sr alloy with enhanced biocompatibility. | Li Liu Bo Huang Xiangmei Liu Wei Yuan Yufeng Zheng Zhaoyang Li Kelvin Wai Kwok Yeung Shengli Zhu Yanqin Liang Zhenduo Cui Shuilin Wu | 2021 | Bioactive Materials2021，6，2： | 4 |
| 6 | Transition to resistance:An unexpected role of the EMT in cancer chemoresistance显示文摘Two recent studies provide intriguing evidence that challenges the role of the epithelialemesenchymal transition(EMT)as a critical mediator of cancer metastasis,while revealing an unexpected role in cancer drug resistance.1,2 While these findings may not settle the EMT’s role in metastasis,these studies suggest that targeting the EMT may inhibit both cancer metastasis and chemoresistance. | Jing Wang Qiang Wei Xin Wang Shengli Tang Hao Liu Fugui Zhang Maryam K.Mohammed Jiayi Huang Dan Guo Minpeng Lu Feng Liu Jianxiang Liu Chao Ma Xue Hu Rex C.Haydon Tong-Chuan He Hue H.Luu | 2016 | Genes & Diseases2016，3，1： | 4 |
| 7 | Correlation Between Microstructure and Corrosion Behavior of Two 90Cu10Ni Alloy Tubes显示文摘Two kinds of 90Cu10 Ni tubes with different service lives(more than 3 years and only 1 year,respectively)under identical working conditions were studied by an immersion test in a 3.5 wt% NaCl solution and the electron backscattered diffraction(EBSD) technique.The morphology after immersion showed severer corrosion attack at the grain boundaries of the tube with shorter service life compared with the tube with longer service life.The grain boundary characterization distributions(GBCDs) of the two tubes obtained by EBSD revealed more Σ3 boundaries and twins,and larger random boundary meshes in the tube with longer service life.A short immersion test in a modified Livingston's solution was conducted to evaluate the tendency to corrosion attack of different types of the grain boundaries.SEM and AFM were used to characterize the corrosion morphologies of the boundaries.A strong correlation between varying depths of corrosion grooves and types of the grain boundaries was obtained.The influence of deviation angle of low Σ boundaries on corrosion resistance of the grain boundaries was also discussed.It is concluded that a special ‘‘grain boundary engineering''(GBE) treatment has been performed on the tube with longer service life.It is proposed that the optimized GBCD is responsible for the better service performance of the tube. | Aili Ma Shengli Jiang Yugui Zheng Zhiming Yao Wei Ke Shuang Xia | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，4： | 4 |
| 8 | Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: a large-scale, multicentre study显示文摘 | Qiujin Shen Jia Fan Xin-Rong Yang Yexiong Tan Weifeng Zhao Yang Xu Ning Wang Yongdong Niu Zheng Wu Jian Zhou Shuang-Jian Qiu Ying-Hong Shi Bin Yu Ning Tang Wei Chu Min Wang Jinhua Wu Zhigang Zhang Shengli Yang Jianren Gu Hongyang Wang Wenxin Qin | 2012 | Lancet Oncology2012，，8： | 4 |
| 9 | Drawing mechanisms for top coal in longwall top coal caving(LTCC):A review of two decades of literature显示文摘This review details the state of the art in research on top coal drawing mechanisms in Longwall top coal caving(LTCC)by examining the relevant literature over the last two decades.It startswith an introduction of the brief history and basic procedures of LTCC.The framework of research on the drawing mechanism,basic concepts,and some theoretical models of LTCC are detailed in sect.research framework of top coal drawingmechanism.The authors note that theTop coal drawbody(TCD),Top coal boundary(TCB)and Top coal recovery ratio(TCRR)are key factors in the drawingmechanism.TheBody-boundary-ratio(BBR)research system has been the classic framework for research over the last 20 years.The modified Bergmark-Roos model,which considers the effects of the supporting rear canopy,flowing velocity of top coal,and its shape factor,is optimal for characterizing the TCD.A 3Dmodel to describe the TCB that considers the thicknesses of the coal seam and roof strata is reviewed.In sect.physical testing and numerical simulation,the physical tests and numerical simulations in the literature are classified for ease of bibliographical review,and classic conclusions regarding the drawing mechanism of top coal are presented and discussedwith elaborate illustrations and descriptions.The deflection of the TCDis noted,and is caused by the shape of the rear canopy.The inclined coal seam always induces a largerTCD,and a deflection in theTCDhas also been observed in it.The effects of the drawing sequence and drawing interval on the TCRR are reviewed,where a long drawing interval is found to lead to significant loss of top coal.Its flowing behavior and velocity distribution are also presented.Sect.practical applications of drawingmechanisms forLTCCmines 4 summarizes over 10 cases where the TCRRof LTCCmines improved due to the guidance of the drawing mechanism.The final section provides a summary of the work here and some open questions.Prospective investigations are highlighted to give researchers guidance on promising issues in future research on LTCC. | Jiachen Wang Shengli Yang Weijie Wei Jinwang Zhang Zhengyang Song | 2021 | International Journal of Coal Science & Technology2021，8，6： | 3 |
| 10 | Growth kinetics of hydrate formation from water–hydrocarbon system显示文摘Gas hydrates have drawn global attentions in the past decades as potential energy resources.It should be noted that there are a variety of possible applications of hydrate-based technologies,including natural gas storage,gas transportation,separation of gas mixture,and seawater desalination.These applications have been critically challenged by insufficient understanding of hydrate formation kinetics.In this work,the literatures on growth kinetic behaviors of hydrate formation from water-hydrocarbon were systematically reviewed.The hydrate crystal growth,hydrate film growth and macroscopic hydrate formation in water system were reviewed,respectively.Firstly,the hydrate crystal growth was analyzed with respect to different positions,such as gas/liquid interface,liquid–liquid interface and gas–liquid–liquid system.Secondly,experimental and modeling studies on the growth of hydrate film at the interfaces between guest phase and water phase were categorized into two groups of lateral growth and thickening growth considering the differences in growth rates.Thirdly,we summarized the promoters and inhibitors reported(biological or chemical,liquid or solid and hydrophobic or hydrophilic)and analyzed the mechanisms affecting hydrate formation in bulk water system.Knowledge gaps and suggestions for further studies on hydrate formation kinetic behaviors are presented. | Youhong Sun Shuhui Jiang Shengli Li Guobiao Zhang Wei Guo | 2019 | Chinese Journal of Chemical Engineering2019，27，9： | 3 |
| 11 | Advanced Noncarbon Materials as Catalyst Supports and Non‑noble Electrocatalysts for Fuel Cells and Metal–Air Batteries显示文摘Electrochemical energy systems such as fuel cells and metal–air batteries can be used as clean power sources in the field of electric transportation and possess great potential in the reduction of various energy and environmental issues.In these systems,the oxygen reduction reaction(ORR)at the cathode is the rate-determining factor for overall system performance,and up to now,platinum group metals supported on carbon materials,especially Pt,remain the highest performing and the most practical ORR electrocatalysts.However,corresponding carbonaceous catalyst supports are extremely susceptible to corrosion under electrochemical operation,and therefore,the extensive exploration of alternative stable materials for ORR electrocatalysts with both high electrochemical stability and catalytic performance is essential.Here,noncarbon materials with high corrosion resistance have been explored to substitute traditional carbon supports or even act directly as low-cost non-noble metal electrocatalysts,and based on this,this review will present a comprehensive overview and deep analysis of the recent progress in noncarbon materials,including metals,oxides,nitrides,carbides,sulfides,and so on.Overall,general attributes associated with noncarbon materials include high corrosion resistance,strong metal–support interaction,and impressive porous structure retention.However,major drawbacks include low electrical conductivity,insufficient chemical stability in acidic or alkaline media,and poor electrochemical stability at ORR electrode potentials.To overcome these challenges,this review will also summarize efficient strategies such as combining with highly conductive materials,introducing dopants and forming vacancies to result in promising electrocatalytic ORR performances.Finally,this review will propose possible research directions to facilitate future research and development toward the practical application of noncarbon-based ORR electrocatalysts. | Shiming Zhang Menghui Chen Xiao Zhao Jialin Cai Wei Yan Joey Chung Yen Shengli Chen Yan Yu Jiujun Zhang | 2021 | Electrochemical Energy Reviews2021，4，2： | 2 |
| 12 | Generation of transgenic cucumbers with expression of a ten-tandem repeat long-acting GLP-1 analogue and their biological function on diabetic rats显示文摘Glucagon-like peptide-1 (GLP-1) is a 30-amino acid peptide hormone, which has the regulatory function of stimulating the secretion of insulin to balance blood glucose levels. In this study, marker-free expression vector pX6 with a fusion gene of ten tandem repeated GLP-1 analog ([Ser8, Gln26 and Asp34]-GLP-1) genes was constructed and transformed into cucumbers by Agrobacterium tumefaciens-mediated transformation method. Four transgenic lines were obtained by PCR and Southern blotting analysis and two transgenic lines successfully expressed the fusion protein (named GLP-T), which was revealed by Western blotting analysis. The biological activity test results showed that the serum glucose level of diabetic rats was significantly decreased after oral administration of the fusion protein GLP-T extracted from the transgenic cucumber fruitage. These results suggest that this may provide a brand-new strategy to prevent and cure the diabetes with no pain. | ZHAO Lei LIAO Fang WANG CuiYan CHEN Miao WEI AiMin DU ShengLi MA BaiCheng HU XiaoYu WU ZhiQiang WANG RuiJu LI MingGang | 2009 | Chinese Science Bulletin2009，54，24： | 2 |
| 13 | Surface modified polyimide fiber-filled ethylene-propylene-diene monomer insulations for a solid rocket motor:processing,morphology,and properties显示文摘 | Han Zhongqiang Qi Shengli Liu Wei | | 0，，03： | 1 |
| 14 | SMM analysis of reflection, absorption, and transmission from nonuni- form magnetized plasma slab 显示文摘 | HU Binjie WEI Gang LAI Shengli | 1999 | IEEE Transactions on Plasma Science1999，27，4： | 1 |
| 15 | Identification of up-regulated genes in tea leaves under mild infestation of green leafhopper显示文摘 | Huimin Yang Suxia Xie Lei Wang Shengli Jing Xiaopei Zhu Xianwen Li Wei Zeng Hongyu Yuan | 2011 | Scientia Horticulturae2011，，2： | 1 |
| 16 | Nume- rical analysis on the effect of swirl ratios on swirl cham- ber combustion system of DI diesel engines 显示文摘 | Wei Shengli Wang Feihu Leng Xianyin | 2013 | Energy Conversion and Management2013，75，： | 1 |
| 17 | SJES14110700417215显示文摘 | Jiachen Wang Shengli Yang Yang Li Like Wei Haohao Liu | 2014 | International Journal of Rock Mechanics and Mining Sciences2014，，： | 1 |
| 18 | Grain Size Effect of IrO_2 Nanocatalysts for the Oxygen Evolution Reaction显示文摘Combined with air annealing, rutile-structured IrO 2 nanoparticles with various sizes were prepared using colloidal method. The nanoparticles were used as the electrocatalysts for the oxygen evolution reaction (OER) in acidic media, and their grain size effect was studied. The results show that with the increase in annealing temperature, the grain size of the catalyst increases, and the voltammetric charges (the electroactive areas) and apparent activity for the OER decrease. The relationship between the intrinsic activity and the annealing temperature exhibits a volcano-type curve and the catalyst annealed at 550 ℃ achieved the best result. | HU Wei CHEN Shengli | 2013 | Wuhan University Journal of Natural Sciences2013，18，4： | 1 |
| 19 | Nitridation-induced metal-organic framework nanosheet for enhanced water oxidation electrocatalysis显示文摘We report the synthesis of nitridation-induced NiFe-MOF through post-synthetic functionalization of terminal ligand in NiFe-MOF nanosheet.We directly identify the key factor of amino ligand in N-NiFe-MOF for boosting the OER performance through combining single X-ray crystallographic characterization and in-situ Raman tracking,as well as ex-situ spectroscopy analysis.Density functional theory(DFT)calculations and experime ntal results indicate irreversible phase rec on structio n from amino ligand oxidation prior to OER could lead to the optimized ΔG_(-O),resulting in the remarkable OER performance with an overpotential of 258 mV to obtain the current density of 100 mA cm^(-2) in 1.0 M KOH solution.Our work will provide new strategy for rational designing advanced MOF-based OER electrocatalysts. | Na Yao Hongnan Jia Zhengyin Fan Lu Bai Wei Xie Hengjiang Cong Shengli Chen Wei Luo | 2022 | Journal of Energy Chemistry2022，31，1： | 1 |
| 20 | Numerical analysis on the effect of swirl ratios on swirl chamber combustion system of DI diesel engines显示文摘 | WEI Shengli WANG Feihu LENG Xianyin | 2013 | Energy Conversion and Management2013，75，12： | 1 |
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