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| 1 | Stenting for symptomatic intracranial arterial stenosis in China:1-year outcome of a multicentre registry study显示文摘background and purpose A multicentre prospective registry study of individually tailored stenting for a patient with symptomatic intracranial atherosclerotic stenosis(ICAS)combined with poor collaterals in China showed that the short-term safety and efficacy of stenting was acceptable.However,it remained uncertain whether the low event rate could be of a long term.We reported the 1-year outcome of this registry study to evaluate the long-term efficacy of individually tailored stenting for patients with severe symptomatic ICAS combined with poor collaterals.Methods Patients with symptomatic ICAS caused by 70%-99% stenosis located at the intracranial internal carotid,middle cerebral,intracranial vertebral or basilar arteries combined with poor collaterals were enrolled.Balloon-mounted stent or balloon plus self-expanding stent were selected based on the ease of vascular access and lesion morphology determined by the operators.The primary outcome was the rate of 30-day stroke,transient ischaemic attack and death,and 12-month ischaemic stroke within the same vascular territory,haemorrhagic stroke and vascular death after stenting.results From September 2013 to January 2015,300 patients(ages 58.3±9.78 years)were recruited.Among them,159 patients were treated with balloon-mounted stent and 141 with balloon plus self-expanding stent.During the 1-year follow-up,25 patients had a primary end point event.The probability of primary outcome at 1 year was 8.1%(95% CI 5.3% to 11.7%).In 76 patients with digital subtraction angiography follow-up,27.6%(21/76)had re-stenosis≥50% and 18.4%(14/76)had re-stenosis≥70%.No baseline characteristic was associated with the primary outcome.Conclusion The event rate remains low over 1 year of individually tailored stenting for patients with severe symptomatic ICAS combined with poor collaterals.Further randomised trial of comparing individually tailored stenting with best medical therapy is needed. | Ning Ma Yong Zhang Jie Shuai Changchun Jiang Qiyi Zhu Kangning Chen Li Liu Baomin Li Xiangqun Shi Lianbo Gao Yajie Liu Feng Wang Yongli Li Tieyan Liu Hongbo Zheng Dapeng Mo Feng Gao Yilong Wang Yongjun Wang Lei Feng Zhongrong Miao | 2018 | Stroke & Vascular Neurology2018，3，3： | 29 |
| 2 | Role of NLRP3 and NLRP1 inflammasomes signaling pathways in pathogenesis of rheumatoid arthritis显示文摘Objective:To investigate the role of NLRP3 and NLRP1 inflammasomes signaling pathways in rheumatoid arthritis(RA).Methods:A total of 36 patients with RA were selected,peripheral blood mononuclear cell(PBMC)and granulocyte were separated from venous blood.RT-qPCR method was used to detect the expression level and diversity of NLRP3 and NLRP1 in PBMC and granulocyte mRNA in patieuts with RA.and detect the mRNA expression of downstream factor IL-1β.The correlation between RA and the expression of NLRP3 aud NLRP1 was analyzed.Normal 30 cases were set as control group.Results:Expression levels of NLRP1.and caspase-1mRNA in PBMC of RA group were significautly lower than those of control group(P<0.05).while there was no significant differeuee in expression levels of NLRP3,ASC.IL-1βmRNA between these two groups(P>0.05);NLRP3,caspase-1,and ASC mRNA expression in granulocyte of RA patients were significantly lower than those in control group(P<0.05).There was no currelation between rheumatoid factor and expression levels of NLRP3.ASC.caspase-1 mRNA in RA group(P>0.05);NLRP1,IL-1βmRNA expression level had a negative corrlation with anti-rheunatoid factor antibody(P=0.0332,0.0340).Conclusions:NLRP3 and NLRP1 inflammasomes signaling pathways are involved in RA inflammatory reaction process as protective factors,and play an important role in RA inflammatory mechanisms. | Tao Wang Chang-Liang Zhu Shuai Wang Li-Wen Mo Guo-Dong Yang Jun Hu Fan Zhang | 2014 | Asian Pacific Journal of Tropical Medicine2014，7，10： | 11 |
| 3 | An Abietane Diterpene and a Sterol from Fungus Phellinus igniarius显示文摘新 abietane diterpene12-hydroxy-7-oxo-5,8,11,13-tetraene-18,6-abietanolide 和新自然 sterolstigmasta-7,22-diene-3beta, 5alpha,6alpha-triol 从真菌 Phellinus igniarius.Their 结构的 fruiting 身体被孤立被分光镜的方法包括 2DNMR 技术阐明。 | Ying WANG Su Juan WANG Shun Yan MO Shuai LI Yong Chun YANG Jian Gong SHI | 2006 | Chinese Chemical Letters2006，17，4： | 10 |
| 4 | Load Sharing Behavior of Star Gearing Reducer for Geared Turbofan Engine显示文摘Load sharing behavior is very important for power-split gearing system,star gearing reducer as a new type and special transmission system can be used in many industry fields.However,there is few literature regarding the key multiple-split load sharing issue in main gearbox used in new type geared turbofan engine.Further mechanism analysis are made on load sharing behavior among star gears of star gearing reducer for geared turbofan engine.Comprehensive meshing error analysis are conducted on eccentricity error,gear thickness error,base pitch error,assembly error,and bearing error of star gearing reducer respectively.Floating meshing error resulting from meshing clearance variation caused by the simultaneous floating of sun gear and annular gear are taken into account.A refined mathematical model for load sharing coefficient calculation is established in consideration of different meshing stiffness and supporting stiffness for components.The regular curves of load sharing coefficient under the influence of interactions,single action and single variation of various component errors are obtained.The accurate sensitivity of load sharing coefficient toward different errors is mastered.The load sharing coefficient of star gearing reducer is 1.033 and the maximum meshing force in gear tooth is about 3010 N.This paper provides scientific theory evidences for optimal parameter design and proper tolerance distribution in advanced development and manufacturing process,so as to achieve optimal effects in economy and technology. | Shuai MO Yidu ZHANG Qiong WU Feiming WANG Shigeki MATSUMURA Haruo HOUJOH | 2017 | Chinese Journal of Mechanical Engineering2017，30，4： | 2 |
| 5 | SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors显示文摘Muta nt isocitrate dehydrog en ase 1(mlDH1)drives tumorigenesis via produci ng on cometabolite R-2-hydroxyglutarate(R-2-HG)across various tumor types.However,mlDHl in hibitors appear only effective in hematological tumors.The therapeutic ben efit in solid tumors remains elusive,likely due to the complex tumor microenvironment.In this study,we discover that R-2-HG produced by IDH1-mutant tumor cells is preferentially imported into vascular endothelial cells and remodels mitochondrial respiration to promote tumor angiogenesis,conferring a therapeutic vulnerability in IDH1-mutant solid tumors.Mechanistically,SLC1 Alz a Na'-depe ndent glutamate tran sporter that is prefere ntially expressed in en dothelial cells,facilitates the in flux of R-2-HG from the tumor microenvironment into the endothelial cells as well as the intracellular trafficking of R-2-HG from cytoplasm to mitochondria.R-2-HG hijacks SLC1A1 to promote mitochondrial Na^(+)/Ca^(2+)exchange,which activates the mitochondrial respiratory chain and fuels vascular en dothelial cell migratio n in tumor an giogenesis.SLC1A1 deficiency in mice abolishes mlDHl-promoted tumor an giogenesis as well as the therapeutic benefit of mlDHl in hibitor in solid tumors.Moreover,we report that HH2301,a newly discovered mlDHl inhibitor,shows promising efficacy in treating IDH1-mutant cholangiocarcinoma in preclinical models.Together,we identify a new role of SLC1A1 as a gatekeeper of R-2-HG-mediated crosstalk between IDH1-mutant tumor cells and vascular en dothelial cells,and dem on strate the therapeutic potential of mlDHl in hibitors in treating IDH1-muta nt solid tumors via disrupting R-2-HG-promoted tumor angiogenesis. | Xiaomin Wang Ziqi Chen Jun Xu Shuai Tang Nan An Lei Jiang Yixiang Zhang Shaoying Zhang Qingli Zhang Yanyan Shen Shijie Chen Xiaojing Lan Ting Wang Linhui Zhai Siyuwei Cao Siqi Guo Yingluo Liu Aiwei Bi Yuehong Chen Xiameng Gai Yichen Duan Ying Zheng Yixian Fu Yize Li Liang Yuan Linjiang Tong Kun Mo Mingcheng Wang Shu-Hai Lin Minjia Tan Cheng Luo Yi Chen Jia Liu Qiansen Zhang Leping Li Min Huang | 2022 | Cell Research2022，32，7： | 2 |
| 6 | Learning to synthesize:robust phase retrieval at low photon counts显示文摘The quality of inverse problem solutions obtained through deep learning is limited by the nature of the priors learned from examples presented during the training phase.Particularly in the case of quantitative phase retrieval,spatial frequencies that are underrepresented in the training database,most often at the high band,tend to be suppressed in the reconstruction.Ad hoc solutions have been proposed,such as pre-amplifying the high spatial frequencies in the examples;however,while that strategy improves the resolution,it also leads to high-frequency artefacts,as well as low-frequency distortions in the reconstructions.Here,we present a new approach that learns separately how to handle the two frequency bands,low and high,and learns how to synthesize these two bands into full-band reconstructions.We show that this“learning to synthesize”(LS)method yields phase reconstructions of high spatial resolution and without artefacts and that it is resilient to high-noise conditions,e.g.,in the case of very low photon flux.In addition to the problem of quantitative phase retrieval,the LS method is applicable,in principle,to any inverse problem where the forward operator treats different frequency bands unevenly,i.e.,is ill-posed. | Mo Deng Shuai Li Alexandre Goy Iksung Kang George Barbastathis | 2020 | Light(Science & Applications)2020，9，1： | 1 |
| 7 | A facile protocol for the synthesis of mono-N-methyl anilines via formimidate intermediates显示文摘 | SUN Nan WANG Shuai MO Wei-min | | 0，，35： | 1 |
| 8 | Clean production of Fe-based amorphous soft magnetic alloys via smelting reduction of high-phosphorus iron ore and apatite显示文摘Separated preparation of prealloys and amorphous alloys results in severe solidification-remelting and beneficial element removal-readdition contradictions,which markedly increase energy consumption and emissions.This study offered a novel strategy for the direct production of FePC amorphous soft magnetic alloys via smelting reduction of high-phosphorus iron ore(HPIO)and apatite.First,the thermodynamic conditions and equilibrium states of the carbothermal reduction reactions in HPIO were calculated,and the element content in reduced alloys was theoretically determined.The phase and structural evolutions,as well as element migration and enrichment behaviors during the smelting reduction of HPIO and Ca_(3)(PO_(4))_(2),were then experimentally verified.The addition of Ca_(3)(PO_(4))_(2)in HPIO contributes to the enrichment of the P element in reduced alloys and the subsequent development of Fe_(3)P and Fe_(2)P phases.The content of P and C elements in the range of 1.52 wt% -14.63 wt% and 0.62 wt% -2.47 wt%,respectively,can be well tailored by adding 0-50 g Ca_(3)(PO_(4))_(2)and controlling the C/O mole ratio of 0.8-1.1,which is highly consistent with the calculated results.These FePC alloys were then successfully formed into amorphous ribbons and rods.The energy consumption of the proposed strategy was estimated to be 2.00×10^(8) kJ/t,which is reduced by 30% when compared with the conventional production process.These results are critical for the comprehensive utilization of mineral resources and pave the way for the clean production of Fe-based amorphous soft magnetic alloys. | Hua Zhang Tuoxiao Wang Guoyang Zhang Wenjie Wu Long Zhao Tao Liu Shuai Mo Hongwei Ni | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，12： | 0 |
| 9 | Purifying Fe-based amorphous alloys to enhance glass-forming ability by designing a novel refining slag显示文摘Designing low melting point and low basicity refining slag suitable for Fe-based amorphous alloys and understanding the inclusions’formation,removal,influencing mechanisms are quite vital in the fields of metallurgy and materials.In this study,a novel 13%SiO_(2)-32%CaO-30%Al_(2)O_(3)-25%B_(2)O_(3)(wt.%)refining slag was designed after careful calculations of the liquid phase region,slag-metal equilibrium,surface tension,viscosity,deoxidation capability and sulfur distribution ratio.After refining with our designed slag,the content of impurities and the number density of inclusions in a representative Fe_(83)Si_(2)B_(15)(at.%)amor-phous alloy were significantly reduced.Moreover,the glass-forming ability(GFA)of the alloy was also enhanced,enabling the preparation of amorphous ribbons with a lower cooling rate.Based on the impu-rities in Fe-based amorphous alloys as well as the calculated oxide and sulfide free energy diagrams,CaO,SiO_(2),Al_(2)O_(3) oxides and CaS,TiS,MnS sulfides will form in the master alloy.The high melting point in-clusions in the melt are generally removed via a floatation-separation-absorption process and the Mn,Ti,S impurities are removed via slag-metal interface reactions during refining.As for the detrimental effect of inclusions on glass formation,the small lattice disregistry between Ti,Mn-containing inclusions and primaryα-Fe gains reveal that these inclusions are effective in promoting the heterogeneous nucleation,and therefore greatly deteriorate the GFA.These findings are important and provide an ideal solution to purifying the Fe-based amorphous alloys by refining and enhancing the GFA for industrial production. | Shuai Mo Jing Zeng Hua Zhang Yinan Wu Tao Liu Hongwei Ni | 2023 | Journal of Materials Science & Technology2023，，12： | 0 |
| 10 | SCGN deficiency is a risk factor for autism spectrum disorder显示文摘Autism spectrum disorder(ASD)affects 1-2%of all children and poses a great social and economic challenge for the globe.As a highly heterogeneous neurodevelopmental disorder,the development of its treatment is extremely challenging.Multiple pathways have been linked to the pathogenesis of ASD,including signaling involved in synaptic function,oxytocinergic activities,immune homeostasis,chromatin modifications,and mitochondrial functions.Here,we identify secretagogin(SCGN),a regulator of synaptic transmission,as a new risk gene for ASD.Two heterozygous loss-of-function mutations in SCGN are presented in ASD probands.Deletion of Scgn in zebrafish or mice leads to autism-like behaviors and impairs brain development.Mechanistically,Scgn deficiency disrupts the oxytocin signaling and abnormally activates inflammation in both animal models.Both ASD probands carrying Scgn mutations also show reduced oxytocin levels.Importantly,we demonstrate that the administration of oxytocin and anti-inflammatory drugs can attenuate ASD-associated defects caused by SCGN deficiency.Altogether,we identify a convergence between a potential autism genetic risk factor SCGN,and the pathological deregulation in oxytocinergic signaling and immune responses,providing potential treatment for ASD patients suffering from SCGN deficiency.Our study also indicates that it is critical to identify and stratify ASD patient populations based on their disease mechanisms,which could greatly enhance therapeutic success. | Zhe Liu Shuai Tan Lianyu Zhou Li Chen Mingfeng Liu Wang Wang Yingying Tang Qin Yang Sensen Chi Peiyan Jiang Yue Zhang Yonghua Cui Junhong Qin Xiao Hu Shenglong Li Qi Liu Lu Chen Song Li Ezra Burstein Wei Li Xiaohu Zhang Xianming Mo Da Jia | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 11 | Gamma ray multiplicity of a^(240)Pu solid sphere simulated by JMCT显示文摘Determining the mass of plutonium metal is an important research objective in the field of nuclear material accounting and control.Based on the 3D neutron and photon transport code JMCT(Jointed Monte Carlo Transport),the gamma ray multiplicity of ^(240)Pu was simulated in this study,and the average number of gamma rays leaking from ^(240)Pu solid spheres with different masses was also obtained.The simulation results show that there is a oneto-one correspondence between the average number of gamma rays and the mass of ^(240)Pu solid spheres in the range of 0.50–3.00 kg.This result provides a basis for using the average number of gamma rays to account for the mass of ^(240)Pu. | Huan-Huan Ding Fan Gao Chang-Bing Lu Rui Li Chen-Guang Li Zhao-Hong Mo Dun-Fu Shi Ming Su De-Shan Zhao Mao-Bing Shuai Zhong-Hua Xiong Bin-Yuan Xia Yun Bai | 2022 | Nuclear Science and Techniques2022，33，5： | 0 |
| 12 | Alteration of the respiratory microbiome in COVID-19 patients with different severities显示文摘Coronavirus disease 2019(COVID-19) is rampant worldwide and has affected more than 215 countries and regions. According to the World Health Organization's report, there were 226,018,919 COVID-19 cases and 4,654,898 deaths as of March 14, 2021, although300,002,228 vaccines have been administered globally. COVID-19patients have different clinical phenotypes and can be divided into asymptomatic, normal, mild, severe, and critical patients. | Zhengtu Li Yinhu Li Linghua Li Xiaoneng Mo Shaoqiang Li Mingzhou Xie Yangqing Zhan Ye Lin Zhun Li Min Xie Zhaoming Chen Airu Zhu Ruosu Ying Le Yu Jin cun Zhao Shuai Cheng Li Weiping Cai Feng Ye | 2022 | Journal of Genetics and Genomics2022，49，3： | 0 |
| 13 | CLSTM-KF reconstruction method for a low-activity moving radiation source localization and tracking with a coded-aperture gamma camera显示文摘Background Accurate localization of a low-activity moving radiation source plays an important role in nuclear security and safety.The coded-aperture gamma camera is generally applied to detect a radiation source,but its reconstruction methods may have some limitations when the radiation source is motional and weak.Purpose The purpose of this paper is to improve the quality of the reconstruction images and the localization accuracy when detecting a low-activity moving radiation source with a gamma camera.Method The CLSTM-KF method consists of the CLSTM network and the Kalman filter.The CLSTM network is applied to improve the CNR of reconstruction images by making an adaptive superposition for sequential reconstruction images decoded by the correlation analysis method.After the CLSTM network,a series of sequential positions would be filtered by the Kalman filter.Results By comparing with the traditional methods of the gamma camera,the CLSTM-KF method performs well in improving both the CNR of reconstruction images and the localization accuracy.Moreover,the computation time of the CLSTM-KF method can also meet the application requirements.Conclusion In summary,the CLSTM-KF method provides a better choice than the traditional methods in locating and tracking a low-activity moving radiation source. | Yi Zou Shuang‑Quan Liu Xiao‑Li Sun Yue Yu Mo‑Han Li Chun‑Miao Li Lei Shuai Long Wei | 2021 | Radiation Detection Technology and Methods2021，5，2： | 0 |
| 14 | Treatment patterns and a prognostic scoring system for elderly acute myeloid leukemia patients:a retrospective multicenter cohort study in China显示文摘Objective:Acute myeloid leukemia(AML)is primarily a malignant disorder affecting the elderly.We aimed to compare the outcomes of different treatment patterns in elderly AML patients and to propose a prognostic scoring system that could predict survival and aid therapeutic decisions.Methods:Patients aged≥60 years who had been diagnosed with AML at 7 hospitals in China were enrolled(n=228).Treatment patterns included standard chemotherapy,low intensity therapy,and best supportive care(BSC).Results:The early mortality rates were 31%,6.8%,and 6.3%for the BSC,low intensity therapy,and standard chemotherapy groups,respectively.The complete remission rate of the standard chemotherapy group was higher than that of the low intensity therapy group.The median overall survival(OS)was 561 days and 222 days for the standard chemotherapy and low intensity therapy groups,respectively,and were both longer than that of the BSC group(86 days).Based on multivariate analyses,we defined a prognostic scoring system that enabled classification of patients into 3 risk groups,in an attempt to predict the OS of patients receiving chemotherapies and low intensity therapies.Low and intermediate risk patients benefited more from standard chemotherapies than from low intensity therapies.However,the median OS was comparable between standard chemotherapies and low intensity therapies in high risk patients.Conclusions:Our prognostic scoring system could predict survival and help select appropriate therapies for elderly AML patients.Standard chemotherapy is important for elderly AML patients,particularly for those categorized into low and intermediate risk groups. | Chunli Zhang Wei Wan Shuai Zhang Jingwen Wang Ru Feng Jiangtao Li Junyue Chai Hebing Zhou Liru Wang Yuping Zhong Xiaodong Mo Mengzhu Shen Hongmei Jing Hui Liu | 2022 | Cancer Biology & Medicine2022，19，6： | 0 |
| 15 | Tra2βEnhances Cell Proliferation by Inducing the Expression of Transcription Factor SP1 in Cervical Cancer显示文摘Objective In this study,the role and potential mechanism of transformer 2β(Tra2β)in cervical cancer were explored.Methods The transcriptional data of Tra2βin patients with cervical cancer from Gene Expression Profiling Interactive Analysis(GEPIA)and cBioPortal databases were investigated.The functions of Tra2βwere evaluated by using Western blot,MTT,colony formation,Transwell assays,and nude mouse tumor formation experiments.Target genes regulated by Tra2βwere studied by RNA-seq.Subsequently,representative genes were selected for RT-qPCR,confocal immunofluorescence,Western blot,and rescue experiments to verify their regulatory relationship.Results The dysregulation of Tra2βin cervical cancer samples was observed.Tra2βoverexpression in Siha and Hela cells enhanced cell viability and proliferation,whereas Tra2βknockdown showed the opposite effect.Alteration of Tra2βexpression did not affect cell migration and invasion.Furthermore,tumor xenograft models verified that Tra2βpromoted cervical cancer growth.Mechanically,Tra2βpositively regulated the mRNA and protein level of SP1,which was critical for the proliferative capability of Tra2β.Conclusion This study demonstrated the important role of the Tra2β/SP1 axis in the progression of cervical cancer in vitro and in vivo,which provides a comprehensive understanding of the pathogenesis of cervical cancer. | LI Mo Juan XIONG Dan WANG Shuai HUANG Hao | 2023 | Biomedical and Environmental Sciences2023，36，2： | 0 |
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