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| 1 | Cancer metabolism and tumor microenvironment:fostering each other?显示文摘The changes associated with malignancy are not only in cancer cells but also in environment in which cancer cells live.Metabolic reprogramming supports tumor cells’high demand of biogenesis for their rapid proliferation,and helps tumor cells to survive under certain genetic or environmental stresses.Emerging evidence suggests that metabolic alteration is ultimately and tightly associated with genetic changes,in particular the dysregulation of key oncogenic and tumor suppressive signaling pathways.Cancer cells activate HIF signaling even in the presence of oxygen and in the absence of growth factor stimulation.This cancer metabolic phenotype,described firstly by German physiologist Otto Warburg,ensures enhanced glycolytic metabolism for the biosynthesis of macromolecules.The conception of metabolite signaling,i.e.,metabolites are regulators of cell signaling,provides novel insights into how reactive oxygen species(ROS)and other metabolites deregulation may regulate redox homeostasis,epigenetics,and proliferation of cancer cells.Moreover,the unveiling of noncanonical functions of metabolic enzymes,such as the moonlighting functions of phosphoglycerate kinase 1(PGK1),reassures the importance of metabolism in cancer development.The metabolic,microRNAs,and ncRNAs alterations in cancer cells can be sorted and delivered either to intercellular matrix or to cancer adjacent cells to shape cancer microenvironment via media such as exosome.Among them,cancer microenvironmental cells are immune cells which exert profound effects on cancer cells.Understanding of all these processes is a prerequisite for the development of a more effective strategy to contain cancers. | Yiyuan Yuan Huimin Li Wang Pu Leilei Chen Dong Guo Hongfei Jiang Bo He Siyuan Qin Kui Wang Na Li Jingwei Feng Jing Wen Shipeng Cheng Yaguang Zhang Weiwei Yang Dan Ye Zhimin Lu Canhua Huang Jun Mei Hua-Feng Zhang Ping Gao Peng Jiang Shicheng Su Bing Sun Shi-Min Zhao | 2022 | Science China(Life Sciences)2022，65，2： | 5 |
| 2 | High-efficiency Joining of C_f/Al Composites and TiAl Alloys under the Heat Effect of Laser-ignited Self-propagating High-temperature Synthesis显示文摘The aim of this study was to develop a high-efficiency joining method of Cf/Al composites and TiA l alloys under the heat effect of laser-ignited self-propagating high-temperature synthesis(SHS). The SHS reaction of Ni–Al–Zr interlayer was induced by laser beam and acted as local high-temperature heat source during the joining. Sound joint was obtained and verified the feasibility of this joining method. Effect of filler metals on the joint microstructure and shear strength was evaluated. When the joining pressure was 2 MPa with additive filler metals, joint shear strength reached the maximum of 41.01 MPa. | Zhuoran Li Guangjie Feng Shiyu Wang Shicheng Feng | 2016 | Journal of Materials Science & Technology2016，32，11： | 4 |
| 3 | Reactive Inorganic Vapor Deposition of Perovskite Oxynitride Films for Solar Energy Conversion显示文摘The synthesis of perovskite oxynitrides,which are promising photoanode candidates for solar energy conversion,is normally accomplished by high-temperature ammonolysis of oxides and carbonate precursors,thus making the deposition of their planar films onto conductive substrates challenging.Here,we proposed a facile strategy to prepare a series of perovskite oxynitride films.Taking SrTaO_(2)N as a prototype,we prepared SrTaO_(2)N films on Ta foils under NH_(3) flow by utilizing the vaporized SrCl_(2)/SrCO_(3) eutectic salt.The SrTaO_(2)N films exhibit solar water-splitting photocurrents of 3.0 mA cm^(-2) at 1.23 V vs.RHE(reversible hydrogen electrode),which increases by 270%compared to the highest photocurrent(1.1 mA cm^(-2) at 1.23 V vs.RHE)of SrTaO_(2)N reported in the literature.This strategy may also be applied to directly prepare a series of perovskite oxynitride films on conductive substrates such as ATaO_(2)N(A=Ca,Ba)and ANbO_(2)N(A=Sr,Ba). | Tao Fang Huiting Huang Jianyong Feng Yingfei Hu Qinfeng Qian Shicheng Yan Zhentao Yu Zhaosheng Li Zhigang Zou | 2019 | Research2019，，1： | 2 |
| 4 | National Alveolar Echinococcosis Distribution--China, 2012−2016显示文摘What is already known about this topic?Both alveolar echinococcosis(AE)and cystic echinococcosis are endemic in China,among which alveolar echinococcosis has a very high mortality rate.What is added by this report?The survey results showed the prevalence and scope of AE in China and identified high-risk groups including children,monks,herdsmen and illiterate people.At the same time,all the cases found in the survey(more than 90%of the patients did not go to the hospital for diagnosis and treatment before survey)were promptly diagnosed and treated.What are the implications for public health practice?This study provides information for the development of a plan for AE prevention and control and for the implementation of interventions targeted to high-risk populations. | Canjun Zheng Chuizhao Xue Shuai Han Zhongjie Li Hu Wang Liying Wang Ying Wang Qian Wang Yu Feng Yanyan Hou Xiao Ma Junying Ma Xiumin Han Gongsang Quzhen Xiaofeng Jiang Weidong Guo Xianglin Wu Yaming Yang Lei Cao Fanka Li Weiqi Chen Xinliu Yan Shicheng Yu Meihua Fu Qing Yu Ning Xiao Jiangping Cao Jun Yan Weiping Wu Xiao-nong Zhou | 2020 | China CDC weekly2020，2，1： | 2 |
| 5 | Polyetheretherketone/nano-fluorohydroxyapatite composite with antimicrobial activity and osseointegration properties显示文摘 | Lixin Wang Shu He Xiaomian Wu Shanshan Liang Zhonglin Mu Jie Wei Feng Deng Yi Deng Shicheng Wei | 2014 | Biomaterials2014，，25： | 1 |
| 6 | Preparation of magnetic porous carbon from waste hydrochar by simultaneous activation and magnetization for tetracycline removal显示文摘 | Xiangdong Zhu Yuchen Liu Feng Qian Chao Zhou Shicheng Zhang Jianmin Chen | 2013 | Bioresource Technology2013，，： | 1 |
| 7 | Protection of a cytidine deaminase gene gainst toxicity of high dose chemotherapy in mice显示文摘探索 transfecting cytidine (CD ) 的可行性的目的基因进老鼠骨髓房间以便观察高剂量 Ara-C 的药抵抗并且改进 myelosuppression 追随者联合化疗的忍耐。方法人的 cytidine 基因是进由制动火箭的老鼠骨髓房间的 transfected 病毒的向量。抵抗形成殖民地的单位 granulocyte 巨噬细胞(CFU 美国通用汽车公司) 试金在 Ara-C 对待的 transfected 老鼠骨髓房间以后被执行。DNA 从老鼠骨髓房间被提取。这药在在 transfection 以后的老鼠骨髓房间的抵抗基因被 PCR 检测。与病毒的制片人房间显示出的制动火箭有教养的施主鼠标的结果骨髓房间这药抵抗殖民地和电阻到 Ara-C,那么确实接受了与 CD 基因移植的鼠标(施主鼠标的 CFU 美国通用汽车公司是 52% , χ
2= 124.62, P <
0.01;接受老鼠是 54% , χ
2= 126.26, P <
0.01,与对比组相比) 。动物幸存率比控制的在基因 transfected 组是显著地更高的(χ
2= 7.42, P <
0.01 ) 。transfected 骨髓房间的 CD 基因被 PCR 证实。结论 CD 基因能高效地是进老鼠的骨髓房间的 transfected 并且增加药抵抗到 Ara-C。 | Bo Chen Caigang Liu Yang Lu Ping Lu Feng Jin Fan Yao Ruishan Zhang Jinlong Liu Shicheng Zhao | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，6： | 0 |
| 8 | Incidence Tendency Analysis on Type 2 Diabetes in 4 Asian Countries—China,Malaysia,Singapore,and Thailand,1990–2019显示文摘Summary What is already known about this topic?Roughly 80%of the global disease burden caused by diabetes comes from low-and-middle income countries,and 60%of diabetics are located in Asia;6 of the top 10 countries with the highest prevalence of diabetes are in Asia.What is added by this report?Compared with 1990,the growth rate of the standardized incidence rate of type 2 diabetes in 2019 in China was significantly lower than that of the entire world,while Malaysia,Singapore. | Wenhui Shi Qiqi Wang Jiaojiao Zhang Jingwen Zhang Feng Tan Shicheng Yu | 2021 | China CDC weekly2021，3，52： | 0 |
| 9 | Local modulation of exc辻ons and trions in monolayer WS2 by carbon nanotubes显示文摘Mixed dimensional van der Waals(VdW)heterostructures constructed by one-dimensional(1D)and two-dimensional(2D)materials exhibit extra degree of freedom to modulate the electronic and optical properties due to the combination of difterent dimensionalities.The charge transfer at the intertace between 1D and 2D materials plays a crucial role in the optoelectronic properties and performance of the heterostructure-based devices.Here,we stacked single-walled carbon nanotubes(SWNTs)on monolayer WS2 for a mixed dimensional vdW heterostructure,and investigated the local modulation of excitions and trions in WS2 by SWNTs.Different directions of charge transfer between SWNTs and WSz are evidenced by the photoluminescence(PL)spectra of WS2.The PL intensity can be either enhanced or weakened by individual SWNTs.In our work,the PL intensity of WS2 is enhanced and the exciton peak position heterostructure is red-shifted about 3 meV due to the charge transfer from WS2 to an individual SWNT(SWNT#1).The change of PL by another SWNT(SWNT#2)can not be well-resolved in far fild,but scanning near field optical microscope(SNOM)measurements show that the PL intensity of WS2 is weakened by the SWNT.The peak position of exciton is blue-shifted by^1 meV while that of trion is redshifted by^1 meV due to the charge transfer from the SWNT to WS2,These results give insight into the charge transfer at the interface of SWNTWS2 heterostructure,and can be useful for design of optoelectronic devices based on mixed dimensional vdW heterostructures. | Rui Feng Shicheng Xu Weiming Liu Peng Gao Jin Zhang Lianming Tong | 2020 | Nano Research2020，13，7： | 0 |
| 10 | Activation of lineage competence in hemogenic endothelium precedes the formation of hematopoietic stem cell heterogeneity显示文摘Hematopoietic stem and progenitor cells (HSPCs) are considered as a heterogeneous population, but precisely when, where and how HSPC heterogeneity arises remain largely unclear. Here, using a combination of single-cell multi-omics, lineage tracing and functional assays, we show that embryonic HSPCs originate from heterogeneous hemogenic endothelial cells (HECs) during zebrafish embryogenesis. Integrated single-cell transcriptome and chromatin accessibility analysis demonstrates transcriptional heterogeneity and regulatory programs that prime lymphoid/myeloid fates at the HEC level. Importantly, spi^(2+) HECs give rise to lymphoid/myeloid-primed HSPCs (L/M-HSPCs) and display a stress-responsive function under acute inflammation. Moreover, we uncover that Spi2 is required for the formation of L/M-HSPCs through tightly controlling the endothelial-to-hematopoietic transition program. Finally, single-cell transcriptional comparison of zebrafish and human HECs and human induced pluripotent stem cell-based hematopoietic differentiation results support the evolutionary conservation of L/M-HECs and a conserved role of SPI1 (spi2 homolog in mammals) in humans. These results unveil the lineage origin, biological function and molecular determinant of HSPC heterogeneity and lay the foundation for new strategies for induction of transplantable lineage-primed HSPCs in vitro. | Jun Xia Mengyao Liu Caiying Zhu Shicheng Liu Lanlan Ai Dongyuan Ma Ping Zhu Lu Wang Feng Liu | 2023 | Cell Research2023，33，6： | 0 |
| 11 | Burden of Acute Viral Hepatitis--China,1990−2019显示文摘What is already known about this topic?The World Health Organization’s(WHO)Global Health Estimates(GHE)reported that acute hepatitis caused 9,213 deaths and 307,720 person years of disability-adjusted life years(DALYs)in 2016,and acute hepatitis B accounted for 85.81%of all DALYs among acute hepatitis types A,B,C,and E in China.What is added by this report?In China,the percent changes in years lived with disability(YLDs)due to acute hepatitis A,B,and E in groups aged 50–69 years and 70 years or more and in all age groups for acute hepatitis C were increased from 2000 to 2019.What are the implications for public health practices?Effective vaccines,interventions,and treatments are key approaches to achieve the WHO’s goal of reducing new hepatitis infections by 90%and deaths by 65%between 2016 and 2030. | Shicheng Yu Qiqi Wang Shujun Wang Jiaojiao Zhang Yuehua Hu Junqi Li Xiaojuan Long Xianglong Xiang Maigeng Zhou Feng Tan | 2020 | China CDC weekly2020，2，31： | 0 |
| 12 | Comparing COVID-19 Case Prediction Between ARIMA Model and Compartment Model—China,December 2019–April 2020显示文摘Introduction:To compare the performance between the compartment model and the autoregressive integrated moving average(ARIMA)model that were applied to the prediction of new infections during the coronavirus disease 2019(COVID-19)epidemic.Methods:The compartment model and the ARIMA model were established based on the daily cases of new infection reported in China from December 2,2019 to April 8,2020.The goodness of fit of the two models was compared using the coefficient of determination(R2).Results:The compartment model predicts that the number of new cases without a cordon sanitaire,i.e.,a restriction of mobility to prevent spread of disease,will increase exponentially over 10 days starting from January 23,2020,while the ARIMA model shows a linear increase.The calculated R2 of the two models without cordon sanitaire were 0.990 and 0.981.The prediction results of the ARIMA model after February 2,2020 have a large deviation.The R2 of complete transmission process fit of the epidemic for the 2 models were 0.964 and 0.933,respectively.Discussion:The two models fit well at different stages of the epidemic.The predictions of compartment model were more in line with highly contagious transmission characteristics of COVID-19.The accuracy of recent historical data had a large impact on the predictions of the ARIMA model as compared to those of the compartment model.&Joint first authors. | Bangguo Qi Nankun Liu Shicheng Yu Feng Tan | 2022 | China CDC weekly2022，4，52： | 0 |
| 13 | Professor Jian Lu’s Interdisciplinary Approach to Modeling the COVID-19 Pandemic显示文摘Editorial Our new column Insights is an ongoing series of interviews prepared by the China CDC Weekly team with researchers,policymakers,experts,and other leaders that strives to disseminate experiences,knowledge,and perspectives in global and public health with a wider community.At the discretion of the Weekly’s team,these interviews will be written into articles,shared as videos,and/or presented as transcripts to best promote plain-language principles and to ease understanding of non-specialized academic readers. | Peter Hao Shicheng Yu Yu Chen Feng Tan | 2020 | China CDC weekly2020，2，27： | 0 |
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