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| 1 | Experimental study on scale inhibition performance of a green scale inhibitor polyaspartic acid显示文摘Static and dynamic experiments were carried out to validate scale inhibition performance of a green scale inhibitor-polyaspartic acid (PASP). From the static experiment, it was shown that below 60℃, polyaspartic acid is very effective in scale inhibition, with the scale inhibition ratio exceeding 90% with only 3 mg/L PASP for the 600 mg/L hardness solution. For a higher hardness solution of 800 mg/L, the scale inhibition ratio can also reach 90% with 6 and 12 mg/L PASP at 30 and 60℃respectively. The SEM photographs of CaCO3 crystals indicate that the crystal structure transforms from a compact stick-shape to a loose shape so that the scale can be washed away easily instead of being deposited on the heat transfer surface. The dynamic experimental results show that almost no scales formed on the heat trans- fer surface and the fouling thermal resistance decreases extraordinarily if PASP is added in the solution. | QUAN ZhenHua CHEN YongChang WANG XiuRong SHI Cheng LIU YunJie MA ChongFang | 2008 | Science China Chemistry2008，51，7： | 18 |
| 2 | A Highly Pathogenic Strain of Porcine Deltacoronavirus Caused Watery Diarrhea in Newborn Piglets显示文摘Porcine deltacoronavirus(PDCoV) is a newly identified virus that causes watery diarrhea in newborn piglets and results in significant economic losses to the pig industry. Since first reported in Hong Kong in 2012, PDCoV has been subsequently detected in USA, South Korea, Thailand, and China's Mainland. Here we isolated a strain of PDCoV, named CHN-GD-2016,from the intestinal content of a diseased newborn piglet with severe diarrhea in a pig farm in Guangdong, China. PDCoV CHN-GD-2016 could be identified by immunofluorescence with PDCoV specific rabbit antisera, and typical crown-shaped particles with spiky surface projections of this PDCoV were observed with electron microscopy. Genomic analysis showed that the PDCoV CHN-GD-2016 was closely related to other Chinese PDCoV strains, with the highest sequence similarity with the strain CHN/Tianjin/2016. Importantly, inoculation of newborn piglets with 1×10~5 TCID_(50) of CHN-GD-2016 by oral feeding successfully reproduced clear clinical symptoms, including vomiting, dehydration, and severe diarrhea in piglets. In addition, the virus RNA in rectal swabs from 1 to 7 days post inoculation was detected, macroscopic and microscopic lesions in small intestine were observed, and viral antigen was also detected in the small intestines with immunohistochemical staining. Collectively, the data show in this study confirms that PDCoV is present in Guangdong,China and is highly pathogenic in newborn piglets. | Zhichao Xu Huiling Zhong Qingfeng Zhou Yunping Du Li Chen Yun Zhang Chunyi Xue Yongchang Cao | 2018 | Virologica Sinica2018，33，2： | 16 |
| 3 | Spherical nano-Sb@C composite as a high-rate and ultra-stable anode material for sodium-ion batteries显示文摘一种喷雾器水花热分解技术被用来综合球形的 nano-Sb@C 合成。仪器的分析表明与 68.8 wt% 的一个优化 Sb 内容合成的 micro-nanostructured 一致地由极端小的 Sb nanoparticles (10 nm ) 组成在一个球形的多孔的 C 矩阵以内嵌入(作为 10-Sb @ C 表示了) 。Sb 的内容和尺寸能被改变先锋的集中控制。作为钠离子电池的阳极材料, 10-Sb @ C 提供 435 mAh 据 ? 椠据畬楤杮愠猠数楣楦 ? 慣慰楣慴据 ? 景ㄠ ? 的一个分泌物能力 ? 术挠浯慰敲 ? 楷桴琠敨瘠污敵漠 ??? 术映牯 ?? 瑡愠挠慨杲 ? 楤' 湛?慲整漠 ?? ‰ ? | Ning Zhang Yongchang Liu Yanying Lu Xiaopeng Han Fangyi Cheng Jun Chen | 2015 | Nano Research2015，8，10： | 14 |
| 4 | Generation of a precise Oct4-hrGFP knockin cynomolgus monkey model via CRISPR/Cas9-assisted homologous recombination显示文摘 | Yiqiang Cui Yuyu Niu Jiankui Zhou Yongchang Chen Yiwei Cheng Shangang Li Zongyong Ai Chu Chu Hong Wang Bo Zheng Xuejin Chen Jiahao Sha Xuejiang Guo Xingxu Huang Weizhi Ji | 2018 | Cell Research2018，28，3： | 13 |
| 5 | Transgenic rhesus monkeys carrying the human MCPH1 gene copies show human-like neoteny of brain development显示文摘Brain size and cognitive skills are the most dramatically changed traits in humans during evolution and yet the genetic mechanisms underlying these human-specific changes remain elusive.Here,we successfully generated 11 transgenic rhesus monkeys(8 first-generation and 3 second-generation)carrying human copies of MCPH1,an important gene for brain development and brain evolution.Brain-image and tissue-section analyses indicated an altered pattern of neural-cell differentiation,resulting in a delayed neuronal maturation and neural-fiber myelination of the transgenic monkeys,similar to the known evolutionary change of developmental delay(neoteny)in humans.Further brain-transcriptome and tissue-section analyses of major developmental stages showed a marked human-like expression delay of neuron differentiation and synaptic-signaling genes,providing a molecular explanation for the observed brain-developmental delay of the transgenic monkeys.More importantly,the transgenic monkeys exhibited better short-term memory and shorter reaction time compared with the wild-type controls in the delayed-matching-to-sample task.The presented data represent the first attempt to experimentally interrogate the genetic basis of human brain origin using a transgenic monkey model and it values the use of non-human primates in understanding unique human traits. | Lei Shi Xin Luo Jin Jiang Yongchang chen Cirong Liu Ting Hu Min Li Qiang Lin Yanjiao Li Jun Huang Hong Wang Yuyu Niu Yundi Shi Martin Styner Jianhong Wang Yi Lu Xuejin Sun Hualin Yu Weizhi Ji Bing Su | 2019 | National Science Review2019，6，3： | 12 |
| 6 | Identification and characterization of an ancient class of small RNAs enriched in serum associating with active infection显示文摘 | Yunfang Zhang Ying Zhang Junchao Shi He Zhang Zhonghong Cao Xuan Gao Wanhua Ren Yunna Ning Lina Ning Yujing Cao Yongchang Chen Weizhi Ji Zi-jiang Chen Qi Chen Enkui Duan | 2014 | Journal of Molecular Cell Biology2014，8，2： | 10 |
| 7 | Review of ice-pavement adhesion study and development of hydrophobic surface in pavement deicing显示文摘Ice adhesion to materials is a significant concern in many fields. Hydrophobic surface has been used for anti-icing in fields of aircraft or transmission line, which prove to be efficacious and economical. However, such technique is seldom employed for road deicing,because of the texture and service environment of pavement. Instead, deicers such as rock salt are frequently used, which leads to serious corrosion problem of roads and bridges. In this paper, a number of studies that characterize mechanism of ice adhesion to common substrates, specifically to pavement, are reviewed. The most important researches undertaken on ice adhesion strength affecting factors are presented. An overview of studies carried out to find hydrophobic surface for asphalt and cement concrete pavement antiicing are presented. It was verified that the hydrophobicity had high correlation with icephobicity, and nano-engineered asphalt and cement concrete pavement surface exhibited favorable hydrophobicity, and also had good performance on weakening pavement-ice bonding. However, most ice-repelling pavements obtain hydrophobic surface via low surface energy coating, which could not exist on pavement for a long time under wheel abrasion. And the nano/micro structures on hydrophobic surfaces are also vulnerable and consumable. Thus, the long-term effect of hydrophobic surface still need to be improved,and durability of the hydrophobic surface should be the research and development priorities of ice-repelling pavement. | Huaxin Chen Yongchang Wu Huiyun Xia Bingyin Jing Qingjiang Zhang | 2018 | Journal of Traffic and Transportation Engineering(English Edition)2018，5，3： | 9 |
| 8 | Germline acquisition of Cas9/RNA-mediated gene modifications in monkeys显示文摘 | Yongchang Chen Yiqiang Cui Bin Shen Yuyu Niu Xiaoyang Zhao Lei Wang Jianying Wang Wei Li Qi Zhou Weizhi Ji Jiahao Sha Xingxu Huang | 2015 | Cell Research2015，25，2： | 8 |
| 9 | Localization of phosphorylated TrkA in carrier vesicles involved in its nuclear translocation in U251 cell line显示文摘A number of transmembrane receptors are targeted to the nucleus and convincingly localized therein. However, what remains a conundrum is how these cell-surface receptors end up in the nucleus. In this study, we reported that the transmembrane receptor phosphorylated TrkA was located in a series of carrier vesicles, including ring-like vesicles near the plasma membrane, large core vesicles and small dense core vesicles around the nuclei, as well as in the nucleus in human glioma cell line U251 using immunocytochemistry and immunofluorescence staining. Meanwhile, we also showed that small dense core vesicles budded from large core vesicles, and interacted with the nuclear envelope. Accordingly, our results suggested that such a series of membrane compartments might be involved in the pathway of nuclear translocation of the transmembrane receptor TrkA. | GONG AiHua, ZHANG ZhiJian, XIAO DeSheng, YANG Yong, WANG YongZhong & CHEN YongChang School of Medicine, Jiangsu University, Zhenjiang 212013, China | 2007 | Science China(Life Sciences)2007，50，2： | 8 |
| 10 | Transgenic Nonhuman Primate Models for Human Diseases:Approaches and Contributing Factors显示文摘非人类的首领(NHP ) 提供有力的试验性的模型学习人的开发,认知功能和骚乱以及复杂行为,因为他们到人的基因、生理的类似。因此, NHP 是为人的疾病的学习的适当模型,例如包括 Parkinson 的, Alzheimer 的并且亨廷顿的疾病的 neurodegenerative 疾病,它由于基因变化发生。然而,折磨人的如此的疾病不在 NHP 自然地发生。那么转基因的 NHP 需要被证实理解疾病病理和致病的病原学。把基因模型,比作啮齿类动物为人的疾病的转基因的 NHP 的产生是低效的,并且为亨廷顿的疾病的一个仅仅转基因的猴子模型被报导了。这评论为产生转基因的 NHP 学习人的疾病集中于潜在的途径和作出贡献的因素。 | Yongchang Chen | 2012 | Journal of Genetics and Genomics2012，39，6： | 5 |
| 11 | Experimental study of viscosity characteristics of hightemperature heat transfer molten salts显示文摘In this paper several kinds of high temperature molten salts were investigated experimentally on viscosity-temperature characteristics with high-temperature viscometer.The viscosities of the molten salts were measured and compared with those from references to verify the reliability of the viscometer and measuring methods,and a good agreement was observed from the comparisons.Then,two new high-temperature molten salts were made from the HITEC salt by some additives and the viscosity-temperature profiles of them were obtained by experiments.The results show that the new molten salts have much lower viscosities,thus suitable for reducing the flow resistance in transportation system of high-temperature solar thermal power generation. | CHEN YongChang WU YuTing REN Nan MA ChongFang | 2011 | Science China(Technological Sciences)2011，54，11： | 5 |
| 12 | Mechanism of Calcium Carbonate Scale Deposition under Subcooled Flow Boiling Conditions显示文摘Fouling of heat transfer surfaces during subcooled flow boiling is a frequent engineering problem in process industries. It has been generally observed that the deposits in such industrial systems consist mainly of calcium carbonate (CaCO3), which has inverse solubility characteristics. This investigation focused on the mechanism to control deposition and the morphology of crystalline deposits. A series of experiments were carried out at different surface and bulk temperatures, fluid velocities and salt ion concentrations. It is shown that the deposition rate is controlled by different mechanism in the range of experimental parameters, depending on salt ion concentration. At higher ion concentration, the fouling rate increases linearly with surface temperature and the effect of flow velocity on deposition rate is quite strong, suggesting that mass diffusion controls the fouling process. On the contrary, at lower ion concentration, the fouling rate increases exponentially with surface temperature and is independent of the velocity, illustrating that surface reaction controls the fouling process. By analysis of the morphology of scale, two types of crystal (calcite and aragonite) are formed. The lower the temperature and ion concentration, the longer the induction period and the higher the percentage of calcite precipitated. | XING Xiaokai(邢晓凯) MA Chongfang(马重芳) CHEN Yongchang(陈永昌) | 2005 | Chinese Journal of Chemical Engineering2005，13，4： | 4 |
| 13 | INFLUENCES OF MARINE FLOOR HYDROTHERMAL ACTIVITY ON ORGANIC MATTER ABUNDANCE IN MARINE CARBONATE ROCKS——A CASE STUDY OF MIDDLE-UPPER PROTEROZOIC IN THE NORTHERN PART OF NORTH CHINA显示文摘Study indicates that the elements rich in marine floor hydrothermal fluids have a positive in- fluence, not only on total organic carbon (TOC), but also on the abundance of SiO2 in some Middle-Upper Proterozoic strata. The TOC bears a better positive correlation with abundance of SiO2. By the correlation analysis between organic matter and sea-floor hot fluid characterized trace elements such as P, Cu, Zn, Ni, Ba, etc in marine carbonate rocks, we conclude that organic matter enrichment of carbonate rocks were related to marine floor hydrothermal activity in a part of layers. Some thin-layered cherts, which were thought to be the indicators of hydrothermal activity, frequently occurring in Gaoyuzhuang, Wumishan, Tieling and Xiamaling formation support our conclu- sion. With the increasing of trace elements in marine carbonate rocks, the TOC and Fe/Ti ratio is creasing. In contrast, the Al/(Al+Fe+Mn) ratio is usually de- creasing. | WANG Jie CHEN Jianfa BAO Zhidong ZHANG Shuichang XU Yongchang WANG Darui | 2006 | Chinese Science Bulletin2006，51，5： | 3 |
| 14 | Clear cell renal cell carcinoma: Contrast-enhanced ultrasound features relation to tumor size显示文摘 | Jun Jiang Yaqing Chen Yongchang Zhou Huizhen Zhang | 2008 | European Journal of Radiology2008，，1： | 3 |
| 15 | A comprehensive understanding of the anionic redox chemistry in layered oxide cathodes for sodium-ion batteries显示文摘Sodium-ion batteries(SIBs) have demonstrated great application prospects in large-scale energy storage systems and low-speed electric vehicles due to the cost effectiveness and abundant resources. Layered transition-metal oxides are recognized as one of the most attractive sodium-ion storage cathode candidates by virtue of their high compositional diversity, environmental friendliness, ease of synthesis, and promising theoretical capacities. The practicability, however, is still limited by the fact that the energy densities of most Na-storage layered oxide cathodes solely using the conventional cationic redox are not comparable to those of the lithium-ion storage counterparts. Recently, the strategy of activating anionic redox(O^(2-)/O^(n-)) which is popular in Li-rich layered materials has been successfully applied in oxide cathodes of SIBs to promote the energy density to a new level. It is interesting to note that excess Na is not the prerequisite to induce anionic redox in sodium oxides, indicating a new mechanism underlying Na-ion materials. Herein, the latest advances on the anionic redox chemistry in layered oxide cathodes for SIBs,including the fundamental theories, triggering strategies, and applicable cathode materials, are comprehensively reviewed.Moreover, the challenges(mainly O_(2) release) facing anionic redox are discussed, and the possible remedies are outlined for future developments toward a highly reversible oxygen usage. We believe that this review can provide a valuable guidance for the exploration of high-energy layered oxide cathode materials of SIBs. | Junteng Jin Yongchang Liu Xuelu Pang Yao Wang Xianran Xing Jun Chen | 2021 | Science China Chemistry2021，64，3： | 3 |
| 16 | Exosome-loaded extracellular matrix-mimic hydrogel with anti-inflammatory property Facilitates/promotes growth plate injury repair显示文摘Growth plate cartilage has limited self-repair ability,leading to poor bone bridge formation post-injury and ultimately limb growth defects in children.The current corrective surgeries are highly invasive,and outcomes can be unpredictable.Following growth plate injury,the direct loss of extracellular matrix(ECM)coupled with further ECM depletion due to the inhibitory effects of inflammation on the cartilage matrix protein greatly hinder chondrocyte regeneration.We designed an exosome(Exo)derived from bone marrow mesenchymal stem cells(BMSCs)loaded ECM-mimic hydrogel to promote cartilage repair by directly supplementing ECM and anti-inflammatory properties.Aldehyde-functionalized chondroitin sulfate(OCS)was introduced into gelatin methacryloyl(GM)to form GMOCS hydrogel.Our results uncovered that GMOCS hydrogel could significantly promote the synthesis of ECM due to the doping of OCS.In addition,the GMOCS-Exos hydrogel could further promote the anabolism of chondrocytes by inhibiting inflammation and ultimately promote growth plate injury repair through ECM remodeling. | Pengfei Guan Can Liu Denghui Xie Shichao Mao Yuelun Ji Yongchang Lin Zheng Chen Qiyou Wang Lei Fan Yongjian Sun | 2022 | Bioactive Materials2022，7，4： | 3 |
| 17 | Recent advances in electrospun electrode materials for sodium-ion batteries显示文摘Sodium-ion batteries(SIBs)have been considered as an ideal choice for the next generation large-scale energy storage applications owing to the rich sodium resources and the analogous working principle to that of lithium-ion batteries(LIBs).Nevertheless,the larger size and heavier mass of Na^(+)ion than those of Li^(+)ion often lead to sluggish reaction kinetics and inferior cycling life in SIBs compared to the LIB counterparts.The pursuit of promising electrode materials that can accommodate the rapid and stable Na-ion insertion/extraction is the key to promoting the development of SIBs toward a commercial prosperity.One-dimensional(1 D)nanomaterials demonstrate great prospects in boosting the rate and cycling performances because of their large active surface areas,high endurance for deformation stress,short ions diffusion channels,and oriented electrons transfer paths.Electrospinning,as a versatile synthetic technology,features the advantages of controllable preparation,easy operation,and mass production,has been widely applied to fabricate the 1 D nanostructured electrode materials for SIBs.In this review,we comprehensively summarize the recent advances in the sodium-storage cathode and anode materials prepared by electrospinning,discuss the effects of modulating the spinning parameters on the materials’micro/nano-structures,and elucidate the structure-performance correlations of the tailored electrodes.Finally,the future directions to harvest more breakthroughs in electrospun Na-storage materials are pointed out. | Yao Wang Yukun Liu Yongchang Liu Qiuyu Shen Chengcheng Chen Fangyuan Qiu Ping Li Lifang Jiao Xuanhui Qu | 2021 | Journal of Energy Chemistry2021，30，3： | 3 |
| 18 | Purification,structural elucidation,and in vitro antitumor effects of novel polysaccharides from Bangia fuscopurpurea显示文摘A water-soluble polysaccharide,designated BFP-3,was isolated from Bangia fuscopurpurea by hot water extraction,anion-exchange,and size-exclusion chromatography and tested to determine its antitumor activity.The structural characteristics of BFP-3 were investigated by chemical and spectroscopic methods,including partial acid hydrolysis,methylation analysis,one-and two-dimensional nuclear magnetic resonance,and gas chromatography-mass spectrometry.The results showed that BFP-3 was mainly comprised of rhamnose,arabinose,mannose,glucose,and galactose.Moreover,the weight-average molecular weight of BFP-3 was estimated to be approximately 333 kDa.The backbone of BFP-3 was primarily composed of repeating 5-α-l-Araf-1→(4-α-d-Glcp-1)_(4)→4,6-β-d-Manp-1 units,and the side chains consisted of repeatingβ-d-Galp-1→(4-β-d-Galp-1)_(4)→4,6-β-d-Galp-1→3,4-α-l-Rhap,β-l-Arap-1→(3-β-d-Galp-1)_(3),andβ-l-Arap-1 units.Counting Kit-8 assays revealed that BFP-3 significantly inhibited the proliferation of A2780,COC1,SKOV3,HO-8910,and OVCAR3 ovarian cancer cells in vitro,indicating that BFP-3 could have potential applications in the treatment of ovarian cancer. | Jingna Wu Xiaoting Chen Kun Qiao Yongchang Su Zhiyu Liu | 2021 | Food Science and Human Wellness2021，10，1： | 3 |
| 19 | Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos显示文摘 | Yuyu Niu Bin Shen Yiqiang Cui Yongchang Chen Jianying Wang Lei Wang Yu Kang Xiaoyang Zhao Wei Si Wei Li Andy Peng Xiang Jiankui Zhou Xuejiang Guo Ye Bi Chenyang Si Bian Hu Guoying Dong Hong Wang Zuomin Zhou Tianqing Li Tao Tan Xiuqiong Pu Fang Wang Shaohu | 2014 | Cell2014，，： | 3 |
| 20 | Microstructure evolution and interface structure of Al-40 wt% Si composites produced by high-energy ball milling显示文摘High silicon content Al-Si composites with a composition of Al-40 wt% Si were fabricated via a highenergy ball milling method. The microstructure evolution of Al-40 wt% Si milled powders and sintered composites has been thoroughly studied by scanning electron microscopy, X-ray diffraction, energydispersive spectrometry and high-resolution transmission electron microscopy. The mechanism of ball milling Al-40 wt% Si powders has been disclosed in detail: fracture mechanism dominating in the early stages, followed by the agglomeration mechanism, finally reaching the balance between the fragments and the agglomerates. It has been found that the average particle sizes of mixed Al-Si powders can be refined to the nanoscale, and the crystallite sizes of Al and Si have been reduced to 10nm and 62nm upon milling for 2h–50h, respectively. The finally formed Al-Si interfaces after ball milling for 50h are wellcohesive. A dense and homogenous Al-40 wt% Si composite have been achieved by solid-state sintering at550?C. The results thus provide an effective support for producing bulk nanostructured Al-Si composites. | Yuanyuan Chen Zhangping Hu Yifei Xu Jiangyong Wang Peter Schützendübe Yuan Huang Yongchang Liu Zumin Wang | 2019 | Journal of Materials Science & Technology2019，35，4： | 2 |
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