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| 1 | Hydrothermal ore deposits in collisional orogens显示文摘Hydrothermal ore deposits at convergent plate boundaries represent extraordinary metal enrichment in the continental crust. They are generally associated with felsic magmatism in extensional settings at high thermal gradients. Although their formation is common during accretionary orogeny, more and more ore deposits have been discovered recently in the collisional orogens of China. Because collisional orogeny was operated in a compressional regime at low thermal gradients, it is not favorable for mobilization of ore-forming elements and thus for the production of hydrothermal ore deposits. Nevertheless, continental collision is generally preceded by oceanic subduction, which enables the preliminary enrichment of ore-forming elements in the mantle wedge due to chemical metasomatism by subducting slab-derived fluids. This gave rise to metal pre-enriched domains in the overriding lithosphere, which may be reactivated by extensional tectonism for hydrothermal mineralization either immediately during accretionary orogeny or at a later time during and after collisional orogeny. It is these tectonic processes that have resulted in the progressive enrichment of ore-forming elements through the geochemical differentiation of the subducting oceanic crust, the metasomatic mantle domains and the mafic juvenile crust, respectively, at different depths. Finally, the reactivation of metal pre-enriched domains by continental rifting in the orogenic lithosphere is the key to the metallogenesis of collisional orogens. | Yongfei Zheng Jingwen Mao Yanjing Chen Weidong Sun Pei Ni Xiaoyong Yang | 2019 | Science Bulletin2019，64，3： | 26 |
| 2 | Structural basis for the impact of phosphorylation on the activation of plant receptor-like kinase BAK1显示文摘 | Liming Yan Yuanyuan Ma Dan Liu Xiaochao Wei Yuna Sun Xiaoyue Chen Huadong Zhao Jingwen Zhou Zhiyong Wang Wenqing Shui Zhiyong Lou | 2012 | Cell Research2012，22，8： | 10 |
| 3 | Integrated transcriptomic and metabolomic analyses of a wax deficient citrus mutant exhibiting jasmonic acid-mediated defense against fungal pathogens显示文摘Naturally,resistant crop germplasms are important resources for managing the issues of agricultural product safety and environment deterioration.We found a spontaneous mutant of‘Newhall’navel orange(Citrus sinensis Osbeck)(MT)with broad-spectrum protections against fungal pathogens in the orchard,postharvest-storage,and artificial inoculation conditions.To understand the defense mechanism of MT fruit,we constructed a genome-scale metabolic network that integrated metabolome and transcriptome datasets.The coordinated transcriptomic and metabolic data were enriched in two sub-networks,showing the decrease in very long chain fatty acid(by 41.53%)and cuticular wax synthesis(by 81.34%),and increase in the synthesis of jasmonic acid(JA)(by 95.23%)and JA-induced metabolites such as 5-dimethylnobietin(by 28.37%)in MT.Furthermore,cytological and biochemical analyses confirmed that the response to fungal infection in MT was independent of wax deficiency and was correlated with the levels of jasmonates,and the expression of plant defensin gene PDF1.2.Results of exogenous application of MeJA and JA inhibitors such as propyl gallate proved that JA-mediated defense contributes to the strong tolerance against pathogens in MT.Our results indicated that jasmonate biosynthesis and signaling are stimulated by the fatty acid redirection of MT,and participate in the tolerance of pathogenic fungi. | Yizhong He Jingwen Han Runsheng Liu Yuduan Ding Jinqiu Wang Li Sun Xiaoming Yang Yunliu Zeng Weiwei Wen Juan Xu Hongming Zhang Xiang Yan Zhaoxing Chen Zuliang Gu Hong Chen Huanqing Tang Xiuxin Deng Yunjiang Cheng | 2018 | Horticulture Research2018，5，1： | 8 |
| 4 | Photodegradation of 2-(2-hydroxy-5-methylphenyl) benzotriazole(UV-P) in coastal seawaters: Important role of DOM显示文摘Benzotriazole UV stabilizers (BT-UVs) have attracted concems due to their ubiquitous occurrence in the aquatic environment,and their bioaccumulative and toxic properties.However,little is known about their aquatic environmental degradation behavior.In this study,photodegradation of a representative of BT-UVs,2-(2-hydroxy-5-methylphenyl) benzotriazole (UV-P),was investigated under simulated sunlight irradiation.Results show that UV-P photodegrades slower under neutral conditions (neutral form) than under acidic or alkaline conditions (cationic and anionic forms).Indirect photodegradation is a dominant elimination pathway of UV-P in coastal seawaters.Dissolved organic matter (DOM) from seawaters accelerate the photodegradation rates mainly through excited triplet DOM (3DOM*),and the roles of singlet oxygen and hydroxyl radical are negligible in the matrixes.DOM from seawaters impacted by mariculture exhibits higher steady-state concentration of 3DOM*([3DOM*]) relative to those from pristine seawaters,leading to higher photosensitizing effects on the photodegradation.Halide ions inhibit the DOM-sensitized photodegradation of UV-P by decreasing [3DOM*].Photodegradation half-lives of UV-P are estimated to range from 24.38 to 49.66 hr in field water bodies of the Yellow River estuary.These results are of importance for assessing environmental fate and risk UV-P in coastal water bodies. | Xi Chen Jieqiong Wang Jingwen Chen Chengzhi Zhou Feifei Cui Guoxin Sun | 2019 | Journal of Environmental Sciences2019，31，11： | 6 |
| 5 | Lx2-32c,a novel semi-synthetic taxane,exerts antitumor activity against prostate cancer cells in vitro and in vivo显示文摘Tubulin has been shown to be an effective target for the development of cytotoxic agents against prostate cancer. Previously, we reported that Lx2-32 c is an anti-tubulin agent with high binding affinity to tubulin. In this study, we investigated the potential of Lx2-32 c to act as an effective cytotoxic agent in the treatment of prostate cancer. MTT assays showed that Lx2-32 c was cytotoxic to all tested prostate cancer cell lines. The Lx2-32c-treated cells typically exhibited a rounded morphology associated with the onset of apoptosis, as evidenced by immunocytochemical staining. Human prostate cancer cell lines treated with Lx2-32 c arrest in the G2/M phase of the cell cycle and the treatment is associated with an increased ratio of cells in the sub-G0/G1 phase as determined by flow cytometry. Furthermore, expression of the cleaved form of poly(ADP-ribose) polymerase in prostate cancer cell lines treated with Lx2-32 c was shown by Western blotting assay. Xenograft implants of LNCa P and PC3-derived tumors in nude mice showed that Lx2-32 c treatment significant inhibited tumor growth with effects equivalent to those of docetaxel. These findings demonstrate the potential of Lx2-32 c as a candidate antitumor agent for the treatment of prostate cancer. | Guangyao Lv Dengjun Sun Jingwen Zhang Xiaoxia Xie Xiaoqiong Wu Weishuo Fang Jingwei Tian Chunhong Yan Hongbo Wang Fenghua Fu | 2017 | Acta Pharmaceutica Sinica B2017，7，1： | 6 |
| 6 | FN-λ: A new spotlight in innate immunity against influenza virus infection显示文摘 | Yeping Sun Jingwen Jiang Po Tien Wenjun Liu Jing Li | 2018 | Protein & Cell2018，9，10： | 5 |
| 7 | Comparison of nonhuman primates identified the suitable model for COVID-19显示文摘Identification of a suitable nonhuman primate(NHP)model of COVID-19 remains challenging.Here,we characterized severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in three NHP species:Old World monkeys Macaca mulatta(M.mulatta)and Macaca fascicularis(M.fascicularis)and New World monkey Callithrix jacchus(C.jacchus).Infected M.mulatta and M.fascicularis showed abnormal chest radiographs,an increased body temperature and a decreased body weight.Viral genomes were detected in swab and blood samples from all animals.Viral load was detected in the pulmonary tissues of M.mulatta and M.fascicularis but not C.jacchus.Furthermore,among the three animal species,M.mulatta showed the strongest response to SARS-CoV-2,including increased inflammatory cytokine expression and pathological changes in the pulmonary tissues.Collectively,these data revealed the different susceptibilities of Old World and New World monkeys to SARS-CoV-2 and identified M.mulatta as the most suitable for modeling COVID-19. | Shuaiyao Lu Yuan Zhao Wenhai Yu Yun Yang Jiahong Gao Junbin Wang Dexuan Kuang Mengli Yang Jing Yang Chunxia Ma Jingwen Xu Xingli Qian Haiyan Li Siwen Zhao Jingmei Li Haixuan Wang Haiting Long Jingxian Zhou Fangyu Luo Kaiyun Ding Daoju Wu Yong Zhang Yinliang Dong Yuqin Liu Yinqiu Zheng Xiaochen Lin Li Jiao Huanying Zheng Qing Dai Qiangming Sun Yunzhang Hu Changwen Ke Hongqi Liu Xiaozhong Peng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 8 | Nasal delivery of broadly neutralizing antibodies protects mice from lethal challenge with SARS-CoV-2 delta and omicron variants显示文摘Multiple new variants of severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)have constantly emerged,as the delta and omicron variants,which have developed resistance to currently gained neutralizing antibodies.This highlights a critical need to discover new therapeutic agents to overcome the variants mutations.Despite the availability of vaccines against coronavirus disease 2019(COVID-19),the use of broadly neutralizing antibodies has been considered as an alternative way for the prevention or treatment of SARS-Co V-2 variants infection.Here,we show that the nasal delivery of two previously characterized broadly neutralizing antibodies(F61 and H121)protected K18-h ACE2 mice against lethal challenge with SARS-Co V-2 variants.The broadly protective efficacy of the F61 or F61/F121 cocktail antibodies was evaluated by lethal challenge with the wild strain(WIV04)and multiple variants,including beta(B.1.351),delta(B.1.617.2),and omicron(B.1.1.529)at 200or 1000 TCID_(50),and the minimum antibody administration doses(5-1.25 mg/kg body weight)were also evaluated with delta and omicron challenge.Fully prophylactic protections were found in all challenged groups with both F61 and F61/H121 combination at the administration dose of 20 mg/kg body weight,and corresponding mice lung viral RNA showed negative,with almost all alveolar septa and cavities remaining normal.Furthermore,low-dose antibody treatment induced significant prophylactic protection against lethal challenge with delta and omicron variants,whereas the F61/H121 combination showed excellent results against omicron infection.Our findings indicated the potential use of broadly neutralizing monoclonal antibodies as prophylactic and therapeutic agent for protection of current emerged SARS-Co V-2 variants infection. | Jia Lu Qiangling Yin Rongjuan Pei Qiu Zhang Yuanyuan Qu Yongbing Pan Lina Sun Ding Gao Cuiqin Liang Jingwen Yang Wei Wu Jiandong Li Zongqiang Cui Zejun Wang Xinguo Li Dexin Li Shiwen Wang Kai Duan Wuxiang Guan Mifang Liang Xiaoming Yang | 2022 | Virologica Sinica2022，37，2： | 4 |
| 9 | Anti-rutting performance evaluation of modified asphalt binders: A review显示文摘Asphalt pavement inevitably suffers rutting distress induced by repeated loads under high temperatures, which can be effectively alleviated by the modification of asphalt binders.This paper summarized the asphalt modifiers for enhancing the performance of asphalt pavement at high temperatures in terms of the modifier type, additive amount and improving effect. Then, the anti-rutting performance evaluation methods of asphalt binder were introduced with details, including the ring and ball(R&B) test, the dynamic viscosity test, the zero/low shear viscosity(ZSV/LSV) test, the dynamic shear rheometer(DSR) test,the repeated creep and recovery(RCR) test, and the multiple stress creep and recovery(MSCR) test. Furthermore, the sensitivity of the evaluation method to asphalt modifier was analyzed using the normalization method. It was found that the indicators from the MSCR test could clearly reveal the influence of asphalt modifiers on high temperature performance of asphalt binder. But it still had some limitations affecting the accuracy of evaluation results, such as the number of creep-recovery cycles, the stress level and the recovery time. In addition, according to the rutting resistance improvement ratio(RRIR),the styrene-butadiene-styrene(SBS) modifier performed better in improving the rutting resistance of asphalt binder, compared with other modifiers when added within the usual dosage range. | Yan Li Peiwen Hao Chaozhi Zhao Jwnqiang Ling Tao Wu Dewen Li Jingwen Liu Bowei Sun | 2021 | Journal of Traffic and Transportation Engineering(English Edition)2021，8，3： | 4 |
| 10 | Band Engineering and Morphology Control of Oxygen‑Incorporated Graphitic Carbon Nitride Porous Nanosheets for Highly Efficient Photocatalytic Hydrogen Evolution显示文摘Graphitic carbon nitride(g-C3N4)-based photocatalysts have shown great potential in the splitting of water.However,the intrinsic drawbacks of g-C3N4,such as low surface area,poor diffusion,and charge separation efficiency,remain as the bottleneck to achieve highly efficient hydrogen evolution.Here,a hollow oxygen-incorporated g-C3N4 nanosheet(OCN)with an improved surface area of 148.5 m2 g^−1 is fabricated by the multiple thermal treatments under the N2/O2 atmosphere,wherein the C–O bonds are formed through two ways of physical adsorption and doping.The physical characterization and theoretical calculation indicate that the O-adsorption can promote the generation of defects,leading to the formation of hollow morphology,while the O-doping results in reduced band gap of g-C3N4.The optimized OCN shows an excellent photocatalytic hydrogen evolution activity of 3519.6μmol g^−1 h^−1 for~20 h,which is over four times higher than that of g-C3N4(850.1μmol g^−1 h^−1)and outperforms most of the reported g-C3N4 catalysts. | Yunyan Wu Pan Xiong Jianchun Wu Zengliang Huang Jingwen Sun Qinqin Liu Xiaonong Cheng Juan Yang Junwu Zhu Yazhou Zhou | 2021 | Nano-Micro Letters2021，13，3： | 3 |
| 11 | Scaled-up synthesis of defect-rich layered double hydroxide monolayers without organic species for efficient oxygen evolution reaction显示文摘The scaled-up synthesis of organic-free monolayer nanomaterials is highly desirable,especially in obtaining green energy by electrocatalysis.In this study,a method for the scaled-up synthesis of the series of monolayer layered double hydroxides(LDHs)without the addition of organic solvents is reported via the separate nucleation and aging steps process.The resulting monolayer LDHs with the thicknesses of less than 1 nm showed a narrow thickness distribution.X-ray absorption fine-structure revealed that monolayer NiFe-LDH nanosheets have a number of oxygen and metal vacancies defects.As a practical application,monolayer NiFe-LDH nanosheets containing defects showed an enhanced electrocatalytic water oxidation activity compared with that of bulk NiFe-LDH.Density functional theory calculations uncovered that excellent catalytic activity is attributed to vacancies defects.The proposed method is an economical and universally applicable strategy for the scaled-up production of monolayer LDHs. | Haoyuan Chi Jingwen Dong Tian Li Sha Bai Ling Tan Jikang Wang Tianyang Shen Guihao Liu Lihong Liu Luyi Sun Yufei Zhao Yu-Fei Song | 2022 | Green Energy & Environment2022，7，5： | 2 |
| 12 | Shell powder as a novel bio-filler for thermal insulation coatings显示文摘The feasibility of employing shell powder as a novel bio-filler to prepare fluorocarbon coating is demonstrated.According to the relevant Chinese standards, the thermal and mechanical properties of the shell powder-filled fluorocarbon coating were evaluated, and compared with those filled by commercial calcium carbonate. All the shell powder-filled coatings can meet the requirements stated in the relevant standards, and with decreasing the particle size of the shell powders, the performance of the thermal insulation coating is enhanced. The coating(SC3) filled by shell powders with an average particle size of 2.81 μm possesses a better thermal insulation performance than the coating(CC) filled by commercial calcium carbonate. The coating SC3 has comparable adhesive force and washing resistance with the coating CC, and in the washing resistance test, after 2000 cycles, the coating SC3 was still able to cover totally their substrates. This work demonstrates a high value-added disposal method for the aquacultural wastes. | Peigen Zhang Jingwen Tang Qiang Tang Minzhao Zhang Luwei Shen Wubian Tian Yamei Zhang Zhengming Sun | 2019 | Chinese Journal of Chemical Engineering2019，27，2： | 2 |
| 13 | Different roles of rhizosphere effect and long-term fertilization in the activity and community structure of ammonia oxidizers in a calcareous fluvo-aquic soil显示文摘 | Chao Ai Guoqing Liang Jingwen Sun Xiubin Wang Ping He Wei Zhou | 2013 | Soil Biology and Biochemistry2013，，： | 2 |
| 14 | A novel chemotherapy strategy for advanced hepatocellular carcinoma: a multicenter retrospective study显示文摘Background:Chemotherapy is a common treatment for advanced hepatocellular carcinoma,but the effect is not satisfactory.The study aimed to retrospectively evaluate the effects of adding all-trans-retinoic acid(ATRA)to infusional fluorouracil,leucovorin,and oxaliplatin(FOLFOX4)for advanced hepatocellular carcinoma(HCC).Methods:We extracted the data of patients with advanced HCC who underwent systemic chemotherapy using FOLFOX4 or ATRA plus FOLFOX4 at the Eastern Hepatobiliary Surgery Hospital,First Hospital of Jilin University,and Zhejiang Sian International Hospital and retrospectively compared for overall survival.The Cox proportional hazards model was used to calculate the hazard ratios for overall survival and disease progression after controlling for age,sex,and disease stage.Results:From July 2013 to July 2018,111 patients with HCC were included in this study.The median survival duration was 14.8 months in the ATRA plus FOLFOX4 group and 8.2 months in the FOLFOX4 only group(P<0.001).The ATRA plus FOLFOX4 group had a significantly longer median time to progression compared with the FOLFOX4 group(3.6 monthsvs.1.8 months,P<0.001).Hazard ratios for overall survival and disease progression were 0.465(95%confidence interval:0.298–0.726;P=0.001)and 0.474(0.314–0.717;P<0.001)after adjusting for potential confounders,respectively.Conclusion:ATRA plus FOLFOX4 significantly improves the overall survival and time to disease progression in patients with advanced HCC. | Juxian Sun Chang Liu Jie Shi Nanya Wang Dafeng Jiang Feifei Mao Jingwen Gu Liping Zhou Li Shen Wan Yee Lau Shuqun Cheng | 2022 | Chinese Medical Journal2022，135，19： | 2 |
| 15 | Multifunctional MXene/C Aerogels for Enhanced Microwave Absorption and Thermal Insulation显示文摘Two-dimensional transition metal carbides and nitrides(MXene)have emerged as promising candidates for microwave absorption(MA)materials.However,they also have some drawbacks,such as poor impedance matching,high self-stacking tendency,and high density.To tackle these challenges,MXene nanosheets were incorporated into polyacrylonitrile(PAN)nanofibers and subsequently assembled into a three-dimensional(3D)network structure through PAN carbonization,yielding MXene/C aerogels.The 3D network effectively extends the path of microcurrent transmission,leading to enhanced conductive loss of electromagnetic(EM)waves.Moreover,the aerogel’s rich pore structure significantly improves the impedance matching while effectively reducing the density of the MXenebased absorbers.EM parameter analysis shows that the MXene/C aerogels exhibit a minimum reflection loss(RL_(min))value of−53.02 dB(f=4.44 GHz,t=3.8 mm),and an effective absorption bandwidth(EAB)of 5.3 GHz(t=2.4 mm,7.44–12.72 GHz).Radar cross-sectional(RCS)simulations were employed to assess the radar stealth effect of the aerogels,revealing that the maximum RCS reduction value of the perfect electric conductor covered by the MXene/C aerogel reaches 12.02 dB m^(2).In addition to the MA performance,the MXene/C aerogel also demonstrates good thermal insulation performance,and a 5-mm-thick aerogel can generate a temperature gradient of over 30℃ at 82℃.This study provides a feasible design approach for creating lightweight,efficient,and multifunctional MXene-based MA materials. | Fushuo Wu Peiying Hu Feiyue Hu Zhihua Tian Jingwen Tang Peigen Zhang Long Pan Michel WBarsoum Longzhu Cai ZhengMing Sun | 2023 | Nano-Micro Letters2023，15，11： | 2 |
| 16 | WSN path optimization based on fusion of improved ant colony algorithm and genetic algorithm显示文摘 | Tian Jingwen Sun Yang | 2010 | Journal of Computational Information Systems2010，6，5： | 1 |
| 17 | Recombinant hirudin treatment modulates aquaporin-4 and aquaporin-9 expression after intracerebral hemorrhage in vivo显示文摘 | Zhe Sun Zhenhuan Zhao Shiguang Zhao Yi Sheng Zonghang Zhao Cheng Gao Jingwen Li Xiangzhen Liu | 2009 | Molecular Biology Reports2009，，5： | 1 |
| 18 | A Survey of kNN Algorithm显示文摘The kNN algorithm is a well-known pattern recognition method,which is one of the best text classifi cation algorithms.It is one of the simplest machine learning algorithms in machine learning classification algorithm.In this paper,we summarize the kNN algorithm and related literature,introduce the idea,principle,implementation steps and implementation code of kNN algorithm in detail,and analyze the advantages and disadvantages of the algorithm and its various improvement schemes.This paper also introduces the development of kNN algorithm,the important published papers.At the end of this paper,the application of kNN algorithm is introduced,and its implementation in text classifi cation is emphasized. | Jingwen Sun Weixing Du Niancai Shi | 2018 | Information Engineering and Applied Computing2018，1，1： | 1 |
| 19 | 13CO mapping study for massive molecular cloud cores显示文摘 | Yuefang Wu Junzhi Wang Jingwen Wu Huirong Yan Chengming Lei Jinjiang Sun Liming Wang | 2001 | Science in China Series A: Mathematics2001，，4： | 1 |
| 20 | Removal of gaseous volatile organic compounds via vacuum ultraviolet photodegradation: Review and prospect显示文摘Volatile organic compounds(VOCs) have attracted much attention for decades as they are the precursors of photochemical smog and are harmful to the environment and human health. Vacuum ultraviolet(VUV) photodegradation is a simple and effective method to decompose VOCs (ranging from tens to hundreds of ppmV) without additional oxidants or catalysts in the air at atmospheric pressure. In this paper, we review the research progress of VOCs removal via VUV photodegradation. The fundamentals are outlined and the key operation factors for VOCs degradation, such as humidity, oxygen content, VOCs initial concentration, light intensity, and flow rate, are discussed. VUV photodegradation of VOCs mixture is elucidated. The application of VUV photodegradation in combination with ozoneassisted catalytic oxidation(OZCO) and photocatalytic oxidation(PCO) systems, and as the pre-treatment technique for biological purification are illustrated. Based on the summary,we propose the challenges of VUV photodegradation and perspectives for its future development. | Xue Sun Chaolin Li Boping Yu Jingwen Wang Wenhui Wang | 2023 | Journal of Environmental Sciences2023，，3： | 1 |
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