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| 1 | Hepatitis B virus X protein promotes liver cell proliferation via a positive cascade loop involving arachidonic acid metabolism and p-ERK1/2显示文摘肝炎 B 病毒 X 蛋白质(HBx ) 在 hepatocellular 癌的发展起一个关键作用。这里,我们寻求了识别 HBx 由调停的机制肝房间增长。我们发现那 HBx upregulated cyclooxygenase-2 (COX-2 ) 的层次, 5-lipoxygenase (5 哈鱼) 和 phosphorylated 在肝房间的细胞外的调整信号的蛋白质 kinases 1/2 (p-ERK1/2 ) 。导致 HBx 的 p-ERK1/2 被 Gi/o 蛋白质,艇长或哈鱼的抑制废除。另外, HBx 增加了前列腺素 E2 (PGE2 ) 的数量,免除房间线的 leukotriene B4 (LTB4 ) 源于 hepatocytes。而且,这些释放 arachidonic 酸代谢物能激活 ERK1/2。有趣地,激活 ERK1/2 能 upregulate 以一种积极反馈方式的 COX-2 和 5 哈鱼的表示。在结论, HBx 经由包含 COX-2, 5 哈鱼,释放 arachidonic 酸代谢物, Gi/o 蛋白质和 p-ERK1/2 的一个积极反馈环提高并且维持肝房间增长。 | Changliang Shan Fuqing Xu Shuai Zhang Jiacong YOU Xiaona You Liyan Qiu Jie Zheng Lihong Ye Xiaodong Zhang | 2010 | Cell Research2010，20，5： | 15 |
| 2 | BTB-BACK-TAZ domain protein MdBT2-mediated MdMYB73 ubiquitination negatively regulates malate accumulation and vacuolar acidification in apple显示文摘As an important primary metabolite,malate plays a key role in regulating osmotic pressure,pH homeostasis,stress tolerance,and fruit quality of apple.The R2R3-MYB transcription factor(TF)MdMYB73 was identified as a protein that plays a critical role in determining malate accumulation and vacuolar acidification by directly regulating the transcription of aluminum-activated malate transporter 9(MdALMT9),vacuolar ATPase subunit A(MdVHA-A),and vacuolar pyrophosphatase 1(MdVHP1)in apple.In addition,the bHLH TF MdCIbHLH1 interacts with MdMYB73 and enhances the transcriptional activity of MdMYB73.Our previous studies demonstrated that the BTB-BACK-TAZ domain protein MdBT2 can degrade MdCIbHLH1 to influence malate accumulation and vacuolar acidification.However,the potential upstream regulators of MdMYB73 are currently unknown.In this study,we found that MdBT2 directly interacts with and degrades MdMYB73 through the ubiquitin/26S proteasome pathway to regulate malate accumulation and vacuolar acidification.A series of functional assays with apple calli and fruit showed that MdBT2 controls malate accumulation and vacuolar acidification in an MdMYB73-dependent manner.Overall,our findings shed light on the mechanism by which the BTB-BACK-TAZ domain protein MdBT2 regulates malate accumulation and vacuolar acidification by targeting MdMYB73 and MdCIbHLH1 for ubiquitination in apple.This information may help guide traditional breeding programs and fruit tree molecular breeding,and lead to improvements in fruit quality and stress tolerance. | Quan-Yan Zhang Kai-Di Gu Jia-Hui Wang Jian-Qiang Yu Xiao-Fei Wang Shuai Zhang Chun-Xiang You Da-Gang Hu Yu-Jin Hao | 2020 | Horticulture Research2020，7，1： | 6 |
| 3 | A new derivative of triterpene with anti-melanoma B16 activity from Conyza canadensis显示文摘A new derivative of triterpene named Erigeronol 1 was isolated from the EtOH extract of the aerial part of Conyza canadensis together with 15 known compounds for the first time from this plant.The structure of Erigeronol 1 was elucidated as 3-O-(hydroxyacetyl) -23,28-dihydroxy-β-amyrin by hydrolysis and spectroscopic analysis.Erigeronol 1 showed potent cytotoxic activity with IC_(50) value of 7.77±0.47μg/mL against melanoma B16 determined by the 3-(4,5-dimethylthiazo-2-yl)-2,5-diphenyltetrazolium bromide(MTT) method. | Ming Ming Yan Ting You Li Da Qing Zhao Shuai Shao Sheng Nan Bi | 2010 | Chinese Chemical Letters2010，21，7： | 4 |
| 4 | A preliminary research establishing the present-time intraplate blocks movement model on the Chinese mainland based on GPS data显示文摘 | Shuo-Yu Zhou Yue-Gang Zhang Guo-Yu Ding Yun Wu Xiao-Jun Qin Shun-Ying Shi Qi Wang Xin-Zhao You Xue-Jun Qiao Ping Shuai Gan-Jin Deng | 1998 | Acta Seismologica Sinica1998，，4： | 1 |
| 5 | Genomic Variations in the Tea Leafhopper Reveal the Basis of Its Adaptive Evolution显示文摘Tea green leafhopper(TGL),Empoasca onukii,is of biological and economic interest.Despite numerous studies,the mechanisms underlying its adaptation and evolution remain enigmatic.Here,we use previously untapped genome and population genetics approaches to examine how the pest adapted to different environmental variables and thus has expanded geographically.We complete a chromosome-level assembly and annotation of the E.onukii genome,showing notable expansions of gene families associated with adaptation to chemoreception and detoxification.Genomic signals indicating balancing selection highlight metabolic pathways involved in adaptation to a wide range of tea varieties grown across ecologically diverse regions.Patterns of genetic variations among 54 E.onukii samples unveil the population structure and evolutionary history across different tea-growing regions in China.Our results demonstrate that the genomic changes in key pathways,including those linked to metabolism,circadian rhythms,and immune system functions,may underlie the successful spread and adaptation of E.onukii.This work highlights the genetic and molecular basis underlying the evolutionary success of a species with broad economic impacts,and provides insights into insect adaptation to host plants,which will ultimately facilitate more sustainable pest management. | Qian Zhao Longqing Shi Weiyi He Jinyu Li Shijun You Shuai Chen Jing Lin Yibin Wang Liwen Zhang Guang Yang Liette Vasseur Minsheng You | 2022 | Genomics, Proteomics & Bioinformatics2022，20，6： | 1 |
| 6 | Preparation of sulphonate-containing core/shell latex particles via seeded emulsion copolymerization显示文摘在这研究, P ( StMAA )种子乳胶粒子首先经由苯乙烯(圣)和甲基丙烯酸( MAA )的没有肥皂的乳剂聚合被准备,然后,种子粒子被允许在房间温度与圣胀大,并且 P ( StMAA ) /P ( StNaSS )核心/壳乳胶粒子然后面对 N 作为开始者用 AIBN 经由圣和钠苯乙烯磺酸盐( NaSS )的播种乳剂 copolymerization 被综合, N-methylenebisacrylamide (咩,水溶性的 crosslinker )。当到全部的单体的咩的比率是不到 3 mol%时,结果证明聚合能顺利被执行,有有粒子的 /P ( StNaSS )核心/壳乳胶大约 200 nm 缩放的 150 nm 和 P ( StMAA )的直径的狭窄的驱散的 P ( StMAA )种子粒子被综合。当NaSS/(圣+ MAA )和咩的 2 mol%的 25/75 鼹鼠比率在播种乳剂聚合被使用时,结果的 P ( StMAA ) /P ( StNaSS )乳胶产品在水抽取以后显示出低重量损失,并且在整个粒子并且在壳的 NaSS 单位内容分别地到达了 11.7 mol%和 34.6 mol%。 | Ji Shuai Wang Wei Deng Yun Shen Chen Cheng You Kan | 2010 | Chinese Chemical Letters2010，21，10： | 1 |
| 7 | Exploiting memris- rive BiFeO3 bilayer structures for compact sequential logics显示文摘 | YOU T SHUAI Y LUO W | 2014 | Advanced Functional Materials2014，24，22： | 1 |
| 8 | All‐ trans ‐retinoic acid ameliorates experimental allergic encephalomyelitis by affecting dendritic cell and monocyte development显示文摘 | Xiao‐Xia Zhan Yu Liu Jin‐Feng Yang Guang‐You Wang Lili Mu Tong‐Shuai Zhang Xiao‐Li Xie Jing‐Hua Wang Yu‐Mei Liu Qing‐Fei Kong Hu‐Lun Li Bo Sun | 2013 | Immunology2013，，： | 1 |
| 9 | A genome-wide association study on growth traits in orangespotted grouper(Epinephelus coioides) with RAD-seq genotyping显示文摘The orange-spotted grouper, Epinephelus coioides, is one of the most popular fish in China and Southeast Asian countries because of its important economic value. However, molecular mechanism underlying the growth of orange-spotted grouper has never been fully understood. Herein, we performed a genome-wide association study(GWAS) on a natural population of 198 individuals aiming to screen the whole genome of orange-spotted grouper for identification of growth-related loci by restrictionsite associated DNA sequencing. In this research, 261,366 single nucleotide polymorphisms(SNPs) were developed, in which110 SNPs were identified to be correlated with growth and 20 SNPs were further confirmed to be associated with both body weight and total length. From these identified SNPs, we annotated a total of 34 genes, including adgrb2, csnkza1, cers5, col22 a1,creb5, dnd1, dzank1, dnai1, npy2 r, fat3, lrrk2, lrp5, map3 k9, and so on. Among these candidate genes, npy2 r(neuropeptide Y receptor Y2) was reported to play a critical role in growth of the orange-spotted grouper. In addition, population structure,principal component analysis, kinship matrix and linkage disequilibrium were examined to verify the accuracy and reliability of our GWAS results. Our data will also provide a valuable genetic resource for further marker-assisted selection program to improve growth quality in groupers. | Hui Yu Xinxin You Jia Li Xinhui Zhang Shuai Zhang Shoujia Jiang Xueqiang Lin Hao-Ran Lin Zining Meng Qiong Shi | 2018 | Science China(Life Sciences)2018，61，8： | 1 |
| 10 | Application of electrical impedance tomography for continuous monitoring of retroperitoneal bleeding after blunt trauma显示文摘 | Shuai W You F Zhang H | 2009 | Ann Biomed Eng2009，37，11： | 1 |
| 11 | Applying electrical impedance tomography to dynamically monitor retroperitoneal bleeding in a renal trauma patient显示文摘 | You l= Shi X Shuai W | 2013 | Intensive Care Med2013，39，6： | 1 |
| 12 | An Organic–Inorganic Hybrid Material Based on Benzo[ghi]perylenetri-imide and Cyclic Titanium-Oxo Cluster for Efficient Perovskite and Organic Solar Cells显示文摘Perovskite and organic solar cells usually require electron-transport interlayers to efficiently transport electrons from the photoactive layer to the metal electrode.In general,pure organic or inorganic materials are applied into the interlayers,but organic–inorganic hybrid materials have been rarely reported for this application.In this work,we report using the first titanium-oxo cluster-based organic–inorganic hybrid as the interlayer material by introducing largeπ-conjugated benzo[ghi]perylenetriimides as an organic part via a simple ligand-exchange reaction.This new hybrid material showed excellent solubility,well-aligned energy levels,and excellent electron mobilities,enabling its great potential application as an interlayer in solar cells such as perovskite and organic solar cells,providing high power conversion efficiencies of>20%and 16%,respectively.Therefore,we claim that our present work introduces a new class of cluster-based organic–inorganic hybrid interlayer materials that exhibit promising application in organic electronics. | Zhou Zhang Faming Han Jie Fang Chaowei Zhao Shuai Li Yonggang Wu Yuefeng Zhang Shengyong You Binghui Wu Weiwei Li | 2022 | CCS Chemistry2022，4，3： | 1 |
| 13 | Reconfigurable physical unclonable cryptographic primitives based on current-induced nanomagnets switching显示文摘Hardware security primitives that preserve secrets are playing a crucial role in the Internet-ofThings(Io T) era. Existing physical unclonable function(PUF) instantiations, exploiting static randomness,generate challenge-response pairings(CRPs) to produce unique security keys that can be used to authenticate devices linked to the Io T. Reconfigurable PUFs(RPUFs) with dynamically refreshable CRPs can enhance the security and robustness of conventional PUFs. The in-plane current-driven perpendicular polarized nanomagnet switching via spin-orbit torque(SOT) possesses great potential for application to memory and logic, as the write-current path is separate from the read-current path, which naturally resolves the write-read interference. However, the stochastic switching of perpendicular magnetization, without an additional symmetry-breaking field, would significantly hinder the technological viability of commercial implementations. Here, we report an initialization-free physical RPUF implemented by SOT-induced stochastic switching of perpendicularly magnetized Ta/Co Fe B/Mg O nanodevices. Using a 15×15 nanomagnet array, we experimentally demonstrate a security primitive that offers a near-ideal 50% uniqueness over 100 reconfiguration cycles, as well as a low correlation coefficient between every two reconfiguration cycles. Our results show that current-induced nanomagnets switching paves the way for developing highly reliable and energy-efficient reconfigurable cryptographic primitives with a smaller footprint. | Shuai ZHANG Jian ZHANG Shihao LI Yaoyuan WANG Zhenjiang CHEN Jeongmin HONG Long YOU | 2022 | Science China(Information Sciences)2022，65，2： | 1 |
| 14 | LBA-EC:Load Balancing Algorithm Based on Weighted Bipartite Graph for Edge Computing显示文摘Compared with cloud computing environment,edge computing has many choices of service providers due to different deployment environments.The flexibility of edge computing makes the environment more complex.The current edge computing architecture has the problems of scattered computing resources and limited resources of single computing node.When the edge node carries too many task requests,the makespan of the task will be delayed.We propose a load balancing algorithm based on weighted bipartite graph for edge computing(LBA-EC),which makes full use of network edge resources,reduces user delay,and improves user service experience.The algorithm is divided into two phases for task scheduling.In the first phase,the tasks are matched to different edge servers.In the second phase,the tasks are optimally allocated to different containers in the edge server to execute according to the two indicators of energy consumption and completion time.The simulations and experimental results show that our algorithm can effectively map all tasks to available resources with a shorter completion time. | SHAO Sisi LIU Shangdong LI Kui YOU Shuai QIU Huajie YAO Xiaoliang JI Yimu | 2023 | Chinese Journal of Electronics2023，32，2： | 1 |
| 15 | Application of electrical impedance tomography for continuous monitoring of retroperitoneal bleeding after blunt trauma显示文摘 | Shuai W You F Zhang H | 2009 | Ann Biomed Eng2009，37，11： | 1 |
| 16 | Hepatitis B Virus X Protein Inhibits Tumor Suppressor miR-205 through Inducing Hypermethylation of miR-205 Promoter to Enhance Carcinogenesis显示文摘 | Tao Zhang Junping Zhang Ming Cui Fabao Liu Xiaona You Yumei Du Yuen Gao Shuai Zhang Zhanping Lu Lihong Ye Xiaodong Zhang | 2013 | Neoplasia2013，，11： | 1 |
| 17 | Heavy ion‑induced MCUs in 28nm SRAM‑based FPGAs:upset proportions,classifications,and pattern shapes显示文摘For modern scaling devices,multiple cell upsets(MCUs)have become a major threat to high-reliability field-programmable gate array(FPGA)-based systems.Thus,both performing the worst-case irradiation tests to provide the actual MCU response of devices and proposing an effective MCU distinction method are urgently needed.In this study,high-and medium-energy heavy-ion irradiations for the configuration random-access memory of 28 nm FPGAs are performed.An MCU extraction method supported by theoretical predictions is proposed to study the MCU sizes,shapes,and frequencies in detail.Based on the extraction method,the different percentages,and orientations of the large MCUs in both the azimuth and zenith directions determine the worse irradiation response of the FPGAs.The extracted largest 9-bit MCUs indicate that high-energy heavy ions can induce more severe failures than medium-energy ones.The results show that both the use of high-energy heavy ions during MCU evaluations and effective protection for the application of high-density 28 nm FPGAs in space are extremely necessary. | Shuai Gao Xin‑Yu Li Shi‑Wei Zhao Ze He Bing Ye Li Cai You‑Mei Sun Guo‑Qing Xiao Chang Cai Jie Liu | 2022 | Nuclear Science and Techniques2022，33，12： | 1 |
| 18 | Involvement of hepatitis B virus X gene (HBx) integration in hepatocarcinogenesis via a recombination of HBx/ Alu core sequence/subtelomeric DNA显示文摘 | Xuan Zhang Xiaona You Nan Li Weiying Zhang Sarantis Gagos Qi Wang Aggelos Banos Na Cai Huakun Zhang Hang Zhang Xuezhi Zhang Changliang Shan Liyan Qiu Shuai Zhang Na Lv Minshan Chen Yumei Du Jianchuan Xia Lihong Ye Xiaodong Zhang | 2012 | FEBS Letters2012，，19： | 1 |
| 19 | Constructing P-CoMoO_(4)@NiCoP heterostructure nanoarrays on Ni foam as efficient bifunctional electrocatalysts for overall water splitting显示文摘Improving catalytic activity and durabilty through the structural and compositional development of bifunctional electrocatalysts with low cost,high activity and stability is a challenging issue in electrochemical water splitting.Herein,we report the fabrication of heterostructured P-CoMoO_(4)@NiCoP on a Ni foam substrate through interface engineering,by adjusting its composition and architecture.Benefitting from the tailored electronic structure and exposed active sites,the heterostructured P-CoMoO_(4)@NiCoP/NF arrays can be coordinated to boost the overall water splitting.In addition,the superhydrophilic and superaerophobic properties of P-CoMoO_(4)@NiCoP/NF make it conducive to water dissociation and bubble separation in the electrocatalytic process.The heterostructured PCoMoO_(4)@NiCoP/NF exhibits excellent bifunctional electrocatalysis activity with a low overpotential of 66 mV at 10 mA cm^(-2) for HER and 252 mV at 100 mA cm^(-2) for OER.Only 1.62 V potential is required to deliver 20 mA cm^(-2) in a two-electrode electrolysis system,providing a decent overall water splitting performance.The rational construction of the heterostructure makes it possible to regulate the electronic structures and active sites of the electrocatalysts to promote their catalytic activity. | Ning You Shuai Cao Mengqiu Huang Xiaoming Fan Kun Shi Haijian Huang Zhangxian Chen Zeheng Yang Weixin Zhang | 2023 | Nano Materials Science2023，5，3： | 0 |
| 20 | Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets显示文摘Hypoxia,characterized by reduced oxygen concentration,is a significant stressor that affects the survival of aerobic species and plays a prominent role in cardiovascular diseases.From the research history and milestone events related to hypoxia in cardiovascular development and diseases,The'hypoxia-inducible factors(HIFs)switch'can be observed from both temporal and spatial perspectives,encompassing the occurrence and progression of hypoxia(gradual decline in oxygen concentration),the acute and chronic manifestations of hypoxia,and the geographical characteristics of hypoxia(natural selection at high altitudes).Furthermore,hypoxia signaling pathways are associated with natural rhythms,such as diurnal and hibernation processes.In addition to innate factors and natural selection,it has been found that epigenetics,as a postnatal factor,profoundly influences the hypoxic response and progression within the cardiovascular system.Within this intricate process,interactions between different tissues and organs within the cardiovascular system and other systems in the context of hypoxia signaling pathways have been established.Thus,it is the time to summarize and to construct a multi-level regulatory framework of hypoxia signaling and mechanisms in cardiovascular diseases for developing more therapeutic targets and make reasonable advancements in clinical research,including FDA-approved drugs and ongoing clinical trials,to guide future clinical practice in the field of hypoxia signaling in cardiovascular diseases. | Yongchao Zhao Weidong Xiong Chaofu Li Ranzun Zhao Hao Lu Shuai Song You Zhou Yiqing Hu Bei Shi Junbo Ge | 2023 | Signal Transduction and Targeted Therapy2023，8，12： | 0 |
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