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| 1 | Percent free prostate-specific antigen for prostate cancer diagnosis in Chinese men with a PSA of 4.0-10.0 ng/mL:Results from the Chinese Prostate Cancer Consortium显示文摘Objective:To test the diagnostic performance of percent free prostate-specific antigen(%fPSA)in predicting any prostate cancer(PCa)and high-grade prostate cancer(HGPCa)in a retrospective multi-center biopsy cohort with a PSA level of 4.0e10.0 ng/mL in China.Methods:Consecutive patients with a PSA of 4.0-10.0 ng/mL who underwent transrectal ultrasound-guided biopsy were enrolled at 16 Chinese medical centers from January 1st,2010 to December 31st,2013.Total and free serum PSA determinations were performed using three types of electro-chemiluminescence immunoassays recalibrated to the World Health Organization(WHO)standard.The diagnostic accuracy of PSA,%fPSA,and %fPSA in combination with PSA(%fPSA t PSA)was determined using the area under the receiver operating characteristic(ROC)curve(AUC).Results:A total of 2310 consecutive men with PSA levels between 4.0 and 10.0 ng/mL were included,and the detection rate of PCa was 25.1%.The AUC of%fPSA and %fPSA t PSA in predicting any PCa was superior to PSA alone in men aged≥60 years(0.623 vs.0.534,p<0.0001)but not in men aged 40e59 years(0.517 vs.0.518,p=0.939).Similar result was yield in predicting HGPCa.Conclusion:In a clinical setting of Chinese men with 4.0e10.0 ng/mL PSA undergoing initial prostate biopsy,adding %fPSA to PSA can moderately improve the diagnostic accuracy for any PCa and HGPCa compared with PSA alone in patients≥60 but not in patients aged 40-59 years. | Rui Chen Liping Xie Xiaobing Cai Yiran Huang Liqun Zhou Lulin Ma Xu Gao Chuanliang Xu Shancheng Ren Pengfei Shao Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Li Lu Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tie Zhou Fubo Wang Biming He Yinghao Sun | 2015 | Asian Journal of Urology2015，2，2： | 8 |
| 2 | Mechanism of dust removal by a standing wave electric curtain显示文摘In this paper,the mechanisms of particle movement on an electric curtain are examined.Intermittent bursts in which particles leaping from a surface of an electric curtain are demonstrated both by numerical simulation and experimental observation.The hopping and surfing modes during particle removal are shown to depend on the particle electric charge and its initial position.The particles initially located on the top of electrode have a large electric charge tend to assume a hopping mode.Transverse movement of the particle initially located between the electrodes is analyzed,and the particle traps along the electric curtain surface are also observed. | SUN QiXia YANG NingNing CAI XiaoBing HU GengKai | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，6： | 4 |
| 3 | Neglected Rural Public Health Issue:The Case of Intestinal Roundworms显示文摘Despite increasing institutional and financial support,certain public health issues are still neglected by the Chinese Government.The present paper examines the soil-transmitted helminth(STH)infection and reinfection rates by conducting a survey on 1724 children in Guizhou Province,China.Our results indicate that 37.5 percent of children had been infected with one or more of the three types of tested STH.However,only 50.4 percent of children reported having taken deworming medicine during the 18-month period before the survey.Of those who reported being dewormed,34.6 percent tested positive for STH infections.Poverty and number of siblings are significantly and positively correlated with infection and reinfection,and parental education is significantly and negatively correlated with infection and reinfection.Given the ineffectiveness of treatment in these areas to date,for anthelmintic campaigns to actually succeed,China must pay more attention to locallevel incentives to improve children's health. | Linxiu Zhang Yingping Cai Xiaobing Wang Xiaochen Ma Alexis Medina D.Scott Smith Scott Rozelle | 2013 | China & World Economy2013，21，3： | 2 |
| 4 | Association of erythropoietin gene rs576236 polymorphism and risk of adrenal tumors in a Chinese population显示文摘Erythropoietin(EPO) is a circulating glycosylated protein hormone and has been implicated in the development and progression of non-hematopoietic tissue tumors.The objective of the present study was to determine if the EPO rs576236 polymorphism was associated with the risk of adrenal tumors.We genotyped the EPO rs576236 polymorphism in a case-control study of 288 adrenal tumor patients and 456 cancer-free controls by using the TaqMan method,and assessed the association between the polymorphism and the adrenal tumor risk by logistic regression.Furthermore,95%confidence interval(CI) was used to assess the genetic association between the polymorphism and the risk of adrenal tumor.Compared with the TT genotype,the TC genotype had a significantly increased risk of adrenal tumor[adjusted odds ratio(OR) = 1.24,95%CI = 1.12-2.22].Furthermore a significantly increased risk of adrenal tumor was found in the combined variant genotypes TC+CC compared with the TT genotype(adjusted OR = 1.17,95%CI = 1.12-2.21).Our present study suggests that the rs576236 polymorphism of EPO confers susceptibility to adrenal tumor in the Chinese population. | Chao Zhang Zhongxing Li Qiang Cao Chao Qin Hongzhou Cai Hai Zhou Jian Qian Xiaobing Ju Changjun Yin | 2014 | The Journal of Biomedical Research2014，28，6： | 2 |
| 5 | Experimental Study for Metamaterials Based on Dielectric Resonators and Wire Frame 显示文摘 | CAI Xiaobing ZHU Rui HU Gengkai | 2008 | Metamaterials2008，2，4： | 1 |
| 6 | Template-free synthesis of homogeneous yolk–shell TiO 2 hierarchical microspheres for high performance lithium ion batteries显示文摘 | Xiaobing Wang Yuanyuan Wang Lin Yang Kui Wang Xiangdong Lou Bibo Cai | 2014 | Journal of Power Sources2014，，： | 1 |
| 7 | AHR mediates the aflatoxin B1 toxicity associated with hepatocellular carcinoma显示文摘Aflatoxin exposure is a crucial factor in promoting the development of primary hepatocellular carcinoma(HCC)in individuals infected with the hepatitis virus.However,the molecular pathways leading to its bioactivation and subsequent toxicity in hepatocytes have not been well-defined.Here,we carried out a genome-wide CRISPR-Cas9 genetic screen to identify aflatoxin B1(AFB1)targets.Among the most significant hits was the aryl hydrocarbon receptor(AHR),a ligand-binding transcription factor regulating cell metabolism,differentiation,and immunity. | Qing Zhu Yarui Ma Junbo Liang Zhewen Wei Mo Li Ying Zhang Mei Liu Huan He Chunfeng Qu Jianqiang Cai Xiaobing Wang Yixin Zeng Yuchen Jiao | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 1 |
| 8 | Adjuvant effect enhancement of porcine interleukin-2 packaged into solid lipid nanoparticles显示文摘 | Guohua Chen Shuang Zeng Huaijie Jia Xiaobing He Yongxiang Fang Zhizhong Jing Xuepeng Cai | 2013 | Research in Veterinary Science2013，，： | 1 |
| 9 | Regeneration of functional sweat gland - like structures by transplanted differentiated bone marrow mesenchymal stem cells 显示文摘 | Sheng Zhiyong Fu Xiaobing Cai Sa | 2009 | Wound Rep Reg2009，17，42： | 1 |
| 10 | Aqueous-phase biphasic dehydroaromatization of bio-derived limonene into p -cymene by soluble Pd nanocluster catalysts显示文摘 | Chen Zhao Weijia Gan Xiaobing Fan Zhipeng Cai Paul J. Dyson Yuan Kou | 2008 | Journal of Catalysis2008，，2： | 1 |
| 11 | microRNA-143, down-regulated in osteosarcoma, promotes apoptosis andsuppresses tumorigenicity by targeting Bcl-2显示文摘 | Hao Zhang Xiaobing Cai Yang Wang Hao Tang Daki Tong Fang Ji | 2010 | Oncology Reports2010，，5： | 1 |
| 12 | Secure Transmission for NOMA Systems with Imperfect SIC显示文摘This paper investigates secure transmission for non-orthogonal multiple access(NOMA)systems where the imperfect successive interference cancellation(SIC)is considered at both legitimate users and eavesdropper(Eve).A power allocation scheme is designed for the legitimate users to mitigate the effect of the SIC error caused by imperfect SIC.For characterizing the secrecy performance of the NOMA system,the closed-form expressions for connection outage probability(COP),secrecy outage probability(SOP),and effective secrecy throughput(EST)are derived over Nakagami-m fading channels in both NOMA and benchmark orthogonal multiple access(OMA)systems.We also provide security and reliability trade-off results(SRT)for the users in the NOMA and OMA systems.Simulation results verify our analysis and show that the strong users achieve better secrecy performance but worse reliability performance and NOMA outperforms OMA in terms of SRT. | Zhongwu Xiang Xiaobing Tong Yueming Cai | 2020 | China Communications2020，17，11： | 1 |
| 13 | Matched-case comparison of neoadjuvant chemotherapy in patients with FIGO stage IB1-IIB cervical cancer to establish selection criteria显示文摘 | Ting Hu Shuang Li Yile Chen Jian Shen Xiong Li Kecheng Huang Ru Yang Li Wu Zhilan Chen Yao Jia Shaoshuai Wang Xiaodong Cheng Xiaobing Han Zhongqiu Lin Hui Xing Pengpeng Qu Hongbing Cai Xiaojie Song Xiaoyu Tian Hongbing Xu Jun Xu Qinghua Zhang Ling Xi Dong | 2012 | European Journal of Cancer2012，，15： | 1 |
| 14 | Etoposide,dexamethasone,and pegaspargase with sandwiched radiotherapy in early-stage natural killer/T-cell lymphoma:A randomized phase III study显示文摘Methotrexate,etoposide,dexamethasone,and pegaspargase(MESA)with sandwiched radiotherapy is known to be effective for early-stage extranodal natural killer/T-cell lymphoma,nasal type(NKTCL).We explored the efficacy and safety of reduced-intensity,non-intravenous etoposide,dexamethasone,and pegaspargase(ESA)with sandwiched radiotherapy.This multicenter,randomized,phase III trial enrolled patients aged between 14 and 70 years with newly diagnosed early-stage nasal NKTCL from 27 centers in China.Patients were randomly assigned(1:1)to receive ESA(pegaspargase 2,500 IU/m^(2)intramuscularly on day 1,etoposide 200 mg orally,and dexamethasone 40 mg orally on days 2–4)or MESA(methotrexate 1 g/m^(2)intravenously on day 1,etoposide 200 mg orally,and dexamethasone 40 mg orally on days 2–4,and pegaspargase 2,500 IU/m^(2)intramuscularly on day 5)regimen(four cycles),combined with sandwiched radiotherapy. | Huijuan Zhong Shu Cheng Xi Zhang Bing Xu Jiayi Chen Xufeng Jiang Jie Xiong Yu Hu Guohui Cui Juying Wei Wenbin Qian Xiaobing Huang Ming Hou Feng Yan Xin Wang Yongping Song Jianda Hu Yuanhua Liu Xuejun Ma Fei Li Chongyang Wu Junmin Chen Li Yu Ou Bai Jingyan Xu Zunmin Zhu Li Liu Xin Zhou Li Huang Yin Tong Ting Niu Depei Wu Hao Zhang Chaofu Wang Binshen Ouyang Hongmei Yi Qi Song Gang Cai Biao Li Jia Liu Zhifeng Li Rong Xiao Luqun Wang Yujie Jiang Yanyan Liu Xiaoyun Zheng Pengpeng Xu Hengye Huang Li Wang Saijuan Chen Weili Zhao | 2023 | The Innovation2023，4，3： | 0 |
| 15 | Correction: AHR mediates the Aflatoxin B1 toxicity associated with hepatocellular carcinoma显示文摘Correction to:Signal Transduction and Targeted Therapy http://gffzzd3cc09b8251d45dfsu55uk6cqubwc6f9u.ffgz.tsg.suse.edu.cn/10.1038/s41392-021-00713-1 z published online 9 August 2021 After online publication of the article^(1),the authors noticed one inadvertent mistake occurred during the production process in Fig.7 that needs to be corrected.The correct data are provided as follows.The key findings of the article are not affected by these corrections.The original article has been corrected. | Qing Zhu Yarui Ma Junbo Liang Zhewen Wei Mo Li Ying Zhang Mei Liu Huan He Chunfeng Qu Jianqiang Cai Xiaobing Wang Yixin Zeng Yuchen Jiao | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 0 |
| 16 | Habitat Suitability and Distribution Pattern Response to Global Climate Change in a Widespread Species,the Asiatic Toad(Bufo gargarizans)显示文摘The distribution and diversity of the species are closely related to the global climate.As the most widely distributed species of Bufonidae in China,the study of the distribution pattern and habitat suitability of the Asiatic toad under climate change can help us understand the reply pattern of Bufonidae habitat to climate change.Here,combined with the Maxent model and GIS technology,the effects of climate change on the distribution pattern and habitat suitability of the Asiatic toad were comprehensively analyzed.The results show that the rainfall during the wettest season(Bio16)and the mean temperature of the driest season(Bio9)have a considerable impact on the distribution of the Asiatic toad.In the next 30 to 50 years,across the overall spacial scale of the Chinese mainland,the habitat of the Asiatic toad will be primarily in the eastern part of China and less in south part,while its distribution area will expand to the midwest and northwest parts of China.Overall,the area in which it can be distributed will be reduced and suitable habitat will shift to some regions of higher latitude and elevation.In a word,we systematically analyzed the changes of the distribution pattern and habitat suitability of the Asiatic toad with climate change,and we aim to provide data on how climatic variation may impact amphibians. | Liuyang YANG Lixin HUANG Huabin ZHANG Pingshin LEE Naijing ZHANG Ruiqing CAI En LI Tao PAN Xiaobing WU | 2023 | Asian Herpetological Research2023，14，2： | 0 |
| 17 | Preparation and Characterization of an Intelligent Multitarget Tracking HA-RGD-CLB-QDs Drug Delivery System显示文摘This work aimed to develop an intelligent multi-target tracking hyaluronic acid-RGDchlorambucil-quantum dots(HA-RGD-CLB-QDs) drug delivery system. After deacetylated, hyaluronic acid was reacted with anticancer drug chlorambucil, RGD, and quantum dots to obtain the HA-RGD-CLB-QDs drug delivery system. The characterization by FT-IR, ~1 H NMR, TEM, XPS, DLS, and UV-vis absorption and fluorescence spectra show that the system is successfully constructed with an average particle size of about 70 nm. The results of the drug release profile show that that the system has a p H and enzyme sensitive controlled release behaviour. Moreover, cellular uptake and toxicity results show that the system has an ideal dual receptormediated endocytosis pathway that significantly enhances the efficacy of CLB tumor therapy and has a lower toxicity to normal cells.The system shows the potential application as a carrier for cancer therapy. | 吴峰政 徐海星 ZHU Zhihua LI Xin Lü Yahui MA Tian CAI Xinjie LI Rui WANG Xiaobing 许沛虎 | 2017 | Journal of Wuhan University of Technology(Materials Science)2017，32，6： | 0 |
| 18 | Tunable Fluid-Type Metasurface for Wide-Angle and Multifrequency Water-Air Acoustic Transmission显示文摘Efficient acoustic communication across the water-air interface remains a great challenge owing to the extreme acoustic impedance mismatch.Few present acoustic metamaterials can be constructed on the free air-water interface for enhancing the acoustic transmission because of the interface instability.Previous strategies overcoming this difficulty were limited in practical usage,as well as the wide-angle and multifrequency acoustic transmission.Here,we report a simple and practical way to obtain the wide-angle and multifrequency water-air acoustic transmission with a tunable fluid-type acoustic metasurface(FAM).The FAM has a transmission enhancement of acoustic energy over 200 times,with a thickness less than the wavelength in water by three orders of magnitude.The FAM can work at an almost arbitrary water-to-air incident angle,and the operating frequencies can be flexibly adjusted.Multifrequency transmissions can be obtained with multilayer FAMs.In experiments,the FAM is demonstrated to be stable enough for practical applications and has the transmission enhancement of over 20 dB for wide frequencies.The transmission enhancement of music signal across the water-air interface was performed to demonstrate the applications in acoustic communications.The FAM will benefit various applications in hydroacoustics and oceanography. | Zhandong Huang Shengdong Zhao Yiyuan Zhang Zheren Cai Zheng Li Junfeng Xiao Meng Su Qiuquan Guo Chuanzeng Zhang Yaozong Pan Xiaobing Cai Yanlin Song Jun Yang | 2022 | Research2022，，1： | 0 |
| 19 | How security bugs are fixed and what can be improved: an empirical study with Mozilla显示文摘Dear editor,A bug is regarded as security related when it creates vulnerability in the software,which the malicious attackers could exploit to attack the system [1].Security bugs widely exist in released software,and are serious threats to organizations,which can cause serious monetary loss and reputation damage.Therefore,addressing security bugs is a top priority in software maintenance [1]. | Xiaobing SUN Xin PENG Kai ZHANG Yang LIU Yuanfang CAI | 2019 | Science China(Information Sciences)2019，62，1： | 0 |
| 20 | Hyaluronic Acid-RGD Peptide Conjugated Mesoporous Silica-coated Gold Nanorods for Cancer Dual-targeted Chemo-photothermal Therapy显示文摘A multifunctional drug delivery system(GNRs@mSiO_2-HA-RGD) was developed by conjugating targeting ligand hyaluronic acid(HA) and RGD with mesoporous silica-coated gold nanorods(GNRs@mSiO_2) for dual-targeted chemo-photothermal therapy. The physiochemical properties of the prepared nanoparticles were characterized by FTIR, UV-vis spectra, and ~1H NMR. Doxorubicin hydrochloride(DOX), an anticancer drug, was used as the model drug to investigate the drug loading, in vitro drug release profiles and cytotoxicity. The experimental results show that DOX-GNRs@mSiO_2-HA-RGD is synthesized with a mean diameter of 116 nm and a sufficient load capacity of about 19.8%. It also has p H-enzyme sensitive and NIRtriggered drug release manner. Cellular uptake indicates that DOX-GNRs@mSiO_2-HA-RGD exhibits a higher cellular uptake via CD44 receptor and integrin receptor mediated endocytosis compared with the GNRs@mSiO_2 modified with one receptor or no receptor. In comparison with chemotherapy or photothermal therapy alone, DOX-GNRs@mSiO_2-HA-RGD displayes the synergistic effects and achieves a higher therapeutic efficacy. It can be expected that DOX-GNRs@mSiO_2-HA-RGD is a potential dual-targeted chemo-photothermal therapeutic platform for effective cancer treatment. | 周汇敏 高玉香 徐海星 LI Xin Lü Yahui MA Tian CAI Xinjie LI Rui WANG Xiaobing 许沛虎 | 2018 | Journal of Wuhan University of Technology(Materials Science)2018，33，2： | 0 |
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