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| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | Effect of microbial mediated iron plaque reduction on arsenic mobility in paddy soil显示文摘The potential of microbial mediated iron plaque reduction, and associated arsenic (As) mobility were examined by iron reducing bacteria enriched from As contaminated paddy soil. To our knowledge, this is the first time to report the impact of microbial iron plaque reduction on As mobility. Iron reduction occurred during the inoculation of iron reducing enrichment culture in the treatments with iron plaque and ferrihydrite as the electron acceptors, respectively. The Fe(II) concentration with the treatment of anthraquinone-2, 6-disulfonic acid (AQDS) and iron reducing bacteria increased much faster than the control. Arsenic released from iron plaque with the iron reduction, and a significant correlation between Fe(II) and total As in culture was observed. However, compared with control, the increasing rate of As was inhibited by iron reducing bacteria especially in the presence of AQDS. In addition, the concentrations of As(III) and As(V) in abiotic treatments were higher than those in the biotic treatments at day 30. These results indicated that both microbial and chemical reductions of iron plaque caused As release from iron plaque to aqueous phase, however, microbial iron reduction induced the formation of more crystalline iron minerals, leading to As sequestration. In addition, the presence of AQDS in solution can accelerate the iron reduction, the As release from iron plaque and subsequently the As retention in the crystalline iron mineral. Thus, our results suggested that it is possible to remediate As contaminated soils by utilizing iron reducing bacteria and AQDS. | WANG Xinjun CHEN Xueping YANG Jing WANG Zhaosu SUN Guoxin | 2009 | Journal of Environmental Sciences2009，21，11： | 11 |
| 3 | Apoptosis of Spodoptera litura larval hemocytes induced byheavy metal zinc显示文摘By adding different amount of zinc into the artificial medium of the insect larvae, the zinc-induced apoptosis of the larvae haemocytes of the herbivorous insect Spodoptera litura Fabricius was investigated with flow cy- tometer. The results showed that the increase of zinc dose in the artificial feed led to the accumulations of zinc in the lar- val hemolymph and fat body, and more zinc was accumu- lated in fat body than in hemolymph. The apoptosis of hemocytes was significantly induced at high zinc concentra- tion (1000 mg·kg?1) in the insect diet, and the apoptosis rate was 63.63%, which was remarkably higher than that at con- trol and lower concentrations (50―500 mg·kg?1). This sug- gests that the high dose of zinc in the artificial diet of S. litura larvae could induce the apoptosis of the larval hemocytes of S. litura. | XIA Qiang SUN Hongxia HU Xinjun SHU Yinghua GU Dexiang ZHANG Guren | 2005 | Chinese Science Bulletin2005，50，24： | 9 |
| 4 | Development and validation of an endoscopic images-based deep learning model for detection with nasopharyngeal malignancies显示文摘Background:Due to the occult anatomic location of the nasopharynx and frequent presence of adenoid hyperpla-sia,the positive rate for malignancy identification during biopsy is low,thus leading to delayed or missed diagnosis for nasopharyngeal malignancies upon initial attempt.Here,we aimed to develop an artificial intelligence tool to detect nasopharyngeal malignancies under endoscopic examination based on deep learning.Methods:An endoscopic images-based nasopharyngeal malignancy detection model(eNPM-DM)consisting of a fully convolutional network based on the inception architecture was developed and fine-tuned using separate training and validation sets for both classification and segmentation.Briefly,a total of 28,966 qualified images were collected.Among these images,27,536 biopsy-proven images from 7951 individuals obtained from January 1st,2008,to December 31st,2016,were split into the training,validation and test sets at a ratio of 7:1:2 using simple randomiza-tion.Additionally,1430 images obtained from January 1st,2017,to March 31st,2017,were used as a prospective test set to compare the performance of the established model against oncologist evaluation.The dice similarity coef-ficient(DSC)was used to evaluate the efficiency of eNPM-DM in automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images,by comparing automatic segmentation with manual segmenta-tion performed by the experts.Results:All images were histopathologically confirmed,and included 5713(19.7%)normal control,19,107(66.0%)nasopharyngeal carcinoma(NPC),335(1.2%)NPC and 3811(13.2%)benign diseases.The eNPM-DM attained an overall accuracy of 88.7%(95%confidence interval(CI)87.8%-89.5%)in detecting malignancies in the test set.In the prospective comparison phase,eNPM-DM outperformed the experts:the overall accuracy was 88.0%(95%CI 86.1%-89.6%)vs.80.5%(95%CI 77.0%-84.0%).The eNPM-DM required less time(40 s vs.110.0±5.8 min)and exhibited encouraging performance in automatic segmentation of nasopharyngeal malignant area from the background,with an average DSC of 0.78±0.24 and 0.75±0.26 in the test and prospective test sets,respectively.Conclusions:The eNPM-DM outperformed oncologist evaluation in diagnostic classification of nasopharyngeal mass into benign versus malignant,and realized automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images. | Chaofeng Li Bingzhong Jing Liangru Ke Bin Li Weixiong Xia Caisheng He Chaonan Qian Chong Zhao Haiqiang Mai Mingyuan Chen Kajia Cao Haoyuan Mo Ling Guo Qiuyan Chen Linquan Tang Wenze Qiu Yahui Yu Hu Liang Xinjun Huang Guoying Liu Wangzhong Li Lin Wang Rui Sun Xiong Zou Shanshan Guo Peiyu Huang Donghua Luo Fang Qiu Yishan Wu Yijun Hua Kuiyuan Liu Shuhui Lv Jingjing Miao Yanqun Xiang Ying Sun Xiang Guo Xing Lv | 2018 | Cancer Communications2018，38，1： | 9 |
| 5 | 声波激励的超小型纳机电系统磁电天线显示文摘当前的小型天线依赖于电磁波的谐振,因此天线的尺寸与电磁波波长相关。典型的天线尺寸大于波长的1/10,而进一步缩小天线尺寸在近十年来都是一个公开的挑战。介绍一种通过悬浮铁氧/压电薄膜异质结构的声波激励纳机械磁电天线。这种磁电天线通过其在声波谐振频率处的磁电效应接收和发射电磁波。磁电天线中的体声波激发铁磁薄膜的磁化振荡,产生电磁波的辐射;反之,天线感应电磁波的磁场,得到压电电压输出。这种磁电天线(尺寸仅为波长的千分之一)比现有小型天线的尺寸小1到2个数量级,但性能却没有降低,在便携式无线通信系统中具有很大的应用潜力。 | Tianxiang Nan Hwaider Lin Yuan Gao Alexei Matyushov Guoliang Yu Huaihao Chen Neville Sun Shengjun Wei Zhiguang Wang Menghui Li Xinjun Wang Amine Belkessam Rongdi Guo Brian Chen James Zhou Zhenyun Qian Yu Hui Matteo Rinaldi Michael E.McConney BrANDon M.Howe Zhongqiang Hu John G.Jones Gail J.Brown Nian Xiang Sun 张建强(翻译) 陈鼎鼎(审校) | 2017 | 通信对抗2017，36，4： | 8 |
| 6 | Third generation high strength low alloy steels with improved toughness显示文摘On-line thermo mechanical controlled processing(TMCP) was conducted to develop the third generation high strength low alloy(HSLA) steel with high toughness economically.The ultra-low carbon content ensured a high level of upper shelf energy while ultrafine lath martensitic structure transformed from super-thin pancaked austenite during controlled rolling and cooling.The reduction of martensite block size decreased ductile-to-brittle transition temperature(DBTT) and compensated the strength loss due to carbon reduction.Consequently,the excellent balance of strength and toughness values was obtained as 950-1060 MPa for yield strength,180 J for Charpy V-notch impact absorbed energy at 30℃,which is much superior to that of traditional martensitic steel.Two mechanisms for the refinement of lath martensite block were proposed:One is the austenite grain refinement in the direction of thickness,and the other is the reduction in the fraction of sub-block boundaries with small misorientation and the increase in the fraction of block boundaries with large misorientation,possibly due to austenite hardening. | SUN XinJun LI ZhaoDong YONG QiLong YANG ZhiGang DONG Han WENG YuQing | 2012 | Science China(Technological Sciences)2012，55，7： | 7 |
| 7 | Highly sensitive integrated flexible tactile sensors with piezoresistive Ge2Sb2Te5 thin films显示文摘Flexible tactile sensor has been extensively investigated as a key component for emerging electronics applications such as robotics,wearable devices,computer hardware,and security systems.Tactile sensors based on various one-dimensional materials have been widely explored.However,precise control of the direction and distribution of these nanomaterials remains a great challenge,and it has been difficult to scale down the device.Here,we introduce highly sensitive integrated flexible tactile sensors based on uniform phase-change Ge_(2)Sb_(2)Te_(5)(GST)thin films that can scale device size down,at least,to micrometer range.Significant piezoresistive effect has been observed in GST-based sensors,showing a giant gauge factor of 338.A proof of concept 5×5 sensor array functioning as a touch panel has been demonstrated.Also,the flexible GST tactile sensor has been utilized for monitoring of radial artery pulse.In addition to the well-known tunable electrical and optical properties,the piezoresistive GST films provide a versatile platform for the integration of sensing,recording,and displaying functions. | Zhiguang Wang Cunzheng Dong Xinjun Wang Menghui Li Tianxiang Nan Xianfeng Liang Huaihao Chen Yuyi Wei Haomiao Zhou Mohsen Zaeimbashi Syd Cash Nian-Xiang Sun | 2018 | npj Flexible Electronics2018，2，1： | 2 |
| 8 | Aquaporin 4 expression and ultrastructure of the blood-brain barrier following cerebral contusion injury显示文摘This study aimed to investigate aquaporin 4 expression and the ultrastructure of the blood-brain barrier at 2-72 hours following cerebral contusion injury,and correlate these changes to the formation of brain edema.Results revealed that at 2 hours after cerebral contusion and laceration injury,aquaporin 4 expression significantly increased,brain water content and blood-brain barrier permeability increased,and the number of pinocytotic vesicles in cerebral microvascular endothelial cells increased.In addition,the mitochondrial accumulation was observed.As contusion and laceration injury became aggravated,aquaporin 4 expression continued to increase,brain water content and blood-brain barrier permeability gradually increased,brain capillary endothelial cells and astrocytes swelled,and capillary basement membrane injury gradually increased.The above changes were most apparent at 12 hours after injury,after which they gradually attenuated.Aquaporin 4 expression positively correlated with brain water content and the blood-brain barrier index.Our experimental findings indicate that increasing aquaporin 4 expression and blood-brain barrier permeability after cerebral contusion and laceration injury in humans is involved in the formation of brain edema. | Xinjun Li Yangyun Han Hong Xu Zhongshu Sun Zengjun Zhou Xiaodong Long Yumin Yang Linbo Zou | 2013 | Neural Regeneration Research2013，8，4： | 2 |
| 9 | Study of the aerostatic and aerodynamic stability of super long-span cable-stayed bridges显示文摘With the increase of span length,the bridge tends to be more flexible,and the wind stability becomes an important problem for the design and construction of super long-span cable-stayed bridges. By taking a super long-span cable-stayed bridge with a main span of 1 400 m as example,the aerostatic and aerodynamic stability of the bridge are investigated by three-dimensional nonlinear aerostatic and aerodynamic stability analysis,and the results are compared with those of a suspension bridge with a main span of 1 385 m,and from the aspect of wind stability,the feasibility of using cable-stayed bridge in super long-span bridge with a main span above 1 000 m is discussed. In addition,the influences of design parameters including the depth and width of the girder,the tower structure,the tower height-to-span ratio,the side-to-main span ratio,the auxiliary piers in the side span and the anchorage system of stay cables,etc on the aerostatic and aerodynamic stability of super long-span cable-stayed bridges are investigated numerically;the key design parameters are pointed out,and also their reasonable values are proposed. | Zhang Xinjun Sun Hailing | 2014 | Engineering Sciences2014，12，2： | 2 |
| 10 | Enhanced work-hardening behavior and mechanical properties in ultrafine-grained steels with large-fractioned metastable austenite显示文摘 | Jie Shi Xinjun Sun Maoqiu Wang Weijun Hui Han Dong Wenquan Cao | 2010 | Scripta Materialia2010，，8： | 2 |
| 11 | Poly(PEGMA) magnetic nanogels:Preparation via photochemical method,characterization and application as drug carrier显示文摘One-pot synthesis of magnetic nanogels with excellent biocompatibility via the photochemical method is reported in this paper.Poly(PEGMA) modified superparamagnetic nanogels(poly(PEGMA) magnetic nanogels) were synthesized by in-situ polymerization using poly(ethylene glycol) methacrylate(PEGMA) as the monomer and N,N'-methylene-bis-(acrylamide)(MBA) as the cross-linking agent in magnetite aqueous suspension under UV irradiation.The surface functional groups and components of magnetic nanogels were analyzed by Fourier transform infrared spectroscopy(FTIR) and a thermogra-vimetric analyzer(TGA).The results indicated that the poly(PEGMA) magnetic nanogels were synthe-sized successfully by coating poly(PEGMA) on the Fe3O4 nanoparticles under UV irradiation,and the Fe3O4 nanoparticles content in this nanogels was above 50 wt%.The morphology,size,zeta-potential and magnetic property were also characterized.The magnetic nanogels had a nearly spherical shape and core-shell structure,the average size in aqueous system measured by photon correlation spec-troscopy(PCS) was 68.4 nm,which was much bigger than that in the dry state,the nanogels behaved superparamagnetically with saturated magnetization of 58.6 emu/g,and the zeta-potential was-16.3-_17.3 mV at physiological pH(6.8-7.4) which could help to maintain stability in blood.The preliminary application as drug carrier was made and the doxorubicin-loaded magnetic nanogels had an excellent property in slow-release.The experiment indicated that the magnetic nanogel was an ideal candidate carrier in target drug delivery systems and other biomedical application. | SUN HanWen ZHANG LianYing ZHU XinJun KONG ChunYan ZHANG CunLan YAO SiDe | 2009 | Science China Chemistry2009，52，1： | 2 |
| 12 | Deformation Induced Ferrite Transformation in Low Carbon Steels显示文摘 | DONG Han SUN Xinjun | 2005 | Current Opinion in Solid State ~ Materials Science2005，9，6： | 1 |
| 13 | Heparin-chitosan- coated aeellular bone matrix enhances perfusion of blood and vascularization in bone tissue engineering scaffolds 显示文摘 | Sun Xinjun Peng Wei Yang Zailiang | 2011 | Tissue Eng Part A2011，17，1920： | 1 |
| 14 | lncRNA-AC130710 targeting by miR-129-5p is upregulated in gastric cancer and associates with poor prognosis显示文摘 | Chunjing Xu Yongfu Shao Tian Xia Yunben Yang Jiawei Dai Lin Luo Xinjun Zhang Weiliang Sun Haojun Song Bingxiu Xiao Junming Guo | 2014 | Tumor Biology2014，，10： | 1 |
| 15 | Experimental and numerical analysis on formation of stable austenite during the intercritical annealing of 5Mn steel显示文摘 | Haiwen Luo Jie Shi Chang Wang Wenquan Cao Xinjun Sun Han Dong | 2011 | Acta Materialia2011，，10： | 1 |
| 16 | Nonlinear aerostatic and aerodynamic analysis of long-span suspension bridges considering wind-structure interactions显示文摘 | Zhang Xinjun Sun Bingnan Xiang Haifan | 2002 | Journalof Wind Engineering and Industrial Aerodynamics2002，90，9： | 1 |
| 17 | Nonlinear aerostatie and aerodynamic analysis of long-span cable-stayed bridges considering wind-structure interaetions显示文摘 | ZHANG Xinjun SUN Bingnan XIANG Haifan | 2002 | Journal of wind Engineering and Industrial Aerodynamics2002，90，9： | 1 |
| 18 | Ausforming effects on anisotropy of mechanical properties in HSLA martensitic steel显示文摘In order to clarify effects of prior pancaked austenitic structure on microstructure and mechanical properties of transformed martensite in ausformed steel,a super-thin pancaked austenite was processed by multi-pass rolling in a 0.03-2.6Mn0.06Nb-0.01Ti(wt%) low alloy steel.The evolution of prior pancaked austenite grain during multi-pass rolling was studied using Ni-30Fe model alloy.Related with the structure and texture in the prior super-thin pancaked austenite in Ni-30Fe alloy,the texture and anisotropy of mechanical properties of transformed martensite in the studied ausformed steel were focused on.There were mainly three kinds of rolling texture components in the super-thin pancaked austenite:Goss {110} 001,copper {112} 111 and brass {110} 112.They were further transformed into the weak {001} 110 and strong {112} 110,{111} 112 texture components in the martensitic structure.The orientation relationship(OR) of lath martensite transformation from pancaked austenite in the ausformed steel deviated larger from the exact Kurdjumov-Sachs(K-S) OR than in the case of equiaxed austenite without deformation.The tensile and yield strengths of the ausformed martensitic steel first decreased and then increased as the angle between tension direction and rolling direction increased.The main reason for the anisotropy of strength was considered as the texture component {112} 110 in martensite.However,the anisotropy of impact toughness was more complex and the main reasons for it are unknown. | LI ZhaoDong SUN XinJun CAO WenQuan YONG QiLong YANG ZhiGang DONG Han WENG YuQing | 2012 | Science China(Technological Sciences)2012，55，7： | 1 |
| 19 | Deformation induced ferrite transformation in low carbon steels显示文摘 | Dong Han Sun Xinjun | 2005 | Current Opinion in Solid State and Materials Science2005，9，6： | 1 |
| 20 | Strain-induced precipitation in a Ti micro-alloyed HSLA steel显示文摘 | Zhenqiang Wang Xinping Mao Zhigang Yang Xinjun Sun Qilong Yong Zhaodong Li Yuqing Weng | 2011 | Materials Science & Engineering A2011，，： | 1 |
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