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| 1 | 4-Hydroxybenzyl-substituted amino acid derivatives from Gastrodia elata显示文摘Seven new 4-hydroxybenzyl-substituted amino acid derivatives(1-7), together with 11 known compounds, were isolated from an aqueous extract of the rhizomes of Gastrodia elata Blume.Their structures were determined by spectroscopic and chemical methods. Compounds 1-3 are pyroglutamate derivatives containing 4-hydroxybenzyl units at the N atom and 4-7 are the first examples of natural products with the 4-hydroxybenzyl unit linked via a thioether bond to 2-hydroxy-3-mercaptopropanoic acid(4-6) and 2-hydroxy-4-mercaptobutanoic acid(7), which would be biogenetically derived from cysteine and homocysteine, respectively. The structures of 1 and 2 were verified by synthesis, while the absolute configurations of 4, 5 and 7 were assigned using Mosher's method based on the MPA determination rule of ΔδRS values. The known compound 4-(hydroxymethyl)-5-nitrobenzene-1,2-diol(8) exhibited activity against Fe^(2+)-cysteine induced rat liver microsomal lipid peroxidation with IC_(50) values of 9.99×10^(-6) mol/L. | Qinglan Guo Yanan Wang Sheng Lin Chenggen Zhu Minghua Chen Zhibo Jiang Chengbo Xu Dan Zhang Huailing Wei Jiangong Shi | 2015 | Acta Pharmaceutica Sinica B2015，5，4： | 18 |
| 2 | Indole alkaloid sulfonic acids from an aqueous extract of Isatis indigotica roots and their antiviral activity显示文摘Six new indole alkaloid sulfonic acids(1–6), together with two analogues(7 and 8) that were previously reported as synthetic products, were isolated from an aqueous extract of the Isatis indigotica root. Their structures including the absolute configurations were determined by spectroscopic data analysis, combined with enzyme hydrolysis and comparison of experimental circular dichroism and calculated electronic circular dichroism spectra. In the preliminary assay, compounds 2 and 4 showed antiviral activity against Coxsackie virus B3 and influenza virus A/Hanfang/359/95(H3N2), respectively. | Lingjie Meng Qinglan Guo Yufeng Liu Minghua Chen Yuhuan Li Jiandong Jiang Jiangong Shi | 2017 | Acta Pharmaceutica Sinica B2017，7，3： | 14 |
| 3 | Three pairs of alkaloid enantiomers from the root of Isatis indigotica显示文摘Three pairs of enantiomerically pure alkaloids with diverse structure features, named isatindigoticoic acid A and epiisatindigoticoic acid A [(—)-1 and(+)-1], phaitanthrin A and epiphaitanthrin A [(—)-2 and(+)-2], and isatindopyrromizol A and epiisatindopyrromizol A [(—)-3and(+)-3], respectively, were isolated from an aqueous extract of the roots of Isatis indigotica. Racemic and scalemic mixtures of these enantiomers were separated by HPLC on a chiral semi-preparative column.Their structures including absolute configurations were determined by extensive spectroscopic analysis in conjunction with the calculation of electronic circular dichroism(ECD) spectra. The enantiomer pairs possess parent structures of 2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylic acid, indolo[2,1-b]quinazolinone, and 3-thioxohexahydro-1H-pyrrolo[1,2-c]imidazol-1-one, respectively. Except for phaitanthrin A[(—)-2] which the configuration was previously undetermined, these compounds are new enantiomeric natural products. | Yufeng Liu Xiaoliang Wang Minghua Chen Sheng Lin Li Li Jiangong Shi | 2016 | Acta Pharmaceutica Sinica B2016，6，2： | 12 |
| 4 | Aromatic compounds from an aqueous extract of “ban lan gen” and their antiviral activities显示文摘A pair of new diphenyl glycerol ether enantiomers(-)-l and(+)-l and two new methyl benzamidobenzoates 2 and 3,named(-)-(R)-and(+)-(S)-isatindigotrioic acid[(-)-l and(+)-l]and isatindigoticamides A(2) and B(3),respectively,were isolated from an aqueous decoction of the roots of Isatis indigotica(ban lan gen).Their structures were elucidated by spectroscopic data analysis including2 D NMR experiments.The absolute configurations of(-)-l and(+)-l were assigned based on the CD exciton chirality method.Compounds 2 and 3 exhibited antiviral activities against HSV-1 with IC_(50)values of 4.87 and 25.87μmol/L,respectively.Compound 2 was also found active against Coxsackie virus B3 and LPS-induced NO production. | Yufeng Liu Minghua Chen Qinglan Guo Yuhuan Li Jiandong Jiang Jiangong Shi | 2017 | Acta Pharmaceutica Sinica B2017，7，2： | 8 |
| 5 | Sulfur-enriched alkaloids from the root of Isatis indigotica显示文摘Five new sulfur-enriched alkaloids isatithioetherins A–E(1–5), and two pairs of scalemic enantiomers(t)-and( à)-isatithiopyrin B(6 a and 6 b) and isoepigoitrin and isogoitrin(7 a and 7 b), along with the known scalemic enantiomers epigoitrin and goitrin(8 a and 8 b), were isolated and characterized from an aqueous extract of the Isatis indigotica roots. Their structures were determined by extensive spectroscopic data analysis, including 2 D NMR and theoretical calculations of electronic circular dichroism(ECD) spectra based on the quantum-mechanical time-dependent density functional theory(TDDFT). Compounds 1–5 represent a novel group of sulfur-enriched alkaloids, biogenetically originating from stereoselective assemblies of epigoitrin-derived units. Isolation and structure characterization of 6 a and 6 b support the postulated biosynthetic pathways for the diastereomers 9 a and 9 b via a rare thio-Diels–Alder reaction. Compounds 2 and 4 showed antiviral activity against the influenza virus A/Hanfang/359/95(H3 N2, IC500.60 and 1.92 μmol/L) and the herpes simplex virus 1(HSV-1, IC503.70 and 2.87 μmol/L), and 2 also inhibited Coxsackie virus B3(IC500.71 μmol/L).& 2018 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license(http://gffzzeb6f7f563f66445dh505wcbxqvoup69pu.ffgz.tsg.suse.edu.cn/licenses/by-nc-nd/4.0/). | Qinglan Guo Chengbo Xu Minghua Chen Sheng Lin Yuhuan Li Chenggen Zhu JiANDong Jiang Yongchun Yang Jiangong Shi | 2018 | Acta Pharmaceutica Sinica B2018，8，6： | 8 |
| 6 | Isatindolignanoside A, a glucosidic indole-lignan conjugate from an aqueous extract of the Isatis indigotica roots显示文摘A glucosidic indole-lignan conjugate with a novel carbon skeleton, named isatindolignanoside A(1), was isolated from an aqueous extract of the Isatis indigotica roots 'ban lan gen'. Its structure was elucidated by comprehensive analysis of spectroscopic data, including J-and NOESY correlation-based configurational analysis, circular dichroism(CD) data, enzyme hydrolysis, and theoretical ECD calculation. In a preliminary assay, compound 1 showed antiviral activity against Coxsackie virus B3. This compound is the first example of natural product having a structural feature of conjugation between indole and lignan units, and its biosynthetic pathway is postulated. | Lingjie Meng Qinglan Guo Minghua Chen JiANDong Jiang Yuhuan Li Jiangong Shi | 2018 | Chinese Chemical Letters2018，29，8： | 7 |
| 7 | miR-137 and miR-491 Negatively Regulate Dopamine Transporter Expression and Function in Neural Cells显示文摘The dopamine transporter(DAT) is involved in the regulation of extracellular dopamine levels.A 40-bp variable-number tandem repeat(VNTR) polymorphism in the 3'-untranslated region(3'UTR) of the DAT has been reported to be associated with various phenotypes that are involved in the aberrant regulation of dopaminergic neurotransmission.In the present study,we found that miR-137 and miR-491 caused a marked reduction of DAT expression,thereby influencing neuronal dopamine transport.Moreover,the regulation of miR-137 and miR-491 on this transport disappeared after the DAT was silenced.The miR-491 seed region that is located on the VNTR sequence in the 3'UTR of the DAT and the regulatory effect of miR-491 on the DAT depended on the VNTR copy-number.These data indicate that miR-137 and miR-491 regulate DAT expression and dopamine transport at the posttranscriptional level,suggesting that microRNA may be targeted for the treatment of diseases associated with DAT dysfunction. | Xiaojian Jia Feng Wang Ying Han XuewenGeng Minghua Li Yu Shi Lin Lu Yun Chen | 2016 | Neuroscience Bulletin2016，32，6： | 5 |
| 8 | The structure and mechanical property of silane-graftedpolyethylene/SiO_(2) nanocomposite fiber rope显示文摘The effect of vinyltrimethoxysilane(VTMS)graft and SiO_(2) on the structure and mechanical properties of silane-grafted-polyethylene/SiO_(2)(VTMS-g-PE/SiO_(2))nanocomposite fibers and ropes was studied.Scanning electron microscopy(SEM),Fourier transfer infrared(FT-IR),differential scanning calorimetry analysis(DSC)and tensile mechanical tests were performed to characterize the morphology,thermal and mechanical properties of nanocomposite fibers and ropes.The results revealed that the SiO_(2) nanoparticles were well dispersed throughout the polymeric matrix.With increasing SiO_(2) content,T_(m),the melt peak width and X_(c),degree of crystallinity,of VTMS-g-PE/SiO_(2) nanocomposite fibers increased.The breaking load and breaking strength of the nanocomposite fiber ropes were remarkably improved compared to pure PE fiber ropes and elongation at break was also decreased. | Wenwen Yu Jiangao Shi Lumin Wang Xiaoxue Chen Minghua Min Lei Wang Yongli Liu | 2017 | Aquaculture and Fisheries2017，2，1： | 2 |
| 9 | A computer aided pulmonary nodule detection system using multiple massivetraining SVMs显示文摘 | Shi Zhenghao Zhao Minghua He Lifeng | 2013 | Applied Mathematics &Information Sciences2013，7，3： | 1 |
| 10 | Analysis of tumor‐induced lymphangiogenesis and lymphatic vessel invasion of pancreatic carcinoma in the peripheral nerve plexus显示文摘 | Peng Cheng Gang Jin Xiangui Hu Min Shi Yijie Zhang Rui Liu Yingqi Zhou Chenghao Shao Jianming Zheng Minghua Zhu | 2012 | Cancer Sci2012，，10： | 1 |
| 11 | Analysis of tumor‐induced lymphangiogenesis and lymphatic vessel invasion of pancreatic carcinoma in the peripheral nerve plexus显示文摘 | Peng Cheng Gang Jin Xiangui Hu Min Shi Yijie Zhang Rui Liu Yingqi Zhou Chenghao Shao Jianming Zheng Minghua Zhu | 2012 | Cancer Sci2012，，10： | 1 |
| 12 | Diagnostic and biological significance of microRNA-192 in pancreaticductal adenocarcinoma显示文摘 | Chenyan Zhao Jing Zhang Shuhui Zhang Danghui Yu Ying Chen Qinghua Liu Min Shi Canrong Ni Minghua Zhu | 2013 | Oncology Reports2013，，1： | 1 |
| 13 | A 24-week,parallel-group,open-label,randomized clinical trial comparing the early antiviral efficacy of telbivudine and entecavir in the treatment of hepatitis B e antigen-positive chronic hepatitis B virus infection in adult Chinese patients显示文摘 | Zheng Minghua Shi Keqing Dai Zhijuan | 2010 | Clin Ther2010，32，4： | 1 |
| 14 | Sulfur and nitrogen codoped cyanoethyl cellulose-derived carbon with superior gravimetric and volumetric capacity for potassium ion storage显示文摘We fabricated sulfur and nitrogen codoped cyanoethyl cellulose-derived carbons(SNCCs)with state-of-the-art electrochemical performance for potassium ion battery(PIB)and potassium ion capacitor(PIC)anodes.At 0.2,0.5,1,2,5,and 10 A g−1,the SNCC shows reversible capacities of 369,328,249,208,150,and 121 mA h g−1,respectively.Due to a high packing density of 1.01 g cm^(−3),the volumetric capacities are also uniquely favorable,being 373,331,251,210,151,and 122 mA h cm^(−3)at these currents,respectively.SNCC also shows promising initial Coulombic efficiency of 69.0%and extended cycling stability with 99.8%capacity retention after 1000 cycles.As proof of principle,an SNCC-based PIC is fabricated and tested,achieving 94.3Wh kg^(−1)at 237.5Wkg^(−1)and sustaining over 6000 cycles at 30 A g−1 with 84.5%retention.The internal structure of S and N codoped SNCC is based on highly dilated and defective graphene sheets arranged into nanometer-scale walls.Using a baseline S-free carbon for comparison(termed NCC),the role of S doping and the resultant dilated structure was elucidated.According to galvanostatic intermittent titration technique and electrochemical impedance spectroscopy analyses,as well as COMSOL simulations,this structure promotes rapid solid-state diffusion of potassium ions and a solid electrolyte interphase that is stable during cycling.X-ray diffraction was used to probe the ion storage mechanisms in SNCC,establishing the role of reversible potassium intercalation and the presence of KC36,KC24,and KC8 phases at low voltages. | Guangzeng Cheng Wenzhe Zhang Wei Wang Huanlei Wang Yixian Wang Jing Shi Jingwei Chen Shuai Liu Minghua Huang David Mitlin | 2022 | Carbon Energy2022，4，5： | 1 |
| 15 | Antibiotics in the surface water of the Yangtze Estuary: Occurrence, distribution and risk assessment显示文摘 | Caixia Yan Yi Yang Junliang Zhou Min Liu Minghua Nie Hao Shi Lijun Gu | 2012 | Environmental Pollution2012，，： | 1 |
| 16 | Responses of ecosystem respiration and its components to fertilization in an alpine meadow on the Tibetan Plateau显示文摘 | Jing Jiang Ning Zong Minghua Song Peili Shi Weiling Ma Gang Fu Zhenxi Shen Xianzhou Zhang Hua Ouyang | 2013 | European Journal of Soil Biology2013，，： | 1 |
| 17 | An efficient digital VLSI implementation of Gaussian mixture mode!s-based classifier显示文摘 | Shi Minghua Bermak A | 2006 | IEEE Trans on Very Large Scale Integration System2006，14，9： | 1 |
| 18 | A new immune genetic algorithm based on uniform design sampling显示文摘 | ZHOU BENDA YAO HONGLIANG SHI MINGHUA | 2012 | Knowledge and Information Systems2012，31，2： | 1 |
| 19 | Antibiotics in the surface water of the Yangtze Estuary: Occurrence, distribution and risk assessment显示文摘 | Caixia Yan Yi Yang Junliang Zhou Min Liu Minghua Nie Hao Shi Lijun Gu | 2012 | Environmental Pollution2012，，： | 1 |
| 20 | Background progenitor activation is associated with recurrence after hepatectomy of combined hepatocellular‐cholangiocarcinoma显示文摘 | Xiong Cai Jian Zhai David E. Kaplan Yijun Zhang Lining Zhou Xutao Chen Guangyang Qian Qiudong Zhao Yonghai Li Lu Gao Wenming Cong Minghua Zhu Zhenlin Yan Lehua Shi Dong Wu Lixin Wei Feng Shen Mengchao Wu | 2012 | Hepatology2012，，5： | 1 |
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