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| 1 | Improvement of oxytetracycline production mediated via cooperation of resistance genes in Streptomyces rimosus显示文摘Increasing the self-resistance levels of Streptomyces is an effective strategy to improve the production of antibiotics.To increase the oxytetracycline(OTC) production in Streptomyces rimosus,we investigated the cooperative effect of three co-overexpressing OTC resistance genes:one gene encodes a ribosomal protection protein(otrA) and the other two express efflux proteins(otrB and otrC).Results indicated that combinational overexpression of otrA,otrB,and otrC(MKABC) exerted a synergetic effect.OTC production increased by 179%in the recombinant strain compared with that of the wild-type strain M4018.The resistance level to OTC was increased by approximately two-fold relative to the parental strain,thereby indicating that applying the cooperative effect of self-resistance genes is useful to improve OTC production.Furthermore,the previously identified cluster-situated activator OtcR was overexpressed in MKABC in constructing the recombinant strain MKRABC;such strain can produce OTC of approximately7.49 g L^((-1)),which represents an increase of 19%in comparison with that of the OtcR-overexpressing strain alone.Our work showed that the cooperative overexpression of self-resistance genes is a promising strategy to enhance the antibiotics production in Streptomyces. | Shouliang Yin Xuefeng Wang Mingxin Shi Fang Yuan Huizhuan Wang Xiaole Jia Fang Yuan Jinliang Sun Tiejun Liu Keqian Yang Yuxiu Zhang Keqiang Fan Zilong Li | 2017 | Science China(Life Sciences)2017，60，9： | 10 |
| 2 | The localization of type 2 diabetes susceptibility gene loci in northern Chinese Han families显示文摘We conducted a genome-wide scan, in which 358 well distributed fluorescent dye-labeled microsatellite marker sets were applied in 32 Chinese Han type 2 diabetes families from Northern China to search for the susceptibility gene loci. The data collected from screening all the chromosomes of genome were genotyped by using genescan and genotyping software, then, parametric and non-parametric multipoint test, and affected sib-pair analysis as well, were used to analyze the data. We identified some susceptibility gene loci residing in chromosomes 1,12,18,20, respectively, or precisely, located around D1S214, D1S207, D1S218, D1S235, D12S336, D18S61 and D20S118. The comparison of this result with those from other regions and races reflected the complexity and heterogeneity of type 2 diabetes. | ZHAO Jinying WANG Heng XIONG Momiao HUANG Wei ZUO Jin CHEN Zhu QIANG Boqin SUN Qi LI Yuxiu LIU Qiuying DU Weinan CHEN Jialun DING Wei YUAN Wentao ZHAO Yang XU Hongyan JIN Li FANG Fude | 2000 | Chinese Science Bulletin2000，45，19： | 8 |
| 3 | Assessment and Comparison of in vitro Immunoregulatory Activity of Three Astaxanthin Stereoisomers显示文摘In recent years,the immune-modulatory role of all-trans astaxanthin from different pigment sources has been studied.It was reported that all-trans astaxanthin might exist as three stereoisomers,and the composition of all-trans stereoisomers in natural materials differs from that of synthetic products.However,the different biological effects of various all-trans stereoisomers still remain unclear.In the present study,we evaluated the bioactivity of three astaxanthin stereoisomers,(3S,3'S)-trans-,(3R,3'R)-transand meso-trans-astaxanthin,in regulating cell-mediated immune response using mice lymphocytes and peritoneal exudates cells(PECs) systems.After the treatment with three astaxanthin stereoisomers(20 μmol L-1),the lymphocyte proliferation capacity,neutral red phagocytosis of PECs and natural killer(NK) cell cytotoxic activity were comparatively assessed.The results showed that all three astaxanthin stereoisomers significantly promoted lymphocyte proliferation,phagocytic capacity of PECs,and cytotoxic activity of NK cells.Moreover,the(3S,3'S)-trans-astaxanthin exhibited a much higher response than others. | SUN Weihong XING Lihong LIN Hong LENG Kailiang ZHAI Yuxiu LIU Xiaofang | 2016 | Journal of Ocean University of China2016，15，2： | 7 |
| 4 | Effects of Sini San used alone and in combination with fluoxetine on central and peripheral 5-HT levels in a rat model of depression显示文摘OBJECTIVE: To investigate the effects of Sini San and fluoxetine on the levels of central and peripheral 5-HT in a rat model of depression, and provide new insight into the treatment of depression with integrated Chinese-Western Medicine.METHODS: A rat model of depression was established by chronic mild stress(CMS). Model rats received either Sini San, fluoxetine, a combination of the two drugs, or no drug treatment. Healthy naive rats were used as controls. Open field and sucrose preference tests were used to assess depression-like behavior. ELISA and immunohistochemistry were used to determine central and peripheral levels of 5-HT.RESULTS: In the group with no drug treatment,central 5-HT expression decreased while peripheral5-HT concentrations increased as CMS continued.Four weeks after CMS, Sini San alone was less effective in reducing depression-like behavior than fluoxetine alone or in combination with Sini San,but combined use was more effective than fluoxetine alone. Eight weeks after CMS, Sini San alone or in combination with fluoxetine was more effective in reducing depression-like behavior than fluoxetine alone. Furthermore Sini San and fluoxetine used alone or in combination notably increased central 5-HT expression and decreased peripheral 5-HT levels in the rat model.CONCLUSION:The results of the present study indicate that there is a synergistic action between the two medicines in the treatment of depression. Sini San exhibited a relatively long lag before its effects were observed; however, by eight weeks the Traditional Chinese Medicine appeared at least as effective as fluoxetine. We suggest that Sini San can replace fluoxetine in the later stages of depression treatment to minimize side effects observed with long-term fluoxetine administration. | Yubo Li Yuxiu Sun Xueling Ma Xiaoxing Xue Wenting Zhang Zhiqian Wu Yulin Ouyang Jianxin Chen Weiming Wang Shuzhen Guo Wei Wang | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 6 |
| 5 | Stable and unique graphitic Raman internal standard nanocapsules for surface-enhanced Raman spectroscopy quantitative analysis显示文摘Graphitic nanomaterials 有的独特、强壮、稳定的拉曼颤动广泛地在化学和 biomedicine 被使用了。然而,作为内部标准(ISs ) 利用他们改进提高表面的拉曼的精确性光谱学(重量的单位) 分析没被尝试。此处,我们报导设计一唯一是由很多金牌组成的 nanostructure nanoparticles (AuNPs ) 在 multilayered graphitic 上装饰了磁性的 nanocapsules (AGN ) 确定 analyte 并且消除与传统的 ISs 联系的问题。AGN 从 graphitic 部件表明了一个独特拉曼乐队,它在拉曼是局部性的 biomolecules 的沉默区域,没有任何背景干扰,使他们成为理想为量的拉曼分析。是从也显示的 AGN 的信号优异稳定性,甚至在严厉条件下面。与装饰 AuNPs 的改进, AGN nanostructures 极大地改进了重量的单位,特别地量的错误源于收集损失的排除和 analytes 的不一致的分发的量的精确性。AGN 进一步为房间染色和拉曼成像被利用,并且他们在 biomedicine 为应用显示出大诺言。 | Yuxiu Zou Long Chen Zhiling Song Ding Ding Yiqin Chen Yiting Xu Shanshan Wang Xiaofang Lai Yin Zhang Yang Sun Zhuo Chen Weihong Tan | 2016 | Nano Research2016，9，5： | 2 |
| 6 | Air-Steam Etched Construction of Hierarchically Porous Metal-Organic Frameworks显示文摘The introduction of mesoporosity into the microporous metal-organic frameworks(MOFs)is expected to expand their applications.Herein,we report a green and facile method to obtain hierarchically porous MOF structures by using an air-steam etching process.By virtue of the protonation reaction between the imidazole moiety and water vapor,the protonated imidazole related linkers leave the framework,resulting in the formation of mesopores in the zeolitic imidazolate frameworks(ZIFs),as exemplified by ZIF-8.Given the mild etching process,the materials'structural integrity and crystallinity are well maintained.Accordingly,the hierarchical porous ZIF-8 exhibited enhanced performance in the dye removal as well as CO_(2) cycloaddition reaction with epichlorohydrin in comparison with microporous ZIF-8,owing to the accelerated mass transfer arising from mesoporous structures.Remarkably,the proposed steam etching approach is generally applicable,which can be readily extended to other ZIFs,such as ZIF-14,ZIF-69,and ZIF-71,thus representing a powerful strategy to construct hierarchically porous MOF materials. | Hongliang Huang Yuxiu Sun Xuemeng Jia Wenjuan Xue Chenxu Geng Xin Zhao Donghai Mei Chongli Zhong | 2021 | Chinese Journal of Chemistry2021，39，6： | 2 |
| 7 | High-throughput RNA sequencing reveals the anti-inflammatory mechanism of baicalin on Propionibacterium acnes-induced acne in rabbits显示文摘Objective:Propionibacterium acnes(P.acnes)plays an important role in the development of acne,an inflammatory skin disease with a high-incidence.In this study,we used high-throughput RNA sequencing(RNA-seq)to reveal the anti-inflammatory mechanism of baicalin on P.acnes-induced acne in rabbits.Methods:The Kligman method was used to induce acne in the ears of New Zealand rabbits.The effect of baicalin on the acne model was evaluated by the number of acne lesions and hematoxylin and eosin(H&E)staining of acne tissues.Enzyme-linked immunoabsorbent assay was used to measure the protein expression levels of tumor necrosis factor a(TNFA),interleukin-1 b(IL1B),IL6,and IL8 in the serum of rabbits.RNA-seq was performed to investigate the mechanism of anti-inflammatory activities of baicalin on acne.Immunohistochemical analysis and Western blot were used to validate the expression levels of related proteins in acne tissues.Results:Baicalin treatment significantly reduced the number of acne lesions and lesions of the ear as well as levels of serum inflammatory cytokines.RNA-seq data showed that baicalin treatment globally suppressed inflammation,especially the TNF signaling pathway and Staphylococcus aureus infection pathway,in the rabbit acne model.Conclusion: Baicalin effectively ameliorates P. acnes-induced acne in rabbits by suppressingthe inflammatory response in rabbits. | Xingzhe Yang Guangrui Huang Leiming You Honghao Sheng Yuxiu Sun Yuyin Feng Qingyi Lu Anlong Xu | 2019 | Journal of Traditional Chinese Medical Sciences2019，6，3： | 2 |
| 8 | Therapeutic effects of a novel tylophorine analog, NK‐007, on collagen‐induced arthritis through suppressing tumor necrosis factor α production and Th17 cell differentiation显示文摘 | Ti Wen Yangguang Li Meng Wu Xiaolin Sun Xiucong Bao Yuquan Lin Jianlei Hao Lin Han Guangchao Cao Ziwen Wang Yuxiu Liu Zhenzhou Wu Zhangyong Hong Puyue Wang Liqing Zhao Zhanguo Li Qingmin Wang Zhinan Yin | 2012 | Arthritis & Rheumatism2012，，9： | 2 |
| 9 | Synthesis and electrochemical properties of MnO 2 nanorods/graphene composites for supercapacitor applications显示文摘 | SiXu Deng Dan Sun ChunHui Wu Hao Wang JingBing Liu YuXiu Sun Hui Yan | 2013 | Electrochimica Acta2013，，： | 1 |
| 10 | Preparation of hydroxyapatite nanoparticles by reverse microemulsion 显示文摘 | Guo Guangsheng Sun Yuxiu Wang Zhihua | 2005 | Ceramics International2005，31，： | 1 |
| 11 | Study of Chiral Ionic Liquid as Stationary Phases for GC显示文摘 | Xiaojie Sun Jiakun Xu Xiaojie Zhao Yuxiu Zhai Jun Xing | 2013 | Chromatographia . 2013 (15-1)2013，，： | 1 |
| 12 | Synthesis and electrochemical properties of MnO 2 nanorods/graphene composites for supercapacitor applications显示文摘 | SiXu Deng Dan Sun ChunHui Wu Hao Wang JingBing Liu YuXiu Sun Hui Yan | 2013 | Electrochimica Acta2013，，： | 1 |
| 13 | Pore engineering of ZIF-8 with ionic liquids for membrane-based CO_(2)separation:bearing functional group effect显示文摘CO_(2)separation performance of polymer membranes can be significantly enhanced by selecting porous fillers with high CO_(2)affinity.Ionic liquids incorporation has been recognized as an effective strategy for improving the separation ability of pristine porous fillers.However,the influence of the specific functional groups of ILs in IL@MOF composites on separation performance of MMMs still remains unclear.Herein,we designed three microenvironment-tuned IL@ZIF-8 composites in which the three ILs contain different functional groups(-CH3,–SO3H,and–NH2).Molecular simulation results showed that the NH2-IL@ZIF-8 has a commendable CO_(2)adsorption capacity and CO_(2)/CH4 adsorptive selectivity,and the results were well confirmed by the following experimental data.More importantly,the prepared NH2-IL@ZIF-8 based MMMs also exhibit superior CO_(2)separation performance among the three IL@ZIF-8 based MMMs owning to its high CO_(2)affinity.Thus,this work can provide guidance for designing IL@MOF composites for MMMs fabrication towards gas separation,and the research mode combining molecular simulation prediction and experimental verification can afford valuable reference for material development in membrane separation field. | Zhengqing Zhang Xuemeng Jia Yuxiu Sun Xiangyu Guo Hongliang Huang Chongli Zhong | 2021 | Green Chemical Engineering2021，2，1： | 1 |
| 14 | 显示文摘 | Sun Yuxiu Guo Guangsheng Tao Dongliang | 2007 | Journal of Physics and Chemistry of Solids2007，68，： | 1 |
| 15 | Metal confined in metal-organic framework-based mixed matrix membranes for efficient butadiene recognition separation显示文摘The efficient separation of butadiene(1,3-C_(4)H_(6))from C_(4)hydrocarbons is a critical step in petrochemical processes.However,the traditional cryogenic distillation suffers from energy-intensity and serious environmental stress,necessitating the development of alternative technologies for efficient 1,3-C_(4)H_(6)separation.Herein,a 1,3-C_(4)H_(6)recognition mixed matrix membrane is reported via incorporating metal copper encapsulated a metal-organic framework(CuBTC@Cu)into elastic poly(dimethylsiloxane)(PDMS).The resulting CuBTC@Cu/PDMS membrane can efficient separate 1,3-C_(4)H_(6)from various C_(4)hydrocarbons including 1,3-C_(4)H_(6)/n-C_(4)H_(8),1,3-C_(4)H_(6)/iso-C_(4)H_(8),1,3-C_(4)H_(6)/n-C_(4)H_(10)and 1,3-C_(4)H_(6)/iso-C_(4)H_(10),yielding superior selectivity of 5.11,6.35,4.78,and 10.30,respectively,with 1,3-C_(4)H_(6)permeability of 53240 Barrer.Notably,the appropriateπ-complexation interaction between butadiene molecules and CuBTC@Cu as well as suitable transmission channel size enable the membrane only permeable to 1,3-C_(4)H_(6)and block the permeation of other C_(4)hydrocarbons,showing a unique 1,3-C_(4)H_(6)recognition behavior in membrane separation.The concept of affinity-relying separation combining molecular sieving would open a new direction for designing gas membranes for efficient light hydrocarbon separations. | Xixi Cen Yuxiu Sun Caijiao Yu Zhihua Qiao Chongli Zhong | 2023 | Aggregate2023，4，5： | 0 |
| 16 | Predicting of Covalent Organic Frameworks for Membrane-based Isobutene/1,3-Butadiene Separation:Combining Molecular Simulation and Machine Learning显示文摘Efficient separation of C4 olefins is of critical importance and a challenging task in petrochemical industry. Covalent organic frameworks(COFs) could be used as promising candidates for membrane-based isobutene/1,3-butadiene(i-C4H8/C4H6) separation. Owing to large amounts of COFs appearing, however, the rapid prediction of optimal COFs is imperative before experimental efforts. In this work, we combine molecular simulation and machine learning to study COF membranes for efficient isolation of i-C4H8 over C4H6. Using molecular simulation, four potential COF membranes, which possess both high membrane performance score (MPS) value and moderate membrane selectivity were screened out and the mechanism of membrane separation further revealed is an adsorption dominated process. Further, random forest(RF) model with high prediction accuracy(R2>0.84) was obtained and used for elucidating key factors in controlling the membrane selectivity and i-C4H8 permeability. Ultimately, the optimal COF features were obtained through structure-performance relationship study. Our results may trigger experimental efforts to accelerate the design of novel COFs with better i-C4H8/C4H6separation performance. | CAO Xiaohao HE Yanjing ZHANG Zhengqing SUN Yuxiu HAN Qi GUO Yandong ZHONG Chongli | 2022 | Chemical Research in Chinese Universities2022，38，2： | 0 |
| 17 | TMCO1是内质网钙离子过载激活的钙离子通道显示文摘钙信号是重要的细胞内离子信号,其在胞内的浓度必须被精确地调控,以达到信号传递的忠实性和准确性。内质网是细胞内的重要钙库,保持内质网(ER)中钙离子浓度的平衡对于触发准确的钙信号和行使正常的细胞功能至关重要。 | Qiao-Chu Wang Qiaoxia Zheng Haiyan Tan Bing Zhang Xiaoling Li Yuxiu Yang Jie Yu Yang Liu Hao Chai Xi Wang Zhongshuai Sun Jiu-Qiang Wang Shu Zhu Fengli Wang Maojun Yang Caixia Guo Heng Wang Qingyin Zheng Yang Li Quan Chen Aimin Zhou 唐铁山 | 2017 | 科学新闻2017，19，4： | 0 |
| 18 | Discrimination of TCM constitutions by biochemical and routine urine indexes显示文摘Objective:To investigate whether the specific traditional Chinese medicine(TCM)constitution of individuals can be defined by certain biological indexes instead of answering the questionnaire,and to explore the possibility of discriminating nine TCM constitutions from each other simultaneously using biological indexes.Methods:Blood and urine samples from 152 individuals with nine TCM constitutions were collected,and the related biological indexes were analyzed combining ANOVA,multiple comparison,discriminant analysis,and support vector machine.Results:We found that 4 out of 24 blood routine indexes,7 out of 10 urine routine indexes,and 12 out of 32 biochemical indexes showed differences among the constitutions.High-sensitivity C-reactive protein,apolipoprotein A1,and alkaline phosphatase were potential candidates for screening out individuals with unbalanced constitutions.Combining uric acid,high-density lipoprotein,apolipoprotein A1,creatine kinase,total protein,aspartate aminotransferase,total bile acid,dehydrogenase,sodium,and calcium levels had the potential to directly distinguish the nine TCM constitutions from each other.Among these indexes,the highest ratio of discriminant analysis between two constitutions was 95.5%,while the lowest was 66.1%.Conclusion:Our results suggest that some biochemical and urine indexes are related to various TCM constitutions,and thus they have the potential to be used for TCM constitution classification. | Xiaoling Liu Pengfei Zhao Jianhua Zhen Shen Zhang Hesong Wang Yuxiu Sun Wei Wang Tingjian Wang Kaiwen Hu Guangrui Huang | 2022 | Journal of Traditional Chinese Medical Sciences2022，9，2： | 0 |
| 19 | SARS-CoV-2 Serological Survey of Cats in China before and after the Pandemic显示文摘Dear Editor,SARS-Co V-2 or COVID-19 has become pandemic and spread to more than 200 countries with over 24 million human infected cases(WHO 2020).The origin of SARSCo V-2 remains unknown,though bat,pangolin,and snake were reported to be the potential animal reservoirs(Ji et al). | Junhua Deng Yuxiu Liu Chunyan Sun Jingjing Bai Jie Sun Liying Hao Xiangdong Li Kegong Tian | 2020 | Virologica Sinica2020，35，6： | 0 |
| 20 | Corrigendum to“High-throughput RNA sequencing reveals the antiinflammatory mechanism of baicalin on Propionibacterium acnesinduced acne in rabbits”[J Trad Chin Med Sci 6(2019)201-210]显示文摘The authors regret | Xingzhe Yang Guangrui Huang Leiming You Honghao Sheng Yuxiu Sun Yuyin Feng Qingyi Lu Anlong Xu | 2020 | Journal of Traditional Chinese Medical Sciences2020，7，2： | 0 |
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