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| 1 | Effects of Land Management Practices on Labile Organic Carbon Fractions in Rice Cultivation显示文摘A research trial with four land management practices, i.e., traditional tillage-fallow (TTF), traditional tillage-wheat (TTW), conservation tillage-fallow (CTF) and conservation tillage-wheat (CTW), was sampled in the 15th year after its establishment to assess the effects of different management practices on labile organic carbon fractions (LOCFs), such as easily oxidizable organic carbon (EOC), dissolved organic carbon (DOC), particulate organic carbon (POC) and microbial biomass carbon (MBC) in a typical paddy soil, Chongqing, Southwest China. The results indicated that LOCFs were significantly influenced by the combination of no-tillage, ridge culture and crop rotation. And, different combination patterns showed different effectiveness on soil LOCFs. The effects of no-tillage, ridge culture and wheat cultivation on EOC, DOC, POC and MBC mainly happened at 0-10cm. At this depth, soil under CTW had higher EOC, DOC, POC and MBC contents, compared to TTF, TTW and CTF, respectively. Moreover, the contents of LOCFs for different practices generally decreased when the soil depth increased. Our findings suggest that the paddy soil in Southwest China could be managed to concentrate greater quantities of EOC, DOC, POC and MBC. | SHAO Jing'an LI Yangbing WEI Chaofu XIE Deti | 2009 | Chinese Geographical Science2009，19，3： | 8 |
| 2 | Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases显示文摘Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel therapeutics.In this study,we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents—findings that evaluated histopathological changes;immune cell signature and inflammatory factor expression in the lungs,spleen and lymph nodes.Here we show that the major pulmonary alterations included diffuse alveolar damage,interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates,macrophage infiltration and abundant production of inflammatory factors(IL-6,IP-10,TNFo?and IL-I f).The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation,including lymphopenia and macrophage accumulation.These findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients. | Qian Liu Yu Shi Jun Cai Yaqi Duan Rongshuai Wang Hongyan Zhang Qiurong Ruan Jiansha Li Lei Zhao Yifang Ping Rong Chen Liang Ren Xiaochun Fei Heng Zhang Rui Tang Xi Wang Tao Luo Xindong Liu Xuequan Huang Zhenhua Liu Qilin Ao Yong Ren Jing Xiong Zhicheng He Haibo Wu Wenjuan Fu Pengnan Zhao Xinwei Chen Guoqiang Qu Yunyun Wang Xi Wang Jia Liu Dongfang Xiang Sanpeng Xu Xiaowei Zhou Qingrui Li Jinghong Ma Heng Li Jie Zhang Sizhe Huang Xiaohong Yao Yiwu Zhou Chaofu Wang Dingyu Zhang Guoping Wang Liang Liu Xiu-Wu Bian | 2020 | National Science Review2020，7，12： | 6 |
| 3 | Extracting the signifi-cant -rare keywords for patent analysis 显示文摘 | Li Yanru Wang Leuohong Hong Chaofu | 2009 | Expert Systems withApplications2009，36，3： | 1 |
| 4 | Extracting the significant-rare keywords for patent analysis显示文摘 | LI Yanru WANG Leuohong HONG Chaofu | 2009 | Expert Systems with Applications2009，36，1： | 1 |
| 5 | THRESHOLD INFRARED IMAGE SEGMENTA- TION BASED ON IMPROVED GENETIC ALGO- RITHM 显示文摘 | Zhang Chaofu Ma Li - Ni Jing Lu - Na | 2012 | Information Science and Control En- gineering (ICISCE) lET International Confer- ence on2012，12，： | 1 |
| 6 | TURBULENT STRUCTURE AND LOCAL SIMILARITY IN THE TOWER LAYER OVER THE NANJING AREA显示文摘 | XU YUMAO ZHOU CHAOFU LI ZHONGKAI ZHANG WEI | 1997 | Boundary - Layer Meteorology1997，，1： | 1 |
| 7 | Turbulent structure and local similarity in the tower layer over the nanjing area 显示文摘 | Xu Yumao Zhou Chaofu Li Zhongkai | 1997 | Bound-Layer Meteor1997，82，： | 1 |
| 8 | Role of depressive symptoms in cardiometabolic diseases and subsequent transitions to all-cause mortality:an application of multistate models in a prospective cohort study显示文摘Background and purpose The role of depression in the development and outcome of cardiometabolic diseases remains to be clarified.We aimed to examine the extent to which depressive symptoms affect the transitions from healthy to diabetes,stroke,heart disease and subsequent all-cause mortality in a middle-aged and elderly European population.Methods A total of 78212 individuals aged≥50 years from the Survey of Health Ageing and Retirement in Europe were included.Participants with any baseline cardiometabolic diseases including diabetes,stroke and heart disease were excluded.Depressive symptoms were measured by the Euro-Depression scale at baseline.Participants were followed up to determine the occurrence of cardiometabolic diseases and all-cause mortality.We used multistate models to estimate the transition-specific HRs and 95%CIs after adjustment of confounders.Results During 500711 person-years of follow-up,4742 participants developed diabetes,2173 had stroke,5487 developed heart disease and 7182 died.Depressive symptoms were significantly associated with transitions from healthy to diabetes(HR:1.12,95%CI:1.05 to 1.20),stroke(HR:1.31,95%CI:1.18 to 1.44),heart disease(HR:1.26,95%CI:1.18 to 1.34)and all-cause mortality(HR:1.41,95%CI:1.34 to 1.49).After cardiometabolic diseases,depressive symptoms were associated with the increased risk of all-cause mortality in patients with diabetes(HR:1.54,95%CI:1.25 to 1.89),patients who had stroke(HR:1.29,95%CI:1.03 to 1.61)and patients with heart disease(HR:1.21,95%CI:1.02 to 1.44).Conclusions Depressive symptoms increase the risk of diabetes,stroke and heart disease,and affect the risk of mortality after the onset of these cardiometabolic conditions.Screening and treatment of depressive symptoms may have profound implications for the prevention and prognosis of cardiometabolic diseases. | Yanan Qiao Siyuan Liu Guochen Li Yanqiang Lu Ying Wu Yi Ding Chaofu Ke | 2021 | Stroke & Vascular Neurology2021，6，4： | 1 |
| 9 | Data-driven engineering framework with AI algorithm of Ginkgo Folium tablets manufacturing显示文摘Smart manufacturing still remains critical challenges for pharmaceutical manufacturing.Here,an original data-driven engineering framework was proposed to tackle the challenges.Firstly,from sporadic indicators to five kinds of systematic quality characteristics,nearly 2,000,000 real-world data points were successively characterized from Ginkgo Folium tablet manufacturing.Then,from simplex to the multivariate system,the digital process capability diagnosis strategy was proposed by multivariate C_(pk)integrated Bootstrap-t.The C_(pk)of Ginkgo Folium extracts,granules,and tablets were discovered,which was 0.59,0.42,and 0.78,respectively,indicating a relatively weak process capability,especially in granulating.Furthermore,the quality traceability was discovered from unit to end-to-end analysis,which decreased from 2.17 to 1.73.This further proved that attention should be paid to granulating to improve the quality characteristic.In conclusion,this paper provided a data-driven engineering strategy empowering industrial innovation to face the challenge of smart pharmaceutical manufacturing. | Lijuan Ma Jing Zhang Ling Lin Tuanjie Wang Chaofu Ma Xiaomeng Wang Mingshuang Li Yanjiang Qiao Yongxiang Wang Guimin Zhang Zhisheng Wu | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 1 |
| 10 | A study on the characteristics of heavy metals in orange ecosystem显示文摘An investigation was conducted to identify the characteristics of heavy metals in orange ecosystem in three areas in the Three Gorge Reservoir Region by using the modified Tessier sequential extraction procedure.The contents of Cu and Pb in different speciation fractions of the soils can be ordered as the Residual(F6)>Reducible(F4)>Oxidable(F5)>Water soluble(F1)>Carbonate(F3)>Exchangeable(F2),and the contents of Zn and Ni follow the order of the Residual(F6)>Oxidable(F5)>Reducible(F4)>Water soluble(F1)>Carbonate(F3)> Exchangeable(F2),and those of Cd follow the order of the Reducible(F4)>Oxidable(F5)>Exchangeable(F2)> Carbonate(F3)>Residual(F6)>Water soluble(F1).The concentrations of Cu in the different organs of oranges follow the increasing sequence of pulp>leaf>pericarp,those of Zn and Ni following the increasing sequence of leaf >pulp>pericarp,and those of Pb and Cd follow the increasing sequence of leaf>pericarp>pulp.Correlation degrees of different forms of same heavy metals in soils are according to the order of Cu>Zn>Cd>Pb>Ni.Correlation degrees of different heavy metals in same forms are according to the order that the forms of Reducible(F4),Oxidable(F5) and Residual(F6) are higher than the forms of Water soluble(F1),Exchangeable(F2) and Carbonate(F3).There are either positive or negative correlations between heavy metals in leaves and in pulp,while there are all positive correlations between heavy mentals in leaves and in pericarp.There are significant correlations between the concentrations of some heavy metals in leaves,pericarp or pulp,and those in speciation fractions in the soils. | LI Qilin WEI Chaofu HUANG Yun WANG Liwei WANG Dingyong | 2010 | Chinese Journal Of Geochemistry2010，29，1： | 1 |
| 11 | TURBULENT STRUCTURE AND LOCAL SIMILARITY IN THE TOWER LAYER OVER THE NANJING AREA显示文摘 | XU YUMAO ZHOU CHAOFU LI ZHONGKAI ZHANG WEI | 1997 | Boundary - Layer Meteorology1997，，1： | 1 |
| 12 | Etoposide,dexamethasone,and pegaspargase with sandwiched radiotherapy in early-stage natural killer/T-cell lymphoma:A randomized phase III study显示文摘Methotrexate,etoposide,dexamethasone,and pegaspargase(MESA)with sandwiched radiotherapy is known to be effective for early-stage extranodal natural killer/T-cell lymphoma,nasal type(NKTCL).We explored the efficacy and safety of reduced-intensity,non-intravenous etoposide,dexamethasone,and pegaspargase(ESA)with sandwiched radiotherapy.This multicenter,randomized,phase III trial enrolled patients aged between 14 and 70 years with newly diagnosed early-stage nasal NKTCL from 27 centers in China.Patients were randomly assigned(1:1)to receive ESA(pegaspargase 2,500 IU/m^(2)intramuscularly on day 1,etoposide 200 mg orally,and dexamethasone 40 mg orally on days 2–4)or MESA(methotrexate 1 g/m^(2)intravenously on day 1,etoposide 200 mg orally,and dexamethasone 40 mg orally on days 2–4,and pegaspargase 2,500 IU/m^(2)intramuscularly on day 5)regimen(four cycles),combined with sandwiched radiotherapy. | Huijuan Zhong Shu Cheng Xi Zhang Bing Xu Jiayi Chen Xufeng Jiang Jie Xiong Yu Hu Guohui Cui Juying Wei Wenbin Qian Xiaobing Huang Ming Hou Feng Yan Xin Wang Yongping Song Jianda Hu Yuanhua Liu Xuejun Ma Fei Li Chongyang Wu Junmin Chen Li Yu Ou Bai Jingyan Xu Zunmin Zhu Li Liu Xin Zhou Li Huang Yin Tong Ting Niu Depei Wu Hao Zhang Chaofu Wang Binshen Ouyang Hongmei Yi Qi Song Gang Cai Biao Li Jia Liu Zhifeng Li Rong Xiao Luqun Wang Yujie Jiang Yanyan Liu Xiaoyun Zheng Pengpeng Xu Hengye Huang Li Wang Saijuan Chen Weili Zhao | 2023 | The Innovation2023，4，3： | 0 |
| 13 | Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets显示文摘Hypoxia,characterized by reduced oxygen concentration,is a significant stressor that affects the survival of aerobic species and plays a prominent role in cardiovascular diseases.From the research history and milestone events related to hypoxia in cardiovascular development and diseases,The'hypoxia-inducible factors(HIFs)switch'can be observed from both temporal and spatial perspectives,encompassing the occurrence and progression of hypoxia(gradual decline in oxygen concentration),the acute and chronic manifestations of hypoxia,and the geographical characteristics of hypoxia(natural selection at high altitudes).Furthermore,hypoxia signaling pathways are associated with natural rhythms,such as diurnal and hibernation processes.In addition to innate factors and natural selection,it has been found that epigenetics,as a postnatal factor,profoundly influences the hypoxic response and progression within the cardiovascular system.Within this intricate process,interactions between different tissues and organs within the cardiovascular system and other systems in the context of hypoxia signaling pathways have been established.Thus,it is the time to summarize and to construct a multi-level regulatory framework of hypoxia signaling and mechanisms in cardiovascular diseases for developing more therapeutic targets and make reasonable advancements in clinical research,including FDA-approved drugs and ongoing clinical trials,to guide future clinical practice in the field of hypoxia signaling in cardiovascular diseases. | Yongchao Zhao Weidong Xiong Chaofu Li Ranzun Zhao Hao Lu Shuai Song You Zhou Yiqing Hu Bei Shi Junbo Ge | 2023 | Signal Transduction and Targeted Therapy2023，8，12： | 0 |
| 14 | Presence of multiple abnormal immunologic markers is an independent prognostic factor of diffuse large B-cell lymphoma显示文摘Autoimmune diseases (ADs) increase the risk of non-Hodgkin's lymphoma and contribute to poor prognosis of patients. However, the association between immunologic markers and clinical outcome has rarely been investigated. This study aims to analyze the prognostic value of pretreatment immunologic markers in newly diagnosed patients with diffuse large B-cell lymphoma (DLBCL). We retrospectively reviewed the data on 502 patients with DLBCL treated in our institution from January 2013 to March 2018. Survival functions were estimated using Kaplan Meier method and Cox regression model. The 3-year progression free survival (PFS) and overall survival (OS) rates were 70.2% and 80.9%, respectively, and the complete remission (CR) rate was 78.1%. Among the patients, those with multiple (≥3) abnormal immunologic markers had significantly shorter 3-year PFS (52.7% vs. 77.3%, P < 0.001) and OS (68.5% vs. 85.8%, P=0.001) than those without multiple abnormal immunologic markers.Multivariate analysis revealed that the presence of multiple abnormal immunologic markers and the elevated serum levels of lactate dehydrogenase were the independent adverse prognostic factors for PFS (P= 0.008, P < 0.001) and OS (P = 0.003, P < 0.001). Meanwhile, advanced Ann Arbor stage was an independent adverse prognostic factor for PFS (P= 0.001) and age > 60 years for OS (P= 0.014). In conclusion, the immunologic status was closely related to lymphoma progression, and this study provides new insights into the risk stratification of patients with DLBCL. | Yiwen Cao Zhenhua Liu Wen Wu Ying Qian Qin Shi Rong Shen Binshen Ouyang Pengpeng Xu Shu Cheng Jin Ye Yiming Lu Chaofu Wang Chengde Yang Li Wang Weili Zhao | 2019 | Frontiers of Medicine2019，13，1： | 0 |
| 15 | The relative contributions of soil hydrophilicity and raindrop impact to soil aggregate breakdown for a series of textured soils显示文摘Soil aggregate breakdown is the first key factor that causes soil erosion.At present,research on the mechanisms of soil aggregate breakdown during rainfall is common.However,the research to on quantifying the relative contributions of internal and external forces to aggregate breakdown remains limited.This paper was conducted to analyse the relative contribution of internal and external forces to aggregate disintegration and the factors affecting aggregate stability during rainfall.Soil aggregates with a series of textures were selected as test soil samples;deionized water was employed as the soaking solution and rainfall material in static disintegration experiments and rainfall simulation tests.The effect of internal force(soil hydrophilicity)on aggregate disintegration was analysed by the static disintegration method,and the combined effects of internal force(soil hydrophilicity)and external force(raindrop impact)on soil aggregate breakdown were analysed by rainfall simulation experiments.The results indicated that external force caused more severe soil aggregate breakdown than internal force,and the crushed aggregate was mainly distributed in the range of 2–0.25 mm.With increasing rainfall kinetic energy,the degree of aggregate breakdown increased gradually,and the degree of aggregation of the soil particles decreased gradually.Furthermore,soil aggregates with a high clay content(>30%)were more stable than medium-clay(20–30%)and low-clay(<20%)soil aggregates,and the correlation coefficient provided a good representation of the relationship between the clay content and soil aggregate stability index(ASI).Therefore,external force contributed more to soil aggregate breakdown than internal force during rainfall,and clay plays an important role in aggregate stability.The results of this study are of great significance for elaborating the mechanism and factors affecting aggregate breakdown. | Jiangwen Li Shouqin Zhong Zhen Han Pengfei Gao Chaofu Wei | 2022 | International Soil and Water Conservation Research2022，10，3： | 0 |
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