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| 1 | Hepatoprotective effect of Solatium xanthocarpum fruit extract against CCl_4 induced acute liver toxicity in experimental animals显示文摘Objective:To investigate the hepatoprotective potential of Solonum xanthocarpum(Solanaceae) (S.xanthocarpum) in experimental rats to validate its traditional claim.Methods:50%ethanolic fruit extract of S.xanthocarpum(SXE,100.200 or 400 mg/kg hods weight) was administered daily for 14davs in experimental animals.Liver injury was induced chemically,by CCl4 administration (1 mL/kg i.p.).The hepatoprotective activity was assessed using various biochemical parameters like aspartate aminotransferase(AST),alanine aminotransferase(ALT).Serum alkaline phosphatise (SALP) and total bilirubin.Meanwhile,in vivo antioxidant activities as lipid peroxidation(LPO), reduced glutathione(GSH).superoxide dismutase(SOD) and calalase(CAT) were screened along with histopathological studies.Results:Obtained results demonstrated that the treatment with SXE significantly(P<0.05- <0.001) and dose-dcpendcntly prevented chemically induced increase in serum levels of hepatic enzymes.Furthermore.SXE significantly(up to P<0.001) reduced the lipid peroxidation in the liver tissue and restored activities of defence antioxidant enzymes GSH,SOU and catalasc towards normal levels.Histopathology of the liver tissue showed that SXE attenuated the hepatocellular necrosis and led to reduction of inflammatory cells inflltration. Conclusions:The results of this study strongly indicate the protective effect of SXE against acute liver injun which may he attributed to its hepatoprotective activity,and there by scientifically support its traditional use. | Ramesh K Gupta Talib Hussain G.Panigrahi Avik Das Gireesh Narayan Singh K Sweety Md Faiyazuddin Chandana Venkateswara Rao | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，12： | 4 |
| 2 | Evaluation of antihepatotoxic potential of Solanum xanthocarpum fruit extract against antitubercular drugs induced hepatopathy in experimental rodents显示文摘Objective:To assess the hepatoprotective effect of Solanum xanthocarpum(S. xanthocarpum) fruit extract against antitubercular drug-induced liver toxicity in experimental animals.Methods:Ethanolic(50%) fruit extract ofS. xanthocarpum(100, 200 and 400 mg/kg bw) was administered daily for 35 days in experimental animals. Liver toxicity was induced by combination of three antitubercular drugs [isoniazid(I) 7.5 mg/kg, rifampicin(R) 10 mg/kg and pyrazinamide(P) 35 mg/kg] given orally as suspension for 35 days in rats. The hepatoprotective activity was assessed using various biochemical parameters like aspartate aminotransferase(AST), alanine aminotransferase(ALT), alkaline phosphatise(ALP), total bilirubin(TBL), albumin(ALB), total protein(TP), lactate dehydroginase(LDH), and serum cholesterol(CHL). Meanwhile,in vivoantioxidant activities as lipid peroxidation(LPO), reduced glutathione(GSH), superoxide dismutase(SOD) and catalase(CAT) were measured in rat liver homogenate. The biochemical observations were supplemented by histopathological examination.Results:The results demonstrated that treatment withS.xanthocarpumsignificantly(P<0.05-P<0.001) and dose-dependently prevented drug induced increase in serum levels of hepatic enzymes. Furthermore,S. xanthocarpumsignificantly(up toP<0.001) reduced the LPO in the liver tissue and restored activities of defence antioxidant enzymes GSH, SOD and CAT towards normal levels. Histopathology of the liver tissue showed that S. xanthocarpumattenuated the hepatocellular necrosis and led to reduction in inflammatory cells infiltration.Conclusions:The results of this study strongly indicate the protective effect of S. xanthocarpumagainst liver injury which may be attributed to its hepatoprotective activity, and thereby scientifically support its traditional use. | Talib Hussain Ramesh K Gupta Sweety K Mohd Sajid Khan Md Sarfaraj Hussain Md Arif Arshad Hussain Md Faiyazuddin Chandana Venkateswara Rao | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，6： | 2 |
| 3 | Chitosan glucose complex-A novel food preservative显示文摘 | Sweetie R Kanatt Ramesh Chander | 2008 | Food Chemistry2008，106，： | 1 |
| 4 | Chitosan glucose complex-A novel food preservative 显示文摘 | Sweetie R Kanatt Ramesh Chander Arun Sharma | 2007 | Food Chemistry2007，106，： | 1 |
| 5 | Protective effect of Eleteria cardamomum(L.) Maton against Pan masala induced damage in lung of male Swiss mice显示文摘Objective:To study the potential ameliorating properties of cardamom Elettaria cardamomum (E.cardamomum) L.Maton against pan masala induced damage in lung of male Swiss mice. Methods:The experimental animals were divided into 3 groups(control,pan masala treated group and pan masala with cardamom treated group) to evaluate pan masala toxicity.The observations were substantiated with profound changes in the lung tissue as revealed in the histologic and transmission electron microscopic examinations.Results:Lung of pan masala treated group showed adenocarcinoma,edema,and inflammation with increased activity of acid phosphatase,alkaline phosphatase,and lactate dehydrogenase.The deleterious effects were seen to be less in cardamom treated group and the enzymatic activity also decreased significantly (P<0.05)\ in the ameliorating group.Conclusions:Thus,the present experiment exciting results are observed when cardamom is supplemented with pan masala,or when given alone. | Sweety Kumari Abhijit Dutta | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，7： | 1 |
| 6 | Effect of radiation processing on the quality of chilled meat products显示文摘 | Sweetie R Kanatt Ramesh Chander Arun Sharma | 2005 | Meat Science2005，69，2： | 1 |
| 7 | New route to process uni-directional carbon fiber reinforced (SiC?+?ZrB2) matrix mini-composites显示文摘 | N. Padmavathi K. K. Ray J. Subrahmanyam P. Ghosal Sweety Kumari | 2009 | Journal of Materials Science2009，，12： | 1 |
| 8 | Chi- tosan glucose complex-A novel food preservative 显示文摘 | Sweetie R Kanatt Ramesh Chander Arun Sharma | 2007 | Food Chemistry2007，106，： | 1 |
| 9 | Chkosan glucose complex A novel food preservative显示文摘 | Sweetie R Kanatt Ramesh Chander Arun Sharma | 2008 | Food Chemistry2008，，106： | 1 |
| 10 | Chitosan glucose complex - A novel food preservative 显示文摘 | Sweetie R Kanatt Ramesh Chander Arun Sharma | 2007 | Food Chemistry2007，106，： | 1 |
| 11 | Nephroprotective activity of Solanum xanthocarpum fruit extract against gentamicin-induced nephrotoxicity and renal dysfunction in experimental rodents显示文摘Objective:To evaluate nephroprotective potential of Solarium xanthocarpum(S.xanthocarpum) fruit extract(SXE) against gentamicin(GM) induced nephrotoxicity) and renal dysfunction. Methods:Twenty-four Wistar rats were divided into four groups(n=6).Control rats that received normal saline(i.p.) and 0.5%carboxymethyl cellulose(p.o.) per day lor 8 d.Nephrotoxicity was induced in rats by intraperitoneal administration of GM(100 mg/kg/d for 8 d) and were treated with SXE(200 and 400 mg/kg/d(p.o.) for 8 d).Plasma and urine urea and creatinine,kidney weight,urine output,blood urea nitrogen,renal enzymatic and non-enzymatic antioxidants and lipid peroxidation was evaluated along with histopathological investigation in various experimental groupsof rats.Results:It was observed that the GM treatment induced significant elevation(P<0.001) in plasma and urine urea,creatinine,kidney weight,blood urea nitrogen, renal lipid peroxidation along with significant decrement(P<0.001) in urine output,renal enzymatic and non-enzymatic antioxidants.SXE 200 and 400 mg/kg treatment to GM treated rats recorded significant decrement(up to P<0.001) in plasma and mine urea and creatinine, renal lipid peroxidation along with significanl increment(up to P<0.001) in renal enzymatic and non-enzvmatic antioxidants.Histological obsenatioiis of kidney tissues too correlated with the biochemical obsenatioiis.Conclusions:These finding powerfully supports that S,xanthocarpum fruit extract acts in the kidney as a potent scavenger of free radicals to prevent the toxic effects of GM both in the biochemical and histopathological parameters and thus validates its elhnomedicinal use. | Talib Hussain Ramesh K Gupta K Sweety Bavani Eswaran M Vijayakumar Chandana Venkateswara Rao | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，9： | 1 |
| 12 | Chitosan glucose complex: A novel food preservative显示文摘 | SWEETIE R K RAMESH C ARUN S | 2008 | Food Chemistry2008，106，2： | 1 |
| 13 | Improvement by Phytotherapeutic Agent of Detrusor Overactivity, Down-Regulation of Pharmacological Receptors and Urinary Cytokines in Rats with Cyclophosphamide Induced Cystitis显示文摘 | Sweety Nasrin Eiji Masuda Haruna Kugaya Yoshihiko Ito Shizuo Yamada | 2013 | The Journal of Urology2013，，： | 1 |
| 14 | Arsenic and iron removal from groundwater by oxidation–coagulation at optimized pH: Laboratory and field studies显示文摘 | Shreemoyee Bordoloi Suresh K. Nath Sweety Gogoi Robin K. Dutta | 2013 | Journal of Hazardous Materials2013，，： | 1 |
| 15 | Chitosan and mint mixture:A new preservative for meat and meat products 显示文摘 | Sweetie R Kanatt Ramesh Chander Arun Sharma | 2008 | Food Chemistry2008，107，： | 1 |
| 16 | Shelf-life extension of convenience meat products sold in Indian supermarkets by radiation processing显示文摘 | SWEETIE R KANATT M SHOBITA RAO S P CHAWLA etal | 2010 | Radiation Physics and Chemistry2010，79，12： | 1 |
| 17 | Chitosan glucose complex:A novel food preservative显示文摘 | SWEETIE R K RAMESHC ARUN S | | 0，，02： | 1 |
| 18 | Effect ofradiation processing on the quality of chilled meatproducts显示文摘 | SWEETIE R K RAMESH C ARUN S | 2005 | Meat Science2005，69，2： | 1 |
| 19 | Mechanical properties of LSI based 3D-stitched-C-SiC composites prepared by coaltar pitch as carbon precursor显示文摘 | Suresh K Sweety K Anil K | 2008 | Scr Mater2008，58，： | 1 |
| 20 | Chitosan glucose complex-A novel food preservative显示文摘 | Sweetie R Kanatt Ramesh Chander | 2008 | Food Chemistry2008，106，： | 1 |
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