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| 1 | Progressive Grey Matter Volume Changes in Patients with Schizophrenia over 6 Weeks of Antipsychotic Treatment and Their Relationship to Clinical Improvement显示文摘Cross-sectional and longitudinal studies have identified widespread and progressive grey matter volume(GMV) reductions in schizophrenia, especially in the frontal lobe. In this study, we found a progressive GMV decrease in the rostral medial frontal cortex(rMFC,including the anterior cingulate cortex) in the patient group during a 6-week follow-up of 40 patients with schizophrenia and 31 healthy controls well-matched for age, gender, and education. The higher baseline GMV in the rMFC predicted better improvement in the positive score on the Positive and Negative Syndrome Scale(PANSS), and this might be related to the improved reality-monitoring. Besides, a higher baseline GMV in the posterior rMFC predicted better remission of general symptoms, and a lesser GMV reduction in this region was correlated with better remission of negative symptoms,probably associated with ameliorated self-referential processing and social cognition. Besides, a shorter disease course and higher educational level contributed to better improvement in the general psychopathological PANSS score, and a family history was negatively associated with improvement of the negative and total PANSS scores.These phenomena might be important for understanding the neuropathological mechanisms underlying the symptoms of schizophrenia and for making clinical decisions. | Xiao Zhang Yuyanan Zhang Jinmin Liao Sisi Jiang Jun Yan Weihua Yue Dai Zhang Hao Yan | 2018 | Neuroscience Bulletin2018，34，5： | 4 |
| 2 | ZNF804A Variation May Affect Hippocampal-Prefrontal Resting-State Functional Connectivity in Schizophrenic and Healthy Individuals显示文摘The ZNF804 A variant rs1344706 has consistently been associated with schizophrenia and plays a role in hippocampal-prefrontal functional connectivity during working memory. Whether the effect exists in the resting state and in patients with schizophrenia remains unclear. In this study, we investigated the ZNF804 A polymorphism at rs1344706 in 92 schizophrenic patients and 99 healthy controls of Han Chinese descent, and used resting-state functional magnetic resonance imaging to explore the functional connectivity in the participants. We found a significant main effect of genotype on the resting-state functional connectivity(RSFC) between the hippocampus and the dorsolateral prefrontal cortex(DLPFC) in both schizophrenic patients and healthy controls. The homozygous ZNF804 A rs1344706 genotype(AA) conferred a high risk of schizophrenia, and also exhibited significantly decreased resting functional coupling between the left hippocampus and right DLPFC(F(2,165) = 13.43,P \ 0.001). The RSFC strength was also correlated with cognitive performance and the severity of psychosis in schizophrenia. The current findings identified the neural impact of the ZNF804 A rs1344706 on hippocampalprefrontal RSFC associated with schizophrenia. | Yuyanan Zhang Hao Yan Jinmin Liao Hao Yu Sisi Jiang Qi Liu Dai Zhang Weihua Yue | 2018 | Neuroscience Bulletin2018，34，3： | 3 |
| 3 | Does Mood Affect the Efficiency of Credit Approval? Evidence from Online Peer-to-Peer Lending显示文摘用从 Paipaidai 获得的大数据集,在中国的一个联机对等的借平台,我们检验是否承认官员心情从单个决策的一个观点影响信用赞同的效率。指在心理学和金融经济学习,我们作为与到学习的贷款的质量有关的变量承认的心情代理,和控制采用季节,温度和天气在不同心情条件下面的赞同行为。结果建议由单个信用官员的信用赞同的效率显著地与他们的 mooda 被相关积极心情改进效率,当时否定心情减少它。明确地,贷款在更好的心情条件下面检验了(例如在春天期间,舒适温度,和阳光充足的天) 如果同意,有赞同,而是缺省的更低的可能性的显著地更高的可能性;并且在更差的心情条件下面检验的那些看赞同的更低的可能性和缺省的更高的可能性是否同意了。当贷款应用更复杂、不正常,或不平常评估时,心情的这效果甚至更强壮。而且,投资者情绪,由闭锁式的资金奖赏表示了,也在信用赞同上有一样的效果。 | Yan Li Sisi Sheng | 2016 | Frontiers of Business Research in China2016，10，3： | 2 |
| 4 | Reflections and Practical Explorations of Rights in Street Design显示文摘Street is the public resource of the city. While the street design is seemingly a technical means for physical space, essentially it is the redistribution of urban space rights. This paper argues that street design should focus on the 'street right,' which can be divided into the right to pass and the right to stay, and it may as well be divided into permanent right and process right. Permanent right mainly includes property right and use right, and process right includes participation right and decision-making right. At present, there are many problems confronted by streets in China, such as uncoordinated division of property right between public and private parties, unfair spatial distribution neglecting the use right of slow traffic, less participation and no decision-making right for citizens during street design process, etc. Based on recent design practices in Shanghai, Xiamen, Shangyu, and several other cities, this paper explores strategies in terms of the coordination and integration of property right and space, fair distribution of street use right, and the public empowerment in street design. | Ge Yan Liu Jinxin(译) Liang Sisi(校) | 2019 | China City Planning Review2019，28，3： | 2 |
| 5 | Microstructure and electrical properties of (Pb 0.87 Ba 0.1 La 0.02 )(Zr 0.68 Sn 0.24 Ti 0.08 )O 3 anti-ferroelectric ceramics fabricated by the hot-press sintering method显示文摘 | Guangzu Zhang Sisi Liu Yan Yu Yike Zeng Yangyang Zhang Xu Hu Shenglin Jiang | 2013 | Journal of the European Ceramic Society2013，，1： | 1 |
| 6 | STIM1 thermosensitivity defines the optimal preference temperature for warm sensation in mice显示文摘Mammals possess a remarkable ability to sense subtle temperature deviations from the thermoneutral skin temperature of -33 ℃, which ensures precise warm sensation.However,the underlying mechanisms remain unclear.Here we show that STIM1,an endoplasmic reticulum (ER)resident transmembrane protein that responds to both ER Ca^2- depletion and heat,mediates temperature-induced Ca^2+ influx in skin keratinocytes via coupling to Orai Ca^2+ channels in plasma membrane.Behaviorally,the keratinocyte-specific knockout of STIM1 shifts the optimal preference temperature (OPT)of mice from -32 ℃ to -34℃,resulting in a strikingly reversed preference between 32℃ and 34℃.Importantly,the thermally inactive STIM1-△K knock-in mice show altered OPT and warm preference behaviors as well,demonstrating the requirement of STIM1 thermosensitivity for warm sensation. Furthermore,the wild-type and mutant mice prefer temperatures closer to their respective OPTs,but poorly distinguish temperatures that are equally but oppositely deviated from their OPTs.Mechanistically,keratinocyte STIM1 affects the in vivo warm responses of sensory neurons by likely involving TRPA1 as a downstream transduction channel.Collectively,our data suggest that STIM1 serves as a novel in vivo thermosensor in keratinocytes to define the OPT,which might be utilized as a peripheral reference temperature for precise warm sensation. | Xiaoling Liu Haiping Wang Yan Jiang Qin Zheng Matt Petrus Mingmin Zhang Sisi Zheng Christian Schmedt Xinzhong Dong Bailong Xiao | 2019 | Cell Research2019，29，2： | 1 |
| 7 | Investigation and analysis of the biosafety awareness of laboratory staff involved in the detection of pathogens in seven provincial Centers for Disease Control and Prevention in China显示文摘This study aims to evaluate the biosafety awareness of laboratory staff working on pathogens detection in seven Centers for Disease Control and Prevention and support these staff's biosafety management and training.A total of 208 laboratory staff from seven provincial CDCs were chosen by stratified random sampling to undergo a self-administered questionnaire survey.The collected data were analyzed using SPSS 22.0.The overall average biosafety awareness of the CDC laboratory staff involved in pathogen detection was 82.5 points.The average biosafety awareness score was the highest in health monitoring(92.63 points)and the lowest in risk assessment and control(41.6 points).Among the seven provincial CDCs,the Guizhou Provincial Center for Disease Control and Prevention laboratory staff showed the lowest average biosafety awareness score(74.3 points).The team who worked for 5–14 years were more likely to score above the passing score(≥88 points;corrected OR 0.400,95%CI:0.168–0.951)than the staff with less than five years of work experience.In addition,the mid-level and junior-level staff,as well as the lower position ones were more likely to score below the passing score(<88 points;junior level and lower:corrected OR 3.473,95%CI:1.028–11.737;mid-level:corrected OR 2.797,95%CI:1.027–7.618)compared with the senior-level staff.Among the surveyed team,66.3%identified a lack of specific funds related to work,61.5%identified a lack of designated personnel for the laboratory biosafety management.The biosafety awareness in CDC laboratory staff involved in pathogen detection is low,especially regarding risk assessment and control.The biosafety awareness in Guizhou and Guangxi Provincial CDC laboratory staff is also low.Laboratory funding,job title,and years of experience in a laboratory influence biosafety awareness in CDC laboratory staff.The biosafety knowledge,education,and training of CDC laboratory staff involved in pathogen detection need to improve by paying attention to the content and coverage of biosafety training,exploring new training modalities,and increasing funding for activities related to biosafety in CDC. | Yan Liu Yuanyuan Guo Sisi Li Bo Liu Jing Wen Chihong Zhao | 2021 | Biosafety and Health2021，3，4： | 1 |
| 8 | Preclinical characterization and comparison between CD3/CD19 bispecific and novel CD3/CD19/CD20 trispecific antibodies against B-cell acute lymphoblastic leukemia:targeted immunotherapy for acute lymphoblastic leukemia显示文摘The CD19-targeting bispecific T-cell engager blinatumomab has shown remarkable efficacy in patients with relapsed/refractory B-cell precursor acute lymphoblastic leukemia.However,several studies showed that blinatumomab has a short plasma half-life due to its low molecular weight,and thus its clinical use is limited.Furthermore,multiple trials have shown that approximately 30%of blinatumomab-relapsed cases are characterized by CD19 negative leukemic cells.Here,we design and characterize two novel antibodies,A-319 and A-2019.Blinatumomab and A-319 are CD3/CD19 bispecific antibodies with different molecular sizes and structures,and A-2019 is a novel CD3/CD19/CD20 trispecific antibody with an additional anti-CD20 function.Our in vitro,ex vivo,and in vivo experiments demonstrated that A-319 and A-2019 are potent antitumor agents and capable of recruiting CD3 positive T cells,enhancing T-cell function,mediating B-cell depletion,and eventually inhibiting tumor growth in Raji xenograft models.The two molecules are complementary in terms of efficacy and specificity profile.The activity of A-319 demonstrated superior to that of A-2019,whereas A-2019 has an additional capability to target CD20 in cells missing CD19,suggesting its potential function against CD19 weak or negative CD20 positive leukemic cells. | Sisi Wang Lijun Peng Wenqian Xu Yuebo Zhou Ziyan Zhu Yushan Kong Stewart Leung Jin Wang Xiaoqiang Yan Jian-Qing Mi | 2022 | Frontiers of Medicine2022，16，1： | 1 |
| 9 | Cloth simulation-based construction of pitfree canopy height models from airborne LiDAR data显示文摘Background:The universal occurrence of randomly distributed dark holes(i.e.,data pits appearing within the tree crown)in LiDAR-derived canopy height models(CHMs)negatively affects the accuracy of extracted forest inventory parameters.Methods:We develop an algorithm based on cloth simulation for constructing a pit-free CHM.Results:The proposed algorithm effectively fills data pits of various sizes whilst preserving canopy details.Our pitfree CHMs derived from point clouds at different proportions of data pits are remarkably better than those constructed using other algorithms,as evidenced by the lowest average root mean square error(0.4981 m)between the reference CHMs and the constructed pit-free CHMs.Moreover,our pit-free CHMs show the best performance overall in terms of maximum tree height estimation(average bias=0.9674 m).Conclusion:The proposed algorithm can be adopted when working with different quality LiDAR data and shows high potential in forestry applications. | Wuming Zhang Shangshu Cai Xinlian Liang Jie Shao Ronghai Hu Sisi Yu Guangjian Yan | 2020 | Forest Ecosystems2020，7，1： | 1 |
| 10 | MicroRNA-503 targets FGF2 and VEGFA and inhibits tumor angiogenesis and growth显示文摘 | Bisheng Zhou Ruihua Ma Wenxia Si Sisi Li Yan Xu Xin Tu Qing Wang | 2013 | Cancer Letters2013，，2： | 1 |
| 11 | Generation of gene-target dogs using CRISPR/Cas9 system显示文摘Dear Editor,Dogs(Canis familiaris)serve as human companions and are raised to herd livestock,aid hunters,guard homes,perform police and rescue work,and guide the blind.Dogs exhibit close similarities to humans in terms of metabolic,physiological,and anatomical characteristics,and thus are ideal genetic and clinical models to study human diseases(Tsai et al.,2007).Gene target technology is a powerful tool to create new strains of animals with favorable traits.However,thus far,gene-target dogs have not been developed due to their unique species-specific reproductive characteristics,which limits the applications of dogs especially in the field of biomedical research.Recently,clustered regularly interspaced short palindromic repeats(CRISPRs)/CRISPR-associated(Cas)9 system was applied to edit specific genes with a high efficiency(Cong et al.,2013;Mali et al.,2013).Here we attempt to explore the feasibility of producing gene knockout(KO)dogs by using this technology.Beagle dog,the most widely used breed in biomedical research,was used as our animal model.Myostatin(MSTN)was chosen as the first gene of interest. | Qingjian Zou Xiaomin Wang Yunzhong Liu Zhen Ouyang Haibin Long Shu Wei Jige Xin Bentian Zhao Sisi Lai Jun Shen Qingchun Ni Huaqiang Yang Huilin Zhong Li Li Minhua Hu Quanjun Zhang Zhidong Zhou Jiaxin He Quanmei Yan Nana Fan Yu Zhao Zhaoming Liu Lin Guo Jiao Huang Guanguan Zhang Jun Ying Liangxue Lai Xiang Gao | 2015 | Journal of Molecular Cell Biology2015，7，6： | 1 |
| 12 | A survey on the current status of burn rehabilitation services in China显示文摘 | Jian Chen Cecilia W.P. Li-Tsang Hong Yan Guangping Liang Jianglin Tan Sisi Yang Jun Wu | 2012 | Burns2012，，： | 1 |
| 13 | Governance of Urban Green Open Space for Responding to Climate Change显示文摘In the global actions to address climate change, urban open green space is one of the main spatial objects that can be used to effectively mitigate greenhouse gases and to promote the implementation of climate adaptive policies. From a global perspective, this paper firstly analyzes the governance strategies and cooperation mechanisms of urban open green space as responding to climate change in European countries. Then, taking the Central City of Beijing as a case, the paper explores its urban thermal environment, distribution of urban open green space, and climate governance operation based on the specific conditions in China. Further, with the digital technologies of GIS and RS, it analyzes the nature and related governance demands of urban open green space and then divides the Central City of Beijing into four governance zones, following which this paper discusses the climate policy strategies and implementation approaches of each governance zone. | Tang Yan Chen Kai Li Caige(译) Liang Sisi(校) | 2017 | China City Planning Review2017，26，3： | 1 |
| 14 | Altering the rate-determining step over cobalt single clusters leading to highly efficient ammonia synthesis显示文摘Activation of high-energy triple-bonds of N2 is the most significant bottleneck of ammonia synthesis under ambient conditions.Here,by importing cobalt single clusters as strong electron-donating promoter into the catalyst,the rate-determining step of ammonia synthesis is altered to the subsequent proton addition so that the barrier of N2 dissociation can be successfully overcome.As revealed by density functional theory calculations,the N2 dissociation becomes exothermic over the cobalt single cluster upon the strong electron backdonation from metal to the N2 antibonding orbitals.The energy barrier of the positively shifted rate-determining step is also greatly reduced.At the same time,advanced sampling molecular dynamics simulations indicate a barrier-less process of the N2 approaching the active sites that greatly facilitates the mass transfer.With suitable thermodynamic and dynamic property,a high ammonia yield rate of 76.2μg h–1 mgcat–1.and superior Faradaic efficiency of 52.9%were simultaneously achieved. | Sisi Liu Mengfan Wang Haoqing Ji Xiaowei Shen Chenglin Yan Tao Qian | 2021 | National Science Review2021，8，5： | 1 |
| 15 | A Triode-like Enzyme-free Catalytic Circuit with Junction Fuel显示文摘Target detection circuits have been previously designed,which are propelled by conventional PCR,isothermal amplification and strand-displacement reaction.These detection circuits obtain the target signal via the replication of the target strand,the aggregation of the signal particles or the branch migration.Here we constructed a tri-ode-like enzyme-free catalyst strand-displacement circuit for target DNA detection.The target strand triggered die reaction and released the fluorescence signal strand circularly through branch migration.However,the main challenge of strand-displacement reaction is the signal leakage.Therefore,we designed a double strand structure'junction fuel',which was used to increase the binding energy across the displacement process.Ultimately,the leakage of the system obtained stable inhabitation due to the junction fuel strand.The limit of detection of the system was as low as 0.11 nmol/L and the gain of the system was as high as 28-fold(the concentration of target was 50 nmol/L).Furthermore,the process of the system was visualized vividly in the reaction curve through the kinetic simulation implemented,which suggests that the combination of the kinetic simulation and the experiment exhibits a promising prospect towards the use of strand-displacement circuit in analytical,diagnostic application and synthetic biology. | LUO Tao WANG Xiaojing FAN Sisi LIU Yan CHENG Jin TANG Linlin SONG Jie | 2020 | Chemical Research in Chinese Universities2020，36，2： | 0 |
| 16 | A unified 3D space-based navigation model for seamless navigation in indoor and outdoor显示文摘Seamless navigation has attracted lots of attention and many methods have been reported in the literature or made available as commercial applications.The process of navigation can be interpreted as a continuous movement of 3D objects from one unoccupied 3D indoor/outdoor space to another.From a technical perspective,a 3D navigation model is one of the critical components that should be available to perform successful navigation.A major approach to build a unified navigation model to support seamless path computation is linking indoor navigation networks to outdoor road/street-based networks.Because of different sources of indoor and outdoor navigation networks,the major approach fails to build up true seamless navigation models.With regards to this,we propose a unified 3D space-based navigation model(U3DSNM).The presented model ensures all types of spaces for navigation(indoor,semi-indoor,semi-outdoor,and outdoor)have the same representation,management methods,and network derivation approach,thereby building up unified navigation networks to support seamless navigation paths planning.The model can be linked to the international standards(data models)that are also based on spaces,such as IndoorGML and the on-going version of CityGML 3.0.Three navigation path planning cases show the feasibility of U3DSNM. | Jinjin Yan Sisi Zlatanova Abdoulaye Diakité | 2021 | International Journal of Digital Earth2021，14，8： | 0 |
| 17 | Improving the estimation of canopy cover from UAV-LiDAR data using a pit-free CHM-based method显示文摘Accurate and rapid estimation of canopy cover(CC)is crucial for many ecological and environmental models and for forest management.Unmanned aerial vehicle-light detecting and ranging(UAV-LiDAR)systems represent a promising tool for CC estimation due to their high mobility,low cost,and high point density.However,the CC values from UAV-LiDAR point clouds may be underestimated due to the presence of large quantities of within-crown gaps.To alleviate the negative effects of within-crown gaps,we proposed a pit-free CHM-based method for estimating CC,in which a cloth simulation method was used to fill the within-crown gaps.To evaluate the effect of CC values and withincrown gap proportions on the proposed method,the performance of the proposed method was tested on 18 samples with different CC values(40−70%)and 6 samples with different within-crown gap proportions(10−60%).The results showed that the CC accuracy of the proposed method was higher than that of the method without filling within-crown gaps(R^(2)=0.99 vs 0.98;RMSE=1.49%vs 2.2%).The proposed method was insensitive to within-crown gap proportions,although the CC accuracy decreased slightly with the increase in withincrown gap proportions. | Shangshu Cai Wuming Zhang Shuangna Jin Jie Shao Linyuan Li Sisi Yu Guangjian Yan | 2021 | International Journal of Digital Earth2021，14，10： | 0 |
| 18 | Li^(+)-ion bound crown ether functionalization enables dual promotion of dynamics and thermodynamics for ambient ammonia synthesis显示文摘Electrosynthesis of ammonia from the reduction of nitrogen is still confronted with the limited supply of gas reactant in dynamics as well as high activation barrier in thermodynamics.Unfortunately,despite tremendous efforts devoted to electrocatalysts themselves,they still fail to tackle the above two challenges simultaneously.Herein,we employ a heterogeneous catalyst adlayer-composed of crown ethers associated with Li^(+)ions-to achieve the dual promotion of dynamics and thermodynamics for ambient ammonia synthesis.Dynamically,the bound Li^(+)ions interact with the strong quadrupole moment of nitrogen,and trigger considerable reactant flux toward the catalyst.Thermodynamically,Li^(+)associated with the oxygen of crown ether achieves a higher density of states at the Fermi level for the catalyst,enabling effortless electron transfer from the catalysts to nitrogen and thus greatly reducing the activation barrier.As expected,the proof-of-concept system achieves an ammonia yield rate of 168.5μg h^(-1)mg^(-1)and a Faradaic efficiency of 75.3%at-0.3 V vs.RHE.This system-level approach opens up pathways for tackling the two key challenges that have limited the field of ammonia synthesis. | Qiyang Cheng Sisi Liu Mengfan Wang Lifang Zhang Yanzheng He Jiajie Ni Jingru Zhang Chengwei Deng Yi Sun Tao Qian Chenglin Yan | 2023 | Journal of Energy Chemistry2023，，10： | 0 |
| 19 | Visual reconstruction of flexible structure based on fiber grating sensor array and extreme learning machine algorithm显示文摘A visual reconstruction method was proposed based on fiber Bragg grating(FBG)sensors and an intelligent algorithm,aiming to solve the problems of low accuracy and complex reconstruction process in conventional reconstruction methods of flexible structures.Firstly,the wavelength data containing structural strain information was captured by FBG sensors,together with deformation displacement information.Subsequently,a predicted model was built based on an extreme learning machine(ELM)and further optimized by the particle swarm optimization(PSO)algorithm.Different deformation patterns were tested on an aluminum alloy plate,indicating the ability of the predicted model to produce the deformation displacement for reconstruction.The experimental results show that the maximum error can be as low as 0.050 mm,which verifies that the proposed method is feasible and satisfied with the deformation monitoring of the spacecraft structure. | ZHANG Sisi YAN Jie JIANG Mingshun SUI Qingmei ZHANG Lei LUO Yuxiang | 2022 | Optoelectronics Letters2022，18，7： | 0 |
| 20 | Eliminating nitrogen chemisorption barrier with single-atom supported yttrium cluster via electronic promoting effect for highly efficient ammonia synthesis显示文摘Nitrogen chemisorption is a prerequisite for efficient ammonia synthesis under ambient conditions,but promoting this process remains a significant challenge.Here,by loading yttrium clusters onto a single-atom support,an electronic promoting effect is triggered to successfully eliminate the nitrogen chemisorption barrier and achieve highly efficient ammonia synthesis.Density functional theory calculations reveal that yttrium clusters with abundant electron orbitals can provide considerable electrons and greatly promote electron backdonation to the N2 antibonding orbitals,making the chemisorption process exothermic.Moreover,according to the“hot atom”mechanism,the energy released during exothermic N2 chemisorption would benefit subsequent N2 cleavage and hydrogenation,thereby dramatically reducing the energy barrier of the overall process.As expected,the proof-of-concept catalyst achieves a prominent NH3 yield rate of 48.1μg·h^(−1)·mg^(−1)at−0.2 V versus the reversible hydrogen electrode,with a Faradaic efficiency of up to 69.7%.This strategy overcomes one of the most serious obstacles for electrochemical ammonia synthesis,and provides a promising method for the development of catalysts with high catalytic activity and selectivity. | Yuzhuo Jiang Mengfan Wang Sisi Liu Lifang Zhang Siyi Qian Yufeng Cao Yu Cheng Tao Qian Chenglin Yan | 2023 | Nano Research2023，16，2： | 0 |
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