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| 1 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 2 | Electron beam irradiation modification of collagen membrane显示文摘 | Bo Jiang Zhihong Wu Huichuan Zhao Fangyuan Tang Jian Lu Qingrong Wei Xingdong Zhang | 2005 | Biomaterials2005，，： | 1 |
| 3 | Exhumation structure and mechanism of the Sulu ultrahigh-pressure metamorphic belt central China显示文摘 | Xu Zhiqin Zhang Zemin Liu Fulai Yang Jingsui Li Haibing Yang Tiannan Qiu Haijun Li Tianfu Meng Fanchong Chen Shizhong Tang Zemin and Chen Fangyuan | | ACTA GEOLOGICA SINICA(CHINESE EDITION)0，，： | 1 |
| 4 | Surface modification on nanoscale titanium dioxide by radiation: preparation and characterization显示文摘 | Jiang Bo Zu Xiaotao Tang Fangyuan | 2006 | Journal of Applied Polymer Science2006，100，05： | 1 |
| 5 | Molecular insights into AabZIP1-mediated regulation on artemisinin biosynthesis and drought tolerance in Artemisia annua显示文摘Artemisia annua is the main natural source of artemisinin production.In A.annua,extended drought stress severely reduces its biomass and artemisinin production while short-term water-withholding or abscisic acid(ABA)treatment can increase artemisinin biosynthesis.ABA-responsive transcription factor AabZIP1 and JA signaling AaMYC2 have been shown in separate studies to promote artemisinin production by targeting several artemisinin biosynthesis genes.Here,we found AabZIP1 promote the expression of multiple artemisinin biosynthesis genes including AaDBR2 and AaALDH1,which AabZIP1 does not directly activate.Subsequently,it was found that AabZIP1 up-regulates AaMYC2expression through direct binding to its promoter,and that AaMYC2 binds to the promoter of AaALDH1to activate its transcription.In addition,AabZIP1 directly transactivates wax biosynthesis genes AaCER1and AaCYP86A1.The biosynthesis of artemisinin and cuticular wax and the tolerance of drought stress were significantly increased by AabZIP1 overexpression,whereas they were significantly decreased in RNAi-AabZIP1 plants.Collectively,we have uncovered the AabZIP1-AaMYC2 transcriptional module as a point of cross-talk between ABA and JA signaling in artemisinin biosynthesis,which may have general implications.We have also identified AabZIP1 as a promising candidate gene for the development of A.annua plants with high artemisinin content and drought tolerance in metabolic engineering breeding. | Guoping Shu Yueli Tang Mingyuan Yuan Ning Wei Fangyuan Zhang Chunxian Yang Xiaozhong Lan Min Chen Kexuan Tang Lien Xiang Zhihua Liao | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 1 |
| 6 | Supplementing Qi and activating blood circulation method to treat vertebrobasilar dolichoectasia with posterior circulatory watershed infarction:a case report of two patients显示文摘Vertebrobasilar dolichoectasia(VBD),a rare posterior circulation vascular variant disease,is an important risk factor for many acute cerebrovascular diseases.An insufficient understanding of VBD often leads to misdiagnose.Two cases of VBD that were initially diagnosed as posterior circulation watershed infarction are reported here.Absence of common causes of stroke including hypoperfusion,blood system diseases,carotid and aortic dissection,and eosinophil elevation,the symptoms of the 2 patients met the diagnostic criteria of VBD.Both patients displayed symptoms that were in line with the Traditional Chinese Medicine(TCM)syndrome pattern of'Qi deficiency and blood stasis'.Accordingly,they were comprehensively treated with Supplementing Qi and activating blood circulation method.The clinical manifestations of the 2 patients were remarkably improved and no recurrence of watershed infarction was found in a 1-year follow-up.A detailed medical history and laboratory examination are capable of improving diagnostic accuracy of VBD.TCM treatment based on syndrome identification might be a promising candidate for VBD management. | LI He SU Wenquan LI Shanshan JI Hanrui CHENG Jiangyan CUI Fangyuan TANG Lu ZHOU Li GAO Ying DONG Xinglu | 2023 | Journal of Traditional Chinese Medicine2023，43，4： | 0 |
| 7 | Differential responses of weaned piglets to supplemental porcine or chicken plasma in diets without inclusion of antibiotics and zinc oxide显示文摘This study was conducted to investigate the effects of spray-dried porcine plasma protein(SDPP)or spray-dried chicken plasma protein(SDCP)supplementation in diets without the inclusion of antibiotics and zinc oxide(ZnO)on growth performance,fecal score,and fecal microbiota in early-weaned piglets.A total of 192 healthy weaning piglets(Duroc×Landrace×Yorkshire,21 d old)were blocked by BW(6.53±0.60 kg)and randomly assigned to 4 dietary treatments:negative control(NC,basal diet),positive control(PC),basal diet+ZnO at 2 g/kg and antibiotics at 0.8 g/kg,SDPP(containing 5%SDPP),and SDCP(containing 5%SDCP).The experiment lasted 14 d.The SDPP group had higher(P<0.05)final BW,average daily gain and average daily feed intake than the NC and SDCP groups.The percentage of piglets with fecal scores at 2 or≥2 was higher(P<0.05)in the NC and SDCP groups than in the PC group.A decreased(P<0.05)bacterial alpha diversity and Bacteroidetes abundance,but increased(P<0.05)Firmicutes abundance were observed in the PC and SDPP groups when compared to the NC group.The relative abundance of Lactobacillus was higher(P<0.05)in the SDPP than in the SDCP group,and that of Streptococcus was higher(P<0.01)in the PC and SDPP groups than in the NC group.The PC group also had higher(P<0.01)Faecalibacterium abundance than the NC and SDCP groups.Additionally,the SDCP group had higher(P<0.05)serum urea nitrogen than those fed other diets,and lower(P<0.10)shortchain fatty acids to branched-chain fatty acids ratio than the PC and SDPP groups.Overall,SDPP was a promising animal protein for piglets in increasing feed intake,modifying gut microbiota profile,reducing gut protein fermentation and alleviating diarrhea frequency,thus promoting growth performance,under the conditions with limited in-feed utilization of antibiotics and ZnO. | Li Zhe Lunxiang Yang Sen Lin Fangyuan Chen Peng Wang Lourens Heres Yong Zhuo Jiayong Tang Yan Lin Shengyu Xu Xiaoling Zhang Xuemei Jiang Lingjie Huang Ruinan Zhang Lianqiang Che Gang Tian Bin Feng De Wu Zhengfeng Fang | 2021 | Animal Nutrition2021，，4： | 0 |
| 8 | Systemic and single cell level responses to 1 nm size biomaterials demonstrate distinct biological effects revealed by multi-omics atlas显示文摘Although ultra-small nanoclusters(USNCs,<2 nm)have immense application capabilities in biomedicine,the investigation on body-wide organ responses towards USNCs is scant.Here,applying a novel strategy of single-cell mass cytometry combined with Nano Genome Atlas of multi-tissues,we systematically evaluate the interactions between the host and calcium phosphate(CaP)USNCs at the organism level.Combining single-cell mass cytometry,and magnetic luminex assay results,we identify dynamic immune responses to CaP USNCs at the single cell resolution.The innate immune is initially activated and followed by adaptive immune activation,as evidenced by dynamic immune cells proportions.Furthermore,using Nano Genome Atlas of multi-tissues,we uncover CaP USNCs induce stronger activation of the immune responses in the cartilage and subchondral bone among the five local tissues while promote metabolic activities in the liver and kidney.Moreover,based on the immunological response profiles,histological evaluation of major organs and local tissue,and a body-wide transcriptomics,we demonstrate that CaP USNCs are not more hazardous than the Food and Drug Administration-approved CaP nanoparticles after 14 days of injection.Our findings provide valuable information on the future clinical applications of USNCs and introduce an innovative strategy to decipher the whole body response to implants. | Tao Zhang Tingyun Lei Ruojin Yan Bo Zhou Chunmei Fan Yanyan Zhao Shasha Yao Haihua Pan Yangwu Chen Bingbing Wu Yuwei Yang Lijuan Hu Shen Gu Xiaoyi Chen Fangyuan Bao Yu Li Hanqi Xie Ruikang Tang Xiao Chen Zi Yin | 2022 | Bioactive Materials2022，7，12： | 0 |
| 9 | Electronic structure modulation with ultrafine Fe_(3)O_(4) nanoparticles on 2D Ni-based metal-organic framework layers for enhanced oxygen evolution reaction显示文摘Two-dimensional(2D)metal organic frameworks(MOFs)are emerging as low-cost oxygen evolution reaction(OER)electrocatalysts,however,suffering aggregation and poor operation stability.Herein,ultrafine Fe_(3)O_(4) nanoparticles(diameter:6±2 nm)are homogeneously immobilized on 2D Ni based MOFs(Ni-BDC,thickness:5±1 nm)to improve the OER stability.Electronic structure modulation for enhanced catalytic activity is studied via adjusting the amount of Fe_(3)O_(4) nanoparticles on Ni-BDC.The optimal Fe_(3)O_(4)/Ni-BDC achieves the best OER performance with an overpotential of 295 mV at 10 mA cm^(-2),a Tafel slope of 47.8 mV dec^(-1) and a considerable catalytic durability of more than 40 h(less than 5 h for Ni-BDC alone).DFT calculations confirm that the active sites for Fe_(3)O_(4)/Ni-BDC are mainly contributed by Fe species with a higher oxidation state,and the potential-determining step(PDS)is the formation of the adsorbed O*species,which are facilitated in the composite. | Wei Huang Chao Peng Jing Tang Fangyuan Diao Murat Nulati Yesibolati Hongyu Sun Christian Engelbrekt Jingdong Zhang Xinxin Xiao Kristian S.Mølhave | 2022 | Journal of Energy Chemistry2022，31，2： | 0 |
| 10 | Strongly nonlinear topological phases of cascaded topoelectrical circuits显示文摘Circuits provide ideal platforms of topological phases and matter,yet the study of topological circuits in the strongly nonlinear regime,has been lacking.We propose and experimentally demonstrate strongly nonlinear topological phases and transitions in one-dimensional electrical circuits composed of nonlinear capacitors.Nonlinear topological interface modes arise on domain walls of the circuit lattices,whose topological phases are controlled by the amplitudes of nonlinear voltage waves.Experimentally measured topological transition amplitudes are in good agreement with those derived from nonlinear topological band theory.Our prototype paves the way towards flexible metamaterials with amplitude-controlled rich topological phases and is readily extendable to two and three-dimensional systems that allow novel applications. | Jijie Tang Fangyuan Ma Feng Li Honglian Guo Di Zhou | 2023 | Frontiers of physics2023，18，3： | 0 |
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