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| 1 | PLP2, a potent deubiquitinase from murine hepatitis virus, strongly inhibits cellular type I interferon production显示文摘由象严重急性呼吸症候群(SARS ) 那样的 coronaviruses 的感染 coronavirus (SCoV ) 和老鼠肝炎病毒 A59 (MHV-A59 ) 导致很小的类型我干扰素(IFN ) 生产由招待细胞,它为与 SARS 联系的快速的病毒的生长和严重 immunopathology 潜在地负责。然而,为在感染 coronaviruses 的房间的低 IFN 生产的分子的机制仍然保持不清楚。这里,我们提供证据象 Papain 一样朊酶领域 2 (PLP2 ) , nonstructural 蛋白质的一个催化领域 3 (nsp3 ) MHV-A59,能绑在 IRF3,引起它的 deubiquitination 并且阻止它的原子 translocation。作为后果, PLP2 的合作表示强烈禁止 CARDIF- ,调停 TBK1 、调停 IRF3 的 IFN 记者活动。另外,我们显示出那野类型的 PLP2 然而并非缺乏 deubiquitinase 的变异的 PLP2 (称) 活动能减少感应的 IFN 并且在感染 VSV 的房间支持病毒的生长。因此,我们的学习揭开了一病毒称它 coronaviruses 可以使用逃离主人天生的抗病毒的回答。 | Dahai Zheng Gang Chen Beichu Guo Genhong Cheng Hong Tang | 2008 | Cell Research2008，18，11： | 20 |
| 2 | Consensus on the application of negative pressure wound therapy of diabetic foot wounds显示文摘Because China is becoming an aging society,the incidence of diabetes and diabetic foot have been increasing.Diabetic foot has become one of the main health-related killers due to its high disability and mortality rates.Negative pressure wound therapy(NPWT)is one of the most effective techniques for the treatment of diabetic foot wounds and great progress,both in terms of research and its clinical application,has been made in the last 20 years of its development.However,due to the complex pathogenesis and management of diabetic foot,irregular application of NPWT often leads to complications,such as infection,bleeding and necrosis,that seriously affect its treatment outcomes.In 2020,under the leadership of Burns,Trauma and Tissue Repair Committee of the Cross-Straits Medicine Exchange Association,the writing group for‘Consensus on the application of negative pressure wound therapy of diabetic foot wounds’was established with the participation of scholars from the specialized areas of burns,endocrinology,vascular surgery,orthopedics and wound repair.Drawing on evidence-based practice suggested by the latest clinical research,this consensus proposes the best clinical practice guidelines for the application and prognostic evaluation of NPWT for diabetic foot.The consensus aims to support the formation of standardized treatment schemes that clinicians can refer to when treating cases of diabetic foot. | Shizhao Ji Xiaobin Liu Jie Huang Junmin Bao Zhaohong Chen Chunmao Han Daifeng Hao Jingsong Hong Dahai Hu Yufeng Jiang Shang Ju Hongye Li Zongyu Li Guangping Liang Yan Liu Gaoxing Luo Guozhong Lv Xingwu Ran Zhongmin Shi Juyu Tang Aiping Wang Guangyi Wang Jiangning Wang Xin Wang Bing Wen Jun Wu Hailin Xu Maojin Xu Xiaofei Ye Liangxi Yuan Yi Zhang Shichu Xiao Zhaofan Xia | 2021 | Burns & Trauma2021，9，1： | 17 |
| 3 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 4 | Influence of chemical reaction rate, diffusion and pore structure on the regeneration ofa coked A1203-catalyst显示文摘 | Tang Dahai Christoph K Andreas J | 2004 | Applied Catalysis A: General2004，272，12： | 1 |
| 5 | Extraction Difficulty of Lithium Ions from Various Crystal Planes of Lithium Titanate显示文摘To study the extraction difficulty of lithium ions from various crystal planes of Li_2 TiO_3, according to the first principle, four representative crystal surfaces of Li_2TiO_3(precursor),(-133),(-206),(002) and(-131), were selected to establish a model and to calculate the surface energy, bond length and population using Materials Studio 5.5(MS 5.5). The results demonstrate that there is no direct relationship between the surface energy and the order of disappearance of the four diffraction peaks when lithium titanate is treated with hydrochloric acid, instead, the difficulty of Li^+ extraction from various crystal faces corresponds to the Li-O bond strength. Lithium ion is easy to remove from(-133) and(-206) due to the relatively weak Li-O bond strength. In contrast, Li+ extraction requires a longer time for(002) and(-131). | 张理元 ZHOU Jiabei HE Gang ZHOU Dali TANG Dahai WANG Fahou | 2018 | Journal of Wuhan University of Technology(Materials Science)2018，33，5： | 1 |
| 6 | CO2 biofixation and fatty acid composition of Scenedesmus obliqus and Chlorella pyrenoidosa in response to different CO2 levels 显示文摘 | Tang Dahai Han Wei Li Penglin | 2010 | Bioresource Technology2010，102，3： | 1 |
| 7 | Silencing JA hydroxylases in Nicotiana attenuata enhances jasmonic acid-isoleucine-mediated defenses against Spodoptera litura显示文摘Jasmonic acid(JA)plays important roles in plant resistance to insect herbivores.One important derivative of JA is 12-OH-JA,which is produced by two independent pathways:direct hydroxylation of JA by jasmonate-induced oxygenases(JOXs)or hydrolyzation of 12-OH-JA-Ile.Yet the function of 12-OH-JA in plant-herbivore interactions remains largely unknown.In this study,we silenced four JOX homologs independently in the wild tobacco Nicotiana attenuata by virus-induced gene silencing(VIGS),and found that all four JOX homologs are involved in JA hydroxylation.Simultaneously silencing the four JA hydroxylases in VIGS-NaJOXs plants decreased herbivory-induced 12-OH-JA by 33%,but JA and JA-Ile levels increased by 45%and 30%,respectively,compared to those in control plants.Compared to direct hydroxylation from JA,hydrolyzation from 12-OH-JA-Ile is equally important for herbivory-induced 12-OHJA accumulation:in the 12-OH-JA-Ile deficient irJAR4/6 plants,12-OH-JA decreased 34%.Moreover,VIGSNaJOXs plants exhibited enhanced resistance to the generalist herbivore Spodoptera litura.The poor larval performance was strongly correlated with high levels of several JA-Ile-dependent direct defense metabolites in the VIGS-NaJOXs plants.When we simultaneously silenced all four JA hydroxylases in the JAIle-deficient irJAR4/6 background,the enhanced herbivore resistance diminished,demonstrating that enhanced herbivore resistance resulted from elevated JA-Ile levels.Given that silencing these NaJOX-like genes did not detectably alter plant growth but highly increased plant defense levels,we propose that JOX genes are potential targets for genetic improvement of herbivore-resistant crops. | Jinxiang Tang Dahai Yang Jianqiang Wu Suiyun Chen Lei Wang | 2020 | Plant Diversity2020，42，2： | 1 |
| 8 | Does Innovation Matter for Chinese High-Tech Exports? A Firm-Level Analysis显示文摘这份报纸在 2005-2007 的时期期间在中国高技术公司的出口决定上调查革新的影响。用一条参量的、仪器的可变途径和一个非参量的匹配方法,我们发现那公司级的革新努力,由花的 R&D 和新产品输出测量了,为国内出口商起仅仅一个次要的作用。外国投资公司统治高技术出口,但是不依靠土生土长的革新活动。这些结果证明中国高技术出口的成功不源于重 R&D 开销和工艺的进步。而且,革新措施的不同类型在出口的可能性的上显示出不同影响。出口上的革新的影响越过工业和中国区域广泛地变化。 | Dahai Fu Yanrui Wu Yihong Tang | 2012 | Frontiers of Economics in China-Selected Publications from Chinese Universities2012，7，2： | 1 |
| 9 | Clavukoelloids A—M,Thirteen Rare N-Containing Nardosinane Type Sesquiterpenoids from the Soft Coral Clavularia koellikeri显示文摘Thirteen new nitrogen-containing nardosinane-type sesquiterpenoids,clavukoelloids A-M(1-13)with unique acrylamide fragments vs.the reported general nardosinane-type sesquiterpenoids containing lactone,were isolated from the soft coral Clavularia koellikeri collected from the South China Sea.The structures and absolute configurations of new compounds were unambiguously determined by analysis of spectroscopic data,CP3,DP4+,ECD spectra,and X-ray diffraction.Compound 6 showed anti-inflammatory activities and hepatoprotective activities in transgenic fluorescent zebrafish. | Xiao Han Zhe Wang Anran Fu Kun Liu Zongchen Ma Xuli Tang Dahai Zhang Guoqiang Li | 2023 | Chinese Journal of Chemistry2023，41，12： | 0 |
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