|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | EXPERIMENTAL STUDY OF FLOWFIELD STRUCTURE AROUND AN OGIVE-CYLINDER显示文摘The flowfield structure and their aerodynamic characteristics over an ogive cylinder were studied by means of flow visualization and surface pressure measurement in a water tunnel and a wind tunnel. The existence of multi asymmetric vortices over long slender bodies was experimentally confirmed at large angles of attack and in the subcritical Reynolds number range. The spatial 3 D characteristics of the multi vortices system were analyzed and a physical model was developed. The topological structure of different patterns in cross flow plane was studied and the mechanism governing the formation of asymmetric vortices and multi vortices was discussed from the viewpoint of stability of the topological structure. It was concluded that the maximum in the sectional side force distribution curve are not caused by the shedding of higher position vortex, but by the cross over to the symmetric plane of the lower position vortex. | Ph.D.Candidate:Wang Gang Fluid Mechanics Institute, Beijing University of Aeronautics and Astronautics, Beijing 100083, China,Supervisor: Deng Xue ying (Beijing University of Aeronautics and Astronautics) Members of Dissertation Defense Committee: Tong Bing gang (Graduate School of the Chinese Academy of Sciences),Chairman Gu Zhi fu (Peking University) Yang Qi de (China Aerodynamics Research and Development Center) Lv Zhi yong (Beijing University of Aeronautics and Astronautics) Liu Pei qing (Beijing University of Aeronautics and Astronautics) | 2003 | Journal of Hydrodynamics2003，15，5： | 18 |
| 3 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 4 | Role of P-selectin and anti-P-selectin monoclonal antibody in apoptosis during hepatic/renal ischemia-reperfusion injury显示文摘AIM To evaluale the potential role of P-selectinand anti-P-selectin monoclonal antibody(mAb)in apoptosis during hepatic/renal ischemia-reperfusion injury.METHODS Plasma P-selectin level,hepatic/renal P-selectin expression and cell apoptosiswere detected in rat model of hepatic/ renalischemia-reperfusion injury.ELISA,immunohist-ochemistry and TUNEL were used.Someischemia-reperfusion rats were treated with anti-P-selectin mAb.RESULTS Hepatic/renal function insuffic-iency,up-regulated expression of P-selectin inplasma and hepatic/renal tissue,hepatic/renalhistopathological damages and cell apoptosiswere found in rats with hepatic/renal ischemia-reperfusion injury,while these changes becameless conspicuous in animals treated with anti-P-selectin mAb.CONCLUSION P-selectin might mediateneutrophil infiltration and cell apoptosis andcontribute to hepatic/renal ischemia-reperfusioninjury,anti-P-selectin mAb might be an efficientapproach for the prevention and treatment ofhepatic/renal ischemia-reperfusion injury. | Pei Wu Xiao Li Tong Zhou Ming Jun Zhang Jin Lian Chen Wei Ming Wang Nan Chen De Chang Dong | 2000 | World Journal of Gastroenterology2000，6，2： | 10 |
| 5 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 6 | Empirical Analysis of City Contact in Zhujiang(Pearl) River Delta, China显示文摘In traditional urban geography, city contact research is a classic study element in city research. In general, researchers use the traditional gravity model to characterize the contacts that exist between two cities. The traditional gravity model assumes ideal conditions, but these preconditions and their results often do not exist in realistic conditions. Thus, we used a modified gravity model to characterize the city contacts within a specific region. This model considers factors such as intercity complementarities, government intervention, and the diversity of the transportation infrastructure which is characterized as the transportation distance instead of the traditional Euclidean distance. We applied this model to an empirical study of city contact in the Zhujiang(Pearl) River Delta(PRD) of China. The regression results indicated that the modified gravity model could measure city contact more accurately and comprehensively than the traditional gravity model, i.e., it yielded a higher adjusted R2 value(0.379) than the traditional gravity model result(0.259). Our study also suggests that, in addition to urban-regional and metropolitan development, the complementarities of the basic functions of cities at the administrative and market levels, as well as the corporeal and immaterial levels, play very significant roles in the characterization of city contact. Given the complexity of city contact, it will be necessary to consider more relevant influential factors in the modified gravity model to characterize the features of city contact in the future. | TONG De LIU Tao LI Guicai YU Lei | 2014 | Chinese Geographical Science2014，24，3： | 7 |
| 7 | Sex-specific and Dose-response Relationship between the Incidence of Gallstones and Components of the Metabolic Syndrome in Jinchang Cohort:A Prospective Study显示文摘Gallstones is a very common gastrointestinal disease,involving the formation of masses in the gall bladder or biliary tract,due to abnormally high concentrations of cholesterol or bilirubin in the bile[1].There is a 10%–20%prevalence of gallstones worldwide,and>20%of patients with gallstones show clinical symptoms,implying a substantial disease burden[1]. | YANG Jing Li HUANG Jun Jun CHENG Ning ZHANG De Sheng LIU Si Min HUANG Wen Ya LI Na HUANG Pei Yao DING Jiao LIU Nian BAO Kai Fang DING Jie CHEN Xiao Liang ZHENG Tong Zhang BAI Ya Na | 2020 | Biomedical and Environmental Sciences2020，33，8： | 4 |
| 8 | A New Type of Polymer-Supported Metallocene Catalyst for Ethylene Polymerization显示文摘A new polymer-supported metallocene catalyst has been prepared. The polymer- supported metallocene displayed considerably high activity in ethylene polymerization, the highest being 3.62(107gPE/molZr(h, the molecular weight of the polyethylene produced was Mn = 1.29(105, about 3-4 times those of corresponding homogeneous zirconocenes. The polymer- supported metallocene keeps the characteristics of homogeneous metallocene catalysts, and offers some features,such as adaptable to gas phase and slurry processes; easy to prepare in low cost; relatively high activity and lower MAO/Zr ratio; lower inorganic residues in the polyolefins as compared to cases of SiO2, Al2O3 or MgCl2; unitary active structure, no complex surface as with SiO2; good control of morphology of the resulting polymer. | Guang Qian YU*, De Ze ZHANG, Fu SHUN, Li Jun QIAO,Tao TANG, Bao Tong HUANG State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Polymer Chemistry Laboratory, Chemistry Academy of S | 2001 | Chinese Chemical Letters2001，12，3： | 4 |
| 9 | Superlinearly Convergent Affine Scaling Interior Trust-Region Method for Linear Constrained LC^1 Minimization显示文摘我们局部地为线性抑制光滑的最小化问题扩大古典仿射的可伸缩的内部信任区域算法到客观功能的坡度仅仅的非光滑的盒子 Lipschitzian。我们为解决客观功能的秒顺序衍生物明确地被要求是的线性抑制 LC 1 优化与非单调的内部回溯线搜索技术联合建议并且分析一个新仿射的可伸缩信任区域方法局部地 Lipschitzian。在建议算法的一般信任区域潜水艇问题被最小化定义一扩充了在扩充平等限制的一个空潜水艇空格仅仅要求客观函数题目的第一和第二个订购信息到仿射的可伸缩的椭圆体的限制的仿射的可伸缩的二次的模型。全球集中和建议算法的快本地集中率在客观功能的光滑两次没被要求的一些合理条件下面被建立。到一些非光滑的优化问题的算法的应用被讨论。 | De Tong ZHU | 2008 | Acta Mathematica Sinica,English Series2008，24，12： | 4 |
| 10 | Chemical Components of Helicia nilagirica Beed.I.Structure of Three New Flavonol Glycosides显示文摘Three new flavonol glycosides were isolated from the leaves of Helicia nilagirica Beed.. The structures were elucidated as kaempferol-3-O-b-D-xylopyranosyl-(16)-b-D-glyco- pyranosyl-(12)-a-L-rhamnopyranoside, quercetin-3-O-b-D-xylopyranosyl-(16)-b-D-glycopy- ranosyl-(12)-[-b-D-xylopyranosyl-(14)]-a-L-rhamnopyranoside, and quercetin-3-O-b-D- xylopyranosyl-(16)-b-D-glycopyranosyl-(12)-a-L-rhamnopyranoside, named as Helicianeoside A、B and C, respectively. | Tong WU, De Yun KONG, Hui Ting LI* Shanghai Institute of Pharmaceutical Industry, Shanghai 200040 | 2002 | Chinese Chemical Letters2002，13，11： | 3 |
| 11 | Determination of Trace Thiocyanate by a Chitosan-Modified Glassy Carbon Electrode显示文摘A chitosan modified glassy carbon electrode(CMGCE) was employed for the determination of thiocyanate. The measurement was carried out by means of anodic stripping voltammetry. The effects of several experimental parameters, such as pH, the amount of modifier, deposition potential and deposition time were studied for analytical application, respectively. A liner response was obtained in the concentration range of 3 5×10 -8 - 9.3×10 -7 g/mL of SCN -. The detection limit was found to be 1.9×10 -8 g/mL. The method was satisfactorily used to detect SCN - in saliva. | LU Guang han 1** , YAO Xin 1, ZHOU Xiang chun 2, ZHAN Tong 1 and LONG De wu 11. Department of Chemistry, Central China Normal University, Wuhan 430079, P. R. China 2. Department of Chemistry, Hubei Jingzhou Teacher College, Jinzhou 434100, P. | 2002 | Chemical Research in Chinese Universities2002，18，3： | 2 |
| 12 | CD8 + T Cells That Produce Interleukin-17 Regulate Myeloid-Derived Suppressor Cells and Are Associated With Survival Time of Patients With Gastric Cancer显示文摘 | Yuan Zhuang Liu–Sheng Peng Yong–Liang Zhao Yun Shi Xu–Hu Mao Weisan Chen Ken C. Pang Xiao–Fei Liu Tao Liu Jin–Yu Zhang Hao Zeng Kai–Yun Liu Gang Guo Wen–De Tong Yan Shi Bin Tang Na Li Shu Yu Ping Luo Wei–Jun Zhang Dong–Shui Lu Pei–Wu Yu Quan–Ming Zou | 2012 | Gastroenterology2012，，4： | 2 |
| 13 | Construction and prokaryotic expression of the fusion protein Stx2B-IntiminC300 of EHEC O157: H7 and its immunoprophylactic potential显示文摘To construct and express the fusion protein Stx2B-IntiminC300 of EHEC 0157 :H7, and to further investigate its immunoprophyiactic potential, the gene of Stx2B (stx2b) from EHEC 0157:H7 chromosome was cloned into pMD18-T vector. Thereafter, the amplified gene was cloned into prokaryotic expression plasmid pET-28a (+)-eaeC300, which was constructed previously. The recombinant pasmid pET-28a(+)-stx2b-eaeC300 was transformed into E. coli BL21(DE3). After inducement, the protein Stx2B-IntiminC300 was successfully expressed and analyzed with sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), Western blotting and N-terminal amino acid residual sequencing. To evaluate its immunoprophyiactic potential, it was primarily purified by ion-exchange chromatography and injected into 30 BALB/c mice with Al(OH)3 in the subscapular region. Ten days after the last booster vaccination, 20 mice were attacked with EHEC 0157: H7 lysate and the protective efficacy was observed. In the present study, the gene of Stx2B-IntiminC300 was successfully cloned into pET-28a (+) vector. The results of SDS-PAGE and Western blotting assay showed that the fusion protein was successfully expressed in the inclusion body form, accounting for 25% of total expression products, and its molecular weight was about 43 kDa. The result of the N-terminal amino acid residual sequencing showed that it was identical to that of the molecular designed. The purity was about 75 % after primary purification. Animal tests revealed that the fusion protein Stx2B-IntiminC300 has elicited high titer of protective antibody relatively. These results demonstrate that the fusion protein Stx2B-IntiminC300 is successfully expressed in prokaryotic expression system and shows certain immunoprophyiactic potential. | YONG YI Xu Hu MAO WEN DE TONG YING MA MING ZEN YONG HONG ZHU QUAN MING ZOU XIA AI JIAN PING CHENG WEI JUN ZHANG JIANG GU PING LUO | 2006 | Journal of Microbiology and Immunology2006，4，2： | 2 |
| 14 | Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: Relevance to Alzheimer's disease 显示文摘 | de la Monte SM Tong M Lester-Coll N | 2006 | J Alzheimers Dis2006，10，1： | 1 |
| 15 | Insulin resistance and neurodegeneration:roles of obesity,type 2 diabetes mellitus and non-alcoholic steatohepatitis显示文摘 | De la Monte SM Longato L Tong M | | 0，，： | 1 |
| 16 | Angiontensin cultured endothelial cells: a potential link between the renin angiotensin syeterm and thrombosis显示文摘 | Vaughan DE Lazos SA Tong K | 1995 | J Clinlnvest1995，95，6： | 1 |
| 17 | snmmary The Ⅱ inte mat tiondl symosium on cytomegalo virus显示文摘 | De Tong Galasso GJ Gazard B | 1998 | Autiviral Res1998，39，： | 1 |
| 18 | Angiotensin Ⅱ regulates expression of plasminogen activtor inhbitor-1 in cultured endothelial cdls显示文摘 | Lazos SA Tong K | 1995 | J Clin Invest1995，95，： | 1 |
| 19 | Brain insulin-like growth factor and neurotrophin resistance in Parkinson′s disease and dementia with Lewy bodies:potential role of manganese neurotoxicity显示文摘 | Tong M Dong M de la Monte SM | 2009 | J Alzheimers Dis2009，16，3： | 1 |
| 20 | Global and Local Convergence of a New Affine Scaling Trust Region Algorithm for Linearly Constrained Optimization显示文摘Chen and Zhang [Sci.China,Ser.A,45,1390–1397(2002)] introduced an affine scaling trust region algorithm for linearly constrained optimization and analyzed its global convergence.In this paper,we derive a new affine scaling trust region algorithm with dwindling filter for linearly constrained optimization.Different from Chen and Zhang's work,the trial points generated by the new algorithm are accepted if they improve the objective function or improve the first order necessary optimality conditions.Under mild conditions,we discuss both the global and local convergence of the new algorithm.Preliminary numerical results are reported. | Chao GU De Tong ZHU | 2016 | Acta Mathematica Sinica,English Series2016，32，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员