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| 1 | Cranial irradiation impairs intrinsic excitability and synaptic plasticity of hippocampal CA1 pyramidal neurons with implications for cognitive function显示文摘Radiation therapy is a standard treatment for head and neck tumors.However,patients often exhibit cognitive impairments following radiation therapy.Previous studies have revealed that hippocampal dysfunction,specifically abnormal hippocampal neurogenesis or neuroinflammation,plays a key role in radiation-induced cognitive impairment.However,the long-term effects of radiation with respect to the electrophysiological adaptation of hippocampal neurons remain poorly characterized.We found that mice exhibited cognitive impairment 3 months after undergoing 10 minutes of cranial irradiation at a dose rate of 3 Gy/min.Furthermore,we observed a remarkable reduction in spike firing and excitatory synaptic input,as well as greatly enhanced inhibitory inputs,in hippocampal CA1 pyramidal neurons.Corresponding to the electrophysiological adaptation,we found reduced expression of synaptic plasticity marker VGLUT1 and increased expression of VGAT.Furthermore,in irradiated mice,long-term potentiation in the hippocampus was weakened and GluR1 expression was inhibited.These findings suggest that radiation can impair intrinsic excitability and synaptic plasticity in hippocampal CA1 pyramidal neurons. | Min-Yi Wu Wen-Jun Zou Pei Yu Yuhua Yang Shao-Jian Li Qiang Liu Jiatian Xie Si-Qi Chen Wei-Jye Lin Yamei Tang | 2022 | Neural Regeneration Research2022，17，10： | 5 |
| 2 | Characterization and potential diagnostic application of monoclonal antibodies specific to rabies virus显示文摘Objective:Rabies is invariably a fatal encephalomyelitis that is considered to be a serious public health problem.It is necessary to develop standard rabies virus diagnostic tools,especially for diagnosing the strains prevalent in China.Methods:Monoclonal antibodies(MAbs)specific to rabies virus were produced and characterized by enzyme linked immunosorbent assay(ELISA),isotyping,affinity assay,immunofluorescence assay(IFA),and immunocytochemistry.The MAb,whose affinity was higher for antigen,was used to establish an antigen captureELISA(AC-ELISA)detection system and test the efficiency by using clinical samples.Results:The heavy chain subclasses of two MAbs were all determined to be IgG2a.The 3C7 MAb showed stronger reactivity with rabies virus protein than the 2C5 MAb in an ELISA analysis,whereas the 3C7 MAb showed the highest affinity for antigen.IFA and immunocytochemistry results also indicated that the two MAbs could recognize rabies virus protein in its native form in cell samples.Data obtained using clinical samples showed that rabies virus could be detected by AC-ELISA detection system using the 3C7 MAb.Conclusion:It was potentially useful for the further development of highly sensitive,easily handled,and relatively rapid detection kits/tools for rabies surveillance in those areas where rabies is endemic,especially in China. | Xinjian Liu Xiaomin Feng Qi Tang Zhongcan Wang Zhenning Qiu Yuhua Li Changjun Wang Zhenqing Feng Jin Zhu Xiaohong Guan | 2010 | The Journal of Biomedical Research2010，24，5： | 5 |
| 3 | Parallel architecture and optimization for discrete-event simulation of spike neural networks显示文摘Spike neural networks are inspired by animal brains,and outperform traditional neural networks on complicated tasks.However,spike neural networks are usually used on a large scale,and they cannot be computed on commercial,off-the-shelf computers.A parallel architecture is proposed and developed for discrete-event simulations of spike neural networks.Furthermore,mechanisms for both parallelism degree estimation and dynamic load balance are emphasized with theoretical and computational analysis.Simulation results show the effectiveness of the proposed parallelized spike neural network system and its corresponding support components. | TANG YuHua ZHANG BaiDa WU JunJie HU TianJiang ZHOU Jing LIU FuDong | 2013 | Science China(Technological Sciences)2013，56，2： | 5 |
| 4 | UAV flight strategy algorithm based on dynamic programming显示文摘Unmanned aerial vehicles(UAVs) may play an important role in data collection and offloading in vast areas deploying wireless sensor networks, and the UAV's action strategy has a vital influence on achieving applicability and computational complexity. Dynamic programming(DP) has a good application in the path planning of UAV, but there are problems in the applicability of special terrain environment and the complexity of the algorithm.Based on the analysis of DP, this paper proposes a hierarchical directional DP(DDP) algorithm based on direction determination and hierarchical model. We compare our methods with Q-learning and DP algorithm by experiments, and the results show that our method can improve the terrain applicability, meanwhile greatly reduce the computational complexity. | ZHANG Zixuan WU Qinhao ZHANG Bo YI Xiaodong TANG Yuhua | 2018 | Journal of Systems Engineering and Electronics2018，29，6： | 4 |
| 5 | EFFECT OF STRAIN RATE(?) ON STRAIN HARDENING EXPONENT n OF SOME METALLIC MATERIALS显示文摘Fariabh strain rate tension tests for 4 metallic materials show that as the strain rate in creases the strain hardening exponent n decreases.The trend follows a two stage linear relation between n and lg(?).When (?)<(?)ep’i.e.under quasi-statie loading,n can be consideredas a constant,but when(?)>(?)ep’,n decreases rapidlv till an ideal plastic state,n=0.Thecharacteri=ations and mechanisms of so fiening induced by high (?)are discussed. | TANG Changguo, ZHU Jinhua, ZHANG Yuhua, ZHOU HuijiuResearch Institute for Strength of Metals. Xi’an Jiaotong University. Xi’an. China | 1994 | Acta Metallurgica Sinica(English Letters)1994，7，3： | 4 |
| 6 | Design of communication relay mission for supporting lunar-farside soft landing显示文摘Chang'E-IV will be the first soft-landing and rover mission on the lunar farside. The relay satellite, which is located near the Earth-Moon L2 point for relay communication, is the key to the landing mission. Based on an analysis of the characteristics of the task and the technical difficulties associated with the relay satellite system, the overall design scheme of the relay communication mission is proposed in terms of trajectory design and communication system design among other aspects. First, according to the complex dynamic environment, a mission orbit that serves as an uninterrupted communication link is presented. A short-duration and low-energy transfer trajectory with lunar flyby is discussed. Orbital correction and a low-cost control strategy for orbit maintenance in the Earth-Moon L2 point region are provided. Second,considering the existing technical constraints, the requirement of relay communication in different stages and the design schemes of frequency division and redundant relay communication system are introduced. Finally,based on the trajectory design index and the performance of the communication system, the overall design scheme of the relay communication mission is proposed. This mission will provide the technical support and reference required for the Chang'E-IV mission. | Weiren WU Yuhua TANG Lihua ZHANG Dong QIAO | 2018 | Science China(Information Sciences)2018，61，4： | 4 |
| 7 | Technological breakthroughs and scientific progress of the Chang’e-4 mission显示文摘Chang’e-4 is the first man-made probe that accomplished landing and roving on the far side of the Moon,which is viewed as a new milestone in the history of Lunar exploration.Beginning with a brief introduction to the progress of domestic and foreign Lunar exploration,this paper reviews the implementation process of the Chang’e-4 project,sorts out the technical breakthroughs achieved,summarizes the exploration achievements,and provides references for subsequent Lunar exploration. | Weiren WU Dengyun YU Chi WANG Jizhong LIU Yuhua TANG He ZHANG Zhe ZHANG | 2020 | Science China(Information Sciences)2020，63，10： | 3 |
| 8 | Ultrafast polarization-dependent all-optical switching of germanium-based metaphotonic devices显示文摘Metamaterials play an important role in the modulation of amplitude and group delay in the terahertz(THz)regime on account of their optical properties,which are rare in natural materials.Here an ultrafast anisotropic switch of the plasmon-induced transparency(PIT)effect is experimentally and numerically demonstrated by metamaterial devices composed of two pairs of planar split-ring resonators and a pair of closed-ring resonators.By integration with a germanium(Ge)film,a recovery time of 3 ps and a decay constant of 785 fs are realized in the metadevice.Stimulated by the exterior optical pump,the PIT windows at different frequencies are switched off with an excellent property of slow light for vertical and horizontal THz polarizations,realizing an astonishing modulation depth as high as 99.06%.This work provides a new platform for ultrafast anisotropic metadevices tunable for amplitude and group delay. | HAO SUN YUZE HU YUHUA TANG JIE YOU JUNHU ZHOU HENGZHU LIU XIN ZHENG | 2020 | Photonics Research2020，8，3： | 3 |
| 9 | The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget’s disease显示文摘Mammary and extramammary Paget’s Diseases(PD)are a malignant skin cancer characterized by the appearance of Paget cells.Although easily diagnosed,its pathogenesis remains unknown.Here,single-cell RNA-sequencing identified distinct cellular states,novel biomarkers,and signaling pathways—including mTOR,associated with extramammary PD.Interestingly,we identified MSI1 ectopic overexpression in basal epithelial cells of human PD skin,and show that Msi1 overexpression in the epidermal basal layer of mice phenocopies human PD at histopathological,single-cell and molecular levels.Using this mouse model,we identified novel biomarkers of Paget-like cells that translated to human Paget cells.Furthermore,single-cell trajectory,RNA velocity and lineage-tracing analyses revealed a putative keratinocyte-to-Paget-like cell conversion,supporting the in situ transformation theory of disease pathogenesis.Mechanistically,the Msi1-mTOR pathway drives keratinocyte-Paget-like cell conversion,and suppression of mTOR signaling with Rapamycin significantly rescued the Paget-like phenotype in Msi1-overexpressing transgenic mice.Topical Rapamycin treatment improved extramammary PD-associated symptoms in humans,suggesting mTOR inhibition as a novel therapeutic treatment in PD. | Yongli Song Christian F.Guerrero-Juarez Zhongjian Chen Yichen Tang Xianghui Ma Cong Lv Xueyun Bi Min Deng Lina Bu Yuhua Tian Ruiqi Liu Ran Zhao Jiuzhi Xu Xiaole Sheng Sujuan Du Yeqiang Liu Yunlu Zhu Shi-jun Shan Hong-duo Chen Yiqiang Zhao Guangbiao Zhou Jianwei Shuai Fazheng Ren Lixiang Xue Zhaoxia Ying Xing Dai Christopher J.Lengner Bogi Andersen Maksim V.Plikus Qing Nie Zhengquan Yu-Show | 2020 | Cell Research2020，30，10： | 2 |
| 10 | An effieient SVPWM algorithm with low computational overhead for three-phase inverters显示文摘 | SHU Zeliang TANG Jian CUO Yuhua | 2007 | IEEE Transactions on Power Electronics2007，22，5： | 1 |
| 11 | An Efficient SVP-WM Algorithm with Low Computational Overhead forThree-phase Inverters显示文摘 | Shu Zeliang Tang Jian Guo Yuhua | 2007 | IEEE Trans on Power Electronics2007，22，5： | 1 |
| 12 | An effecient SVPWM algorithm with low computational overhead for three-phase inverters显示文摘 | Shu Zeliang Tang Jian Guo Yuhua | 2007 | IEEE Transaction on Power Electronics2007，22，5： | 1 |
| 13 | lncR-GAS5 upregulates the splicing factor SRSF10 to impair endothelial autophagy,leading to atherogenesis显示文摘Long noncoding RNAs(lncRNAs)play a critical role in the regulation of atherosclerosis.Here,we investigated the role of the lncRNA growth arrest-specific 5(lncR-GAS5)in atherogenesis.We found that the enforced expression of lncR-GAS5 contributed to the development of atherosclerosis,which presented as increased plaque size and reduced collagen content.Moreover,impaired autophagy was observed,as shown by a decreased LC3II/LC3I protein ratio and an elevated P62 level in lncR-GAS5-overexpressing human aortic endothelial cells.By contrast,lncR-GAS5 knockdown promoted autophagy.Moreover,serine/arginine-rich splicing factor 10(SRSF10)knockdown increased the LC3II/LC3I ratio and decreased the P62 level,thus enhancing the formation of autophagic vacuoles,autolysosomes,and autophagosomes.Mechanistically,lncR-GAS5 regulated the downstream splicing factor SRSF10 to impair autophagy in the endothelium,which was reversed by the knockdown of SRSF10.Further results revealed that overexpression of the lncR-GAS5-targeted gene miR-193-5p promoted autophagy and autophagic vacuole accumulation by repressing its direct target gene,SRSF10.Notably,miR-193-5p overexpression decreased plaque size and increased collagen content.Altogether,these findings demonstrate that lncR-GAS5 partially contributes to atherogenesis and plaque instability by impairing endothelial autophagy.In conclusion,lncR-GAS5 overexpression arrested endothelial autophagy through the miR-193-5p/SRSF10 signaling pathway.Thus,miR-193-5p/SRSF10 may serve as a novel treatment target for atherosclerosis. | Yuhua Fan Yue Zhang Hongrui Zhao Wenfeng Liu Wanqing Xu Lintong Jiang Ranchen Xu Yue Zheng Xueqing Tang Xiaohan Li Limin Zhao Xin Liu Yang Hong Yuan Lin Hui Chen Yong Zhang | 2023 | Frontiers of Medicine2023，17，2： | 1 |
| 14 | Reconfigurable asymmetric optical burst switching for concurrent DWDM multimode switching:architecture and research directions显示文摘 | Yuhua Chen Wenjing Tang | 2010 | Communications Magazine2010，48，5： | 1 |
| 15 | Synthesis and photoluminescence properties of a new green emitting phosphor La 2 SrB 10 O 19 :Tb 3+显示文摘 | Rui Guo Songling Tang Baochang Cheng Dunqiang Tan Yuhua Xiong | 2013 | Optical Materials2013，，8： | 1 |
| 16 | Set-valued ordered information systems显示文摘 | YUHUA QIAN CHUANGYIN DANG YIYE LIANG DAWE TANG | | 0，，： | 1 |
| 17 | Effect of orbital shadow at an Earth-Moon Lagrange point on relay communication mission显示文摘The shadow effect is an important constraint to be considered during the implementation of exploration missions. In this paper, for the Earth-Moon Lagrange point L2 relay communication mission, shadow effect issues on a periodic orbit about L2 are investigated. A systematic analysis based on the time domain and phase space is performed including the distribution, duration, and frequency of shadows. First, the LindstedtPoincare and second-order differential correction methods are used in conjunction with the DE421 planetary ephemeris to achieve a mission trajectory family in a high-precision ephemeris model. Next, on the basis of a conical shadow model, the influence of different orbital phases and amplitudes on the shadow is analyzed. The distribution of the shadow is investigated as well. Finally, the configuration of the shadow and its characteristics are studied. This study provides an important reference and basis for mission orbit design and shadow avoidance for relay satellites at an Earth-Moon Lagrange point. | Yuhua TANG Weiren WU Dong QIAO Xiangyu LI | 2017 | Science China(Information Sciences)2017，60，11： | 1 |
| 18 | Acute effects of microcystins on the transcription of antioxidant enzyme genes in cmcian carp Carassius auratus显示文摘 | SUN Yuhua TANG Rong Li Dapeng | 2008 | Environ Toxicol2008，23，2： | 1 |
| 19 | Theory and Application of Multi-robot Service-oriented Architecture显示文摘In order to solve the problem of heterogeneity in multi-robot cooperation, a new service-oriented architecture is proposed for multi-robot cooperation. Service provision and energy consumption are the basic cooperative behaviors. A set of basic concepts of robot service are proposed. A layered multi-robot service-oriented architecture is designed. Finally, the experiments illustrate the superiority of the proposed architecture which makes robot's underlying functional components be transparently encapsulated and the services in upper layer be transparently invoked, which will effectively avoid the impact of heterogeneous characteristics in multi-robot cooperation and facilitate the system construction, expansion, restructuring and maintenance. | Yunfei Cai Zhenmin Tang Yuhua Ding Bin Qian | 2016 | IEEE/CAA Journal of Automatica Sinica2016，3，1： | 1 |
| 20 | Mapping of de novo mutations in primary biliary cholangitis to a disease-specific co-expression network underlying homeostasis and metabolism显示文摘Primary biliary cholangitis(PBC) is an autoimmune disease involving dysregulation of a broad array of homeostatic and metabolic processes. Although considerable single-nucleotide polymorphisms have been unveiled, a large fraction of risk factors remains enigmatic. Candidate genes with rare mutations that tend to confer more deleterious effects need to be identified. To help pinpoint cellular and developmental mechanisms beyond common noncoding variants, we integrate whole exome sequencing with integrative network analysis to investigate genes harboring de novo mutations. Prominent convergence has been revealed on a network of disease-specific co-expression comprised of 55 genes associated with homeostasis and metabolism. The transcription factor gene MEF2 D and the DNA repair gene PARP2 are highlighted as hub genes and identified to be up-and down-regulated, respectively, in peripheral blood data set. Enrichment analysis demonstrates that altered expression of MEF2 D and PARP2 may trigger a series of molecular and cellular processes with pivotal roles in PBC pathophysiology. Our study identifies genes with de novo mutations in PBC and suggests that a subset of genes in homeostasis and metabolism tend to act in synergy through converging on co-expression network, providing novel insights into the etiology of PBC and expanding the pool of molecular candidates for discovering clinically actionable biomarkers. | Lu Wang Jinchen Li Chan Wang Ruqi Tang Jialong Liang Yuhua Gong Yaping Dai Ningling Ding Jian Wu Na Dai Lei Liu Yi Zhao Youlin Shao Weifeng Zhao Peng Jiang Xingjuan Shi Weichang Chen Ye Tian Xiangdong Liu Xiong Ma Zhongsheng Sun | 2022 | Journal of Genetics and Genomics2022，49，2： | 1 |
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