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| 1 | Sediment provenance and evolution of the East Asian winter monsoon since 700 ka recorded by major elements in the West Philippine Sea显示文摘To synthetically realize the character of major-element compositions as well as its significance for provenance and paleoenvironment recorded in core sediments of the West Philippine Sea over the last 700 ka,grain size and major elements of 221 bulk sediments,together with major-element compositions in the detrital phase of 16 typical samples,in core MD06-3047 collected from the Benham Rise were analyzed.Both discrimination plot and R-mode factor analysis indicate that vertical changes of major elements are mainly controlled by the sedimentation of nearby volcanic matter and the eolian dust input,whereas influences from marine biologic deposition and hydrothermal activity are minor.In particular,Al2O3 and K2O are representative of an eolian dust factor.The variation in the eolian dust factor score is characterized by the obviously glacial-interglacial periodicity and can be well compared with the paleotemperature record of the Antarctic ice core and the evolution of the East Asian winter monsoon(EAWM) recorded in the Chinese loess sequence,and then offers a new proxy for the evolution history of eolian dust input into the study area that is controlled by the EAWM intensity and aridity in the continental source regions of atmospheric dust. | XU ZhaoKai LI TieGang YU XinKe LI AnChun TANG Zheng CHOI JinYong NAN QingYun | 2013 | Chinese Science Bulletin2013，58，9： | 7 |
| 2 | Response of the northwestern Pacific upper water δ^(13)C to the last deglacial ventilation of the deep Southern Ocean显示文摘The deglacial δ~13C minimum events that originated from the ventilation of the deep Southern Ocean around Antarctica, have been recorded in a range of marine sediments from the southern to tropical oceans in late Pleistocene. However, the broad δ~13C minimum event was also reported as far as to the northern middle latitudes, in northwestern Pacific marginal sea areas, during the last deglaciation. In the northwestern Pacific, forcing from the northern high latitudes is strongly expressed, while the records of in- fluence from the southern high latitudes are few. The Kuroshio Source Region (KSR) forms a boundary between the northwestern Pacific and the southern, tropical Pacific. So, high-resolution planktonic foraminiferal records in core MD06-3054 from the KSR are well positioned to identify signals from the southern hemisphere in the northwestern Pacific. Planktonic foraminiferal tests from the upper 1030 cm of the core were subject to AMS14C, carbon and oxygen isotopic measurements. A negative excursion was found to occur from about 20.0-6.0 ka BP in δ~13C records of both surface (Globigerinoides ruber) and subsurface (Pulleni- atina obliquiloculata) dwellers, but the overall trends of the two curves have reversed since 26.5 ka BP. Moreover, the δ~13C rec- ord of G. ruber (the surface dweller) shows a robust link to the record of atmospheric CO2, and its changes precede the records of P. obliquiloculata (the subsurface dweller). According to the hydrologic conditions, the broad δ~13C minimum event recorded in the KSR is also a response to the increasing ventilation of the deep Southern Ocean around Antarctica during the last deglaciation. The inconsistency between the records of the surface and subsurface dwellers was possibly caused by the ways that the low δ~13C signal was transmitted. Subsurface water primarily received the low δ~13C signal from the Antarctic Intermediate Water (AAIW), whereas the surface water was probably mainly impacted by atmospheric CO2 in the KSR. The records from the KSR confirm the deduction that the broad δ~13C minimum event in the Okinawa Trough was due to the impact of tropical Pacific surface water dur- ing the last deglaciation, and suggest that signals from the southern high latitudes also can be delivered to the northern middle latitudes. | CHEN ShuangXi LI TieGang TANG Zheng QIU XiaoHua XIONG ZhiFang NAN QingYun XU ZhaoKai CHANG FengMing | 2011 | Chinese Science Bulletin2011，56，24： | 5 |
| 3 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 4 | Calcareous nannofossil bioevents and microtektite stratigraphy in the Western Philippine Sea during the Quaternary显示文摘Two sediment cores, MD06-3050 and MD06-3047, were analyzed to study the Quaternary calcareous nannofossil and microtektite records. We dated bioevents and the microtektite impact event by calibrating with oxygen isotope stratigraphy. Seven calcareous nannofossil bioevents were identified over the past 2.36 Ma including the last appearance of data for Discoaster brouweri, Calcidiscus macintyrei, large Gephyrocapsa and Pseudoemiliania lacunosa, the first appearance of data for large Gephyrocapsa and Emiliania huxleyi, and the abrupt increase in the abundance of Gephyrocapsa caribbeanica. In addition, we fortunately observed that Australasian microtektites were distributed in core MD06-3050 from 1340 to 1374 cm. | SUN HanJie LI TieGang SUN RongTao YU XinKe CHANG FengMing TANG Zheng | 2011 | Chinese Science Bulletin2011，56，25： | 3 |
| 5 | A high-performance bio-tissue imaging method using air flow-assisted desorption electrospray ionization coupled with a high-resolution mass spectrometer显示文摘Mass spectrometry imaging (MSI) technology can simultaneously obtain the spatial distribution of thousands of chemical compounds and has unique advantages compared to other techniques that allow mapping the surface of bio-tissue. Here, we combined an air flow-assisted desorption electrospray ionization (AFADESI) MSI device with a high-resolution mass spectrometer to optimize the system parameters and achieve more accurate spatial distribution characteristics for compounds of interest while investigating bio-tissue sections. The platform set-up, required instrumentation, sample pretreatment, parameter optimization and bio-tissue characterization are described and discussed.Finally, the parameter conditions that can provide optimal ionic intensity and enhanced resolution were confirmed. The reasonable resolution and sensitivity improvements of AFADESI-MSI have been achieved through tandem a high-resolution mass spectrometer system, therefore, it would be a promising technique for the bio-tissue imaging analysis. | Yiwei Lv Tiegang Li Chengan Guo Chenglong Sun Fei Tang Luojiao Huang Zhigang Luo Xin Li Ruiping Zhang Qingce Zang Jiuming He Zeper AbliZ | 2019 | Chinese Chemical Letters2019，30，2： | 2 |
| 6 | Transition metal coordination polymers with polycarboxylic acid as bridging ligands:Synthesis and structure characterization of[Fe(μ_(4)-bta)_(0.5)(phen)(OH)]_(n)显示文摘A new 2D (two-dimensional) coordination polymer, [Fe(μ4-bta)0.5(phen)(OH)]n (1), has been hydrothermally synthesized with FeCl3·6H2O, Na4bta (H4bta = 1,2,4,5-benzentetra- carboxylic acid), 1,10-phen (1,10-phenanthroline) and H2O as raw materials. The crystals of the compound belong to monoclinic P21/n space group, a = 1.0129(2) nm, b = 0.9265(2) nm, c = 1.5696(3) nm,β = 91.37(3) o, V = 1.4721(5) nm3, Z = 3, final R1 = 0.0292, Wr2 = 0.0798 for 2572 [I > 2σ (I )] observed reflections. The result of structure determination shows that in the compound each bta ligand is connected with four FeIII, forming a new μ4-coordination mode. Four deprotonated carboxylic groups of bta link to FeIII ions alternatively through monodentate and bidentate coordination fashion, constructing 2D layer network. The measurement of variable temperature magnetic susceptibility indicates that there exist antiferromagnetic interactions between FeIII ions in the compound. The TGA spectrum displays relatively fine thermal stability of the compound. In addition, IR and UV-Vis spectra of compound 1 have also been measured. | XU Jiqing, CHU Deqing, YU Jiehui, WANG Tiegang & TANG AoqingCollege of Chemistry and State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jilin University, Changchun 130023, China Institute of Theoretical Chemistry, Jilin University, Changchun 130023, China | 2004 | Science China Chemistry2004，47，1： | 2 |
| 7 | Modulating Endothelial Barrier Function by Targeting Vimentin Phosphorylation显示文摘 | Tiegang Liu Maher M. Ghamloush Ali Aldawood Rod Warburton Deniz Toksoz Nicholas S. Hill Dale D. Tang Usamah S. Kayyali | 2014 | Physiol2014，，10： | 1 |
| 8 | An improved technique of expanding metal ring experiment under high explosive loading显示文摘 | Tang Tiegang Ren Guowu Guo Zhaoliang | 2013 | Review of Scientific Instruments2013，84，： | 1 |
| 9 | Longitudinal propagation of fracture surface in cylindrical metal shells under explosive loading 显示文摘 | Hu Haibo Tang Tiegang Hu Bayi | 2007 | AIP Conference Proceedings2007，955，1： | 1 |
| 10 | Crystal and Molecular Structure of Mo_2[(μ_2-S)SCNEt_2]_2(S_2CNEt_2)_2显示文摘Crystal structure of the title complex was determined by X-ray diffraction method. It crystallizes in space group P21/n with cell dimensions:α=10. 041(5) , b=10. 719(4) , c= 1. 5671(6) nm, β=104. 36(3)°. The structure was solved by Patterson method. The final residual factor is R=0. 050. | Sun Chunting, Huang Qijun, Li Shuqin and Wang Tiegang(Department of Chemistry, Jilin University, Changchun)Zhang Guangren, Qu Xiangbang, Tang Zhongkun, He Guoqiang and Shen Yankui (Logistics Engineering Institute, Chongqing) Jin Zhongsheng and Wei Gecheng (Changchun Institute of Applied Chemistry, Changchun) | 1991 | Chemical Research in Chinese Universities1991，7，2： | 0 |
| 11 | Relating the composition of continental margin surface sediments from the Ross Sea to the Amundsen Sea,West Antarctica,to modern environmental conditions显示文摘Investigating the multiple proxies involving productivity,organic geochemistry,and trace element(TE)enrichment in surface sediments could be used as paleoenvironment archives to gain insights into past and future environmental conditions changes.We present redox-sensitive TEs(Mn,Ni,Cu,U,P,Mo,Co,V,Zn,and Cd),productivity-related proxies(total organic carbon and opal),and total nitrogen and CaCO_(3) contents of bulk surface sediments of this area.The productivity proxies from the shelf and coastal regions of the Ross and the Amundsen seas showed that higher productivity was affiliated with an area of nutrient-rich deep water upwelling.The upwelling of weakly corrosive deep water may be beneficial for preserving CaCO_(3),while highly corrosive dense water,if it forms on the shelf near the coastal region(coastal polynya),could limit the preservation of CaCO_(3) in modern conditions.There were no oxic or anoxic conditions in the study area,as indicated by the enrichment factors of redox-sensitive TEs(Mn,Co,and U).The enrichment factor of Cd,which is redox-sensitive,indicated suboxic redox conditions in sediment environments because of high primary productivity and organic matter preservation/decomposition.The enrichment factors of other redox-sensitive TEs(P,Ni,Cu,V,and Zn)and the correlations between the element/Ti ratio with productivity and nutrient proxies indicated that the organic matter decomposed,and there was massive burial of phytoplankton biomass.There was variation in the enrichment,such that sediments were enriched in P,Mo,and Zn,but depleted in Ni,Cu,and V. | WANG Jiakai LI Tiegang TANG Zheng XIONG Zhifang LIU Yanguang CHEN Zhihua CHANG Fengming | 2022 | Advances in Polar Science2022，33，1： | 0 |
| 12 | Calcification of planktonic foraminifer Neogloboquadrina pachyderma(sinistral) controlled by seawater temperature rather than ocean acidification in the Antarctic Zone of modern Sothern Ocean显示文摘Neogloboquadrina pachyderma(sinistral), the dominant planktonic foraminiferal species in the mid-to-high latitude oceans, represents a major component of local calcium carbonate(CaCO) production. However, the predominant factors,governing the calcification of this species and its potential response to the future marine environmental changes, are poorly understood. The present study utilized an improved cleaning method for the size-normalized weight(SNW) measurement to estimate the SNW of N. pachyderma(sin.) in surface sediments from the Amundsen Sea, the Ross Sea, and the Prydz Bay in the Antarctic Zone of the Southern Ocean. It was found that SNW of N. pachyderma(sin.) is not controlled by deep-water carbonate dissolution post-mortem, and can be therefore, used to reflect the degree of calcification. The comparison between N. pachyderma(sin.) SNW and environmental parameters(temperature, salinity, nutrient concentration, and carbonate system) in the calcification depth revealed that N. pachyderma(sin.) SNWs in the size ranges of 200–250, 250–300, and 300–355 μm are significantly and positively correlated with seawater temperature. Moreover, SNW would increase by ~30% per degree increase in temperature, thereby suggesting that the calcification of N. pachyderma(sin.) in the modern Antarctic Zone of the Southern Ocean is mainly controlled by temperature, rather than by other environmental parameters such as ocean acidification. Importantly, a potential increase in calcification of N. pachyderma(sin.) in the Antarctic Zone to produce CaCOwill release COinto the atmosphere. In turn, the future ocean warming will weaken the ocean carbon sink, thereby generating positive feedback for global warming. | Qianwei SONG Bingbin QIN Zheng TANG Yanguang LIU Zhihua CHEN Jingteng GUO Zhifang XIONG Tiegang LI | 2022 | Science China Earth Sciences2022，65，9： | 0 |
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