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| 1 | Heart Disease and Stroke Statistics—2009 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee显示文摘 | Donald Lloyd-Jones Robert Adams Mercedes Carnethon Giovanni De Simone T Bruce Ferguson Katherine Flegal Earl Ford Karen Furie Alan Go Kurt Greenlund Nancy Haase Susan Hailpern Michael Ho Virginia Howard Brett Kissela Steven Kittner Daniel Lackland Lynda L | 2009 | Circulation2009，，3： | 4 |
| 2 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 3 | 在 7T 的多原子的磁性的回声光谱学的应用显示文摘 AIM: To discuss the advantages of ultra-high field (7T) for 1H and 13C magnetic resonance spectroscopy (MRS) studies of metabolism.made at both 3 and 7T using 1H MRS. Measurements of glycogen and lipids in muscle were measured using 13C and 1H MRS respectively. RESULTS: In the brain, increased signal-to-noise ratio (SNR) and dispersion allows spectral separation of the amino-acids glutamate, glutamine and γ-aminobutyric acid (GABA), without the need for sophisticated editing sequences. Improved quantification of these me-tabolites is demonstrated at 7T relative to 3T. SNR was 36% higher, and measurement repeatability (% coefficients of variation) was 4%, 10% and 10% at 7T, vs 8%, 29% and 21% at 3T for glutamate, glutamine and GABA respectively. Measurements at 7T were used to compare metabolite levels in the anterior cingulate cortex (ACC) and insula. Creatine and glutamate levels were found to be significantly higher in the insula compared to the ACC (P < 0.05). In muscle, the increased SNR and spectral resolution at 7T enables interleaved studies of glycogen (13C) and intra-myocellular lipid (IMCL) and extra-myocellular lipid (EMCL) (1H) following exercise and refeeding. Glycogen levels were sig-nificantly decreased following exercise (-28% at 50% VO2 max; -58% at 75% VO2 max). Interestingly, levels of glycogen in the hamstrings followed those in the quadriceps, despite reduce exercise loading. No changes in IMCL and EMCL were found in the study. CONCLUSION: The demonstrated improvements in brain and muscle MRS measurements at 7T will increase the potential for use in investigating human metabolism and changes due to pathologies. | Mary C Stephenson Frances Gunner Antonio Napolitano Paul L Greenhaff Ian A MacDonald Nadeem Saeed William Vennart Susan T Francis Peter G Morris | 2011 | World Journal of Radiology2011，3，4： | 2 |
| 4 | The Impact of E-commerce on Supply Chain Relationships 显示文摘 | Susan L Golicic Donna F Davis Teresa M McCar-thy John T Mentzer | 2002 | International Journal of Physical Distribution & Logistics Management2002，32，910： | 1 |
| 5 | Growth of anaerobic rumen fungi on defined and semi-defined media lacking rumen fluid显示文摘 | Susane E L Michael K T Anthony P J T | 1985 | J General Microbiology1985，131，： | 1 |
| 6 | An improved colorimetric assay for the measurement of transglutaminase (type Ⅱ) ε- (γ-glutamyl) 1 ysinecross-linking activity显示文摘 | Susan M Trigwell Paul T L Alan J Hargreaves | 2004 | Anal Bioehem2004，330，： | 1 |
| 7 | Vanadia catalysts on anatase, rutile, and TiO2(B) for the ammoxidation of toluene: an ESR and high-resolution electron microscopy characterization显示文摘 | Mehri Sanati Reine L Wallenberg Arne Andersson Susan Jansen Yanping T | 1991 | Journal of Catalysis1991，132，1： | 1 |
| 8 | Monitoring pressure ulcer heal-ing in persons with disabilities 显示文摘 | Marla M Susans T Maria L | 2005 | Rehabil Nurs2005，30，3： | 1 |
| 9 | Vanadium induced inhibition of renal Na+,K+-ATPase in the chicken after chronic dietary exposure显示文摘 | Phillips T D Bohdan R N Susan L N | 1982 | J Toxical Environ Healthy1982，，9： | 1 |
| 10 | The effects of wording on the understanding and use of uncertainty information in a threshold forecasting decision显示文摘 | Susan L J Greenberg L N Meng U T | | 0，，8： | 1 |
| 11 | Lipid productivity as a key characteristic for choosing algal species for biodiesel production显示文摘 | Griffiths M J Susan T L Harrison | 2009 | Journal of Applied Phycology2009，21，： | 1 |
| 12 | Targeted Recombination within the Spike Gene of Murine Coro- navirus Mouse Hepatitis Virus-A59:Q159 Is a Deter- minant of Hepatotropism显示文摘 | Isabelle L G Susan T H MING M C | 1998 | J Virol1998，72，12： | 1 |
| 13 | Cir- cadian clock mutation disrupts estrous cyclicity and maintenance of pregnancy 显示文摘 | BROOKE H M SUSAN L O FRED W T | 2004 | Curt Biol2004，14，： | 1 |
| 14 | 显示文摘 | Adam T Susan L | 2000 | Chest2000，117，： | 1 |
| 15 | Revealing the Vulnerability of people and places : A case study of Geogetown County, South Carolina显示文摘 | Susan L Cutter Jerry T Mitchell Michael S Scott | 2000 | Annals of Association of American Geographers2000，90，4： | 1 |
| 16 | Racial/ethnic disparities in hepatocellular carcinoma treatment and survival in California, 1988-2012显示文摘AIM To describe racial/ethnic differences in treatment and survival among liver cancer patients in a populationbased cancer registry.METHODS Invasive cases of primary hepatocellular carcinoma, n = 33270, diagnosed between January 1, 1988-December 31, 2012 and reported to the California Cancer Registry were analyzed by race/ethnicity, age, gender, geographical region, socio-economic status, time period of diagnosis, stage, surgical treatment, and survival. Patients were classified into 15 racial/ethnic groups: non-Hispanic White(White, n = 12710), Hispanic(n = 8500), Chinese(n = 2723), non-Hispanic Black(Black, n = 2609), Vietnamese(n = 2063), Filipino(n = 1479), Korean(n = 1099), Japanese(n = 658), American Indian/Alaskan Native(AIAN, n = 281), Laotian/Hmong (n = 244), Cambodian(n = 233), South Asian(n = 190), Hawai`ian/Pacific Islander(n = 172), Thai(n = 95), and Other Asian(n = 214). The main outcome measures were receipt of surgical treatment, and cause-specific and all-cause mortality.RESULTS After adjustment for socio-demographic characteristics, time period, and stage of disease, compared to Whites, Laotian/Hmong [odds ratio(OR) = 0.30, 95%CI: 0.17-0.53], Cambodian(OR = 0.65, 95%CI: 0.45-0.96), AIAN(OR = 0.66, 95%CI: 0.46-0.93), Black(OR = 0.76, 95%CI: 0.67-0.86), and Hispanic(OR = 0.78, 95%CI: 0.72-0.84) patients were less likely, whereas Chinese(OR = 1.58, 95%CI: 1.42-1.77), Koreans(OR = 1.45, 95%CI: 1.24-1.70), Japanese(OR = 1.41, 95%CI: 1.15-1.72), and Vietnamese(OR = 1.26, 95%CI: 1.12-1.42) were more likely to receive surgical treatment. After adjustment for the same covariates and treatment, cause-specific mortality was higher for Laotian/Hmong [(hazard ratio(HR) = 1.50, 95%CI: 1.29-1.73)], Cambodians(HR = 1.35, 95%CI: 1.16-1.58), and Blacks(HR = 1.07, 95%CI: 1.01-1.13), and lower for Chinese(HR = 0.82, 95%CI: 0.77-0.86), Filipinos(HR = 0.84, 95%CI: 0.78-0.90), Vietnamese(HR = 0.85, 95%CI: 0.80-0.90), Koreans(HR = 0.90, 95%CI: 0.83-0.97), and Hispanics(HR = 0.91, 95%CI: 0.88-0.94); results were similar for all-cause mortality.CONCLUSION Disaggregated data revealed substantial racial/ethnic differences in liver cancer treatment and survival, demonstrating the need for development of targeted interventions to mitigate disparities. | Susan L Stewart Sandy L Kwong Christopher L Bowlus Tung T Nguyen Annette E Maxwell Roshan Bastani Eric W Chak Moon S Chen Jr | 2016 | World Journal of Gastroenterology2016，22，38： | 1 |
| 17 | Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms显示文摘 | Emad M El-Omar Charles S Rabkin Marilie D Gammon Thomas L Vaughan Harvey A Risch Janet B Schoenberg Janet L Stanford Susan T Mayne James Goedert William J Blot Joseph F Fraumeni Wong-ho Chow | 2003 | Gastroenterology2003，，5： | 1 |
| 18 | Revealing theVulnerability of People and Places : A Case Study of GeorgetownCounty, South Carolina显示文摘 | Susan L Cutter Jerry T Mitchell Michael S Scott | 2000 | Annals of the Association of Ameri-can Geographers2000，90，4： | 1 |
| 19 | Indexing by latent semantic analysis显示文摘 | SCOTT C D SUSAN T D THOMAS K L | 1990 | Journal of the American Society for Information Science1990，41，6： | 1 |
| 20 | Revealing the Vulnerabilityof People and Places : A Case Study of Georgetown County,South Carolina 显示文摘 | Susan L Cutter Jerry T Mitchell Michael S Scott | 2000 | Annals of the Association of American Geographers2000，90，4： | 1 |
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