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| 1 | Regulation of extracellular signal-regulated kinase 1/2 influences hippocampal neuronal survival in a rat model of diabetic cerebral ischemia显示文摘Activation of extracellular signal-regulated kinase 1/2 has been demonstrated in acute brain ischemia. We hypothesized that activated extracellular signal-regulated kinase 1/2 can protect hippocampal neurons from injury in a diabetic model after cerebral ischemia/reperfusion. In this study, transient whole-brain ischemia was induced by four-vessel occlusion in normal and diabetic rats, and extracellular signal-regulated kinase 1/2 inhibitor(U0126) was administered into diabetic rats 30 minutes before ischemia as a pretreatment. Results showed that the number of surviving neurons in the hippocampal CA1 region was reduced, extracellular signal-regulated kinase 1/2 phosphorylation and Ku70 activity were decreased, and pro-apoptotic Bax expression was upregulated after intervention using U0126. These findings demonstrate that inhibition of extracellular signal-regulated kinase 1/2 activity aggravated neuronal loss in the hippocampus in a diabetic rat after cerebral ischemia/reperfusion, further decreased DNA repairing ability and accelerated apoptosis in hippocampal neurons. Extracellular signal-regulated kinase 1/2 activation plays a neuroprotective role in hippocampal neurons in a diabetic rat after cerebral ischemia/ reperfusion. | Yaning Zhao Jianmin Li Qiqun Tang Pan Zhang Liwei Jing Changxiang Chen Shuxing Li | 2014 | Neural Regeneration Research2014，9，7： | 10 |
| 2 | Protective effects of dl-3n-butylphthalide against diffuse brain injury显示文摘Dl-3n-butylphthalide can effectively treat cerebral ischemia;however,the mechanisms underlying the effects of dl-3n-butylphthalide on microcirculation disorders following diffuse brain injury remain unclear.In this study,models of diffuse brain injury were established in Sprague-Dawley rats with the vertical impact method.Dl-3n-butylphthalide at 80 and 160 mg/kg was given via intraperitoneal injection immediately after diffuse brain injury.Ultrastructural changes in the cerebral cortex were observed using electron microscopy.Cerebral blood flow was measured by laser Doppler flowmetry,vascular density was marked by tannic acid-ferric chloride staining,vascular permeability was estimated by the Evans blue method,brain water content was measured using the dry-wet method,and rat behavior was measured by motor function and sensory function tests.At 6,24,48,and 72hours after administration of dl-3n-butylphthalide,reduced cerebral ultrastructure damage,increased vascular density and cerebral blood flow,and improved motor and sensory functions were observed.Our findings demonstrate that dl-3n-butylphthalide may have protective effects against diffuse brain injury by ameliorating microcirculation disorder and reducing blood-brain barrier damage and cerebral edema. | Yaning Zhao Jianmin Li Pan Zhang Changxiang Chen Shuxing Li | 2013 | Neural Regeneration Research2013，8，28： | 7 |
| 3 | Riemann boundary value problems and reflection of shock for the Chaplygin gas显示文摘In this paper,we study two-dimensional Riemann boundary value problems of Euler system for the isentropic and irrotational Chaplygin gas with initial data being two constant states given in two sectors respectively,where one sector is a quadrant and the other one has an acute vertex angle.We prove that the Riemann boundary value problem admits a global self-similar solution,if either the initial states are close,or the smaller sector is also near a quadrant.Our result can be applied to solving the problem of shock reflection by a ramp. | CHEN ShuXing 1,& QU AiFang 2 1 School of Mathematical Sciences,Fudan University,Shanghai 200433,China 2 Wuhan Institute of Physics and Mathematics,Chinese Academy of Sciences,Wuhan 430071,China | 2012 | Science China Mathematics2012，55，4： | 6 |
| 4 | Gene characterization and molecular pathway analysis of reverse thermosensitive genic male sterility in eggplant(Solanum melongena L.)显示文摘The naturally occurring mutant eggplant line 05ms was identified with reverse thermosensitive genic male sterility(rTGMS),but its temperature-responsive fertility mechanisms remain largely unknown.Here,we studied the flower morphology,anther cellular structure,and genome-wide gene expression of this rTGMS line.Candidate genes for thermosensitive male sterility during the microspore development of 05ms and the temperature-insensitive line S63 under low-temperature(LT)and high-temperature(HT)conditions were identified.Under LT,tapetum cells were vacuolated and had delayed disintegration in 05ms.RNA-seq analysis indicated that DEGs were enriched in the KEGG pathways‘plant hormone signal transduction’,‘starch and sucrose metabolism’,and‘phenylpropanoid biosynthesis’.We identified two genes,4CLL1(Sme2.5_00368.1_g00010.1)and CKI1(Sme2.5_10056.1_g00002.1),which could potentially regulate eggplant anther development and may be candidate genes for rTGMS.Finally,we propose a working model of anther abortion for rTGMS in eggplant.CKI1 responds to LT stress and causes expression changes in genes related to anther development,such as 4CLL1,and the cellular structure of the tapetum becomes abnormal,causing male sterility.The findings of this study explain the underlying molecular mechanisms of male sterility in eggplant rTGMS lines. | Bing Li Xueping Chen Yanrong Wu Aixia Gu Jingjing Zhang Shuangxia Luo Xiurui Gao Jianjun Zhao Xiuqing Pan Shuxing Shen | 2019 | Horticulture Research2019，6，1： | 5 |
| 5 | The fundamental solution of the Keldysh typeoperator显示文摘In this paper we discuss the fundamental solution of the Keldysh type operator Lαu■ 2u x2 + y 2yu y2 + α u y1 , which is a basic mixed type operator different from the Tricomi operator. The fundamental solution of the Keldysh type operator with α>-1/2 is obtained. It is shown that the fundamental solution for such an operator generally has stronger singularity than that for the Tricomi operator. Particularly, the fundamental solution of the Keldysh type operator with α<1/2 has to be defined by using the finite part of divergent integrals in the theory of distributions. | CHEN ShuXing School of Mathematical Sciences, Fudan University, Shanghai 200433, China | 2009 | Science China Mathematics2009，52，9： | 3 |
| 6 | Comparative transcriptome analysis reveals defense responses against soft rot in Chinese cabbage显示文摘Pectobacterium carotovorum ssp.carotovorum(Pcc)is a necrotrophic bacterial species that causes soft rot disease in Chinese cabbage.In this study,plants harboring the resistant mutant sr gene,which confers resistance against Pcc,were screened from an 800 M2 population mutated by ethyl methane sulfonate(EMS)and scored in vitro and in vivo for lesion size.The transcript profiles showed~512 differentially expressed genes(DEGs)between sr and WT plants occurring between 6 and 12 h postinoculation(hpi),which corresponded to the important defense regulation period(resistance)to Pcc in Chinese cabbage.The downstream defense genes(CPK,CML,RBOH MPK3,and MPK4)of pathogen pattern-triggered immunity(PTI)were strongly activated during infection at 12 hpi in resistant mutant sr;PTI appears to be central to plant defense against Pcc via recognition by three putative pattern recognition receptors(PRRs;BrLYM1-BrCERK1,BrBKK1/SERK4-PEPR1,BrWAKs).Pcc triggered the upregulation of the jasmonic acid(JA)and ethylene(ET)biosynthesis genes in mutant sr,but auxins and other hormones may have affected some negative signals.Endogenous hormones(auxins,JAs,and SA),as well as exogenous auxins(MEJA and BTH),were also verified as functioning in the immune system.Concurrently,the expression of glucosinolate and lignin biosynthesis genes was increased at 12 hpi in resistant mutant sr,and the accumulation of glucosinolate and lignin also indicated that these genes have a functional defensive role against Pcc.Our study provides valuable information and elucidates the resistance mechanism of Chinese cabbage against Pcc infection. | Mengyang Liu Fang Wu Shan Wang Yin Lu Xueping Chen Yanhua Wang Aixia Gu Jianjun Zhao Shuxing Shen | 2019 | Horticulture Research2019，6，1： | 2 |
| 7 | Exogenous melatonin improves the chilling tolerance and preharvest fruit shelf life in eggplant by affecting ROS-and senescence-related processes显示文摘Low temperature is the most common abiotic stress factors during the eggplant cultivation in solar greenhouses.Melatonin plays important roles in plant resistance to low temperature.However,the role of melatonin in regulating chilling tolerance and extending the preharvest shelf life of eggplant fruits is still unknown.In this study,we investigated the effects of exogenous melatonin on eggplant plants and fruits in response to low temperature.Under simulated low-temperature conditions,exogenous melatonin significantly relieved the chilling symptoms of seedlings by reducing reactive oxygen species (ROS) and malondialdehyde (MDA) levels and relative leakage rates.These reductions were caused by higher superoxide dismutase (SOD) and catalase (CAT) activities and increased endogenous polyamine and melatonin levels compared with those in untreated seedlings.Notably,the expression levels of SOD,CAT1/2,and polyamine synthesis genes (ADC and ODC) were also increased by 100μmol·L~(-1)melatonin,as well as those of genes involved in melatonin synthesis (TDC,T5H,SNAT,ASMT,and COMT) and cold regulation (COR1,CBFa/b,and ZAT2/6/12).To further investigate the effects of melatonin on eggplant leaves and fruits under natural low temperature conditions,100μmol·L~(-1)melatonin was sprayed on the functional leaves at three days before commodity maturation.Melatonin significantly alleviated chilling injury in the leaves and pericarp and extended the preharvest shelf life of the fruit by increasing the expression of COR1,CBF,ZAT2/6/12,and API5 and decreasing the expression of senescence-related genes (NCED1/2 and SAG12).Therefore,100μmol·L~(-1)melatonin improved chilling tolerance and fruit shelf life by upregulating ZAT2/6/12 to affect ROS-and senescence-related processes,which provides a reference for alleviating cold stress and extending the preharvest fruit shelf life in eggplant. | Lijun Song Zhuo Tan Weiwei Zhang Qiang Li Zhaoxiang Jiang Shuxing Shen Shuangxia Luo Xueping Chen | 2023 | Horticultural Plant Journal2023，9，3： | 2 |
| 8 | Multidimensional Riemann problem for semilinear wave equations显示文摘 | Chen Shuxing | 1992 | Comm Partial Differential Equations1992，17，： | 1 |
| 9 | Supersonic flow past a concave double wedge显示文摘 | Chen Shuxing | 1998 | Science in China Series A: Mathematics1998，，1： | 1 |
| 10 | Apolipoprotein E mimetic peptide protects against diffuse brain injury显示文摘Apolipoprotein E plays a crucial role in inhibiting chronic neurodegenerative processes. However, its impact on neurological function following diffuse brain injury is still unclear. This study was designed to evaluate the therapeutic effects and mechanisms of action of apolipoprotein E mimetic peptide on diffuse brain injury. Apolipoprotein E mimetic peptide was administered into the caudal vein of rats with diffuse brain injury before and after injury. We found that apolipoprotein E mimetic peptide significantly decreased the number of apoptotic neurons, reduced extracellular signal-regulated kinase1/2 phosphorylation, down-regulated Bax and cytochrome c expression, decreased malondialdehyde content, and increased superoxide dismutase activity in a dose-dependent manner. These experimental findings demonstrate that apolipoprotein E mimetic peptide improves learning and memory function and protects against diffuse brain injury-induced apoptosis by inhibiting the extracellular signal-regulated kinase1/2-Bax mitochondrial apoptotic pathway. | Yaning Zhao Jianmin Li Qiqun Tang Junling Gao Changxiang Chen Liwei Jing Pan Zhang Shuxing Li | 2014 | Neural Regeneration Research2014，9，5： | 1 |
| 11 | A new sparse grid based method for uncertainty propagation显示文摘 | Fenfen Xiong Steven Greene Wei Chen Ying Xiong Shuxing Yang | 2010 | Structural and Multidisciplinary Optimization2010，，3： | 1 |
| 12 | Expression Analyses of ABCDE Model Genes and Changes in Levels of Endogenous Hormones in Chinese Cabbage Exhibiting Petal-Loss显示文摘Abnormal formation of floral organs affects plant reproduction and can directly interfere with the progress of breeding programs. Using PCR amplification, ABCDE model genes BraAP2, BraAP3, BraPI, BraAG, BraSHP, and BraSEP were isolated from Chinese cabbage(Brassica rapa L.ssp. pekinensis). We examined six development stages of floral buds collected from Chinese cabbage and compared between a line demonstrating normal flowering(A-8) and two mutated lines that exhibited plants having petal-loss(A-16 and A-17). The expression of ABCDE model genes has been analyzed by qRT-PCR. Compared with flower buds of petal-loss plants and normal plants, the expression of A-class gene BraAP2 was significantly decreased during the first to fourth stages, C-class gene BraAG expression was significantly decreased during the first to fifth stages,and D-class gene Bra SHP expression was significantly decreased during the first to third stages. Furthermore, B-class gene BraAP3 and BraPI and E-class gene BraSEP expressions were significantly decreased during all six stages of petal-loss plants compared with normal plants. Enzymelinked immunosorbent assays detected nine endogenous phytohormones during all stages examined here. Except for the second-stage and third-stage buds, levels of the auxin IAA and cytokinin dhZR were always higher in the petal-loss plants than the normal plants at corresponding time points. Meanwhile, concentrations of GA_(1+3) at the first, fourth, and fifth stages were higher in the petal-loss plants than in the normal plants. Our results provide a theoretical basis for future exploration of the molecular mechanism that determines petal loss and the effects that hormones have on such development in Chinese cabbage plants. | MENG Chuan GU Aixia ZHAO Jianjun WANG Yanhua CHEN Xueping SHEN Shuxing | 2017 | Horticultural Plant Journal2017，3，4： | 1 |
| 13 | Propagation of anomalous Singularities of Solutions to semilinear hyperbolic equation of higher order显示文摘 | | 2001 | Northeastern Math J2001，，1： | 1 |
| 14 | Electrodeposition of a dendrite-free 3D Al anode for improving cycling of an aluminum-graphite battery显示文摘Aluminum-metal batteries show great potential as next-generation energy storage due to their abundant resources and intrinsic safety.However,the crucial limitations of metallic Al anodes,such as dendrite and corrosion problems in conventional aluminum-metal batteries,remain challenging and elusive.Here,we report a novel electrodeposition strategy to prepare an optimized 3D Al anode on carbon cloth with an uniform deposition morphology,low local current density,and mitigatory volume change.The symmetrical cells with the 3D Al anode show superior stable cycling(>450 h)and low-voltage hysteresis(~170 mV)at 0.5 mA cm^(−2).High reversibility(~99.7%)is achieved for the Al plating/stripping.The graphite||Al‐4/CC full batteries show a long lifespan of 800 cycles with 54 mAh g^(−1) capacity at a high current density of 1000 mA g^(−1),benefiting from the high capacitive-controlled distribution.This study proposes a novel strategy to design 3D Al anodes for metallic-Al-based batteries by eliminating the problems of planar Al anodes and realizing the potential applications of aluminum-graphite batteries. | Junfeng Li Kwan San Hui Shunping Ji Chenyang Zha Chengzong Yuan Shuxing Wu Feng Bin Xi Fan Fuming Chen Zongping Shao Kwun Nam Hui | 2022 | Carbon Energy2022，4，2： | 1 |
| 15 | Digital economy,industrial structure,and carbon emissions:An empirical study based on a provincial panel data set from China显示文摘This paper uses the mediation effect and a spatial panel model using panel data from 30 provinces in China from 2011 to 2019 to study the relationship between the digital economy,industrial structure,and carbon emission.The research results show that the development of digital economy can effectively promote the reduction of carbon emissions.The development of the digital economy has a significant role in promoting the rationalization of the industrial structure.The digital economy not only directly suppresses carbon emissions,but also indirectly has a significant inhibitory effect on carbon emissions by promoting the rationalization and improvement of the industrial structure.The development of the digital economy suppresses the optimization of the industrial structure.The improvement of industrialization has hindered the industrialization process.It is necessary to strengthen research and development into digital technology and enhance the capacity of the digital economy to promote carbon emissions reduction. | Shuxing Chen Denglong Ding Guihong Shi Gengxuan Chen | 2022 | Chinese Journal of Population,Resources and Environment2022，20，4： | 1 |
| 16 | Generalized Riemann problem for Euler system Dedicated to Professor LI TaTsien on the Occasion of His 80th Birthday显示文摘This article is a survey on the progress in the study of the generalized Riemann problems for MD Euler system. A new result on generalized Riemann problems for Euler systems containing all three main nonlinear waves(shock, rarefaction wave and contact discontinuity) is also introduced. | CHEN ShuXing LI DeNing | 2017 | Science China Mathematics2017，60，4： | 1 |
| 17 | Stability of a Maeh configuration 显示文摘 | Chen Shuxing | 2006 | Communications on Pure and Applied Mathe- matics2006，59，1： | 1 |
| 18 | Mach configuration in pseudo-sta- tionary compressible flow显示文摘 | Chen Shuxing | 2008 | Journal of the Amer- ican Mathematical Society2008，21，1： | 1 |
| 19 | Construction of a high-density mutant population of Chinese cabbage facilitates the genetic dissection of agronomic traits显示文摘Chinese cabbage(Brassica rapa ssp.pekinensis)is an economically important vegetable crop throughout the world,especially in Asia.High-quality genome sequences are available for Chinese cabbage,but gene functional studies remain challenging.To promote functional genomic studies of Chinese cabbage,we generated an ethyl methane sulfonate(EMS)mutant population of~8000 M_(2) plants using the double haploid inbred line A03 as the parent.The genome of A03 was sequenced and used as a reference for high-throughput functional characterization of gene mutations at the whole-genome level.A total of 300 M_(2) to M_(5) EMS mutants were phenotypically screened and then sequenced,revealing 750629 SNPs and 46272 InDel mutations that cover 98.27%of all predicted genes in the A03 genome.A forward-genetics approach was successfully used to identify two genes with chloroplast-related functions that are responsible for the yellow leaf mutant trait.A reverse-genetics approach was also used to identify associations between mutations in five genes of the glucosinolate biosynthetic pathway and variations in glucosinolate content of the mutant plants.In addition,we built the Chinese cabbage EMS mutation database(CCEMD,www.bioinformaticslab.cn/EMSmutation/home)to increase the usability of this mutant population resource.In summary,we performed large-scale screening of a heading Chinese cabbage EMS mutant collection at the phenotypic and genotypic levels,which will facilitate gene mining of Chinese cabbage and might also be useful for the study of other Brassica crops. | Xiaoxue Sun Xing Li Yin Lu Shan Wang Xiaomeng Zhang Kang Zhang Xiangjie Su Mengyang Liu Daling Feng Shuangxia Luo Aixia Gu Yu Fu Xueping Chen Shuxin Xuan Yanhua Wang Donghui Xu Shumin Chen Wei Ma Shuxing Shen Feng Cheng Jianjun Zhao | 2022 | Molecular Plant2022，15，5： | 1 |
| 20 | Decoration of BiOI quantum size nanoparticles with reduced graphene oxide in enhanced visible-light-driven photocatalytic studies显示文摘 | Zhang Liu Weicheng Xu Jianzhang Fang Xiaoxin Xu Shuxing Wu Ximiao Zhu Zehua Chen | 2012 | Applied Surface Science2012，，： | 1 |
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