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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Climate Sensitivity and Feedbacks of a New Coupled Model CAMS-CSM to Idealized CO_2 Forcing: A Comparison with CMIP5 Models显示文摘Climate sensitivity and feedbacks are basic and important metrics to a climate system. They determine how large surface air temperature will increase under CO_2 forcing ultimately, which is essential for carbon reduction policies to achieve a specific warming target. In this study, these metrics are analyzed in a climate system model newly developed by the Chinese Academy of Meteorological Sciences(CAMS-CSM) and compared with multi-model results from the Coupled Model Comparison Project phase 5(CMIP5). Based on two idealized CO_2 forcing scenarios, i.e.,abruptly quadrupled CO_2 and CO_2 increasing 1% per year, the equilibrium climate sensitivity(ECS) and transient climate response(TCR) in CAMS-CSM are estimated to be about 2.27 and 1.88 K, respectively. The ECS is near the lower bound of CMIP5 models whereas the TCR is closer to the multi-model ensemble mean(MME) of CMIP5 due to compensation of a relatively low ocean heat uptake(OHU) efficiency. The low ECS is caused by an unusually negative climate feedback in CAMS-CSM, which is attributed to cloud shortwave feedback(λSWCL) over the tropical Indo-Pacific Ocean.The CMIP5 ensemble shows that more negative λSWCL is related to larger increase in low-level(925–700 hPa)cloud over the tropical Indo-Pacific under warming, which can explain about 90% of λSWCL in CAMS-CSM. Static stability of planetary boundary layer in the pre-industrial simulation is a critical factor controlling the low-cloud response and λSWCL across the CMIP5 models and CAMS-CSM. Evidently, weak stability in CAMS-CSM favors lowcloud formation under warming due to increased low-level convergence and relative humidity, with the help of enhanced evaporation from the warming tropical Pacific. Consequently, cloud liquid water increases, amplifying cloud albedo, and eventually contributing to the unusually negative λSWCL and low ECS in CAMS-CSM. Moreover, the OHU may influence climate feedbacks and then the ECS by modulating regional sea surface temperature responses. | Xiaolong CHEN Zhun GUO Tianjun ZHOU Jian LI Xinyao RONG Yufei XIN Haoming CHEN Jingzhi SU | 2019 | Journal of Meteorological Research2019，33，1： | 11 |
| 3 | Cystathionine-γ-lyase ameliorates the histone demethylase JMJD3-mediated autoimmune response in rheumatoid arthritis显示文摘Cystathionine-γ-lyase(CSE),an enzyme associated with hydrogen sulfide(H2S)production,is an important endogenous regulator of inflammation.Jumonji domain-containing protein 3(JMJD3)is implicated in the immune response and inflammation.Here,we investigated the potential contribution of JMJD3 to endogenous CSE-mediated inflammation in rheumatoid arthritis(RA).Upregulated CSE and JMJD3 were identified in synovial fibroblasts(SFs)from RA patients as well as in the joints of arthritic mice.Knocking down CSE augmented inflammation in IL-1β-induced SFs by increasing JMJD3 expression.In addition,CSE−/−mice with collagen-induced arthritis(CIA)developed severe joint inflammation and bone erosion.Conversely,overexpressing CSE inhibited JMJD3 expression by the transcription factor Sp-1 and was accompanied by reduced inflammation in IL-1β-treated SFs.Furthermore,JMJD3 silencing or the administration of the JMJD3 inhibitor GSK-J4 significantly decreased the inflammatory response in IL-1β-treated SFs,mainly by controlling the methylation status of H3K27me3 at the promoter of its target genes.GSK-J4 markedly attenuated the severity of arthritis in CIA mice.In conclusion,suppressing JMJD3 expression by the transcription factor Sp-1 is likely responsible for the ability of CSE to negatively modulate the inflammatory response and reduce the progression of RA. | Weijun Wu Ming Qin Wanwan Jia Zheng Huang Zhongzheng Li Di Yang Mengwei Huang Chenxi Xiao Fen Long Jianchun Mao Philip K.Moore Xinhua Liu Yi Zhun Zhu | 2019 | Cellular & Molecular Immunology2019，16，8： | 9 |
| 4 | The FGOALS climate system model as a modeling tool for supporting climate sciences:An overview显示文摘Climate system models are useful tools for understanding the interactions among the components of the climate system and predicting/projecting future climate change. The development of climate models has been a central focus of the State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics, Institute of Atmospheric Physics, Chinese Academy of Sciences(LASG/IAP) since the establishment of the laboratory in 1985. In China, many pioneering component models and fully coupled models of the climate system have been developed by LASG/IAP. The fully coupled climate system developed in the recent decade is named FGOALS(Flexible Global Ocean-Atmosphere-Land System Model). In this paper, an application-oriented review of the LASG/IAP FGOALS model is presented. The improved model performances are demonstrated in the context of cloud-radiation processes, Asian monsoon, ENSO phenomena, Atlantic Meridional Overturning Circulation(AMOC) and sea ice. The FGOALS model has contributed to both CMIP5(Coupled Model Intercomparison Project-phase 5) and IPCC(Intergovernmental Panel on Climate Change) AR5(the Fifth Assessment Report). The release of FGOALS data has supported the publication of nearly 500 papers around the world. The results of FGOALS are cited ~106 times in the IPCC WG1(Working Group 1) AR5. In addition to the traditional long-term simulations and projections, near-term decadal climate prediction is a new set of CMIP experiment, progress of LAGS/IAP in the development of nearterm decadal prediction system is reviewed. The FGOALS model has supported many Chinese national-level research projects and contributed to the national climate change assessment report. The crucial role of FGOALS as a modeling tool for supporting climate sciences is highlighted by demonstrating the model's performances in the simulation of the evolution of Earth's climate from the past to the future. | TianJun Zhou Bin Wang YongQiang Yu YiMin Liu WeiPeng Zheng LiJuan Li Bo Wu PengFei Lin Zhun Guo WenMin Man Qing Bao AnMin Duan HaiLong Liu XiaoLong Chen Bian He JianDong Li LiWei Zou XiaoCong Wang LiXia Zhang Yong Sun WenXia Zhang | 2018 | Earth and Planetary Physics2018，2，4： | 6 |
| 5 | Reactive power optimization of a distribution network with high-penetration of wind and solar renewable energy and electric vehicles显示文摘As high amounts of new energy and electric vehicle(EV)charging stations are connected to the distribution network,the voltage deviations are likely to occur,which will further affect the power quality.It is challenging to manage high quality voltage control of a distribution network only relying on the traditional reactive power control mode.If the reactive power regulation potentials of new energy and EVs can be tapped,it will greatly reduce the reactive power optimization pressure on the network.Keeping this in mind,our reasearch first adds EVs to the traditional distribution network model with new forms of energy,and then a multi-objective optimization model,with achieving the lowest line loss,voltage deviation,and the highest static voltage stability margin as its objectives,is constructed.Meanwihile,the corresponding model parameters are set under different climate and equipment conditions.Ultimately,the optimization model under specific scenarios is obtained.Furthermore,considering the supply and demand relation-ship of the network,an improved technique for order preference by similarity to an ideal solution decision method is proposed,which aims to judge the adaptability of different algorithms to the optimized model,so as to select a most suitable algorithm for the problem.Finally,a comparison is made between the constructed model and a model without new energy.The results reveal that the constructed model can provide a high quality reactive power regula-tion strategy. | Biao Xu Guiyuan Zhang Ke Li Bing Li Hongyuan Chi Yao Yao Zhun Fan | 2022 | Protection and Control of Modern Power Systems2022，7，1： | 4 |
| 6 | Computational functionality-driven design of semiconductors for optoelectronic applications显示文摘The rapid development of the semiconductor industry has motivated researchers passion for accelerating the discovery of advanced optoelectronic materials.Computational functionality-driven design is an emerging branch of material science that has become effective at making material predictions.By combining advanced solid-state knowledge and high-throughput firstprinciples computational approaches with intelligent algorithms plus database development,experts can now efficiently explore many novel materials by taking advantage of the power of supercomputer architectures.Here,we discuss a set of typical design strategies that can be used to accelerate inorganic optoelectronic materials discovery from computer simulations:In silico computational screening;knowledge-based inverse design;and algorithm-based searching.A few representative examples in optoelectronic materials design are discussed to illustrate these computational functionality-driven modalities.Challenges and prospects for the computational functionality-driven design of materials are further highlighted at the end of the review. | Zhun Liu Guangren Na Fuyu Tian Liping Yu Jingbo Li Lijun Zhang | 2020 | InfoMat2020，2，5： | 4 |
| 7 | Receptor modeling of PM 2.5 , PM 10 and TSP in different seasons and long-range transport analysis at a coastal site of Tianjin, China显示文摘 | Shaofei Kong Bin Han Zhipeng Bai Li Chen Jianwu Shi Zhun Xu | 2010 | Science of the Total Environment2010，，20： | 2 |
| 8 | Effect of light quality on total gypenosides accumulation and related key enzyme gene expression in Gynostemma pentaphyllum显示文摘Objective: Light quality has effect on the accumulation of gypenosides in the medicinal plant Gynostemma pentaphyllum in the family Cucurbitaceae,while the squalene synthase(SS)and squalene epoxidase(SE)are the key enzymes for gypenoside biosynthesis.The objective of this study was to elucidate the relationship between light quality and biosynthesis key enzyme involving the regulation of gypenoside accumulation.Methods: The content of total gypenosides was measured by colorimetric method and the expression of SS and SE gene was determined by quantitative Real-time PCR in the seedlings of G.pentaphyllum which were grown with different light quality.Results: Light quality showed remarkable impacts on the accumulation of total gypenosides.The highest content of total gypenosides in the plant under red light condition was determined,followed by blue light and white light,while the lowest content was recorded under dark condition.q RT-PCR analysis proved that the expression levels of SS and SE genes were also affected by light quality.The high-level gene expressions of SS and SE were found in the plant under red light condition,followed by blue light,with the least content in darkness.The statistical analysis revealed that the total gypenosides were significantly different in different light treatment and the content of total gypenosides was positively related to the expression of SS and SE genes.Conclusions: Light quality regulates gypenoside accumulation via altering the expression of SS and SE in G.pentaphyllum. | ting wang xiang-rong tian xiao-yu wu zhun luo gui li xiao-lie peng shi-biao liu | 2018 | Chinese Herbal Medicines2018，10，1： | 2 |
| 9 | Development of a large nanocrystalline soft magnetic alloy core with highμ'_(p)Qf products for CSNS-Ⅱ显示文摘A waterproof nanocrystalline soft magnetic alloy core with a size of O.D.850 mm×I.D.316 mm×H.25 mm for radio frequency acceleration was successfully developed by winding 18μm 1k107b MA ribbons.Theμ'_(p)Qf products reached 7.5,10,and 12 GHz at 1,3,and 5 MHz,respectively.Theμ'_(p)Qf products of the MA core(O.D.250 mm×I.D.100 mm×H.25 mm)manufactured using a 13μm MA ribbon further increased by 30%.Detailed improvements on the MA core manufacture process are discussed herein.Continuous high-power tests on the new MA cores demonstrated its good performance of waterproofness,particularly its stability of highμ'_(p)Qf products.The MA core with highμ'pQf product and large size can operate under a high average RF power,high electric field,and in deionized water,which will be used in the China Spallation Neutron Source PhaseⅡ(CSNS-Ⅱ). | Bin Wu Xiao Li Zhun Li Chun-Lin Zhang Yang Liu Wei Long Xiang Li Jian Wu | 2022 | Nuclear Science and Techniques2022，33，8： | 2 |
| 10 | Signaling pathways in rheumatoid arthritis:implications for targeted therapy显示文摘Rheumatoid arthritis(RA)is an incurable systemic autoimmune disease.Disease progression leads to joint deformity and associated loss of function,which significantly impacts the quality of life for sufferers and adds to losses in the labor force.In the past few decades,RA has attracted increased attention from researchers,the abnormal signaling pathways in RA are a very important research field in the diagnosis and treatment of RA,which provides important evidence for understanding this complex disease and developing novel RA-linked intervention targets.The current review intends to provide a comprehensive overview of RA,including a general introduction to the disease,historical events,epidemiology,risk factors,and pathological process,highlight the primary research progress of the disease and various signaling pathways and molecular mechanisms,including genetic factors,epigenetic factors,summarize the most recent developments in identifying novel signaling pathways in RA and new inhibitors for treating RA.therapeutic interventions including approved drugs,clinical drugs,pre-clinical drugs,and cutting-edge therapeutic technologies.These developments will hopefully drive progress in new strategically targeted therapies and hope to provide novel ideas for RA treatment options in the future. | Qian Ding Wei Hu Ran Wang Qinyan Yang Menglin Zhu Meng Li Jianghong Cai Peter Rose Jianchun Mao Yi Zhun Zhu | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 2 |
| 11 | Amorphous FeNiCoCuSiBCr Alloys with Superior Direct Current Tolerant Characteristics显示文摘Amorphous Fe62-xNi19CoxCu0.1Si3.8B14Cr1.1(x=0,1,5,10)ribbons were annealed under magnetic field and tensile stress,respectively,and their magnetic properties were investigated.Fe73.5Cu1Nb3Si15.5B7 and Fe66Ni10-Cu1Nb3Si11B9 nanocrystalline alloy ribbons were also fabricated for comparison.Excellent DC tolerant property was obtained in the amorphous FeNiCoCuSiBCr ribbons after thermomagnetic treatment and the constant permeable property was improved with increasing Co content.The relative permeability was constant up to the DC bias field of approximately 6×10-4,9×10-4,and 10×10-4 T and the values of relative permeabilityμrwere 1 650,1 200,and 1000 with the Co content being 0,5at.%,and 10 at.%,respectively.Besides,stress-annealed FeNiCoCuSiBCr alloy ribbons were proved to exhibit positive saturation magnetostriction constantλs. | Xiao-rong WU De-ren LI Zhun LI Zhi-chao LU | 2015 | Journal of Iron and Steel Research(International)2015，22，2： | 2 |
| 12 | Responses of Cloud-Radiative Forcing to Strong El Nino Events over the Western Pacific Warm Pool as Simulated by CAMS-CSM显示文摘Cloud-radiative forcing(CRF)at the top of the atmosphere(TOA)over the western Pacific warm pool(WP)shows unique characteristics in response to El Nino events.In this region,the responses of CRF to El Nino events have been a useful metric for evaluating climate models.Satellite data are used to analyze the CRF anomalies to El Nino events simulated by the new and old versions of the Climate System Model of the Chinese Academy of Meteorological Sciences(CAMS-CSM),which has participated in the Atmospheric Model Intercomparison Project(AMIP).Here,simulations for super El Nino years,El Nino years,and normal years are compared with observations.The results show that the mean values of both longwave CRF(LWCRF)and shortwave CRF(SWCRF)in CAMS-CSM are weaker than the observations for each category of El Nino events.Compared with the old version of CAMS-CSM,the decrease in LWCRF during El Nino events is well simulated by the new version of CAMS-CSM.However,both new and old models cannot reproduce the anomalous SWCRF in El Nino events.The biases in the CRF response to El Nino events are attributed to the biases in the cloud vertical structure because of a weaker crash of the Walker circulation in CAMS-CSM.Due to the modification of the conversion rate from cloud droplets to raindrops in the cumulus convection scheme,the new version of CAMS-CSM has better CRF skills in normal years,but biases in El Nino events still exist in the new version.Improving the response of the Walker circulation to El Nino events is key to higher skills in simulating the cloud radiative responses. | Baichao ZHANG Zhun GUO Xiaolong CHEN Tianjun ZHOU Xinyao RONG Jian LI | 2020 | Journal of Meteorological Research2020，34，3： | 2 |
| 13 | Buckling of composite cylindrical shells with ovality and thickness variation subjected to hydrostatic pressure显示文摘The initial geometric imperfection is one of the primary factors affecting the buckling behaviors of composite cylindrical shells under hydrostatic pressure.In this study,ovality and thickness variations as two representative types of the geometric imperfections are considered.After measuring the geometric imperfections,a typical carbon fiber reinforced polymers(CFRP)cylindrical shell is tested to obtain the buckling pressure.The buckling behaviors of the shell sample are analyzed in combination with the strain responses.By using the nonlinear numerical analysis,the buckling shapes of the CFRP cylinder shells with different combinations of ovality and thickness variation are firstly discussed.The rules of influence of such imperfections on the buckling pressure are then obtained by nonlinear regression method.Finally,an empirical formula is proposed to predict the buckling pressure of the composite cylinder shells,and the calculated results from the formula are in good agreement with the numerical results. | Zhun Li Ke-chun Shen Xin-hu Zhang Guang Pan | 2022 | Defence Technology(防务技术)2022，18，5： | 2 |
| 14 | Successful tubes treatment of esophageal fistula显示文摘Aim: To discuss the merits of 'tubes treatment' for esophageal fistula (EF). Methods: A 66-year-old female who suffered from a bronchoesophageal and esophagothoratic fistula underwent a successful 'three tubes treatment' (close chest drainage, negative pressure suction at the leak, and nasojejunal feeding tube), combination of antibiotics, antacid drugs and nu-tritional support. Another 55-year-old male patient developed an esophagopleural fistula (EPF) after esophageal carcinoma operation. He too was treated conservatively with the three tubes strategy as mentioned above towards a favorable outcome. Results: The two patients recovered with the tubes treatment, felt well and became able to eat and drink, presenting no complaint. Con-clusion: Tubes treatment is an effective basic way for EF. It may be an alternative treatment option. | ZHOU Ning, CHEN Wei-xing, LI You-ming, XIANG Zhun, GAO Ping, FANG Ying (Department of Gastroenterology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China) | 2007 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2007，8，10： | 1 |
| 15 | Effect of Chinese propolis on PC-PLC activity and TLR4 expression in LPS-treated vascular endothelial cells显示文摘 | XUAN Hong - zhun SANG Qing LI Ya - jing HU Fu - liang | 2011 | 中国病理生理杂志2011，27，7： | 1 |
| 16 | Polymorph selection and nanocrystallite rearrangement of calcium carbonate in carboxymethyl chitosan aqueous solution: Thermo - dynamic and kinetic analysis 显示文摘 | Zhao Donghui Zhun Yingchun Li Fang | 2010 | Materials Research Bulletin2010，，45： | 1 |
| 17 | Needle immersed vitrification can lower the concentration of cryoproteetant in human ovarian tissue cryopreservation 显示文摘 | Xiao Zhun Wang Yan Li Lei | 2010 | Fertil Steri12010，94，6： | 1 |
| 18 | Neuron navigator 2 is a novel mediator of rheumatoid arthritis显示文摘Rheumatoid arthritis(RA)is a systemic autoimmune disease mainly characterized by synovial tumor-like hyperplasia,synovial inflammation,and damage to adjacent cartilage and bones.^(1) Our previous study provided evidence that cystathionine-γ-lyase(CSE)and the histone demethylase JMJD3 are significantly increased in RA,and CSE was found to negatively regulate the inflammatory response in fibroblast-like synoviocytes(FLSs),which was mainly attributed to JMJD3 inhibition,in RA. | Ran Wang Meng Li Qian Ding Jianghong Cai Yue Yu Xinhua Liu Jianchun Mao Yi Zhun Zhu | 2021 | Cellular & Molecular Immunology2021，18，9： | 1 |
| 19 | Association between interleukin-10 promoter polymorphisms and endometriosis: A meta-analysis显示文摘 | Wei Fan Shangwei Li Qiong Chen Zhongying Huang Qianhong Ma Zhun Xiao | 2012 | Gene2012，，： | 1 |
| 20 | Enhanced Acid/Base Catalysis in High Temperature Liquid Water显示文摘Two novel and environmentally benign solvent systems, organic acids-enriched high temperature liquid water (HTLW) and NH3-enriched HTLW, were developed, which can enhance the reaction rate of acid/base-catalyzed organic reactions in HTLW. We investigated the decomposition of fructose in organic acids-enriched HTLW, hydrolysis of cinnamaldehyde and aldol condensation of phenylaldehyde with acetaldehyde in NH3-enriched HTLW. The experimental results demonstrated that organic acids-enriched or NH3-enriched HTLW can greatly accelerate acid/base-catalyzed organic reactions in HTLW. | Xiu Yang LU Qi JING Zhun LI Lei YUAN Fei GAO Xin LIU | 2006 | Chinese Chemical Letters2006，17，6： | 1 |
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