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| 1 | Positioning error compensation of an industrial robot using neural networks and experimental study显示文摘Due to the characteristics of high efficiency,wide working range,and high flexibility,industrial robots are being increasingly used in the industries of automotive,machining,electrical and electronic,rubber and plastics,aerospace,food,etc.Whereas the low positioning accuracy,resulted from the serial configuration of industrial robots,has limited their further developments and applications in the field of high requirements for machining accuracy,e.g.,aircraft assembly.In this paper,a neural-network-based approach is proposed to improve the robots’positioning accuracy.Firstly,the neural network,optimized by a genetic particle swarm algorithm,is constructed to model and predict the positioning errors of an industrial robot.Next,the predicted errors are utilized to realize the compensation of the target points at the robot’s workspace.Finally,a series of experiments of the KUKA KR 500–3 industrial robot with no-load and drilling scenarios are implemented to validate the proposed method.The experimental results show that the positioning errors of the robot are reduced from 1.529 mm to 0.344 mm and from 1.879 mm to 0.227 mm for the no-load and drilling conditions,respectively,which means that the position accuracy of the robot is increased by 77.6%and 87.9%for the two experimental conditions,respectively. | Bo LI Wei TIAN Chufan ZHANG Fangfang HUA Guangyu CUI Yufei LI | 2022 | Chinese Journal of Aeronautics2022，35，2： | 9 |
| 2 | Variation in cis-regulation of a NAC transcription factor contributes to drought tolerance in wheat显示文摘Drought is a major environmental factor limiting wheat production worldwide,and developing drought-tolerant cultivars is a central challenge for wheat breeders globally.Therefore,it is important to identify genetic components determining drought tolerance in wheat.In this study,we identified a wheat NAC gene(TaNAC071-A)that is tightly associated with drought tolerance by a genome-wide association study.Knockdown of TaNAC071-A in wheat attenuated plant drought tolerance,whereas its overexpression significantly enhanced drought tolerance through improved water-use efficiency and increased expression of stress-responsive genes.This heightened water-saving mechanism mitigated the yield loss caused by water deficit.Further candidate gene association analysis showed that a 108-bp insertion in the promoter of TaNAC071-A alters its expression level and contributes to variation in drought tolerance among wheat accessions.This insertion contains two MYB cis-regulatory elements(CREs)that can be directly bound by the MYB transcription activator,TaMYBL1,thereby leading to increased TaNAC071-A expression and plant drought tolerance.Importantly,introgression of this 108-bp insertion allele,TaNAC071-AIn-693,into drought-sensitive cultivars could improve their drought tolerance,demonstrating that it is a valuable genetic resource for wheat breeding.Taken together,our findings highlight a major breakthrough in determining the genetic basis underlying phenotypic variation in wheat drought tolerance and showcase the potential of exploiting CRE-containing indels for improving important agronomical traits. | Hude Mao Shumin Li Bin Chen Chao Jian Fangming Mei Yifang Zhang Fangfang Li Nan Chen Tian Li Linying Du Li Ding Zhongxue Wang Xinxiu Cheng Xiaojing Wang Zhensheng Kang | 2022 | Molecular Plant2022，15，2： | 9 |
| 3 | A novel lncRNA, Lnc-OC1, promotes ovarian cancer cell proliferation and migration by sponging miR-34a and miR-34c显示文摘Long non-coding RNAs(lncRNAs) have been reported to be of great importance in tumorigenesis and progression of a variety of cancers. However, the role of lncRNAs in ovarian cancer(OC) remains largely unknown. In the present study, we identified a novel lncRNA, LOC100288181(named as Lnc-OC1), which acted as a key regulator in the development and progression of OC. The combined Gene Expression Omnibus(GEO) database analysis revealed that Lnc-OC1 was significantly upregulated in OC tissues and Kaplan-Meier survival analysis confirmed that high Lnc-OC1 expression was associated with poor prognosis of OC patients. Importantly, we also demonstrated that knockdown of Lnc-OC1 suppressed cell proliferation, colony formation, invasion and migration in vitro and inhibited tumorigenicity in vivo.Mechanistically, Lnc-OC1 repressed the expression of endogenous miR-34 a and miR-34 c as a sponge and vice versa. Moreover, rescue experiments demonstrated that the oncogenic function of Lnc-OC1 at least partially depended on suppressing miR-34 a and miR-34 c. In conclusion, our results suggest that the LncOC1-miR-34 a/34 c axis may play a pivotal role in OC, and may serve as a potential diagnostic biomarker and a powerful therapeutic target for OC. | Fangfang Tao Xinxin Tian Mengxi Lu Zhiqian Zhang | 2018 | Journal of Genetics and Genomics2018，45，3： | 8 |
| 4 | MODIS observations of water color of the largest 10 lakes in China between 2000 and 2012显示文摘Forel-Ule(FU)index of water color is an important parameter in traditional water quality investigations.We retrieved the FU index of the largest 10 lakes in China during 2000-2012 from MODerate-resolution Imaging Spectroradiometer surface reflectance product(MOD09)images.Since FU index is an optical parameter,it can be derived from optical remote sensing data by direct formulas,which is invariant with region and season.Based on validation by in situ measured reflectance data,the FU index products are reliable,with average relative error of 7.7%.FU index can be used to roughly assess water clarity:the clearer a water body is,and the bluer it is in color,the smaller its FU index is.FU index can also be used to roughly classify trophic state into three classes:oligotrophic,mesotrophic,and eutrophic.We analyzed the spatial,interannual,and seasonal variations of the FU index and its implications for water clarity and trophic state,and the findings are mostly consistent with the results from related literature.All in all,it might be a feasible way to roughly assess inland water quality by FU index in large region and over long time period. | Junsheng Li Shenglei Wang Yanhong Wu Bing Zhang Xiaoling Chen Fangfang Zhang Qian Shen Dailiang Peng Liqiao Tian | 2016 | International Journal of Digital Earth2016，9，8： | 5 |
| 5 | Development and validation of a questionnaire-based risk scoring system to identify individuals at high risk for gastric cancer in Chinese populations显示文摘Objective:This study aimed to develop and validate a risk scoring system to identify high-risk individuals carrying malignant lesions in stomach for tailored gastric cancer screening.Methods:A gastric cancer risk scoring system(GC-RSS)was developed based on questionnaire-based predictors for gastric cancer derived from systematic literature review.To assess the capability of this system for discrimination,risk scores for 8,214 and 7,235 outpatient subjects accepting endoscopic examination in two endoscopy centers,and 32,630 participants in a community-based cohort in China were calculated to plot receiver operating characteristic curves and generate area under the curve(AUC).To evaluate the performance of GC-RSS,the screening proportion,sensitivity and detection rate ratio compared to universal screening were used under different risk score cutoff values.Results:GC-RSS comprised nine predictors including advanced age,male gender,low body mass index(<18.5 kg/m^(2)),family history of gastric cancer,cigarette smoking,consumption of alcohol,preference for salty food,irregularity of meals and consumption of preserved food.This tool performed well in determining the risk of malignant gastric lesions with AUCs of 0.763,0.706 and 0.696 in three validation sets.When subjects with risk scores≥5 were evaluated with endoscopy,nearly 50%of these endoscopies could be saved with a detection rate of over 1.5 times achieved.When the cutoff was set at 8,only about 10%of subjects with the highest risk would be offered endoscopy,and detection rates for gastric cancer could be increased 2-4 fold compared to universal screening.Conclusions:An effective questionnaire-based GC-RSS was developed and validated.This tool may play an important role in establishing a tailored screening strategy for gastric cancer in China. | Ren Zhou Hongchen Zheng Mengfei Liu Zhen Liu Chuanhai Guo Hongrui Tian Fangfang Liu Ying Liu Yaqi Pan Huanyu Chen Zhe Hu Hong Cai Zhonghu He Yang Ke | 2021 | Chinese Journal of Cancer Research2021，33，6： | 3 |
| 6 | A Recommendation Mechanism for Web Publishing Based on Sentiment Analysis of Microblog显示文摘Microblog is a social platform with huge user community and mass data. We propose a semantic recommendation mechanism based on sentiment analysis for microblog. Firstly, the keywords and sensibility words in this mechanism are extracted by natural language processing including segmentation, lexical analysis and strategy selection. Then, we query the background knowledge base based on linked open data(LOD) with the basic information of users. The experiment result shows that the accuracy of recommendation is within the range of 70%-89% with sentiment analysis and semantic query. Compared with traditional recommendation method, this method can satisfy users' requirement greatly. | TIAN Pingfang ZHU Zhonghua XIONG Li XU Fangfang | 2015 | Wuhan University Journal of Natural Sciences2015，20，2： | 2 |
| 7 | In vivo biocompatibility and degradability of a Zn-Mg-Fe alloy osteosynthesis system显示文摘Zinc is generally considered to be one of the most promising materials to be used in biodegradable implants,and many zinc alloys have been optimized to improve implant biocompatibility,degradation,and mechanical properties.However,long-term degradation leads to the prolonged presence of degradation products,which risks foreign body reactions.Herein,we investigated the in vivo biocompatibility and degradation of a biodegradable Zn-Mg-Fe alloy osteosynthesis system in the frontal bone,mandible,and femur in beagles for 1 year.Results of the routine blood,biochemical,trace element,and histological analyses of multiple organs,peripheral blood CD4/CD8a levels,and serum interleukin 2 and 4 levels showed good biocompatibility of the Zn-Mg-Fe alloy.Zinc content analysis revealed zinc accumulation in adjacent bone tissue,but not in the liver,kidney,and spleen,which was related to the degradation of the Zn-Mg-Fe alloy.The alloy demonstrated a uniform slowing degradation rate in vivo.No degradation differences in the frontal bone,mandible,and femur were observed.The degradation products included zinc oxide[ZnO],zinc hydroxide[Zn(OH)_(2)],hydrozincite[Zn_(5)(OH)_(6)(CO_(3))_(2)],and hopeite[Zn_(3)(PO_(4))_(2)⋅4H_(2)O].The good biocompatibility and degradation properties of the Zn-Mg-Fe alloy render it a very attractive osteosynthesis system for clinical applications. | Xiaoxi Shao Xiang Wang Fangfang Xu Taiqiang Dai Jack G.Zhou Jiang Liu Kun Song Lei Tian Bin Liu Yanpu Liu | 2022 | Bioactive Materials2022，7，1： | 1 |
| 8 | Synthesis of a novel hydrazone derivative and biophysical studies of its interactions with bovine serum albumin by spectroscopic, electrochemical, and molecular docking methods显示文摘 | TIAN Fangfang JIANG Fenglei HAN Xin | 2010 | The Journal of Physical Chemistry B2010，114，14： | 1 |
| 9 | Opportunistic mainte- nance optimization for wind turbine systems considering imperfect maintenance actions显示文摘 | DING Fangfang TIAN Zhigang | 2011 | International Journal of Reliability Quality and Safety Engineering2011，18，5： | 1 |
| 10 | Opportunistic maintenance for wind farms considering multi-level imperfect maintenance thresholds显示文摘 | DING Fangfang TIAN Zhigang | 2012 | Renewable Energy2012，45，1： | 1 |
| 11 | Opportunistic maintenance optimization for wind turbine systems considering imperfect maintenance actions显示文摘 | DING Fangfang TIAN Zhigang | 2011 | International Journal of Reliability Quality and Safety Engineering2011，18，5： | 1 |
| 12 | Risk SNP-induced lncRNA-SLCCl drives colorectal cancer through activating glycolysis signaling显示文摘Long non-coding RNAs(lncRNAs)play key roles in colorectal carcinogenesis.Here,we aimed to identify the risk SNP-induced lncRNAs and to investigate their roles in colorectal carcinogenesis.First,we identified rs6695584 as the causative SNP in 1 q41 locus.The A>G mutation of rs6695584 created a protein-binding motif of BATF,altered the enhancer activity,and subsequently activated IncSLCCl expression.Further validation in two independent CRC cohorts confirmed the upregulation of IncSLCCl in CRC tissues,and revealed that increased IncSLCCl expression was associated with poor survival in CRC patients.Mechanistically,lncRNA-SLCCl interacted with AHR and transcriptionally activated HK2 expression,the crucial enzyme in glucose metabolism,thereby driving the glycolysis pathway and accelerating CRC tumor growth.The functional assays revealed that IncSLCCl induced glycolysis activation and tumor growth in CRC mediated by HK2.In addition,HK2 was upregulated in colorectal cancer tissues and positively correlated with IncSLCCl expression and patient survival.Taken together,our findings reveal a risk SNP-mediated oncogene lncRNA-SLCCl promotes CRC through activating the glycolysis pathway. | Tingting Yan Chaoqin Shen Penglei Jiang Chenyang Yu Fangfang Guo Xianglong Tian Xiaoqiang Zhu Shiyuan Lu Bingshe Han Ming Zhong Jinxian Chen Qiang Liu Yingxuan Chen Junfang Zhang Jie Hong Haoyan Chen Jing-Yuan Fang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 1 |
| 13 | Synthesis of a novel hydrazone derivative and biophysical studies of its interactions with bovine serum albumin by spectroscopic, electrochemical, and molecular docking methods显示文摘 | TIAN Fangfang JIANG Fenglei HAN Xin | 2010 | The Journal of Physical Chemistry B2010，114，14： | 1 |
| 14 | An outbreak of Mycobacterium marinum infection associated with handling seabass in China显示文摘To the Editor:Mycobacterium marinum is a nontuberculous mycobacterium that can cause opportunistic infections in humans,ranging from a single cutaneous lesion to disseminated disease.[1]It was first isolated from a fish in 1926 and identified as a cause of human infection in 1951.[1]The estimated annual incidence ranges from 0.04 to 0.27 per 100,000 persons in different countries.Outbreaks of M.marinum infections related to handling fish are not common,but have also been reported. | Qing Zhao Fangfang Bao Zihao Mi Zhenzhen Wang Pengcheng Huai Qing Pan Zheng Pang Yaoming Li Nan Cao Xiaotong Xue Buyan Li Xuechao Chen Jinliang Wang Yanxia Cui Wenqian Chang Yuan Zhang Zhenhua Yue Yongxia Liu Zhenhua Wang Weiguo Yan Jinyong Li Hongqing Tian Xianmei Lu Guizhi Zhou Jianjun Liu Hong Liu Furen Zhang | 2022 | Chinese Medical Journal2022，135，21： | 1 |
| 15 | S1PR1 serves as a viable drug target against pulmonary fibrosis by increasing the integrity of the endothelial barrier of the lung显示文摘Idiopathic pulmonary fibrosis(IPF)is a progressive lung disease with unclear etiology and limited treatment options.The median survival time for IPF patients is approximately 2–3 years and there is no effective intervention to treat IPF other than lung transplantation.As important components of lung tissue,endothelial cells(ECs)are associated with pulmonary diseases.However,the role of endothelial dysfunction in pulmonary fibrosis(PF)is incompletely understood.Sphingosine-1-phosphate receptor 1(S1PR1)is a G protein-coupled receptor highly expressed in lung ECs.Its expression is markedly reduced in patients with IPF.Herein,we generated an endothelial-conditional S1pr1 knockout mouse model which exhibited inflammation and fibrosis with or without bleomycin(BLM)challenge.Selective activation of S1PR1 with an S1PR1 agonist,IMMH002,exerted a potent therapeutic effect in mice with bleomycin-induced fibrosis by protecting the integrity of the endothelial barrier.These results suggest that S1PR1 might be a promising drug target for IPF therapy. | Mengyao Hao Rong Fu Jun Tai Zhenhuan Tian Xia Yuan Yang Chen Mingjin Wang Huimin Jiang Ming Ji Fangfang Lai Nina Xue Liping Bai Yizhun Zhu Xiaoxi Lv Xiaoguang Chen Jing Jin | 2023 | Acta Pharmaceutica Sinica B2023，13，3： | 1 |
| 16 | Detail description of Lithophyllum okamurae(Lithophylloideae,Corallinales), a widely distributed crustose coralline alga in marine ecosystems显示文摘Lithophyllum okamurae is one of the important encrusting coralline algae,which plays important roles as primary producer,carbonate sediment builder,and habitat provider in the marine ecosystems.In this study,L.okamurae was collected from tropical coast of Sanya,and firstly described based on both detailed morph-anatomical characteristics and molecular studies of typic DNA sequences.The structure of the thalli of L.okamurae was pseudoparenchymatous construction with radially organized dimerous organizations in the crustose portion.The pseudoparenchymatous construction were composed of three parts,including 1 to 3 layers of epithelia cells which had flatten to round outermost walls,one layer of square or rectangular cells of the hypothallia and multiple layers of square or elongated rectangular peripheral cells.Palisade cells were observed,and the cells of the contiguous vegetative filaments were connected by secondary pit-connections with cell fusions absent.The carposporangial conceptacles,the spermatangial conceptacles,the bisporangial conceptacles and the tetrasporangial conceptacles were observed,and all these four kinds of conceptacles were uniporate.The spermatangial conceptacles were slightly convex and buried at shallow depths in the thalli tissues,and the carposporangial conceptacles and asexual conceptacles were protruding and conical.Phylogenetic studies based on DNA barcoding markers of 18 S rDNA,COI,rbc L and psb A revealed that L.okamurae clustered with the closest relation of L.atlanticum,and formed a distinct branch.Based on the comparative anatomical features and the molecular data,the detailed description of the valid species of L.okamurae was firstly given in this study to provide theoretical basis for algae resources utilization and conservation in marine ecosystems. | Qunju Hu Fangfang Yang Zhangliang Wei Jiahao Mo Chao Long Xinpeng Tian Lijuan Long | 2020 | Acta Oceanologica Sinica2020，39，6： | 0 |
| 17 | Characterization of 3D DNA Assemblies Using Cryogenic Electron Microscopy显示文摘DNA nanotechnology utilizes DNA double strands as building units for self-assembly of DNA nanostructures.The specific base-pairing interaction between DNA molecules is the basis of these assemblies.After decades of development,this technology has been able to construct complex and programmable structures.With the increase in delicate nature and complexity of the synthesized nanostructures,a characterization technology that can observe these structures in three dimensions has become necessary,and developing such a technology is considerably challenging.DNA assemblies have been studied using different characterization methods including atomic force microscopy(AFM),scanning electron microscopy(SEM),and transmission electron microscopy(TEM).However,the three-dimensional(3D)DNA assemblies always collapse locally due to the dehydration during the drying process.Cryogenic electron microscopy(cryo-EM)can overcome the challenge by maintaining three-dimensional morphologies of the cryogenic samples and reconstruct the 3D models from cryogenic samples accordingly by collecting thousands of two-dimensional(2D)projection images,which can restore their original morphologies in solution.Here,we have reviewed several typical cases of 3D DNA-assemblies and highlighted the applications of cryo-EM in characterization of these assemblies.By comparing with some other characterization methods,we have shown how cryo-EM promoted the development of structural characterization in the field of DNA nanotechnology. | WANG Mingyang DUAN Jialin DAI Lizhi XIN Xiaodong WANG Fangfang LI Zheng TIAN Ye | 2020 | Chemical Research in Chinese Universities2020，36，2： | 0 |
| 18 | Paclitaxel-loaded and folic acid-modified PLGA nanomedicine with glutathione response for the treatment of lung cancer显示文摘Targeted delivery and smart response of nanomedicine hold great promise for improving the therapeutic efficacy and alleviating the side effects of chemotherapy agents in cancer treatment.However,availability of only a few studies that discuss organic nanomedicines with these properties limits the development prospects of nanomedicines.In the present study,folic acid(FA)-targeted delivery and glutathione(GSH)smart responsive nanomedicine were rationally designed for pacli-taxel(PTX)delivery for the treatment of lung cancer.Compared with other stimuli-responsive nanomedicines,this nanocarrier was not only sensitive to biologically relevant GSH for on-demand drug release but also biodegradable into biocompatible products after fulfilling its delivery task.The nanomedicine first entered tumor cells via FA and its receptor-mediated endocytosis.After the lysosomal escape,poly(lactic-co-glycolic acid)(PLGA)nanomedicine was triggered by a higher level of GSH and released its cargo into the tumor microenvironment.In vitro and in vivo results revealed that the PLGA nanomedicine not only inhibited the proliferation and promoted the apoptosis of lung cancer cells significantly but also possessed less toxic side effects when compared with free PTX.Therefore,the proposed drug delivery system demonstrates the potential of a multifunctional nano-platform to enhance bioavailability and reduce the side effects of chemotherapy agents. | Wang Yao Jialiang Yao Fangfang Qian Zujun Que Pan Yu Tianle Luo Dan Zheng Zhanxia Zhang Jianhui Tian | 2021 | Acta Biochimica et Biophysica Sinica2021，53，8： | 0 |
| 19 | The role of O-GlcNAcylation in innate immunity and inflammation显示文摘O-linkedβ-N-acetylglucosaminylation(O-GlcNAcylation)is a highly dynamic and widespread post-translational modification(PTM)that regulates the activity,subcellular localization,and stability of target proteins.O-GlcNAcylation is a reversible PTM controlled by two cycling enzymes:O-linked N-acetylglucosamine transferase and O-GlcNAcase.Emerging evidence indicates that O-GlcNAcylation plays critical roles in innate immunity,inflammatory signaling,and cancer development.O-GlcNAcylation usually occurs on serine/threonine residues,where it interacts with other PTMs,such as phosphorylation.Thus,it likely has a broad regulatory scope.This review discusses the recent research advances regarding the regulatory roles of O-GlcNAcylation in innate immunity and inflammation.A more comprehensive understanding ofO-GlcNAcylation could help to optimize therapeutic strategies regarding inflammatory diseases and cancer. | Yongqiang Wang Xiuwu Fang Shuai Wang Bin Wang Feng Chu Zhixin Tian Long Zhang Fangfang Zhou | 2022 | Journal of Molecular Cell Biology2022，14，9： | 0 |
| 20 | A high-sensitive and self-selective humanoid mechanoreceptor for spatiotemporal tactile stimuli cognition显示文摘The cognition of spatiotemporal tactile stimuli,including fine spatial stimuli and static/dynamic temporal stimuli,is paramount for intelligent robots to feel their surroundings and complete manipulation tasks.However,current tactile sensors have restrictions on simultaneously demonstrating high sensitivity and performing selective responses to static/dynamic stimuli,making it a challenge to effectively cognize spatiotemporal tactile stimuli.Here,we report a high-sensitive and self-selective humanoid mechanoreceptor(HMR)that can precisely respond to spatiotemporal tactile stimuli.The HMR with PDMS/chitosan@CNTs(PDMS:polydimethylsiloxane;CNT:carbon nanotube)graded microstructures and polyurethane hierarchical porous spacer exhibits high sensitivity of 3790.8 kPa^(-1).The HMR demonstrates self-selective responses to static and dynamic stimuli with mono signal through the hybrid of piezoresistive and triboelectric mechanisms.Consequently,it can respond to spatiotemporal tactile stimuli and generate distinguishable and multi-type characteristic signals.With the assistance of the convolutional neural network,multiple target objects can be easily identified with a high accuracy of 99.1%.This work shows great potential in object precise identification and dexterous manipulation,which is the basis of intelligent robots and natural human-machine interactions. | Shuxin Bi Xuan Zhao Fangfang Gao Xiaochen Xun Bin Zhao Liangxu Xu Tian Ouyang Qingliang Liao Yue Zhang | 2024 | Nano Research2024，17，5： | 0 |
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