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| 1 | Phosphorus fractions and its release in the sediments of Haihe River,China显示文摘The amounts and forms of phosphorus(P) in surface sediments of Haihe River,Tianjin,North China,were examined using a sequential chemical extraction procedure.Five fractions of sedimentary P,including loosely sorbed P(NH4Cl-P),redox-sensitive P(BD-P),metal oxide bound P(NaOH-P),calcium bound P(HCl-P),and residual P(Res-P)(organic and refractory P),were separately quantified.The results indicated that the contents of different P fractions in the sediments varied greatly.The total P(TP) contents ranged from 968 to 2017 mg/kg.Phosphorus contents in NH4Cl-P,BD-P,NaOH-P,and HCl-P ranged from 6.7 to 26.6 mg/kg,54.5 to 90.2 mg/kg,185.2 to 382.5 mg/kg,and 252.3 to 425.5 mg/kg,respectively,which represented 1.2%-3.2%,7.7%-13%,33.3%-48.9%,and 36.2%-54.2% of the sedimentary inorganic P,respectively.For all the sediment samples,the rank order of P-fractions was Res-P > HCl-P > NaOH-P > BD-P > NH4Cl-P.The highly positive relationship between the amounts of P released from the sediments and those in the NH4Cl-P and BD-P fractions,indicated that NH4Cl-P and BD-P were the main fractions that can release P easily. | SUN Shujuan HUANG Suiliang SUN Xueming WEN Wei | 2009 | Journal of Environmental Sciences2009，21，3： | 53 |
| 2 | Gene expression signatures for phlegm-dampness constitution of Chinese Medicine显示文摘Dear Editor,The term'individualized medicine'was first used in Biochemistry Individuality in 1956 by Williams(Williams et al.,1956).With the emergence of the post-genome era in the21st century,individualized precision medicine has attracted increasing attention.In traditional Chinese medicine(TCM),there is also concept of individualized medicine,which is known as the Chinese constitutional theory,proposed in the1970s(Wang,2012).According to this theory,the | Lingru Li Juan Feng Haiqiang Yao Lan Xie Yu Chen Lingling Yang Shujuan Hou Shipeng Zhao Ranran Sun Yanling Wu Tongtong Bai Yingshuai Li Ruoxi Yu Ji Wang Qi Wang | 2017 | Science China(Life Sciences)2017，60，1： | 13 |
| 3 | Apoptosis-linked antifungal effect of ambroxol hydrochloride by cystolic calcium concentration disturbance in resistant Candida albicans显示文摘Dear Editor,Since the early 1980s,the incidence of fungal infections has significantly increased in immunocompromised individuals(WisplinghofF et al.,2004;Pfaller and Diekema,2007).However,due to the extensive and indiscriminate use of available antifungal agents,an increasing number of antifungal-resistant pathogens have been isolated over the past few decades(Sanglard and Odds,2002).C.albicans,an important opportunistic fxingal pathogen,is becoming increasingly resistant to several antifungal agents,particularly triazole compounds.Drug resistance in C.albicans has emerged as an important public health concern(Sanglard and Odds,2002).Although ambroxol hydrochloride(ABH)has recently been found to display antifungal activity against susceptible C.albicans,its antifungal effect and mechanism against resistant C.albicans have not yet been thoroughly investigated.The aim of this study was to elucidate the antifungal effects(in vitro and in vivo)and mechanisms of ABH against resistant C.albicans. | Xiuyun Li Xuexin Wu Yan Gao Lina Hao Shujuan Sun | 2019 | Science China(Life Sciences)2019，62，12： | 8 |
| 4 | PERFORMANCE IMPROVEMENT OF CENTRIFUGAL FAN BY MEANS OF NUMERICAL SIMULATION显示文摘数字模拟被用来在一台模型离心通风机调查流动地让蒸气发电站以便改进表演。在测试模型扇子期间,效率仅仅与入口盒子是 62.5% ,这被发现,没有它效率是 83% 。另外,测试钻塔的强壮的颤动与入口盒子被观察。如果扇子的气体动力学能被学习,它将是高度合乎需要的。因此,数字模拟被执行与入口盒子调查一把模型扇子的内部流动特征。从入口的整个区域关的 CFD 分析表演的结果被作为转子的方向相反地旋转的一个螺线旋涡占据,它显著地在扇子内影响大多数流动区域。为这个原因,一个哑巴盘子在入口盒子中被安排阻碍螺线旋涡的产生,从在改革以后的 CFD 的结果证明修正是安静的有效,以前的大螺线顶点有效地被破坏了,大的被代替赞成二个小旋涡。然而,二个小旋涡在转子和下列部分的内部流动上有小效果。最后,模型扇子的效率被测试改进,测试钻塔的强壮的颤动消失。这类修正尽最大努力被使用了车站,扇子效率成功地涨到 84% 。 | ZHANG Bo HUANG Shujuan SUN Zhongwei HUI Shien LIU Jiayu QI Chunsong | 2006 | Chinese Journal of Mechanical Engineering2006，19，1： | 8 |
| 5 | A Local Cluster of Omicron Variant COVID-19 Likely Caused by Internationally Mailed Document——Beijing Municipality,China,January 2022显示文摘On January 15,2022,a 26 years old female(Case A)went to a sampling site for coronavirus disease 2019(COVID-19)testing due to excessive fatigue and fever for two days.This patient preliminarily tested positive for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)using a quantitative real-time reverse transcription polymerase chain reaction(qRT-PCR)method. | Daitao Zhang Shuangsheng Wu Zhenyong Ren Ying Sun Xiangfeng Dou Zhaomin Feng Fu Li Yi Tian Shujuan Cui Baiwei Liu Bing Lyu Xiaoli Wang Feng Liu Lina Jin Chu Jiang Lina Tian Zhenjiang Xin Zhichao Liang Lei Jia Quanyi Wang Yang Pan Peng Yang | 2022 | China CDC weekly2022，4，14： | 6 |
| 6 | Upregulation of annexin A5 affects the biological behaviors of lung squamous carcinoma cells in vitro显示文摘Annexin A5 is a Ca2?-dependent phospholipidbinding protein and protein kinase C inhibitory protein. It has a potential role in cellular signal transduction, inflammation, growth and differentiation. In this study, we evaluated the expression of this protein in lung tumor tissues and subsequently established a NCI-H520 cell line that stably expresses the wild-type ANXA5 gene to determine the effects of annexin A5 upregulation on the cell morphology, proliferation and metastasis potential in vitro.The effects of annexin A5 on NCI-H520 cells were tested by crystal violet staining, CCK-8 assay, scratch wound assay, and Transwell assay. The expressions of Akt,PCNA, vimentin, and E-cadherin were examined by Western blot assay. In this study, we demonstrated that annexin A5 is expressed at lower levels in tumor tissues compared with normal tissues. Additionally, the upregulation of this protein may inhibit the proliferation, migration, and invasion abilities of NCI-H520 cells in vitro. The transfected cells were arrested in the G1/S phase of the cell cycle, and the expression levels of Akt, PCNA and Vimentin were downregulated, while E-cadherin was upregulated. | Linlin Gong Haoqi Zhao Lan Wang Bing Sun Lijun Yu Xiaoyu Qi Xin Zhou Liyuan Zhang Hongwei Guan Shujuan Shao | 2014 | Chinese Science Bulletin2014，59，28： | 6 |
| 7 | Autophagy and apoptosis during adult adipose-derived stromal cells differentiation into neuron-like cells in vitro显示文摘β-mercaptoethanol can induce adult adipose-derived stromal cells to rapidly and efficiently differentiate into typical neuron-like cells in vitro.Immunohistochemistry showed that neuron specific enolase and neurofilament-200 expression gradually increased with the extension of induction time,and peaked at 5 hours.By contrast,glial fibrillary acidic protein was negatively expressed at all time points.Induced cells possessed a typical Nissl body,apoptosis showing condensed chromatin in the nucleus,autophagosomes with a bilayered membrane and autolysosomes in the cytoplasm at 5 hours.TUNEL assay and immunohistochemistry and immunofluorescence demonstrated that apoptosis and caspase-3 expression increased and peaked at 8 hours.Immunohistochemistry and immunofluorescence showed that microtubule-associated protein light chain 3 gradually increased with induction and reached a peak at 5 hours.These results indicate that autophagy played an important role in protecting cells during adult adipose-derived stromal cells differentiation into neuron-like cells in vitro. | Yanhui Lu Xiaodong Yuan Ya Ou Yanan Cai Shujuan Wang Qiaoyu Sun Wenli Zhang | 2012 | Neural Regeneration Research2012，7，16： | 5 |
| 8 | Classification of traditional Chinese medicine constitution based on facial features in color images显示文摘Objective:To explore the possible correlation between traditional Chinese medicine(TCM)constitution and facial features in color images and to improve the accuracy of automated constitution classification.Methods:Color images were taken of 5150 individuals of different professions.Automated face detection and key point positioning were performed on the collected images,which were then transformed into a standard size.The relationship between facial features and TCM constitution based on the red,green,blue(RGB)pixel and the local binary pattern(LBP)texture features was explored.Results:The overall accuracy rate and robustness of TCM constitution classification based on RGB features were low.Classification results of the phlegm-dampness,damp-heat,blood stasis,and balance constitutions achieved high accuracy rates.Classification accuracy rate using the LBP texture feature was higher than that of the RGB feature,with the best accuracy observed for the balance constitution.Conclusion:Application of computer image acquisition and processing of facial features may serve as an adjunct to the TCM diagnostic method of inspection. | Jian Zhang Shujuan Hou Ji Wang Lingru Li Pin Li Junwen Han Haiqiang Yao Ranran Sun Ziqing Li Zhen Lei Qi Wang | 2016 | Journal of Traditional Chinese Medical Sciences2016，3，3： | 5 |
| 9 | Development of High Sensitivity Eight-Element Multiplexed Fiber Laser Acoustic Pressure Hydrophone Array and Interrogation System显示文摘纤维激光水中听音器由于唯一的优点和宽广申请前景得到了普遍担心。在这篇论文,研究八元素的多路的纤维激光结果声学的压力数组和讯问系统被介绍,包含的低噪音的分布式的反馈纤维激光(DFB-FL ) 制造,包装的敏感改进,和 interferometric 表明解调。系统的频率反应范围是 10Hz-10kHz,声学的压力敏感到达的激光频率 115 dB re Hz/Pa,和声学的压力是的相等的噪音不到 60Pa/Hz 1/2 。系统的动态范围比 120 dB 大。 | Ming LI Zhihui SUN Xiaolei ZHANG Shujuan LI Zhiqiang SONG Meng WANG Jian GUO Jiasheng NI Chang WANG Gangding PENG Xiangang XU | 2017 | Photonic Sensors2017，7，3： | 4 |
| 10 | Restoration of hyper-eutrophic water with a modularized and air adjustable constructed submerged plant bed显示文摘A modularized and air adjustable constructed submerged plant bed(CSPB)which can be used to restore the eutrophic water is introduced in this paper.This plant bed helps hydrophyte grow under poor conditions such as frequently changed water depth,impaired water transparency,algae bloom and substantial duckweed in summer,which are not naturally suitable for growing hydrophyte.This pilot study in Waihuan River of Tianjin,China,revealed that reduction of Chemical Oxygen Demand(COD),Total Nitrogen(TN)and Total Phosphorus(TP)by the use of CSPB could be reached 30%-35%,35%-40%,30%-40%respectively in the growing season(from March to October)and 5%-10%,5%-15%,7%-20%respectively in the winter(from November to February)when the detention time was 6 d.The relationships between the concentration of COD,TN,TP and the detention time fit the first-order kinetic equation well and the coefficients of determination(R^(2))were all above 0.9.The attenuation coefficients k of the kinetic equation were a function of the water temperature.When the water temperature was quite low or quite high,k was not significantly changed with increasing or decreasing water temperature.While when the temperature was in a moderate range,an increase or decrease of water temperature would lead to a rapid increase or decrease in k. | Jinzhong LI Xueju LI Shujuan SUN Xuegong LIU Suiliang HUANG | 2011 | Frontiers of Environmental Science & Engineering2011，5，4： | 3 |
| 11 | Effects of Reaction Temperature on Microstructure and Advanced Pseudocapacitor Properties of NiO Prepared via Simple Precipitation Method显示文摘Morphology-controlled synthesis and large-scale self-assembly of nanoscale building blocks into complex nanoarchitectures is still a great challenge in nanoscience. In this work, various porous NiO nanostructures are obtained by a simple ammonia precipitation method and we find that the reaction temperature has a significant impact on their microstructures. Nanoflowers and nanoflakes have been obtained at 0 and50, while, weakly self-assembly nanoflowers with nanoflakes are formed at 20. In order to understand the process-structure-property relationship in nanomaterial synthesis and application, the as-prepared NiO is used as supercapacitor electrode materials, and evaluated by electrochemical measurement. The experimental results indicate that the material obtained at lower temperature has higher pseudocapacitance, the specific capacitance of 944, 889 and 410 F/g are reached for the materials prepared at 0, 20 and 50 and further calcined at 300, respectively. While the material obtained at higher temperature has excellent rate capacity. This offers us an opportunity searching for exciting new properties of NiO, and be useful for fabricating functional nanodevices. | Qiangqiang Sun Shujuan Bao | 2013 | Nano-Micro Letters2013，5，4： | 3 |
| 12 | The effect of capping with natural and modified zeolites on the release of phosphorus and organic contaminants from river sediment显示文摘A microcosm system that included river sediment,water and different zeolite capping materials(natural zeolite,surfactant-modified zeolite(SMZ),or aluminum modified zeolite(AMZ))was designed to study the effect of capping on the release of phosphorus and three organic pollutants(phenol,pyridine,and pyrene)from the sediment to the overlying water over the course of three month.For the same amount of the three capping materials,the efficiency of phosphorus inactivation was in the order of SMZ>AMZ>natural zeolite.The inactivation of phosphorus was mainly caused by the covering effect,co-precipitation and adsorption by the capping materials.The different zeolites gave different results for the release of phenol,pyridine,and pyrene from the sediment.When natural zeolite was used as the capping material,there was no effect on the release of pyrene and pyridine,whereas capping the sediment with SMZ or AMZ inhibited the release of pyrene and pyridine but to different extents.However,for controlling the release of phenol from the sediment,aluminum modified zeolite was the most efficient material,whereas no effects were observed when natural zeolite or SMZ were used.The different capabilities of the zeolite materials for controlling the release of different organic pollutants are related to the differences in the electrical properties of these pollutants. | Shujuan SUN Lei WANG Suiliang HUANG Teng TU Hongwen SUN | 2011 | Frontiers of Chemical Science and Engineering2011，5，3： | 3 |
| 13 | Revisiting lithium-storage mechanisms of molybdenum disulfide显示文摘Molybdenum disulfide(MoS_(2)),a typical two-dimensional transition metallic layered material,attracts tremendous attentions in the electrochemical energy storage due to its excellent physicochemical properties.However,with the deepening of the research and exploration of the lithium storage mechanism of these advanced MoS_(2)-based anode materials,the complex reaction process influenced by internal and external factors hinders the exhaustive understanding of the lithium storage process.To design stable anode material with high performance,it is urgent to review the mechanisms of reported anode materials and summarize the related factors that influence the reaction processes.This review aims to dissect all possible side reactions during charging and discharging process,uncover internal and external factors inducing various anode reactions and finally put forward strategies of controlling high cycling capacity and super-stable lithium storage capability of MoS_(2).This review will be helpful to the design of MoS_(2)-based lithium-ion batteries(LIBs) with excellent cycle performance to enlarge the application fields of these advanced electrochemical energy storage devices. | Chun Sun Mingming Liu Longlu Wang Lingbin Xie Weiwei Zhao Jianmin Li Shujuan Liu Dafeng Yan Qiang Zhao | 2022 | Chinese Chemical Letters2022，33，4： | 3 |
| 14 | Enhanced sympathetic activity and cardiac sympathetic afferent reflex in rats with heart failure induced by adriamycin显示文摘Our previous studies have shown that the cardiac sympathetic afferent reflex is enhanced in rats with chronic heart failure(CHF) induced by coronary artery ligation and contributes to the over-excitation of sympathetic activity.We sought to determine whether sympathetic activity and cardiac sympathetic afferent reflex were enhanced in adriamycin-induced CHF and whether angiotensin II(Ang II) in the paraventricular nucleus(PVN) was involved in enhancing sympathetic activity and cardiac sympathetic afferent reflex.Heart failure was induced by intraperitoneal injection of adriamycin for six times during 2 weeks(15 mg/kg).Six weeks after the first injection,the rats underwent anesthesia with urethane and α-chloralose.After vagotomy and baroreceptor denervation,cardiac sympathetic afferent reflex was evaluated by renal sympathetic nerve activity and mean arterial pressure(MAP) response to epicardial application of capsaicin(1.0 nmol).The response of MAP to ganglionic blockade with hexamethonium in conscious rats was performed to evaluate sympathetic activity.The renal sympathetic nerve activity and cardiac sympathetic afferent reflex were enhanced in adriamycin rats and the maximum depressor response of MAP induced by hexamethonium was significantly greater in adriamycin rats than that in control rats.Bilateral PVN microinjection of angiotensin II(Ang II) caused larger responses of the cardiac sympathetic afferent reflex,baseline renal sympathetic nerve activity and MAP in adriamycin rats than control rats.These results indicated that both sympathetic activity and cardiac sympathetic afferent reflex were enhanced and Ang II in the PVN was involved in the enhanced sympathetic activity and cardiac sympathetic afferent reflex in rats with adriamycin-induced heart failure. | Shujuan Zhang Feng Zhang Haijian Sun Yebo Zhou Ying Han | 2012 | The Journal of Biomedical Research2012，26，6： | 3 |
| 15 | Influence of synthesis temperatures on the crystalline grain growth and morphology of lanthanum magnesium hexaaluminate显示文摘Lanthanum magnesium hexaaluminate(LaMgAl_(11)O_(19), LMA) was prepared at different temperatures by solid-state reaction. Phase compositions and crystal morphologies of specimens synthesized at different temperatures were investigated using X-ray diffraction(XRD), scanning electron microscopy(SEM). It was observed that the crystalline grain size of LMA was not only dependent on the preparation temperature but also on its powder morphology. In the temperature range of 1300 e1550℃, LMA showed platelet grain and the average crystalline grain size increases with the increase in temperature. At1600℃, if the powder was sintered for two times, the equiaxed grain could be found with the decrease in grain space, resulting in the reduction of the crystalline grain size. Styles of specimens(powder or disk) might have no obvious influence on morphologies and sizes of LMA crystalline grains which were synthesized with the well-dispersed raw material mixtures. The synthesis temperature played a key role in influencing the free space for the formation and growth of crystalline grains. | Junbin Sun Jinshuang Wang Wenzhi Huang Yu Hui Xin Zhou Lifen Li Jianing Jiang Longhui Deng Yunya Niu Shujuan Dong Xueqiang Cao | 2017 | Journal of Rare Earths2017，35，12： | 2 |
| 16 | Analysis of the Mechanism and Effectiveness of Lignin in Improving the High-Temperature Thermal Stability of Asphalt显示文摘The use of lignin,which is a by-product of the pulp and paper industry,in the development of asphalt binders would contribute to waste reduction,providing environmental,economic,and social benefits.In this study,samples of lignin-modified asphalt binder samples with different content of lignin(3%,6%,9%,12%,and 15%)and unmodified asphalt(control)were tested using Fourier transform infrared spectroscopy(FTIR),dynamic shear rheometer(DSR),and thermogravimetry.The mechanism and effectiveness of lignin in improving the thermal stability of asphalt at high temperatures were analyzed.The FTIR analysis shows that no new characteristic absorption peak is seen in the infrared spectral of the lignin-modified asphalt binder samples,and some bands characteristic of lignin-related peaks gradually increased with the increase of lignin content.This suggests that the modification of lignin-modified asphalt binder samples was due to physical blending rather than chemical modification.The increase of lignin content in the lignin-modified asphalt samples increases the complex shear modulus G*of the samples and decreases the phase angles of the samples.Similarly,the anti-rutting performance(G*/sinδ)of the samples improves with the increase in lignin content,but this is not significant after any addition of lignin that exceeds 12%of asphalt mass.Thermal characterizations show that the thermal decomposition rate of lignin is lower,and its residual amount is higher compared to that of asphalt,which is a major reason for the improved stability of lignin-modified asphalt binders at high temperatures.The effect of lignin on the thermal stability of asphalt is dependent on both lignin content and temperature.It has a positive effect on the thermal stability of asphalt at high temperatures within the range of asphalt service temperature(25℃–200℃).Additionally,from the pyrolysis viewpoint,it was explained that excessive lignin addition is not beneficial to the thermal stability of asphalt at high temperatures,which is consistent with the DSR test result conducted high temperatures. | Cheng Cheng Weiwei Sun Bo Hu Guixiang Tao Chao Peng Yanjuan Tian Shujuan Wu | 2020 | Journal of Renewable Materials2020，8，10： | 2 |
| 17 | Calcipotriol abrogates cancer-associated fibroblast-derived IL-8-mediated oxaliplatin resistance in gastric cancer cells via blocking PI3K/Akt signaling显示文摘Activation of vitamin D receptor(VDR)in cancer-associated fibroblasts(CAFs)has been implicated in hesitating tumor progression and chemoresistance of several human malignancies.Yet,the role of VDR in CAF-induced chemotherapy resistance of gastric cancer(GC)cells remains elusive.In this study we first conducted immunohistochemistry analysis on tissue microarrays including 88 pairs of GC and normal mucosa samples,and provided clinical evidence that VDR was mainly expressed in gastric mucous cells but almost invisible in CAFs,and VDR expression was negatively correlated with malignant clinical phenotype and advanced stages,low VDR expression confers to poor overall survival rate of patients with GC.In a co-culture system of primary CAFs and cancer cells,we showed that treatment of HGC-27 and AGS GC cells with VDR ligand calcipotriol(Cal,500 nM)significantly inhibited CAF-induced oxaliplatin resistance.By using RNA-sequencing and Human Cytokine Antibody Array,we demonstrated that IL-8 secretion from CAFs induced oxaliplatin resistance via activating the PI3K/AKT pathway in GC,whereas Cal treatment greatly attenuated the tumor-supportive effect of CAF-derived IL-8 on GC cells.Taken together,this study verifies the specific localization of VDR in GC tissues and demonstrates that activation of VDR abrogates CAF-derived IL-8-mediated oxaliplatin resistance in GC via blocking PI3K/Akt signaling,suggesting vitamin D supplementation as a potential strategy of enhancing the anti-tumor effect of chemotherapy in GC. | Zhen-xiong Zhao Yan-qiu Zhang Hui Sun Zi-qi Chen Jin-jia Chang Xin Wang Xu Wang Cong Tan Shujuan Ni Wei-wei Weng Meng Zhang Lei Wang Dan Huang Yun Feng Wei-qi Shen Mi-die Xu | 2023 | Acta Pharmacologica Sinica2023，44，1： | 2 |
| 18 | A near-infrared phosphorescent probe for F^- based on a cationic iridium(Ⅲ) complex with triarylboron moieties显示文摘In this work, a near-infrared (NIR) phosphorescent probe for F- based on a cationic Ir(Ⅲ) complex [Ir(Bpq)2(quqo)]PF6 (1) with dimesitylboryl (Mes2B) groups on the cyclometalated C^N ligands (Bpq) and 2-(quinolin-2-yl)quinoxaline (quqo) as N^N ligand was designed and synthesized. The excited state properties of 1 were investigated in detail using molecular orbital cal- culations and experimental methods. Upon excitation, complex 1 shows NIR phosphorescent emission around 680 nm. Inter- estingly, the complex can be excited with long wavelength around 610 nm. Such long-wavelength excitation can reduce the background emission interference and improve the signal-to-noise ratio. Furthermore, the selective binding between boron at- om and F- can give rise to the quenching of emission and realize the near-infrared phosphorescent sensing for F-. We wish that the results reported herein will be helpful for the further design of excellent near-infrared phosphorescent probes based on heavy-metal complexes. | XU WenJuan LIU ShuJuan ZHAO Qiang MA TingChun SUN Shi ZHAO XinYan HUANG Wei | 2011 | Science China Chemistry2011，54，11： | 2 |
| 19 | Induced12 norm control for LPV system with specified class ofdisturbance inputs 显示文摘 | Sun Guanghui Ge Dongming Wang Shujuan | 2013 | Journal of the FranklinInstitute2013，350，2： | 1 |
| 20 | Human cytomegalovirus miR-US5-1 inhibits viral replication by targeting Geminin mRNA显示文摘Viruses commonly create favorable cellular conditions for their survival through multiple mechanisms. Micro RNAs(mi RNAs), which function as post-transcriptional regulators, are utilized by human cytomegalovirus(HCMV) in its infection and pathogenesis. In the present study, the DNA replication inhibitor Geminin(GMNN) was identified to be a direct target of hcmv-mi R-US5-1. Overexpression of hcmv-mi R-US5-1 could block the accumulation of GMNN during HCMV infection, and the decrease of GMNN expression caused by hcmv-mi R-US5-1 or GMNN specific si RNA reduced HCMV DNA copies in U373 cells. Meanwhile, ectopic expression of hcmv-mi R-US5-1 and consequent lower expression of GMNN influenced host cell cycle and proliferation. These results imply that hcmv-mi R-US5-1 may affect viral replication and host cellular environment by regulating expression kinetics of GMNN during HCMV infection. | Shujuan Jiang Yujing Huang Ying Qi Rong He Zhongyang Liu Yanping Ma Xin Guo Yaozhong Shao Zhengrong Sun Qiang Ruan | 2017 | Virologica Sinica2017，32，5： | 1 |
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