|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effects of adacolumn selective leukocytapheresis on plasma cytokines during active disease in patients with active ulcerative colitis显示文摘瞄准:调查在临床的活动索引的 ulcerative (UC )( 蔡) 和 IL-1ra, IL-10, IL-6 和 IL-18 的传播层次之间的关系。方法:IL-1ra, IL-10, IL-6 和 IL-18 的血层次与活跃 UC 在 31 个病人被测量,吝啬的蔡是 11.1,从 5-25 ;并且是的 12 个健康个人控制。病人们与 Adacolumn 被给粒细胞和单核白血球 adsorptive 词首字母的脱落(GMA ) 。忍受 FcgammaR 并且补充受体的白细胞被吸附到列 leucocytapheresis 搬运人。每个病人能在 8 wk 上收到多达 11 个 GMA 会议。结果:我们发现了在蔡和 IL-10 之间的强壮的关联(r = 0.827, P <
0.001 ) , IL-6 (r = 0.785, P <
0.001 ) 并且 IL-18 (r = 0.791, P <
0.001 ) 。IL-1ra 没与蔡一起被相关。后面的 GMA 治疗, 31 个病人中的 24 个完成了宽恕,所有 4 cytokines 的层次掉在健康控制里到层次。进一步, IL-1ra 和 IL-10 的血层次在从遵守了搬运人的白细胞建议版本的 60 min 在列流出和流入增加了。 | Hiroyuki Hanai Takayuki Iida Masami Yamada Yoshihiko Sato Ken Takeuchi Tatsuo Tanaka Kenji Kondo Masataka Kikuyama Yasuhiko Maruyama Yasushi Iwaoka Akiko Nakamura Kazuhisa Hirayama Abby R Saniabadi Fumitoshi Watanabe | 2006 | World Journal of Gastroenterology2006，12，21： | 8 |
| 2 | Decrease of reactive-oxygen-producing granulocytes and release of IL-10 into the peripheral blood following leukocytapheresis in patients with active ulcerative colitis显示文摘AIM: To investigate the clinical efficacy of leukocytapheresis (LCAP) in patients with active ulcerative colitis (UC), and to elucidate the mechanisms by determining the changes in the cytokine levels in the peripheral blood and of the functions of the peripheral blood leukocytes in these patients.METHODS: The subjects were 19 patients with active UC, with a mean clinical activity index (CAI) of 9.2. The LCAP was conducted using Cellsorba E. In each session of LCAP, 2-3 L of blood at the flow rate of 30-50 mL/min was processed. The treatment was carried out in approximately 1-h sessions, once a week, for 5-10 wk. Blood samples for determination of the cytokine levels were collected from the inflow side of the column (site of dehematization; at the start of LCAP) and outflow side of the column (at the end of LCAP). Blood samples for the determination of reactive-oxygen-producing cells were collected from the peripheral blood before and after LCAP.RESULTS: LCAP resulted in clinical improvement in all the 19 patients of UC recruited for this study. Remission (CAI: ≤4) was noted in 15 (79%) of the 19 patients. The blood level of the pro-inflammatory cytoline IL-6 was found to be decreased following treatment by LCAP, and the level of the anti-inflammatory cytokine IL-10 at the outflow side of the LCAP column was found to be significantly elevated as compared to that at the inflow side of the column. The reactive-oxygen-producing granulocytes in the peripheral blood of UC patients was increased as compared to that in healthy persons and the increase was found to be decreased following treatment by LCAP.CONCLUSION: LCAP exerted a high therapeutic efficacy in patients with active UC. Our findings suggest that LCAP is associated with enhanced production of the inhibitory cytokine IL-10 to indirectly inhibit the functions of the inflammatory leukocytes, and that inflammation is also considerably attenuated by the direct removal of reactiveoxygen-producing neutrophils from the peripheral blood. | Hiroyuki Hanai Takayuki Iida Ken Takeuchi Fumitoshi Watanabe Yasuhiko Maruyama Masataka Kikuyama Tatsuo Tanaka Kenji Kondo Kou Tanaka Kenji Takai | 2005 | World Journal of Gastroenterology2005，11，20： | 7 |
| 3 | Prevalence and Mechanism of Nonsteroidal Anti-Inflammatory Drug–Induced Clinical Relapse in Patients With Inflammatory Bowel Disease显示文摘 | Ken Takeuchi Simon Smale Purushothaman Premchand Laurence Maiden Roy Sherwood Bjarni Thjodleifsson Einar Bjornsson Ingvar Bjarnason | 2006 | Clinical Gastroenterology and Hepatology2006，，2： | 4 |
| 4 | Curcumin Maintenance Therapy for Ulcerative Colitis: Randomized, Multicenter, Double-Blind, Placebo-Controlled Trial显示文摘 | Hiroyuki Hanai Takayuki Iida Ken Takeuchi Fumitoshi Watanabe Yasuhiko Maruyama Akira Andoh Tomoyuki Tsujikawa Yosihihide Fujiyama Keiichi Mitsuyama Michio Sata Masami Yamada Yasushi Iwaoka Kazunari Kanke Hideyuki Hiraishi Kazuhisa Hirayama Hajime Arai Shi | 2006 | Clinical Gastroenterology and Hepatology2006，，12： | 2 |
| 5 | Optimal Propofol Plasma Concentration during Upper Gastrointeral Endoscopy in Young,Middle-aged,and Elderly Patients显示文摘 | TOMIEI KAZAMA MD KEN TAKEUCHI MD KAZUYUKI LKEDA MD | 2000 | Anesthesiology2000，93，： | 1 |
| 6 | Colloidal silver iodide: synthesis by a reverse micelle method and investigation by a small-angle neutron scattering study 显示文摘 | Tamura Sanae Takeuchi Ken Mao Guomin | 2003 | Journal of Electroanalytical Chemistry2003，559，： | 1 |
| 7 | Development and Flight Test of Metallined CFRP Cryogenic Tank for Reusable Rocket 显示文摘 | Higuchi Ken Takeuchi Shinsuke Sato Eiichi | 2005 | Acta Astronautica2005，57，： | 1 |
| 8 | The practical synthesis of a uterine relaxant,bis(2- ethyl] amino) -1,2,3,4-tetrahydronaphthalen-7-yl] oxy] -N,N-dimethylacetamide)sulfate (KUR-1246)显示文摘 | Ken Kikuchi Hideki Takeuchi | 2001 | Chem Pharm Bull2001，49，8： | 1 |
| 9 | Compound effects of additional Zn,Cu and Mn on elecrochemical properties and corrosion resistance of aluminum显示文摘 | Ken Tohma Noriaki Takahashi and Yo Takeuchi | 1983 | Jonsnal of Japan Institute of Light Metals1983，33，9： | 1 |
| 10 | Effects of Fluridone and Norflurazon on Conditioning and Germination of Striga asiatica Seeds显示文摘 | Dai Kusumoto Sang Heon Chae Ken Mukaida Kaori Yoneyama Koichi Yoneyama Daniel M. Joel Yasutomo Takeuchi | 2006 | Plant Growth Regulation2006，，1： | 1 |
| 11 | IEEE Journal of SOLID-STATE Circuits显示文摘 | Ken Takeuchi | 2009 | April2009，44，4： | 1 |
| 12 | Electro- deposition of Nb3Sn Alloy Film from Lewis Basic NbC1s-SnC12-EMIC Melt 显示文摘 | Ui Koichi Sakai Hirokazu Takeuchi Ken | 2009 | Electrochemistry2009，77，9： | 1 |
| 13 | Er- ror-prediction LDPC and error-recovery schemes for highly reliable solid-state drives (SSDs)显示文摘 | Tanakamaru Shuhei Yanagihara Yuki Takeuchi Ken | 2013 | IEEE Jour- nal of Solid-state Circuits2013，48，11： | 1 |
| 14 | Novel co-design of NAND flash memory and NAND flash controller circuits for sub-30nm low-power high-speed solid-state drives(SSD)显示文摘 | Ken Takeuchi | 2009 | IEEE Journal of Solid-State Circuits2009，44，4： | 1 |
| 15 | Blood Pressure and Hypertension Are Associated With 7 Loci in the Japanese Population显示文摘 | Fumihiko Takeuchi Masato Isono Tomohiro Katsuya Ken Yamamoto Mitsuhiro Yokota Takao Sugiyama Toru Nabika Akihiro Fujioka Keizo Ohnaka Hiroyuki Asano Yukio Yamori Shuhei Yamaguchi Shotai Kobayashi Ryoichi Takayanagi Toshio Ogihara Norihiro Kato | 2010 | Circulation2010，，21： | 1 |
| 16 | EML4-ALK Fusion Is Linked to Histological Characteristics in a Subset of Lung Cancers显示文摘 | Kentaro Inamura Kengo Takeuchi Yuki Togashi Kimie Nomura Hironori Ninomiya Michiyo Okui Yukitoshi Satoh Sakae Okumura Ken Nakagawa Manabu Soda Young Lim Choi Toshiro Niki Hiroyuki Mano Yuichi Ishikawa | 2008 | Journal of Thoracic Oncology2008，，1： | 1 |
| 17 | Curcumin Maintenance Therapy for Ulcerative Colitis: Randomized, Multicenter, Double-Blind, Placebo-Controlled Trial显示文摘 | Hiroyuki Hanai Takayuki Iida Ken Takeuchi Fumitoshi Watanabe Yasuhiko Maruyama Akira Andoh Tomoyuki Tsujikawa Yosihihide Fujiyama Keiichi Mitsuyama Michio Sata Masami Yamada Yasushi Iwaoka Kazunari Kanke Hideyuki Hiraishi Kazuhisa Hirayama Hajime Arai Shi | 2006 | Clinical Gastroenterology and Hepatology2006，，12： | 1 |
| 18 | Expression of Muscarinic Receptor Subtypes in Rat Gastric Smooth Muscle显示文摘 | Masayoshi Kajimura Ken Takeuchi | 1997 | Digestive Diseases and Sciences1997，42，5： | 1 |
| 19 | Effects of Fluridone and Norflurazon on Conditioning and Germination of Striga asiatica Seeds显示文摘 | Dai Kusumoto Sang Heon Chae Ken Mukaida Kaori Yoneyama Koichi Yoneyama Daniel M. Joel Yasutomo Takeuchi | 2006 | Plant Growth Regulation2006，，1： | 1 |
| 20 | Magnifying narrow-band imaging of surface maturation in early differentiated-type gastric cancers after Helicobacter pylori eradication显示文摘 | Masaaki Kobayashi Satoru Hashimoto Ken Nishikura Ken-ichi Mizuno Manabu Takeuchi Yuichi Sato Yoichi Ajioka Yutaka Aoyagi | 2013 | Journal of Gastroenterology2013，，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员